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SaveScalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet
Cardinal-David, Benoit; Shekhar, Shashank; Phillips, Eric M.; Swift, Elizabeth C.; Kotecki, Brian; Ickes, Andrew R.; Storer, Gregory E.; Caspi, Daniel D.; Verma, Anuj; Moschetta, Eric G.; Tao, Daniel; Morrill, Westin H.; Bellettini, John R.; Nordstrom, Fredrik L.; Mattei, Alessandra; Springer, Kirsten; Qiu, Haixiao; Bien, Jeffrey T.; Manjrekar, Onkar; Henry, Rodger F.; Wallace, Grier A.; Schaffter, Lisa; Voight, Eric A.
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SaveA Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC
Lee, Miseon; Wu, Jiang-Ping; Lee, Jaehee; Wang, Jun; White, Jada A. H.; Rugg, Kyle W.; Sienkiewicz, Alexander; Lorenz, Jon C.; Greb, Peter; Bunner, Matthew H.; Hirsh, David A.; Gonnella, Nina C.; Nordstrom, Fredrik L.; Kofink, Christiane; Weinstabl, Harald; Reeves, Jonathan T.
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SaveConcomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity Rejection
Nordstrom, Fredrik L.; Paolello, Mitchell; Yao, Na; Armiger, Travis; Jiang, Qi; Nicholson, James; Kratz, Joseph; Toresco, Michael; Lipp, Alexander; Witte, Swjatoslaw; Henry, Manuel; Shultz, C. Scott; Sirota, Eric; Capellades, Gerard
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SaveConcomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization - Part 2: Industrial Case Studies
Nordstrom, Fredrik L.; Paolello, Mitchell; Yao, Na; Armiger, Travis; Jiang, Qi; Nicholson, James; Kratz, Joseph; Toresco, Michael; Lipp, Alexander; Witte, Swjatoslaw; Henry, Manuel; Shultz, C. Scott; Sirota, Eric; Capellades, Gerard
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SavePrevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations
Nordstrom, Fredrik L.; Sirota, Eric; Hartmanshenn, Clara; Kwok, Thomas T.; Paolello, Mitchell; Li, Huayu; Abeyta, Vincent; Bramante, Tommasina; Madrigal, Emma; Behre, Taylor; Capellades, Gerard
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