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A First-In-Human Study of the SUMOylation Inhibitor Subasumstat in Patients with Advanced/Metastatic Solid Tumors or Relapsed/Refractory Hematologic Malignancies Juric, Dejan; Anderson, Daniel; Dowlati, Afshin; Rodon, Jordi; Lugowska, Iwona; Mandziuk, Slawomir; Song, Yuqin; Woei-A-Jin, Feng Jung Sherida H.; Andre, Marc; Tybor, Joanna Gora; Hernandez-Rivas, Jose-Angel; Kurzrock, Razelle; Lopez-Guillermo, Armando; Schroder, David; Stec, Rafal; Berger, Allison; Chao, Bo; Chudnovsky, Aleksander; Gibbs, John P.; Long, Tao; Stroopinsky, Dina; Dong, Qi; Olszanski, Anthony J. Share Save
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A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma Goyal, L.; DiToro, D.; Facchinetti, F.; Martin, E. E.; Peng, P.; Baiev, I.; Iyer, R.; Maurer, J.; Reyes, S.; Zhang, K.; Majeed, U.; Berchuck, J. E.; Chen, C. T.; Walmsley, C.; Pinto, C.; Vasseur, D.; Gordan, J. D.; Mody, K.; Borad, M.; Karasic, T.; Damjanov, N.; Danysh, B. P.; Wehrenberg-Klee, E.; Kambadakone, A. R.; Saha, S. K.; Hoffman, I. D.; Nelson, K. J.; Iyer, S.; Qiang, X.; Sun, C.; Wang, H.; Li, L.; Javle, M.; Lin, B.; Harris, W.; Zhu, A. X.; Cleary, J. M.; Flaherty, K. T.; Harris, T.; Shroff, R. T.; Leshchiner, I.; Parida, L.; Kelley, R. K.; Fan, J.; Stone, J. R.; Uboha, N. V.; Hirai, H.; Sootome, H.; Wu, F.; Bensen, D. C.; Hollebecque, A.; Friboulet, L.; Lennerz, J. K.; Getz, G.; Juric, D. Share Save
Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer Turner, N. C.; Im, S-A; Saura, C.; Juric, D.; Loibl, S.; Kalinsky, K.; Schmid, P.; Loi, S.; Sunpaweravong, P.; Musolino, A.; Li, H.; Zhang, Q.; Nowecki, Z.; Leung, R.; Thanopoulou, E.; Shankar, N.; Lei, G.; Stout, T. J.; Hutchinson, K. E.; Schutzman, J. L.; Song, C.; Jhaveri, K. L. Share Save
Financial toxicity in early-phase cancer clinical trial participants Durbin, Sienna M.; Lundquist, Debra; Pelletier, Andrea; Petrillo, Laura A.; Bame, Viola; Turbini, Victoria; Heldreth, Hope; Lynch, Kaitlyn; Boulanger, Mary; Lam, Anh; Mcintyre, Casandra; Ferrell, Betty R.; Jimenez, Rachel; Juric, Dejan; Nipp, Ryan D. Share Save
Paediatric strategy forum for medicinal product development of PI3-K, mTOR, AKT and GSK3β inhibitors in children and adolescents with cancer Pearson, Andrew D. J.; DuBois, Steven G.; Macy, Margaret E.; de Rojas, Teresa; Donoghue, Martha; Weiner, Susan; Knoderer, Holly; Bernardi, Ronald; Buenger, Vickie; Canaud, Guillaume; Cantley, Lewis; Chung, John; Fox, Elizabeth; Friend, John; Glade-Bender, Julia; Gorbatchevsky, Igor; Gore, Lia; Gupta, Abha; Hawkins, Douglas S.; Juric, Dejan; Lang, Leigh Anna; Leach, Danielle; Liaw, Danny; Lesa, Giovanni; Ligas, Franca; Lindberg, Gavin; Lindberg, Wendy; Ludwinski, Donna; Marshall, Lynley; Mazar, Andrew; McDonough, Joe; Nysom, Karsten; Urs, Christopher O.; Pappo, Alberto; Parsons, D. William; Rosenfeld, Amy; Scobie, Nicole; Smith, Malcolm; Taylor, Danielle; Weigel, Brenda; Weinstein, Amy; Karres, Dominik; Vassal, Gilles Share Save
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases Ferrer, Christina M.; Cho, Hyo Min; Boon, Ruben; Bernasocchi, Tiziano; Wong, Lai Ping; Cetinbas, Murat; Haggerty, Elizabeth R.; Mitsiades, Irene; Wojtkiewicz, Gregory R.; Mcloughlin, Daniel E.; Aboushousha, Reem; Abdelhamid, Hend; Kugel, Sita; Rheinbay, Esther; Sadreyev, Ruslan; Juric, Dejan; Janssen-Heininger, Yvonne M. W.; Mostoslavsky, Raul Share Save
Phase Ib dose-escalation trial of taselisib (GDC-0032) in combination with HER2-directed therapies in patients with advanced HER2 D breast cancer Grinshpun, A.; Ren, S.; Graham, N.; Demeo, M. K.; Wrabel, E.; Carter, J.; Tayob, N.; Pereslete, A.; Hamilton, E.; Juric, D.; Mayer, E. L.; Tolaney, S. M.; Krop, I. E.; Metzger, O. Share Save
Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors Chen, Jian Jenny; Vincent, Melanie Y.; Shepard, Dale; Peereboom, David; Mahalingam, Devalingam; Battiste, James; Patel, Manish R.; Juric, Dejan; Wen, Patrick Y.; Bullock, Andrea; Selfridge, Jennifer Eva; Pant, Shubham; Liu, Joyce; Li, Wendy; Fyfe, Susanne; Wang, Suming; Zota, Victor; Mahoney, James; Watnick, Randolph S.; Cieslewicz, Michael; Watnick, Jing Share Save
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis Thomas, Molly Fisher; Slowikowski, Kamil; Manakongtreecheep, Kasidet; Sen, Pritha; Samanta, Nandini; Tantivit, Jessica; Nasrallah, Mazen; Zubiri, Leyre; Smith, Neal P.; Tirard, Alice; Ramesh, Swetha; Arnold, Benjamin Y.; Nieman, Linda T.; Chen, Jonathan H.; Eisenhaure, Thomas; Pelka, Karin; Song, Yuhui; Xu, Katherine H.; Jorgji, Vjola; Pinto, Christopher J.; Sharova, Tatyana; Glasser, Rachel; Chan, Puiyee; Sullivan, Ryan J.; Khalili, Hamed; Juric, Dejan; Boland, Genevieve M.; Dougan, Michael; Hacohen, Nir; Li, Bo; Reynolds, Kerry L.; Villani, Alexandra-Chloe Share Save
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma Zhen, Yuanli; Liu, Kai; Shi, Lei; Shah, Simran; Xu, Qin; Ellis, Haley; Balasooriya, Eranga R.; Kreuzer, Johannes; Morris, Robert; Baldwin, Albert S.; Juric, Dejan; Haas, Wilhelm; Bardeesy, Nabeel Share Save
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations Varkaris, Andreas; de la Cruz, Ferran Fece; Martin, Elizabeth; Nordern, Bryanna; Chevalier, Nicholas; Leshchiner, Ignaty; Stavridi, Anastasia; Kim, Janice; Papatheodoridi, Alkistis; Gunaydin, Hakan; Danysh, Brian; Parida, Laxmi; Sanidas, Ioannis; Ji, Yongli; Lau, Kayao; Wulf, Gerburg; Bardia, Aditya; Spring, Laura; Isakoff, Steven; Lennerz, Jochen; Pierce, Levi; Pazolli, Ermira; Getz, Gad; Corcoran, Ryan; Juric, Dejan Share Save
Vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, plus palbociclib in ER-positive/human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer: phase 1b cohort Hamilton, Erika; Jeselsohn, Rinath; Hurvitz, Sara; Juric, Dejan; Han, Hyo; Telli, Melinda; Zahrah, George; Nanda, Rita; Zhang, Yuanyuan; Tan, Weiwei; Duperret, Elizabeth; Zhi, Eric; Mather, Cecile; Schott, Anne Share Save
Effect of Alpelisib Dose Modification for AE Management on Progression-Free Survival and Treatment Duration in SOLAR-1 and BYLieve Clinical Trials Rugo, Hope; Gennari, Alessandra; Chia, Stephen; Juric, Dejan; Vasan, Neil; Kuemmel, Sherko; Neven, Patrick; Lerebours, Florence; Ruiz-Borrego, Manuel; Razavi, Pedram; Singh, Jyotika; Chattar, Yogesh; Akdere, Murat; Ciruelos, Eva Share Save
INAVO121: Phase III study of inavolisib plus fulvestrant vs alpelisib plus fulvestrant in patients with hormone receptorpositive, HER2-negative, PIK3CAmutated locally advanced or metastatic breast cancer Juric, Dejan; Kalinsky, Kevin; Im, Seock-Ah; Ciruelos, Eva; Bianchini, Giampaolo; Barrios, Carlos; Jacot, William; Schmid, Peter; Loi, Sherene; Rugo, Hope; Craine, Veronica; Hutchinson, Katherine; Flechais, Aulde; Thanopoulou, Eirini; Harbeck, Nadia Share Save
A Phase.b Study of D-0502 as Monotherapy for Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer: Results from the Dose-Expansion Stage Wang, Jiayu; Sun, Tao; Zhang, Qingyuan; Shi, Yanxia; Wang, Xu; Chen, Yiding; Ouyang, Quchang; Li, Kunyan; Bupathi, Manojkumar; Edenfield, W. Jeffery; Silber, Andrea L. M.; Zong, Hong; Hamilton, Erika; Juric, Dejan; Lathrop, Kate; Zhang, Yihong; Stazzone, Kathryn; Shi, Zhe; Wang, Yaolin; Zhang, Ling; Xu, Binghe Share Save
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