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Leveraging paired germline and somatic analysis to improve the classification of DDX41 variants George, Andrew; Rolf, Elisabeth; Domeradzka, Monika; Ribeiro, Sara; Mills, Brittany; Hallett, April; Macmahon, Suzanne; Proszek, Paula; Shaikh, Ridwan; Yuan, Lina; Hubank, Michael; Petrizan, Mikel Valganon; Mcveigh, Terri P.; Khorashad, Jamshid S. Share Save
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BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial Torr, Bethany; Jones, Christopher; Kavanaugh, Grace; Hamill, Monica; Allen, Sophie; Choi, Subin; Garrett, Alice; Valganon-Petrizan, Mikel; MacMahon, Suzanne; Yuan, Lina; Way, Rosalind; Harder, Helena; Gold, Rochelle; Taylor, Amy; Gabe, Rhian; Lucassen, Anneke; Manchanda, Ranjit; Fallowfield, Lesley; Jenkins, Valerie; Gandhi, Ashu; Evans, D. Gareth; George, Angela; Hubank, Michael; Kemp, Zoe; Bremner, Stephen; Turnbull, Clare Share Save
Stratified Medicine Paediatrics2-advancing precision medicine in paediatric cancer Vedi, Aditi; George, Sally; Jacques, Thomas; Cortes-Ciriano, Isidro; Hubank, Michael; Beggs, Andrew; Cheang, Maggie; Porta, Nuria; Hutchinson, Ciaran; Hopkins, Louise; Bukhari, Amina; Barfoot, Regan; Clifford, Steve; O'Connor, David; Ritzmann, Timothy; Burke, Amos; Anderson, John; Hargrave, Darren; Chesler, Louis Share Save
The Stratified Medicine Paediatrics programme for cancers of childhood: Cell free DNA and serial tumour sequencing identifies subtype specific evolution and epigenetic states George, Sally L.; Lynn, Claire; Stankunaite, Reda; Hughes, Debbie; Chalker, Jane; Ahmed, Saira Waqar; Oostveen, Minou; Proszek, Paula; Yuan, Lina; Shaikh, Ridwan; Jamal, Sabri; Tall, Jennifer; Shipley, Janet; Tweddle, Deborah; Marshall, Lynley; Jones, Chris; Gatz, Susanne; Vedi, Aditi; Angelini, Paola; Anderson, John; Cresswell, George; Graham, Trevor A.; Al-Lazikani, Bissan; Kearns, Pamela; Hutchinson, J. Ciaran; Hargrave, Darren; Jacques, Thomas; Hubank, Michael; Sottoriva, Andrea; Chesler, Louis Share Save
Whole genome sequencing provides practice-changing benefits when performed on consecutive, unselected children with suspected cancer Hodder, Angus; Leiter, Sarah M.; Kennedy, Jonathan; Addy, Dilys; Ahmed, Munaza; Ajithkumar, Thankamma; Allinson, Kieren; Ancliff, Phil; Bailey, Shivani; Barnard, Gemma; Burke, G. A. Amos; Burns, Charlotte; Cano-Flanagan, Julian; Chalker, Jane; Coleman, Nicholas; Cheng, Danny; Clinch, Yasmin; Dryden, Caryl; Ghorashian, Sara; Griffin, Blanche; Horan, Gail; Hubank, Michael; May, Phillippa; McDerra, Joanna; Nagrecha, Rajvi; Nicholson, James; O'Connor, David; Pavasovic, Vesna; Quaegebeur, Annelies; Rao, Anupama; Roberts, Thomas; Samarasinghe, Sujith; Stasevich, Iryna; Tadross, John A.; Trayers, Claire; Trotman, Jamie; Vora, Ajay; Watkins, James; Chitty, Lyn S.; Bowdin, Sarah; Armstrong, Ruth; Murray, Matthew J.; Hook, Catherine E.; Tarpey, Patrick; Vedi, Aditi; Bartram, Jack; Behjati, Sam Share Save
The STAMPEDE2 niraparib-abiraterone acetate plus prednisolone trial: A phase III, randomised, open-label trial in patients with metastatic prostate cancer (mPC) with a deleterious alteration in a homologous recombination repair (HRR) gene starting androgen deprivation therapy (ADT) Howlett, S.; Kayani, M.; Brown, L. C.; Amos, C. L.; Dutey-Magni, P.; Yogeswaran, Y.; O'Shea, L.; Hogan, C.; Wingate, A.; Lall, S.; Eeles, R.; Hubank, M.; Williams, P.; Cross, W.; Sachdeva, A.; Clarke, N.; Parmar, M. K.; James, N. D.; Grist, E.; Attard, G. Share Save
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer Fernandez-Mateos, Javier; Cresswell, George D.; Trahearn, Nicholas; Webb, Katharine; Sakr, Chirine; Lampis, Andrea; Stuttle, Christine; Corbishley, Catherine M.; Stavrinides, Vasilis; Zapata, Luis; Spiteri, Inmaculada; Heide, Timon; Gallagher, Lewis; James, Chela; Ramazzotti, Daniele; Gao, Annie; Kote-Jarai, Zsofia; Acar, Ahmet; Truelove, Lesley; Proszek, Paula; Murray, Julia; Reid, Alison; Wilkins, Anna; Hubank, Michael; Eeles, Ros; Dearnaley, David; Sottoriva, Andrea Share Save
Benefits for children with suspected cancer from routine whole-genome sequencing Hodder, Angus; Leiter, Sarah M.; Kennedy, Jonathan; Addy, Dilys; Ahmed, Munaza; Ajithkumar, Thankamma; Allinson, Kieren; Ancliff, Phil; Bailey, Shivani; Barnard, Gemma; Burke, G. A. Amos; Burns, Charlotte; Cano-Flanagan, Julian; Chalker, Jane; Coleman, Nicholas; Cheng, Danny; Clinch, Yasmin; Dryden, Caryl; Ghorashian, Sara; Griffin, Blanche; Horan, Gail; Hubank, Michael; May, Phillippa; McDerra, Joanna; Nagrecha, Rajvi; Nicholson, James; O'Connor, David; Pavasovic, Vesna; Quaegebeur, Annelies; Rao, Anupama; Roberts, Thomas; Samarasinghe, Sujith; Stasevich, Iryna; Tadross, John A.; Trayers, Claire; Trotman, Jamie; Vora, Ajay; Watkins, James; Chitty, Lyn S.; Bowdin, Sarah; Armstrong, Ruth; Murray, Matthew J.; Hook, Catherine E.; Tarpey, Patrick; Vedi, Aditi; Bartram, Jack; Behjati, Sam Share Save
Longitudinal pro fi ling identi fi es co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer Harvey-Jones, E.; Raghunandan, M.; Robbez-Masson, L.; Magraner-Pardo, L.; Alaguthurai, T.; Yablonovitch, A.; Yen, J.; Xiao, H.; Brough, R.; Frankum, J.; Song, F.; Yeung, J.; Savy, T.; Gulati, A.; Alexander, J.; Kemp, H.; Starling, C.; Konde, A.; Marlow, R.; Cheang, M.; Proszek, P.; Hubank, M.; Cai, M.; Trendell, J.; Lu, R.; Liccardo, R.; Ravindran, N.; Llop-Guevara, A.; Rodriguez, O.; Balmana, J.; Lukashchuk, N.; Dorschner, M.; Drusbosky, L.; Roxanis, I.; Serra, V.; Haider, S.; Pettitt, S. J.; Lord, C. J.; Tutt, A. N. J. Share Save
Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction Gasparoli, Luca; Virely, Clemence; Tsakaneli, Alexia; Che, Noelia; Edwards, Darren; Bartram, Jack; Hubank, Michael; Pal, Deepali; Heidenreich, Olaf; Martens, Joost H. A.; de Boer, Jasper; Williams, Owen Share Save
BRCA-DIRECT: A randomised UK study evaluating a digital pathway for germline genetic testing and non-inferiority of digitally-delivered information in women with breast cancer Torr, B.; Choi, S.; Allen, S.; Hamill, M.; Kavanaugh, G.; MacMahon, S.; Poyastro-Pearson, E.; Yuan, L.; Valganon-Petrizan, M.; George, A.; Jenkins, V. A.; Fallowfield, L.; Manchanda, R.; Gandhi, A.; Evans, G.; Kemp, Z.; Hubank, M.; Turnbull, C. Share Save
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Bailey, Chris; Sanderson, Theo; Townsley, Hermaleigh; Goldman, Jacki; Black, James R. M.; Young, George; Goldstone, Robert; Fowler, Ashley S.; Ward, Sophia; Jackson, Deborah J.; Cubitt, Laura; Dearing, Vicky; O'Neil, Olga; Crawford, Marg; Snell, Daniel; Finadis, Makis; Edwards, Amelia; Perez-Lloret, Jimena; Gahir, Joshua; Carr, Edward J.; Riddell, Andy; Aitken, Jim; Ambrose, Karen; Sawyer, Chelsea; O'Reilly, Nicola; Caidan, Simon; Wu, Mary Y.; Walker, Philip A.; Hindmarsh, Steve; Howell, Michael; Jordan, Andrew; Fleming, James; Houlihan, Catherine; Nastouli, Eleni; Moores, Rachel; Hsu, Desmond; Papineni, Padmasayee; Corrah, Tumena; Gilson, Richard; MacRae, James; Hubank, Michael; Van As, Nicholas; Turajlic, Samra; Beale, Rupert; Levi, Marcel; Barrell, Sam; Williams, Bryan; Gamblin, Steve; Nicod, Jerome; Gandhi, Sonia; Bauer, David L., V; Wall, Emma C.; Swanton, Charles Share Save
Impact of pharmacogenomic DPYD variant guided dosing on toxicity in patients receiving fluoropyrimidines for gastrointestinal cancers in a high-volume tertiary centre Lau, David K.; Fong, Caroline; Arouri, Faten; Cortez, Lillian; Katifi, Hannah; Gonzalez-Exposito, Reyes; Razzaq, Muhammad Bilal; Li, Su; Macklin-Doherty, Aislinn; Hernandez, Monica Arenas; Hubank, Michael; Fribbens, Charlotte; Watkins, David; Rao, Sheela; Chau, Ian; Cunningham, David; Starling, Naureen Share Save
ctDNA guided adjuvant chemotherapy versus standard of care adjuvant chemotherapy after curative surgery in patients with high risk stage II or stage III colorectal cancer: a multi-centre, prospective, randomised control trial (TRACC Part C) Slater, Susanna; Bryant, Annette; Chen, Hsiang-Chi; Begum, Ruwaida; Rana, Isma; Aresu, Maria; Peckitt, Clare; Zhitkov, Oleg; Lazaro-Alcausi, Retchel; Borja, Victoria; Powell, Rachel; Lowery, David; Hubank, Michael; Rich, Thereasa; Anandappa, Gayathri; Chau, Ian; Starling, Naureen; Cunningham, David Share Save
Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with moderate- and high-risk early-stage triple-negative breast cancer Turner, N. C.; Swift, C.; Jenkins, B.; Kilburn, L.; Coakley, M.; Beaney, M.; Fox, L.; Goddard, K.; Garcia-Murillas, I.; Proszek, P.; Hall, P.; Harper-Wynne, C.; Hickish, T.; Kernaghan, S.; Macpherson, I. R.; Okines, A. F. C.; Palmieri, C.; Perry, S.; Randle, K.; Snowdon, C.; Stobart, H.; Wardley, A. M.; Wheatley, D.; Waters, S.; Winter, M. C.; Hubank, M.; Allen, S. D.; Bliss, J. M. Share Save
Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma De Noon, Solange; Piggott, Robert; Trotman, Jamie; Tadross, John A.; Fittall, Matthew; Hughes, Debbie; Ye, Hongtao; Munasinghe, Emani; Murray, Matthew; Tirabosco, Roberto; Amary, Fernanda; Coleman, Nicholas; Watkins, James; Hubank, Michael; Tarpey, Patrick; Behjati, Sam; Flanagan, Adrienne M. Share Save
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