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Quantitative surfaceome profiling of high-risk medulloblastoma prioritizes the oncofetal antigen GPC2 for potent CAR-T cell therapy Usta, Diren; Gwynne, William; Suk, Yujin; Chen, Yiyun; Radosevic, Molly T.; Chernova, Daria; Delaidelli, Alberto; Feng, Yushen; Nasajpour, Emon; Trissal, Maria C.; Poetschke, Rebecca D.; Dunham, Christopher; Labanie, Louai; Van Der Lugt, Jasper; Nierkens, Stefan; Filbin, Mariella G.; Petritsch, Claudia K.; Sorensen, Poul; Ryan, Katherine J.; Venugopal, Chitra; Sotillo, Elena; Mackall, Crystal L.; Singh, Sheila K.; Heitzeneder, Sabine Share Save
HUMANIZED ANTI-CAR ANTIBODIES AFFECT DURABLE RESPONSE TO GD2-CAR T-CELLS IN DIFFUSE MIDLINE GLIOMA Chen, Yiyun; Song, Kun-Wei; Huang, Ying-Wen; Iswari, Nadya; Desai, Moksha; Ehlinger, Zachary; Daghagh, Hossein; Reynolds, Kevin; Mahdi, Jasia; Majzner, Robbie; Richards, Becky; Kamens, Jennifer; Barsan, Valentin; Campen, Cynthia; Partap, Sonia; Madhav, Divya; Moon, Jennifer; Baggott, Christina; Fujimoto, Michelle; Li, Amy; Jariwala, Sneha; Mavroukakis, Sharon; Egeler, Emily; Jacobs, Ashley; Erickson, Courtney; Kaur, Aanchal Preet; Soundaranayagi, Smriti; Rietberg, Skyler; Schultz, Liora; Davis, Kara; Feldman, Steven; Heitzeneder, Sabine; Yamada-Hunter, Sean; Sotillo, Elena; Good, Zinaida; Sahaf, Bita; Monje, Michelle; Ramakrishna, Sneha; Mackall, Crystal Share Save
SINGLE-CELL LANDSCAPE OF B7H3-CAR T THERAPY IN GLIOMA: MECHANISMS OF RESISTANCE AND SIGNATURES OF LONG-TERM RESPONSE Chen, Yiyun; Song, Kun-Wei; Desai, Moksha; Ehlinger, Zach; Daghagh, Hossein; Rietberg, Skyler; Feeney, Anne-Marie; Tanner, Kelly; Dyson, Kyle; Stockdale, Brian; Dhapola, Gaurav; Lohman, Claire; Patil, Sunita; Kuo, Adam; Good, Zinaida; Prabhu, Snehit; Kong, Katherine; Egeler, Emily; Beebe, Barbara; Carr, Casey; Mahdi, Jasia; Bertrand, Sophie; Iv, Michael; Threlkeld, Zachary; Charu, Vivek; Tunuguntla, Ramya; Therkelsen, Kate; Nagpal, Seema; Monje, Michelle; Scott, Brian; Li, Gordon; Lim, Michael; Sotillo, Elena; Sahaf, Bita; Ramakrishna, Sneha; Thomas, Reena; Mackall, Crystal Share Save
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GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency Guerrero, Justin A.; Klysz, Dorota D.; Chen, Yiyun; Malipatlolla, Meena; Lone, Jameel; Fowler, Carley; Stuani, Lucille; May, Audre; Bashti, Malek; Xu, Peng; Huang, Jing; Michael, Basil; Contrepois, Kevin; Dhingra, Shaurya; Fisher, Chris; Svensson, Katrin J.; Davis, Kara L.; Kasowski, Maya; Feldman, Steven A.; Sotillo, Elena; Mackall, Crystal L. Share Save
IKAROS mediates antigen escape following CD19-or CD22-targeted immunotherapies in r/r B-ALL Domizi, Pablo; Sarno, Jolanda; Jager, Astraea; Merchant, Milton; Pacheco, Kaithlen; Yamada-Hunter, Sean; Rotiroti, Maria Caterina; Liu, Yuxuan; Baskar, Reema; Reynolds, Warren; Sworder, Brian; Sahaf, Bita; Bendall, Sean; Mullighan, Charles; Alizadeh, Ash; Leahy, Allison; Myers, Regina; Grupp, Stephan; Majzner, Robbie; Barrett, David; Sotillo, Elena; Davis, Kara Share Save
The cytokine Meteorin-like inhibits anti-tumor CD8+T cell responses by disrupting mitochondrial function Jackson, Christopher M.; Pant, Ayush; Dinalankara, Wikum; Choi, John; Jain, Aanchal; Nitta, Ryan; Yazigi, Eli; Saleh, Laura; Zhao, Liang; Nirschl, Thomas R.; Kochel, Christina M.; Bergsneider, Brandon Hwa-Lin; Routkevitch, Denis; Patel, Kisha; Cho, Kwang Bog; Tzeng, Stephany; Neshat, Sarah Y.; Kim, Young-Hoon; Smith, Barbara J.; Ramello, Maria Cecilia; Sotillo, Elena; Wang, Xinnan; Green, Jordan J.; Bettegowda, Chetan; Li, Gordon; Brem, Henry; Mackall, Crystal L.; Pardoll, Drew M.; Drake, Charles G.; Marchionni, Luigi; Lim, Michael Share Save
Enhancing pediatric access to cell and gene therapies Mackall, Crystal L.; Bollard, Catherine M.; Goodman, Nancy; Carr, Casey; Gardner, Rebecca; Rouce, Rayne; Sotillo, Elena; Stoner, Rich; Urnov, Fyodor D.; Wayne, Alan S.; Park, Julie; Kohn, Donald B. Share Save
Lineage tracing defines responding CAR T cells in patients with B cell malignancies Good, Zinaida; Hamilton, Mark P.; Spiegel, Jay Y.; Desai, Moksha H.; Ehlinger, Zachary J.; Quinn, Patrick J.; Chen, Yiyun; Prabhu, Snehit; Chiou, Shin-Heng; Kurra, Sreevidya; Yang, Eric; Ozawa, Michael G.; Frank, Matthew J.; Muffly, Lori; Claire, Gursharan K.; Bharadwaj, Sushma; Dahiya, Saurabh; Kong, Katherine A.; Davis, Mark M.; Plevritis, Sylvia K.; Sotillo, Elena; Sahaf, Bita; Miklos, David B.; Mackall, Crystal L. Share Save
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Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing Balke-Want, Hyatt; Keerthi, Vimal; Gkitsas, Nikolaos; Mancini, Andrew G.; Kurgan, Gavin L.; Fowler, Carley; Xu, Peng; Liu, Xikun; Asano, Kyle; Patel, Sunny; Fisher, Christopher J.; Brown, Annie K.; Tunuguntla, Ramya H.; Patel, Shabnum; Sotillo, Elena; Mackall, Crystal L.; Feldman, Steven A. Share Save
Inosine endows CAR T cells with features of increased stemness and anti-tumor potency Klysz, Dorota; Freitas, Katie; Malipatlolla, Meena; Maier, Stefanie; Fowler, Carley; Labanieh, Louai; Stuani, Lucille; Daniel, Bence; Sandor, Katalin; Xu, Peng; Huang, Jing; Leruste, Amaury; Keerthi, Vimal; Gkitsas, Nikolaos; Patel, Shabnum; Arredondo-Guerrero, Justin; Fisher, Chris; Asano, Kyle; Patel, Sunny; Satpathy, Ansuman; Davis, Kara; Sotillo, Elena; Feldman, Steven; Mackall, Crystal Share Save
Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy Yamada-Hunter, Sean A.; Theruvath, Johanna; Radosevich, Molly T.; McIntosh, Brianna J.; Freitas, Katherine A.; Martinez-Velez, Naiara; Sotillo, Elena; Leruste, Amaury; Xu, Peng; Desai, Moksha H.; Sahaf, Bita; Banuelos, Allison; Wasserman, Savannah L.; Weissman, Irving L.; Cochran, Jennifer R.; Mackall, Crystal L. Share Save
Immune determinants of CAR-T expansion in solid tumor patients receiving GD2 CAR-T cell therapy Murty, Tara; Kaczanowska, Sabina; Alimadadi, Ahmad; Contreras, Cristina; Duault, Caroline; Balasubrahmanyan, Priyanka; Reynolds, Warren; Gutierrez, Norma; Baskar, Reema; Wu, Catherine; Michor, Franziska; Altreuter, Jennifer; Liu, Yang; Jhaveri, Aashna; Duong, Vandon; Anbunathan, Hima; Moravec, Radim; Hong, Joyce; Biswas, Roshni; Van Nostrand, Stephen; Lindsay, James; Pichavant, Mina; Sotillo, Elena; Sahaf, Bita; Bendall, Sean; Maecker, Holden; Highfill, Steven; Stroncek, David; Merchant, Melinda; Glod, John; Hedrick, Catherine; Mackall, Crystal; Ramakrishna, Sneha; Kaplan, Rosandra Share Save
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum Bagashev, Asen; Sotillo, Elena; Tang, Chih-Hang Anthony; Black, Kathryn L.; Perazzelli, Jessica; Seeholzer, Steven H.; Argon, Yair; Barrett, David M.; Grupp, Stephan A.; Hu, Chih-Chi Andrew; Thomas-Tikhonenko, Andrei Share Save
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum (vol 38, e00383-18, 2018) Bagashev, Asen; Sotillo, Elena; Tang, Chih-Hang Anthony; Black, Kathryn L.; Perazzelli, Jessica; Seeholzer, Steven H.; Argon, Yair; Barrett, David M.; Grupp, Stephan A.; Hu, Chih-Chi Andrew; Thomas-Tikhonenko, Andrei Share Save
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication Theruvath, Johanna; Menard, Marie; Smith, Benjamin A. H.; Linde, Miles H.; Coles, Garry L.; Dalton, Guillermo Nicolas; Wu, Wei; Kiru, Louise; Delaidelli, Alberto; Sotillo, Elena; Silberstein, John L.; Geraghty, Anna C.; Banuelos, Allison; Radosevich, Molly Thomas; Dhingra, Shaurya; Heitzeneder, Sabine; Tousley, Aidan; Lattin, John; Xu, Peng; Huang, Jing; Nasholm, Nicole; He, Andy; Kuo, Tracy C.; Sangalang, Emma R. B.; Pons, Jaume; Barkal, Amira; Brewer, Rachel E.; Marjon, Kristopher D.; Vilches-Moure, Jose G.; Marshall, Payton L.; Fernandes, Ricardo; Monje, Michelle; Cochran, Jennifer R.; Sorensen, Poul H.; Daldrup-Link, Heike E.; Weissman, Irving L.; Sage, Julien; Majeti, Ravindra; Bertozzi, Carolyn R.; Weiss, William A.; Mackall, Crystal L.; Majzner, Robbie G. Share Save
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NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity Richards, Rebecca M.; Zhao, Feifei; Freitas, Katherine A.; Parker, Kevin R.; Xu, Peng; Fan, Amy; Sotillo, Elena; Daugaard, Mads; Oo, Htoo Zarni; Liu, Jie; Hong, Wan-Jen; Sorensen, Poul H.; Chang, Howard Y.; Satpathy, Ansuman T.; Majzner, Robbie G.; Majeti, Ravindra; Mackall, Crystal L. Share Save
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