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I

I. Sadaf Farooqi

Addenbrooke's Hospital

105H-index
462Paper Count
5.6WCitation Count
Published Papers 170
Publication Date
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A Hormone Cell Atlas maps the human endocrine system at cellular resolution
errScience
IF45.8
err2026-05-28
err0
PREAI
errLijiang Fei; Isabel Huang-Doran; Katherine Lawler; Yizhou Yu; Jan Patrick Pett; Kevin M. Méndez-Acevedo; Dinesh Shah; Jaume Margalef-Rieres; Joseph S. Pohlman; Batuhan Cakir; Madelyn R. Moy; Robert G. Legg; Chuan Xu; Ken To; Duy Pham; Alexander V. Predeus; Ruth Hanssen; Tessa M. Cacciottolo; Rakesh K. Kapuge; Krzysztof Polanski; Amanda J. Oliver; Sarah A. Teichmann; I. Sadaf Farooqi
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Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance
errMolecular Metabolism
IF6.6
err2025-12-10
err0
errOAAI
errKatie Duckett; Alyce McClellan; Laura J. Corbin; Irene Cimino; Ahmed Elhakeem; Ana Goncalves Soares; Alice Williamson; Eloise Cross; Zammy Fairhurst-Hunter; Slave Petrovski; Debra Rimmington; Jesus Alegre-Diaz; Jaime Berumen; Pablo Kuri-Morales; Roberto Tapia-Conyer; Jacek Mokrosinski; I.Sadaf Farooqi; Asif Rasheed; Danish Saleheen; Adam S. Butterworth
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Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy
errOBESITY FACTS
IF4.7
err2025-11-01
err0
PREAI
errWiedemann, Urs C. H.; van den Akker, Erica L. T.; Barber, Thomas M.; Clement, Karine; Farooqi, Sadaf; Goldstone, Anthony P.; Haqq, Andrea M.; Marcus, Claude; Molnar, Denes; Moreno, Luis A.; Nadler, Evan P.; Poitou, Christine; Schorfheide, Jan Luca; Touchot, Nicolas; Wabitsch, Martin; Kuehnen, Peter
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Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites
errJournal of Biological Chemistry
IF3.9
err2025-10-22
err0
errOAAI
errAliki Perdikari; Virgil A. Woods; Ali Ebrahim; Katherine Lawler; Rebecca Bounds; Dinesh S. Shah; Nathanael I. Singh; Tamar (Skaist) Mehlman; Blake T. Riley; Shivani Sharma; Jackson W. Morris; Julia M. Keogh; Elana Henning; Miriam Smith; I.Sadaf Farooqi; Daniel A. Keedy
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Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
errNature Medicine
IF50
err2025-10-16
err0
errOAAI
errStefanie Zorn; Rebecca Bounds; Alice Williamson; Katherine Lawler; Ruth Hanssen; Julia Keogh; Elana Henning; Miriam Smith; Barbara A. Fielding; A. Margot Umpleby; Summaira Yasmeen; Maria Marti-Solano; Claudia Langenberg; Martin Wabitsch; Tinh-Hai Collet; I. Sadaf Farooqi
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Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response
errreviews in endocrine metabolic disorders
IF0
err2025-06-25
err0
errOAAI
errJesús Argente; Karine Clément; Jessica Duis; I. Sadaf Farooqi; Peter Kühnen; Jennifer L. Miller; Christian L. Roth; Erica van den Akker
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An appetite for research: an interview with Sadaf Farooqi
errDISEASE MODELS & MECHANISMS
IF3.3
err2025-04-28
err0
errOAAI
errFarooqi, Sadaf
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Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans
errScience
IF45.8
err2025-03-28
err0
PREAI
errNatalie J. Wallis; Alyce McClellan; Alexander Mörseburg; Katherine A. Kentistou; Aqfan Jamaluddin; Georgina K. C. Dowsett; Ellen Schofield; Anna Morros-Nuevo; Sadia Saeed; Brian Y. H. Lam; Natasha T. Sumanasekera; Justine Chan; Sambhavi S. Kumar; Rey M. Zhang; Jodie F. Wainwright; Marie Dittmann; Gabriella Lakatos; Kara Rainbow; David Withers; Rebecca Bounds; Marcella Ma; Alexander J. German; Jane Ladlow; David Sargan; Philippe Froguel; I. Sadaf Farooqi; Ken K. Ong; Giles S. H. Yeo; John A. Tadross; John R. B. Perry; Caroline M. Gorvin; Eleanor Raffan
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Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study
errJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
err2025-03-01
err0
errOAAI
errJia, Raina Y.; Lockhart, Sam; Lam, Brian Y. H.; Zhao, Yajie; Kentistou, Katherine A.; Gardner, Eugene J.; Farooqi, I. Sadaf; O'Rahilly, Stephen; Day, Felix R.; Ong, Ken K.; Perry, John R. B.
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A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-08-01
err0
errOAAI
errBaird, Harry J. M.; Shun-Shion, Amber S.; de Oliveira, Edson Mendes; Stalder, Daniele; Liang, Lu; Eden, Jessica; Chambers, Joseph E.; Farooqi, I. Sadaf; Gershlick, David C.; Fazakerley, Daniel J.
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An overview of benefits and risks of chronic melanocortin-1 receptor activation
errJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
IF8
err2024-07-31
err1
errOAAI
errBoehm, M.; Robert, C.; Malhotra, S.; Clement, K.; Farooqi, S.
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Understanding the genetic complexity of puberty timing across the allele frequency spectrum
errNATURE GENETICS
IF31.8
err2024-07-01
err3
errOAAI
errKentistou, Katherine A.; Kaisinger, Lena R.; Stankovic, Stasa; Vaudel, Marc; de Oliveira, Edson Mendes; Messina, Andrea; Walters, Robin G.; Liu, Xiaoxi; Busch, Alexander S.; Helgason, Hannes; Thompson, Deborah J.; Santoni, Federico; Petricek, Konstantin M.; Zouaghi, Yassine; Huang-Doran, Isabel; Gudbjartsson, Daniel F.; Bratland, Eirik; Lin, Kuang; Gardner, Eugene J.; Zhao, Yajie; Jia, Raina Y.; Terao, Chikashi; Riggan, Marjorie J.; Bolla, Manjeet K.; Yazdanpanah, Mojgan; Yazdanpanah, Nahid; Bradfield, Jonathan P.; Broer, Linda; Campbell, Archie; Chasman, Daniel I.; Cousminer, Diana L.; Franceschini, Nora; Franke, Lude H.; Girotto, Giorgia; He, Chunyan; Jarvelin, Marjo-Riitta; Joshi, Peter K.; Kamatani, Yoichiro; Karlsson, Robert; Luan, Jian'an; Lunetta, Kathryn L.; Magi, Reedik; Mangino, Massimo; Medland, Sarah E.; Meisinger, Christa; Noordam, Raymond; Nutile, Teresa; Concas, Maria Pina; Polasek, Ozren; Porcu, Eleonora; Ring, Susan M.; Sala, Cinzia; Smith, Albert V.; Tanaka, Toshiko; Van der Most, Peter J.; Vitart, Veronique; Wang, Carol A.; Willemsen, Gonneke; Zygmunt, Marek; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antoniou, Antonis C.; Auer, Paul L.; Barnes, Catriona L. K.; Beckmann, Matthias W.; de Gonzalez, Amy Berrington; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Buring, Julie E.; Canzian, Federico; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Crisponi, Laura; Czene, Kamila; Daly, Mary B.; Demerath, Ellen W.; Dennis, Joe; Devilee, Peter; De Vivo, Immaculata; Doerk, Thilo; Dunning, Alison M.; Dwek, Miriam; Eriksson, Johan G.; Fasching, Peter A.; Fernandez-Rhodes, Lindsay; Ferreli, Liana; Fletcher, Olivia; Gago-Dominguez, Manuela; Garcia-Closas, Montserrat; Garcia-Saenz, Jose A.; Gonzalez-Neira, Anna; Grallert, Harald; Guenel, Pascal; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Hakonarson, Hakon; Hart, Roger J.; Hickey, Martha; Hooning, Maartje J.; Hoppe, Reiner; Hopper, John L.; Hottenga, Jouke-Jan; Hu, Frank B.; Huebner, Hanna; Hunter, David J.; Jernstrom, Helena; John, Esther M.; Karasik, David; Khusnutdinova, Elza K.; Kristensen, Vessela N.; Lacey, James V.; Lambrechts, Diether; Launer, Lenore J.; Lind, Penelope A.; Lindblom, Annika; Magnusson, Patrik K. E.; Mannermaa, Arto; McCarthy, Mark I.; Meitinger, Thomas; Menni, Cristina; Michailidou, Kyriaki; Millwood, Iona Y.; Milne, Roger L.; Montgomery, Grant W.; Nevanlinna, Heli; Nolte, Ilja M.; Nyholt, Dale R.; Obi, Nadia; O'Brien, Katie M.; Offit, Kenneth; Oldehinkel, Albertine J.; Ostrowski, Sisse R.; Palotie, Aarno; Pedersen, Ole B.; Peters, Annette; Pianigiani, Giulia; Plaseska-Karanfilska, Dijana; Pouta, Anneli; Pozarickij, Alfred; Radice, Paolo; Rennert, Gad; Rosendaal, Frits R.; Ruggiero, Daniela; Saloustros, Emmanouil; Sandler, Dale P.; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Marjanka K.; Small, Kerrin; Spedicati, Beatrice; Stampfer, Meir; Stone, Jennifer; Tamimi, Rulla M.; Teras, Lauren R.; Tikkanen, Emmi; Turman, Constance; Vachon, Celine M.; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Zemel, Babette S.; Zheng, Wei; van Dijk, Ko W.; Alizadeh, Behrooz Z.; Bandinelli, Stefania; Boerwinkle, Eric; Boomsma, Dorret I.; Ciullo, Marina; Chenevix-Trench, Georgia; Cucca, Francesco; Esko, Tonu; Gieger, Christian; Grant, Struan F. A.; Gudnason, Vilmundur; Hayward, Caroline; Kolcic, Ivana; Kraft, Peter; Lawlor, Deborah A.; Martin, Nicholas G.; Nohr, Ellen A.; Pedersen, Nancy L.; Pennell, Craig E.; Ridker, Paul M.; Robino, Antonietta; Snieder, Harold; Sovio, Ulla; Spector, Tim D.; Stockl, Doris; Sudlow, Cathie; Timpson, Nic J.; Toniolo, Daniela; Uitterlinden, Andre; Ulivi, Sheila; Volzke, Henry; Wareham, Nicholas J.; Widen, Elisabeth; Wilson, James F.; Pharoah, Paul D. P.; Li, Liming; Easton, Douglas F.; Njolstad, Pal R.; Sulem, Patrick; Murabito, Joanne M.; Murray, Anna; Manousaki, Despoina; Juul, Anders; Erikstrup, Christian; Stefansson, Kari; Horikoshi, Momoko; Chen, Zhengming; Farooqi, I. Sadaf; Pitteloud, Nelly; Johansson, Stefan; Day, Felix R.; Perry, John R. B.; Ong, Ken K.
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Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
errNATURE GENETICS
IF31.8
err2024-04-04
err2
errOAAI
errZhao, Yajie; Chukanova, Maria; Kentistou, Katherine A.; Fairhurst-Hunter, Zammy; Siegert, Anna Maria; Jia, Raina Y.; Dowsett, Georgina K. C.; Gardner, Eugene J.; Lawler, Katherine; Day, Felix R.; Kaisinger, Lena R.; Tung, Yi-Chun Loraine; Lam, Brian Yee Hong; Chen, Hsiao-Jou Cortina; Wang, Quanli; Berumen-Campos, Jaime; Kuri-Morales, Pablo; Tapia-Conyer, Roberto; Alegre-Diaz, Jesus; Barroso, Ines; Emberson, Jonathan; Torres, Jason M.; Collins, Rory; Saleheen, Danish; Smith, Katherine R.; Paul, Dirk S.; Merkle, Florian; Farooqi, I. Sadaf; Wareham, Nick J.; Petrovski, Slave; O'Rahilly, Stephen; Ong, Ken K.; Yeo, Giles S. H.; Perry, John R. B.
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Classification of Congenital Leptin Deficiency
errJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
err2024-03-12
err2
errOAAI
errvon Schnurbein, Julia; Zorn, Stefanie; Nunziata, Adriana; Brandt, Stephanie; Moepps, Barbara; Funcke, Jan-Bernd; Hussain, Khalid; Farooqi, I. Sadaf; Fischer-Posovszky, Pamela; Wabitsch, Martin
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Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model
errSCIENCE ADVANCES
IF12.5
err2024-03-08
err1
errOAAI
errDittmann, Marie T.; Lakatos, Gabriella; Wainwright, Jodie F.; Mokrosinski, Jacek; Cross, Eloise; Farooqi, I. Sadaf; Wallis, Natalie J.; Halsey, Lewis G.; Wilson, Rory; O'Rahilly, Stephen; Yeo, Giles S. H.; Raffan, Eleanor
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Obesity and thinness: insights from genetics
errPHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
IF4.7
err2023-09-04
err1
errOAAI
errFarooqi, Sadaf
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errSave
High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor
errCELL REPORTS MEDICINE
IF10.6
err2023-09-01
err12
errOAAI
errSaeed, Sadia; Khanam, Roohia; Janjua, Qasim M.; Manzoor, Jaida; Ning, Lijiao; Hanook, Sharoon; Canouil, Mickael; Ali, Muhammad; Ayesha, Hina; Khan, Waqas I.; Farooqi, I. Sadaf; Yeo, Giles S. H.; O'Rahilly, Stephen; Bonnefond, Amelie; Butt, Taeed A.; Arslan, Muhammad; Froguel, Philippe
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Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity
errCELL GENOMICS
IF9
err2023-08-01
err12
errOAAI
errKaisinger, Lena R.; Kentistou, Katherine A.; Stankovic, Stasa; Gardner, Eugene J.; Day, Felix R.; Zhao, Yajie; Morseburg, Alexander; Carnie, Christopher J.; Zagnoli-Vieira, Guido; Puddu, Fabio; Jackson, Stephen P.; O'Rahilly, Stephen; Farooqi, I. Sadaf; Dearden, Laura; Pantaleao, Lucas C.; Ozanne, Susan E.; Ong, Ken K.; Perry, John R. B.
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The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium
errAMERICAN JOURNAL OF CLINICAL NUTRITION
IF6.9
err2023-07-01
err3
errOAAI
errBecetti, Imen; Bwenyi, Esther L.; de Araujo, Ivan E.; Ard, Jamy; Cryan, John F.; Farooqi, Ismaa Sadaf; Ferrario, Carrie R.; Gluck, Marci E.; Holsen, Laura M.; Kenny, Paul J.; Lawson, Elizabeth A.; Lowell, Bradford B.; Schur, Ellen A.; Stanley, Takara L.; Tavakkoli, Ali; Grinspoon, Steven K.; Singhal, Vibha
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Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity
errNEW ENGLAND JOURNAL OF MEDICINE
IF78.5
err2023-06-15
err14
errOAAI
errFuncke, Jan-Bernd; Moepps, Barbara; Roos, Julian; von Schnurbein, Julia; Verstraete, Kenneth; Froehlich-Reiterer, Elke; Kohlsdorf, Katja; Nunziata, Adriana; Brandt, Stephanie; Tsirigotaki, Alexandra; Dansercoer, Ann; Suppan, Elisabeth; Haris, Basma; Debatin, Klaus-Michael; Savvides, Savvas N.; Farooqi, I. Sadaf; Hussain, Khalid; Gierschik, Peter; Fischer-Posovszky, Pamela; Wabitsch, Martin
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Research Directions

No research directions
Co-authors
Cooperation Journals
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George Davey Smith
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Cornelia M. van Duijn
H-index: 238 · Papers: 1.9K
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Cyrus Cooper
H-index: 236 · Papers: 3.2K
A
André G. Uitterlinden
H-index: 234 · Papers: 2.0K
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Nicholas J. Wareham
H-index: 233 · Papers: 2.2K
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