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Interpretable machine learning leverages proteomics to improve cardiovascular disease risk prediction and biomarker identification Climente-Gonzalez, Hector; Oh, Min; Chajewska, Urszula; Hosseini, Roya; Mukherjee, Sudipto; Gan, Wei; Traylor, Matthew; Hu, Sile; Fatemifar, Ghazaleh; Ghouse, Jonas; Del Villar, Paul Pangilinan; Vernet, Erik; Koelling, Nils; Du, Liang; Abraham, Robin; Li, Chuan; Howson, Joanna M. M. Share Save
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits Keaton, Jacob M.; Kamali, Zoha; Xie, Tian; Vaez, Ahmad; Williams, Ariel; Goleva, Slavina B.; Ani, Alireza; Evangelou, Evangelos; Hellwege, Jacklyn N.; Yengo, Loic; Young, William J.; Traylor, Matthew; Giri, Ayush; Zheng, Zhili; Zeng, Jian; Chasman, Daniel I.; Morris, Andrew P.; Caulfield, Mark J.; Hwang, Shih-Jen; Kooner, Jaspal S.; Conen, David; Attia, John R.; Morrison, Alanna C.; Loos, Ruth J. F.; Kristiansson, Kati; Schmidt, Reinhold; Hicks, Andrew A.; Pramstaller, Peter P.; Nelson, Christopher P.; Samani, Nilesh J.; Risch, Lorenz; Gyllensten, Ulf; Melander, Olle; Riese, Harriette; Wilson, James F.; Campbell, Harry; Rich, Stephen S.; Psaty, Bruce M.; Lu, Yingchang; Rotter, Jerome I.; Guo, Xiuqing; Rice, Kenneth M.; Vollenweider, Peter; Sundstrom, Johan; Langenberg, Claudia; Tobin, Martin D.; Giedraitis, Vilmantas; Luan, Jian'an; Tuomilehto, Jaakko; Kutalik, Zoltan; Ripatti, Samuli; Salomaa, Veikko; Girotto, Giorgia; Trompet, Stella; Jukema, J. Wouter; van der Harst, Pim; Ridker, Paul M.; Giulianini, Franco; Vitart, Veronique; Goel, Anuj; Watkins, Hugh; Harris, Sarah E.; Deary, Ian J.; van der Most, Peter J.; Oldehinkel, Albertine J.; Keavney, Bernard D.; Hayward, Caroline; Campbell, Archie; Boehnke, Michael; Scott, Laura J.; Boutin, Thibaud; Mamasoula, Chrysovalanto; Jarvelin, Marjo-Riitta; Peters, Annette; Gieger, Christian; Lakatta, Edward G.; Cucca, Francesco; Hui, Jennie; Knekt, Paul; Enroth, Stefan; De Borst, Martin H.; Polasek, Ozren; Concas, Maria Pina; Catamo, Eulalia; Cocca, Massimiliano; Li-Gao, Ruifang; Hofer, Edith; Schmidt, Helena; Spedicati, Beatrice; Waldenberger, Melanie; Strachan, David P.; Laan, Maris; Teumer, Alexander; Dorr, Marcus; Gudnason, Vilmundur; Cook, James P.; Ruggiero, Daniela; Kolcic, Ivana; Boerwinkle, Eric; Traglia, Michela; Lehtimaki, Terho; Raitakari, Olli T.; Johnson, Andrew D.; Newton-Cheh, Christopher; Brown, Morris J.; Dominiczak, Anna F.; Sever, Peter J.; Poulter, Neil; Chambers, John C.; Elosua, Roberto; Siscovick, David; Esko, Tonu; Metspalu, Andres; Strawbridge, Rona J.; Laakso, Markku; Hamsten, Anders; Hottenga, Jouke-Jan; de Geus, Eco; Morris, Andrew D.; Palmer, Colin N. A.; Nolte, Ilja M.; Milaneschi, Yuri; Marten, Jonathan; Wright, Alan; Zeggini, Eleftheria; Howson, Joanna M. M.; O'Donnell, Christopher J.; Spector, Tim; Nalls, Mike A.; Simonsick, Eleanor M.; Liu, Yongmei; van Duijn, Cornelia M.; Butterworth, Adam S.; Danesh, John N.; Menni, Cristina; Wareham, Nicholas J.; Khaw, Kay-Tee; Sun, Yan V.; Wilson, Peter W. F.; Cho, Kelly; Visscher, Peter M.; Denny, Joshua C.; Levy, Daniel; Edwards, Todd L.; Munroe, Patricia B.; Snieder, Harold; Warren, Helen R. Share Save
Hepatocyte mARC1 promotes fatty liver disease Lewis, Lara C.; Chen, Lingyan; Hameed, L. Shahul; Kitchen, Robert R.; Maroteau, Cyrielle; Nagarajan, Shilpa R.; Norlin, Jenny; Daly, Charlotte E.; Szczerbinska, Iwona; Hjuler, Sara Toftegaard; Patel, Rahul; Livingstone, Eilidh J.; Durrant, Tom N.; Wondimu, Elisabeth; BasuRay, Soumik; Chandran, Anandhakumar; Lee, Wan-Hung; Hu, Sile; Gilboa, Barak; Grandi, Megan E.; Toledo, Enrique M.; Erikat, Abdullah H. A.; Hodson, Leanne; Haynes, William G.; Pursell, Natalie W.; Coppieters, Ken; Fleckner, Jan; Howson, Joanna M. M.; Andersen, Birgitte; Ruby, Maxwell A. Share Save
Prognostic modelling of clinical outcomes after first-time acute coronary syndrome in New Zealand Earle, Nikki J.; Poppe, Katrina K.; Rolleston, Anna; Pilbrow, Anna; Aish, Sara; Bradbury, Kathryn; Choi, Yeunhyang; Devlin, Gerry; Gladding, Patrick A.; Grey, Corina; Harrison, Wil; Henare, Kimiora; Howson, Joanna; Kerr, Andrew; Lumley, Thomas; Pera, Vijaya; Porter, Graeme; Stewart, Ralph; Troughton, Richard W.; Wihongi, Helen; Richards, A. Mark; Cameron, Vicky A.; Legget, Malcolm E.; Doughty, Robert N. Share Save
Rare and common genetic determinants of metabolic individuality and their effects on human health Surendran, Praveen; Stewart, Isobel D.; Yeung, Victoria P. W. Au; Pietzner, Maik; Raffler, Johannes; Worheide, Maria A.; Li, Chen; Smith, Rebecca F.; Wittemans, Laura B. L.; Bomba, Lorenzo; Menni, Cristina; Zierer, Jonas; Rossi, Niccolo; Sheridan, Patricia A.; Watkins, Nicholas A.; Mangino, Massimo; Hysi, Pirro G.; Di Angelantonio, Emanuele; Falchi, Mario; Spector, Tim D.; Soranzo, Nicole; Michelotti, Gregory A.; Arlt, Wiebke; Lotta, Luca A.; Denaxas, Spiros; Hemingway, Harry; Gamazon, Eric R.; Howson, Joanna M. M.; Wood, Angela M.; Danesh, John; Wareham, Nicholas J.; Kastenmueller, Gabi; Fauman, Eric B.; Suhre, Karsten; Butterworth, Adam S.; Langenberg, Claudia Share Save
Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke Chen, Lingyan; Peters, James E.; Prins, Bram; Persyn, Elodie; Traylor, Matthew; Surendran, Praveen; Karthikeyan, Savita; Yonova-Doing, Ekaterina; Di Angelantonio, Emanuele; Roberts, David J.; Watkins, Nicholas A.; Ouwehand, Willem H.; Danesh, John; Lewis, Cathryn M.; Bronson, Paola G.; Markus, Hugh S.; Burgess, Stephen; Butterworth, Adam S.; Howson, Joanna M. M. Share Save
Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications Tomaszewski, Maciej; Morris, Andrew P.; Howson, Joanna M. M.; Franceschini, Nora; Eales, James M.; Xu, Xiaoguang; Dikalov, Sergey; Guzik, Tomasz J.; Humphreys, Benjamin D.; Harrap, Stephen; Charchar, Fadi J. Share Save
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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus (vol 13, 1222, 2022) Stacey, David; Chen, Lingyan; Stanczyk, Paulina J.; Howson, Joanna M. M.; Mason, Amy M.; Burgess, Stephen; MacDonald, Stephen; Langdown, Jonathan; McKinney, Harriett; Downes, Kate; Farahi, Neda; Peters, James E.; Basu, Saonli; Pankow, James S.; Tang, Weihong; Pankratz, Nathan; Sabater-Lleal, Maria; de Vries, Paul S.; Smith, Nicholas L.; Dehghan, Abbas; Dehghan, Abbas; Heath, Adam S.; Morrison, Alanna C.; Reiner, Alex P.; Johnson, Andrew; Richmond, Anne; Peters, Annette; van Hylckama Vlieg, Astrid; McKnight, Barbara; Psaty, Bruce M.; Hayward, Caroline; Ward-Caviness, Cavin; O'Donnell, Christopher; Chasman, Daniel; Strachan, David P.; Tregouet, David A.; Mook-Kanamori, Dennis; Gill, Dipender; Thibord, Florian; Asselbergs, Folkert W.; Leebeek, Frank W. G.; Rosendaal, Frits R.; Davies, Gail; Homuth, Georg; Temprano, Gerard; Campbell, Harry; Taylor, Herman A.; Bressler, Jan; Huffman, Jennifer E.; Rotter, Jerome I.; Yao, Jie; Wilson, James F.; Bis, Joshua C.; Hahn, Julie M.; Desch, Karl C.; Wiggins, Kerri L.; Raffield, Laura M.; Bielak, Lawrence F.; Yanek, Lisa R.; Kleber, Marcus E.; Mueller, Martina; Kavousi, Maryam; Mangino, Massimo; Conomos, Matthew P.; Liu, Melissa; Brown, Michael R.; Jhun, Min-A; Chen, Ming-Huei; de Maat, Moniek P. M.; Peyser, Patricia A.; Elliot, Paul; Wei, Peng; Wild, Philipp S.; Morange, Pierre E.; van der Harst, Pim; Yang, Qiong; Le, Ngoc-Quynh; Marioni, Riccardo; Li, Ruifang; Damrauer, Scott M.; Cox, Simon R.; Trompet, Stella; Felix, Stephan B.; Volker, Uwe; Koenig, Wolfgang; Jukema, J. Wouter; Guo, Xiuqing; Gelinas, Amy D.; Schneider, Daniel J.; Janjic, Nebojsa; Samani, Nilesh J.; Ye, Shu; Summers, Charlotte; Chilvers, Edwin R.; Danesh, John; Paul, Dirk S. Share Save
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus Stacey, David; Chen, Lingyan; Stanczyk, Paulina J.; Howson, Joanna M. M.; Mason, Amy M.; Burgess, Stephen; MacDonald, Stephen; Langdown, Jonathan; McKinney, Harriett; Downes, Kate; Farahi, Neda; Peters, James E.; Bas, Saonli; Pankowf, James S.; Tang, Weihong; Pankratz, Nathan; Sabater-Llear, Maria; de Vries, Paul S.; Smith, Nicholas L.; Gelinas, Amy D.; Schneider, Daniel J.; Janjic, Nebojsa; Samani, Nilesh J.; Ye, Shu; Summers, Charlotte; Chilvers, Edwin R.; Danesh, John; Paul, Dirk S. Share Save
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Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases Cai, Na; Gomez-Duran, Aurora; Yonova-Doing, Ekaterina; Kundu, Kousik; Burgess, Annette, I; Golder, Zoe J.; Calabrese, Claudia; Bonder, Marc J.; Camacho, Marta; Lawson, Rachael A.; Li, Lixin; Williams-Gray, Caroline H.; Di Angelantonio, Emanuele; Roberts, David J.; Watkins, Nick A.; Ouwehand, Willem H.; Butterworth, Adam S.; Stewart, Isobel D.; Pietzner, Maik; Wareham, Nick J.; Langenberg, Claudia; Danesh, John; Walter, Klaudia; Rothwell, Peter M.; Howson, Joanna M. M.; Stegle, Oliver; Chinnery, Patrick F.; Soranzo, Nicole Share Save
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure Daghlas, Iyas; Karhunen, Ville; Ray, Devleena; Zuber, Verena; Burgess, Stephen; Tsao, Philip S.; Lynch, Julie A.; Lee, Kyung Min; Voight, Benjamin F.; Chang, Kyong-Mi; Baker, Emma H.; Damrauer, Scott M.; Howson, Joanna M. M.; Vujkovic, Marijana; Gill, Dipender Share Save
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020) Surendran, Praveen; Feofanova, Elena V.; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T.; Cartwright, James H.; Hellwege, Jacklyn N.; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J.; Prins, Bram P.; Stewart, Isobel D.; Cabrera, Claudia P.; Eales, James M.; Akbarov, Artur; Auer, Paul L.; Bielak, Lawrence F.; Bis, Joshua C.; Braithwaite, Vickie S.; Brody, Jennifer A.; Daw, E. Warwick; Warren, Helen R.; Drenos, Fotios; Nielsen, Sune Fallgaard; Faul, Jessica D.; Fauman, Eric B.; Fava, Cristiano; Ferreira, Teresa; Foley, Christopher N.; Franceschini, Nora; Gao, He; Giannakopoulou, Olga; Giulianini, Franco; Gudbjartsson, Daniel F.; Guo, Xiuqing; Harris, Sarah E.; Havulinna, Aki S.; Helgadottir, Anna; Huffman, Jennifer E.; Hwang, Shih-Jen; Kanoni, Stavroula; Kontto, Jukka; Larson, Martin G.; Li-Gao, Ruifang; Lindstrom, Jaana; Lotta, Luca A.; Lu, Yingchang; Luan, Jian'an; Mahajan, Anubha; Malerba, Giovanni; Masca, Nicholas G. D.; Mei, Hao; Menni, Cristina; Mook-Kanamori, Dennis O.; Mosen-Ansorena, David; Muller-Nurasyid, Martina; Pare, Guillaume; Paul, Dirk S.; Perola, Markus; Poveda, Alaitz; Rauramaa, Rainer; Richard, Melissa; Richardson, Tom G.; Sepulveda, Nuno; Sim, Xueling; Smith, Albert V.; Smith, Jennifer A.; Staley, James R.; Stanakova, Alena; Sulem, Patrick; Theriault, Sebastien; Thorsteinsdottir, Unnur; Trompet, Stella; Varga, Tibor V.; Velez Edwards, Digna R.; Veronesi, Giovanni; Weiss, Stefan; Willems, Sara M.; Yao, Jie; Young, Robin; Yu, Bing; Zhang, Weihua; Zhao, Jing-Hua; Zhao, Wei; Zhao, Wei; Evangelou, Evangelos; Aeschbacher, Stefanie; Asllanaj, Eralda; Blankenberg, Stefan; Bonnycastle, Lori L.; Bork-Jensen, Jette; Brandslund, Ivan; Braund, Peter S.; Burgess, Stephen; Cho, Kelly; Christensen, Cramer; Connell, John; de Mutsert, Renee; Dominiczak, Anna F.; Dorr, Marcus; Eiriksdottir, Gudny; Farmaki, Aliki-Eleni; Gaziano, J. Michael; Grarup, Niels; Grove, Megan L.; Hallmans, Goran; Hansen, Torben; Have, Christian T.; Heiss, Gerardo; Jorgensen, Marit E.; Jousilahti, Pekka; Kajantie, Eero; Kamat, Mihir; Karajamaki, AnneMari; Karpe, Fredrik; Koistinen, Heikki A.; Kovesdy, Csaba P.; Kuulasmaa, Kari; Laatikainen, I; Lannfelt, Lars; Lee, I-Te; Lee, Wen-Jane; Linneberg, Allan; Martin, Lisa W.; Moitry, Marie; Nadkarni, Girish; Neville, Matt J.; Palmer, Colin N. A.; Papanicolaou, George J.; Pedersen, Oluf; Peters, James; Poulter, Neil; Rasheed, Asif; Rasmussen, Katrine L.; Rayner, N. William; Magi, Reedik; Renstrom, Frida; Rettig, Rainer; Rossouw, Jacques; Schreiner, Pamela J.; Sever, Peter S.; Sigurdsson, Emil L.; Skaaby, Tea; Sun, Yan V.; Sundstrom, Johan; Thorgeirsson, Gudmundur; Esko, Tonu; Trabetti, Elisabetta; Tsao, Philip S.; Tuomi, Tiinamaija; Turner, Stephen T.; Tzoulaki, Ioanna; Vaartjes, Ilonca; Vergnaud, Anne-Claire; Willer, Cristen J.; Wilson, Peter W. F.; Witte, Daniel R.; Yonova-Doing, Ekaterina; Zhang, He; Aliya, Naheed; Almgren, Peter; Amouyel, Philippe; Asselbergs, Folkert W.; Barnes, Michael R.; Blakemore, Alexandra I.; Boehnke, Michael; Bots, Michiel L.; Bottinger, Erwin P.; Buring, Julie E.; Chambers, John C.; Chen, Yii-Der Ida; Chowdhury, Rajiv; Conen, David; Correa, Adolfo; Davey Smith, George; Boer, Rudolf A. de; Deary, Ian J.; Dedoussis, George; Deloukas, Panos; Di Angelantonio, Emanuele; Elliott, Paul; Felix, Stephan B.; Ferrieres, Jean; Ford, Ian; Fornage, Myriam; Franks, Paul W.; Franks, Stephen; Frossard, Philippe; Gambaro, Giovanni; Gaunt, Tom R.; Groop, Leif; Gudnason, Vilmundur; Harris, Tamara B.; Hayward, Caroline; Hennig, Branwen J.; Herzig, Karl-Heinz; Ingelsson, Erik; Tuomilehto, Jaakko; Jarvelin, Marjo-Riitta; Jukema, J. Wouter; Kardia, Sharon L. R.; Kee, Frank; Kooner, Jaspal S.; Kooperberg, Charles; Launer, Lenore J.; Lind, Lars; Loos, Ruth J. F.; Majumder, Abdulla al Shafi.; Laakso, Markku; McCarthy, Mark I.; Melander, Olle; Mohlke, Karen L.; Murray, Alison D.; Nordestgaard, Borge Gronne; Orho-Melander, Marju; Packard, Chris J.; Padmanabhan, Sandosh; Palmas, Walter; Polasek, Ozren; Porteous, David J.; Prentice, Andrew M.; Province, Michael A.; Relton, Caroline L.; Rice, Kenneth; Ridker, Paul M.; Rolandsson, Olov; Rosendaal, Frits R.; Rotter, Jerome I.; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Sattar, Naveed; Sheu, Wayne H. -H.; Smith, Blair H.; Soranzo, Nicole; Spector, Timothy D.; Starr, John M.; Sebert, Sylvain; Taylor, Kent D.; Lakka, Timo A.; Timpson, Nicholas J.; Tobin, Martin D.; van der Harst, Pim; van der Meer, Peter; Ramachandran, Vasan S.; Verweij, Niek; Virtamo, Jarmo; Volker, Uwe; Weir, David R.; Zeggini, Eleftheria; Charchar, Fadi J.; Wareham, Nicholas J.; Langenberg, Claudia; Tomaszewski, Maciej; Butterworth, Adam S.; Caulfield, Mark J.; Danesh, John; Edwards, Todd L.; Holm, Hilma; Hung, Adriana M.; Lindgren, Cecilia M.; Liu, Chunyu; Manning, Alisa K.; Morris, Andrew P.; Morrison, Alanna C.; O'Donnell, Christopher J.; Psaty, Bruce M.; Saleheen, Danish; Stefansson, Kari; Boerwinkle, Eric; Chasman, Daniel I.; Levy, Daniel; Newton-Cheh, Christopher; Munroe, Patricia B.; Howson, Joanna M. M. Share Save
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A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis Bell, Steven; Rigas, Andreas S.; Magnusson, Magnus K.; Ferkingstad, Egil; Allara, Elias; Bjornsdottir, Gyda; Ramond, Anna; Sorensen, Erik; Halldorsson, Gisli H.; Paul, Dirk S.; Eggertsson, Hannes P.; Burgdorf, Kristoffer S.; Howson, Joanna M. M.; Thorner, Lise W.; Kristmundsdottir, Snaedis; Astle, William J.; Erikstrup, Christian; Sigurdsson, Jon K.; Vuckovic, Dragana; Dinh, Khoa M.; Tragante, Vinicius; Surendran, Praveen; Pedersen, Ole B.; Vidarsson, Brynjar; Jiang, Tao; Paarup, Helene M.; Onundarson, Pall T.; Akbari, Parsa; Nielsen, Kaspar R.; Lund, Sigrun H.; Juliusson, Kristinn; Magnusson, Magnus, I; Frigge, Michael L.; Oddsson, Asmundur; Olafsson, Isleifur; Kaptoge, Stephen; Hjalgrim, Henrik; Runarsson, Gudmundur; Wood, Angela M.; Jonsdottir, Ingileif; Hansen, Thomas F.; Sigurdardottir, Olof; Stefansson, Hreinn; Rye, David; Peters, James E.; Westergaard, David; Holm, Hilma; Soranzo, Nicole; Banasik, Karina; Thorleifsson, Gudmar; Ouwehand, Willem H.; Thorsteinsdottir, Unnur; Roberts, David J.; Sulem, Patrick; Butterworth, Adam S.; Gudbjartsson, Daniel F.; Danesh, John; Brunak, Soren; Di Angelantonio, Emanuele; Ullum, Henrik; Stefansson, Kari Share Save
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