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Adam Shlien

The Hospital for Sick Children

49H-index
480Paper Count
2.2WCitation Count
Published Papers 92
Publication Date
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Prior therapy defines mutation profiles in childhood cancer at relapse
errNature
IF48.5
err2026-07-22
err0
errOAAI
errMehdi Layeghifard; Marcos Díaz-Gay; Erik N. Bergstrom; Mathepan J. Mahendralingam; Nicholas Light; Sasha Blay; Joshua O. Nash; Nathaniel D. Anderson; Jessica N. Au; Scott Davidson; Pedro L. Ballester; Timmy Wen; Syed Kashif Daud; Lisa-Monique Edward; S. M. Ashiqul Islam; Azhar Khandekar; Burçak Otlu; Ledia Brunga; Rawan Hammad; Shimaa Nassif; Nirav H. Thacker; Tara Feltham; Noemi A. Fuentes-Bolanos; Marie Wong-Erasmus; Max F. Levine; Katherine E. Miller; Neerav N. Shukla; Michael D. Kinnaman; Dominik Glodzik; Carol Portwine; Sabrina Millson; Alexandra P. Zorzi; Mariam Mikhail; Conrad V. Fernandez; Laura Wheaton; Gunes Gundem; Andrew L. Kung; Uri Tabori; Chelsea Mayoh; Elli Papaemmanuil; Mark J. Cowley; David Malkin; Anita Villani; Ludmil B. Alexandrov; Adam Shlien
errShare
errSave
Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma
errNature Genetics
IF29
err2025-12-22
err0
PREAI
errNicholas R. Fernandez; Yuan Chang; Nuno M. Nunes; Jose R. Dimayacyac; Adrian Levine; Amit Ringel; Logine Negm; Ayse Bahar Ercan; Julian M. Hess; Olfat Ahmad; Caitlin Lee; Lucie Stengs; Vanessa Bianchi; Melissa Edwards; Sheradan Doherty; Jiil Chung; Liana Nobre; Julie Bennett; Andrew J. Dodgshun; David T. W. Jones; Stefan M. Pfister; Anita Villani; David Malkin; Vijay Ramaswamy; Annie Huang; Eric Bouffet; Melyssa Aronson; Peter B. Dirks; Adam Shlien; Gad Getz; Yosef E. Maruvka; Birgit Ertl-Wagner; Cynthia Hawkins; Anirban Das; Uri Tabori
errShare
errSave
Clinical utility of targeted RNA sequencing in cancer molecular diagnostics
errNature Medicine
IF50
err2025-07-17
err0
PREAI
errRobert Siddaway; Aida I. Glembocki; Anthony Arnoldo; Jordan Staunton; Anthony P. Y. Liu; Kyoko E. Yuki; Man Yu; Sarah Cohen-Gogo; Adam Shlien; Anita Villani; James A. Whitlock; Johann Hitzler; Uri Tabori; Adrian B. Levine; Anthea Lafrenière; Anita Nagy; Haiying Chen; Bo-Yee Ngan; Gino R. Somers; Mohamed Abdelhaleem; Rose Chami; Cynthia Hawkins
errShare
errSave
Assessing the diagnostic impact of blood transcriptome profiling in a pediatric cohort previously assessed by genome sequencing
errnpj Genomic Medicine
IF4.8
err2025-07-01
err0
PREAI
errHuayun Hou; Kyoko E. Yuki; Gregory Costain; Anna Szuto; Sierra Barnes; Arun K. Ramani; Alper Celik; Michael Braga; Meagan Gloven-Brown; Dimitri J. Stavropoulos; Sarah Bowdin; Ronald D. Cohn; Roberto Mendoza-Londono; Stephen W. Scherer; Michael Brudno; Christian R. Marshall; M. Stephen Meyn; Adam Shlien; James J. Dowling; Michael D. Wilson; Lianna Kyriakopoulou
errShare
errSave
DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition
errCELL REPORTS
IF6.9
err2025-04-01
err0
errOAAI
errHayes, Madeline N.; Cohen-Gogo, Sarah; Kee, Lynn; Xiong, Xueting; Weiss, Alex; Layeghifard, Mehdi; Ladumor, Yagnesh; Valencia-Sama, Ivette; Rajaselvam, Anisha; Kaplan, David R.; Villani, Anita; Shlien, Adam; Morgenstern, Daniel A.; Irwin, Meredith S.
errShare
errSave
Inter-chromosomal contacts demarcate genome topology along a spatial gradient
errNATURE COMMUNICATIONS
IF15.7
err2024-11-13
err0
errOAAI
errMokhtaridoost, Milad; Chalmers, Jordan J.; Soleimanpoor, Marzieh; McMurray, Brandon J.; Lato, Daniella F.; Nguyen, Son C.; Musienko, Viktoria; Nash, Joshua O.; Espeso-Gil, Sergio; Ahmed, Sameen; Delfosse, Kate; Browning, Jared W. L.; Barutcu, A. Rasim; Wilson, Michael D.; Liehr, Thomas; Shlien, Adam; Aref, Samin; Joyce, Eric F.; Weise, Anja; Maass, Philipp G.
errShare
errSave
Expansion of GATA1-Mutant Clones in Blood Samples of Patients with Transient Abnormal Myelopoiesis (TAM) during Clinical Follow up Heralds Transformation to Myeloid Leukemia Associated with Down Syndrome (ML-DS)
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errChen, Jian; Ripsman, Ryan; Vernier, Rose; Schwertschkow, Astra; Shlien, Adam; Hitzler, Johann K.
errShare
errSave
Characterization of circulating tumor DNA in a pediatric oncology cohort and implementation into the SickKids Cancer Sequencing (KiCS) precision oncology program
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errCohen-Gogo, Sarah; Choi, Taegi; Ripsman, Ryan; Hudson, Matt; Fong, Sandy; Khan, Reem; Venier, Rosemarie E.; Charlinski, Tristan; Villani, Anita; Malkin, David; Shlien, Adam
errShare
errSave
Chemotherapy is a major mutagen in relapsed childhood cancer
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errLayeghifard, Mehdi; Light, Nicholas; Bergstrom, Erik; Gay, Marcos Diaz; Mahendralingam, Mathepan J.; Blay, Sasha; Davidson, Scott; Ballester, Pedro L.; Hammad, Rawan; Bolanos, Noemi Fuentes; Nassif, Shimaa; Thacker, Nirav H.; Mayoh, Chelsea; Malkin, David; Papaemmanuil, Elli; Cowley, Mark J.; Villani, Anita; Alexandrov, Ludmil B.; Shlien, Adam
errShare
errSave
Transcriptome-based assessment of immune infiltration for molecular selection of pediatric patients with solid tumors for combination immune checkpoint inhibitor therapy
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errShen, Yaoqing; Mayoh, Chelsea; Nabbi, Arash; Santiago, Raoul; Bianco, Stephanie; Bancarz, Iain R.; Williamson, Laura; Corbett, Richard; Krekhno, Zakhar; Davidson, Scott; Fortuna, Alexander; Yuki, Kyoko E.; Connolly, Denise; Morgenstern, Daniel; Ekert, Paul G.; Shlien, Adam; Jones, Steven J. M.; Deyell, Rebecca J.; Cohen-Gogo, Sarah
errShare
errSave
A transcriptional atlas provides a universal diagnostic platform for mesenchymal tumors and validation of preclinical models
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errNash, Joshua O.; Ballestar, Pedro L.; Davidson, Scott; Schwertschkow, Astra; Babichev, Yael; Lees, Jodi; Alon, Noa; Gokgoz, Nalan; Yu, Stephen M.; Yuki, Kyoko; Lorenti, Miranda; Liu, Zhanqin; McGoey, Alaina; Spatare, Famida; Castro, Bernard; Tsoi, Kim; Peretz-Soroka, Hagit; Brzezinski, Jack; Villani, Anita; Razaq, Albiruni; Gupta, Abha; Demicco, Elizabeth; Przybyl, Joanna; van de Rijn, Matt; Garzia, Livia; Wunder, Jay; Andrulis, Irene L.; Malkin, David; Chami, Rose; Dickson, Brendan C.; Gladdy, Rebecca A.; Shlien, Adam
errShare
errSave
Infant ALL without KMT2A rearrangements harbor clinically relevant alterations and share common origins with childhood ALL
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errZatzman, Matthew; Seelisch, Jennifer; Comitani, Federico; Fuligni, Fabio; Davidson, Scott; Yuki, Kyoko E.; Edwards, Lisa-Monique; Brunga, Ledia; Guest, Erin; Hunger, Stephen P.; Loh, Mignon L.; Raetz, Elizabeth A.; Chen, John; Bartram, Jack; Hitzler, Johann K.; Brown, Patrick A.; Gupta, Sumit; Shlien, Adam
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errSave
Timing the development of chemoresistance in relapsed pediatric cancer with mutational signatures
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errBlay, Sasha; Layeghifard, Mehdi; Davidson, Scott; Chen, David; Schwertschkow, Astra; Ramaswamy, Vijay; Taylor, Michael; Papaemmanuil, Elli; Villani, Anita; Malkin, David; Alexandrov, Ludmil; Cowley, Mark; Shlien, Adam
errShare
errSave
DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errHayes, Madeline N.; Cohen-Gogo, Sarah; Kee, Lynn; Layeghifard, Mehdi; Valencia-Sama, Ivette; Rajaselvam, Anisha; Kaplan, David; Villani, Anita; Shlien, Adam; Morgenstern, Daniel A.; Irwin, Meredith S.
errShare
errSave
LIBERTY: LIquid Biopsy for rElapsed/RefracTorY neuroblastoma - a pilot study of characterization of circulating tumor DNA alterations in patients with relapsed and refractory neuroblastoma using a clinically validated liquid biopsy platform
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errCohen-Gogo, Sarah; Revon-Riviere, Gabriel; Jegathisawaran, Jathishinie; Shlien, Adam; Villani, Anita; Irwin, Meredith; Morgenstern, Daniel A.
errShare
errSave
Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns
errNATURE COMMUNICATIONS
IF15.7
err2024-08-27
err0
errOAAI
errWong, Derek; Tageldein, Maha; Luo, Ping; Ensminger, Erik; Bruce, Jeffrey; Oldfield, Leslie; Gong, Haifan; Fischer, Nicholas William; Laverty, Brianne; Subasri, Vallijah; Davidson, Scott; Khan, Reem; Villani, Anita; Shlien, Adam; Kim, Raymond H.; Malkin, David; Pugh, Trevor J.
errShare
errSave
A systematic assessment of the impact of rare canonical splice site variants on splicing using functional and in silico methods
errHUMAN GENETICS AND GENOMICS ADVANCES
IF3.6
err2024-07-01
err4
errOAAI
errOh, Rachel Y.; Almail, Ali; Cheerie, David; Guirguis, George; Hou, Huayun; Yuki, Kyoko E.; Haque, Bushra; Thiruvahindrapuram, Bhooma; Marshall, Christian R.; Mendoza-Londono, Roberto; Shlien, Adam; Kyriakopoulou, Lianna G.; Walker, Susan; Dowling, James J.; Wilson, Michael D.; Costain, Gregory
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errSave
miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage
errPLOS GENETICS
IF3.7
err2024-05-28
err4
errOAAI
errPrykhozhij, Sergey V.; Ban, Kevin; Brown, Zane L.; Kobar, Kim; Wajnberg, Gabriel; Fuller, Charlotte; Chacko, Simi; Lacroix, Jacynthe; Crapoulet, Nicolas; Midgen, Craig; Shlien, Adam; Malkin, David; Berman, Jason N.
errShare
errSave
The Virtual Child
errCANCER DISCOVERY
IF33.3
err2024-04-04
err1
errOAAI
errGilbertson, Richard J.; Behjati, Sam; Boettcher, Anna-Lisa; Bronner, Marianne E.; Burridge, Matthew; Clausing, Henrick; Clifford, Harry; Danaher, Tracey; Donovan, Laura K.; Drost, Jarno; Eggermont, Alexander M. M.; Emerson, Chris; Flores, Mona G.; Hamerlik, Petra; Jabado, Nada; Jones, Andrew; Kaessmann, Henrick; Kleinman, Claudia L.; Kool, Marcel; Kutscher, Lena M.; Lindberg, Gavin; Linnane, Emily; Marioni, John C.; Maris, John M.; Monje, Michelle; Macaskill, Alexandra; Niederer, Steven; Northcott, Paul A.; Peeters, Elizabeth; Plieger-van Solkema, Willemijn; Preussner, Liane; Rios, Anne C.; Rippe, Karsten; Sandford, Peter; Sgourakis, Nikolaos G.; Shlien, Adam; Smith, Pete; Straathof, Karin; Sullivan, Patrick J.; Suva, Mario L.; Taylor, Michael D.; Thompson, Emma; Vento-Tormo, Roser; Wainwright, Brandon J.; Wechsler-Reya, Robert J.; Westermann, Frank; Winslade, Shannon; Al-Lazikani, Bissan; Pfister, Stefan M.
errShare
errSave
Timing the development of chemoresistance in relapsed pediatric cancer
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errBlay, Sasha; Layeghifard, Mehdi; Davidson, Scott; Chen, David; Schwertschkow, Astra; Ramaswamy, Vijay; Taylor, Michael; Papaemmanuil, Elli; Villani, Anita; Malkin, David; Alexandrov, Ludmil; Cowley, Mark; Shlien, Adam
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
G
Gad Getz
H-index: 248 · Papers: 1.8K
S
Steven J.M. Jones
H-index: 189 · Papers: 1.3K
M
Michael R. Stratton
H-index: 179 · Papers: 644
S
Stephen W. Scherer
H-index: 161 · Papers: 1.1K
P
P. Andrew Futreal
H-index: 159 · Papers: 1.3K
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