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M

Marc Freichel

ruprechts-karl university heidelberg

62H-index
245Paper Count
1.1WCitation Count
Published Papers 117
Publication Date
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Sex-specific differences of amlexanox in a mouse model for atherosclerosis and MASLD
errMolecular Metabolism
IF6.6
err2026-07-21
err0
errOAAI
errEleonora Mungo; Michelle Haß; Denis Benning; Tobias Schmid; Silvia Kuntschar; Sofie P. Meyer; Lisa Hahnefeld; Erika Dorochow; Urs Christen; Edith Hintermann; Rebekka Medert; Marc Freichel; Gerd Geisslinger; Ellen Niederberger
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JPT2/HN1L functions as an NAADP-binding protein in a cell-type-specific manner
errCell Calcium
IF4
err2026-05-27
err0
errOAAI
errRoger Ottenheijm; Kai Winterberg; Vivien Throm; Michelle Malz; Merima Bukva; Volodymyr Tsvilovskyy; Rebekka Medert; Andreas H. Guse; Marc Freichel
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Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits
errRedox Biology
IF11.9
err2026-05-04
err0
errOAAI
errRajinikanth Gogiraju; Beichen Sun; Magdalena L. Bochenek; Ilka Wittig; Flávia Rezende; Melina Lopez; Angela Wirth; Wenjia Zhao; Elsa W. Böhm; Payal Guliani; Kateryna Moiko; Michael Molitor; Philip Wenzel; Marc Freichel; Philipp Lurz; Ralf P. Brandes; Katrin Schäfer
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Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure
errNature Communications
IF15.7
err2026-02-27
err0
errOAAI
errManju Kumari; Ioannis Evangelakos; Anushka Deshpande; Kirstie A. De Jong; Nesrin Schmiedel; Nicolàs Palacio-Escat; Adriano de Britto Chaves-Filho; Roberto Carlos Frias-Soler; Glynis Klinke; Hyun Cheol Roh; Luisa Lange; Michael Berlin; Marceline M. Fuh; Jakob Johannes Buss; Tian Tian; Carolin Lerchenmüller; Marc Freichel; Almut Schulze; Viacheslav O. Nikolaev; Thomas Eschenhagen; Evan D. Rosen; Ludger Scheja; Ashraf Yusuf Rangrez; Joerg Heeren; Norbert Frey
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ABE9 fused to SpRY Cas9 nickase enables precise generation of bystander free mouse models
errScientific Reports
IF3.9
err2026-02-20
err0
errOAAI
errJun Kai Ong; Sayari Bhunia; Beate Hilbert; Vanessa Kirschner; Sascha Duglosz; Frank Zimmermann; Marc Freichel; Alex Cornean
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Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
errNeuron
IF15
err2026-01-02
err0
errOAAI
errRam R. Dereddi; Minou Djannatian; Frederic Fiore; Darshana Kalita; Clement Verkest; Felipe Bodaleo Torres; Wiebke Möbius; Babak Khodaie; Torben Ruhwedel; Khaleel Alhalaseh; Martina Schifferer; Angela Wirth; Anthony Hill; Roger Ottenheijm; Annarita Patrizi; Oliver Kann; Stefan G. Lechner; Marc Freichel; Amit Agarwal
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Adenosine-Specific Transcriptional Programs in Murine Connective Tissue-Type Mast Cells
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2026-01-01
err0
PREAI
errLiang, Qihua; Tsvilovskyy, Volodymyr; Belkacemi, Anouar; Bukva, Merima; Richter, Christin; Ludwig, Nicole; Keller, Andreas; Freichel, Marc
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Differential Sensitivity of TRPC- and ORAI-Mediated Calcium Entries to 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole Chloride (SKF-96365)
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-11-01
err0
PREAI
errSusperreguy, Sebastian; Formoso, Karina; Mansilla Ricartti, Julieta; Freichel, Marc; Birnbaumer, Lutz
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errSave
TRPV6 channel function is involved in endometrial epithelial cell Ca2+ signaling and female mouse fecundity
errCellular and Molecular Life Sciences
IF6.2
err2025-10-07
err0
errOAAI
errAdela Sota; Andreas Beck; Philipp Wartenberg; Anna-Lena Gehl; Manuel Winter; Ulrich Wissenbach; Marc Freichel; Markus R. Meyer; Ulrich Boehm; Veit Flockerzi; Claudia Fecher-Trost; Petra Weissgerber
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Call for Papers - Purinergic Signaling: Medicinal Chemistry, Biology, Pharmacology, and Translation into Diagnostic and Therapeutic Drugs
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-02-18
err0
PREAI
errMüller, CE; Nicke, A; Lohr, C; Freichel, M; Guse, AH
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Two-pore channel regulators - Who is in control?
errFRONTIERS IN PHYSIOLOGY
IF3.4
err2025-01-10
err1
errOAAI
errDeutsch, Rebecca; Kudrina, Veronika; Freichel, Marc; Grimm, Christian
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Genetic evidence against involvement of TRPC proteins in SOCE, ROCE, and CRAC channel function
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-11-27
err0
PREAI
errSusperreguy, Sebastian; Yamashita, Megumi; Choi, Chan-il; Liao, Yanhong; Burch, Lauranell H.; Blankenship, Terry L.; Hayes, Erika; Sliwa, Thomas; Zhang, Yingpei; Grenet, Dagoberto; Walker, Mitzie; Plummer, Nicholas W.; Abramowitz, Joel; Kinet, Jean Pierre; Formoso, Karina; Johnson, Brandon E.; Fleig, Andrea; Hazlehurst, Lori; Penner, Reinhold; Freichel, Marc; Flockerzi, Veit; Prakriya, Murali; Birnbaumer, Lutz
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The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond
errCELL CALCIUM
IF4
err2024-11-01
err1
PREAI
errFreichel, Marc; Tsvilovskyy, Volodymyr; Philippaert, Koenraad; Schulte, Uwe; Ottenheijm, Roger
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TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia
errEMBO JOURNAL
IF8.3
err2024-10-07
err2
PREAI
errBroeker-Lai, Jenny; Terol, Jose Rego; Richter, Christin; Mathar, Ilka; Wirth, Angela; Kopf, Stefan; Moreno-Perez, Ana; Buettner, Michael; Tan, Linette Liqi; Makke, Mazen; Poschet, Gernot; Hermann, Julia; Tsvilovskyy, Volodymyr; Haberkorn, Uwe; Wartenberg, Philipp; Susperreguy, Sebastian; Berlin, Michael; Ottenheijm, Roger; Philippaert, Koenraad; Wu, Moya; Wiedemann, Tobias; Herzig, Stephan; Belkacemi, Anouar; Levinson, Rebecca T.; Agarwal, Nitin; Londono, Juan E. Camacho; Klebl, Bert; Dinkel, Klaus; Zufall, Frank; Nussbaumer, Peter; Boehm, Ulrich; Hell, Ruediger; Nawroth, Peter; Birnbaumer, Lutz; Leinders-Zufall, Trese; Kuner, Rohini; Zorn, Markus; Bruns, Dieter; Schwarz, Yvonne; Freichel, Marc
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TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission
errADVANCED SCIENCE
IF14.1
err2024-09-28
err0
errOAAI
errSun, Zhi-Chuan; Han, Wen-Juan; Dou, Zhi-Wei; Lu, Na; Wang, Xu; Wang, Fu-Dong; Ma, Sui-Bin; Tian, Zhi-Cheng; Xian, Hang; Liu, Wan-Neng; Liu, Ying-Ying; Wu, Wen-Bin; Chu, Wen-Guang; Guo, Huan; Wang, Fei; Ding, Hui; Liu, Yuan-Ying; Tao, Hui-Ren; Freichel, Marc; Birnbaumer, Lutz; Li, Zhen-Zhen; Xie, Rou-Gang; Wu, Sheng-Xi; Luo, Ceng
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MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP
errNATURE COMMUNICATIONS
IF15.7
err2024-09-13
err0
errOAAI
errKrukenberg, Sarah; Moeckl, Franziska; Weiss, Mariella; Dekiert, Patrick; Hofmann, Melanie; Gerlach, Fynn; Winterberg, Kai J.; Kovacevic, Dejan; Khansahib, Imrankhan; Troost, Berit; Hinrichs, Macarena; Granato, Viviana; Nawrocki, Mikolaj; Hub, Tobis; Tsvilovskyy, Volodymyr; Medert, Rebekka; Woelk, Lena-Marie; Foerster, Fritz; Li, Huan; Werner, Rene; Altfeld, Marcus; Huber, Samuel; Clarke, Oliver Biggs; Freichel, Marc; Diercks, Bjoern-Philipp; Meier, Chris; Guse, Andreas H.
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OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-04-01
err1
errOAAI
errTsvilovskyy, Volodymyr; Ottenheijm, Roger; Kriebs, Ulrich; Schuetz, Aline; Diakopoulos, Kalliope Nina; Jha, Archana; Bildl, Wolfgang; Wirth, Angela; Boeck, Julia; Jaslan, Dawid; Ferro, Irene; Taberner, Francisco J.; Kalinina, Olga; Hildebrand, Staffan; Wissenbach, Ulrich; Weissgerber, Petra; Vogt, Dominik; Eberhagen, Carola; Mannebach, Stefanie; Berlin, Michael; Kuryshev, Vladimir; Schumacher, Dagmar; Philippaert, Koenraad; Camacho-Londono, Juan E.; Mathar, Ilka; Dieterich, Christoph; Klugbauer, Norbert; Biel, Martin; Wahl-Schott, Christian; Lipp, Peter; Flockerzi, Veit; Zischka, Hans; Alguel, Hana; Lechner, Stefan G.; Lesina, Marina; Grimm, Christian; Fakler, Bernd; Schulte, Uwe; Muallem, Shmuel; Freichel, Marc
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Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport
errACTA PHYSIOLOGICA
IF5.6
err2024-03-22
err1
errOAAI
errPfeffer, Tilman; Krug, Susanne M.; Kracke, Tamara; Schuerfeld, Robin; Colbatzky, Florian; Kirschner, Philip; Medert, Rebekka; Freichel, Marc; Schumacher, Dagmar; Bartosova, Maria; Zarogiannis, Sotiris G.; Muckenthaler, Martina U.; Altamura, Sandro; Pezer, Silvia; Volk, Nadine; Schwab, Constantin; Duensing, Stefan; Fleming, Thomas; Heidenreich, Elena; Zschocke, Johannes; Hell, Ruediger; Poschet, Gernot; Schmitt, Claus P.; Peters, Verena
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Calcium channel ß3 subunit regulates ATP-dependent migration of dendritic cells
errSCIENCE ADVANCES
IF12.5
err2023-09-22
err7
errOAAI
errWoo, Marcel S.; Ufer, Friederike; Sonner, Jana K.; Belkacemi, Anouar; Tintelnot, Joseph; Saez, Pablo J.; Krieg, Paula F.; Mayer, Christina; Binkle-Ladisch, Lars; Engler, Jan Broder; Bauer, Simone; Kursawe, Nina; Vieira, Vanessa; Mannebach, Stefanie; Freichel, Marc; Flockerzi, Veit; Vargas, Pablo; Friese, Manuel A.
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Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-08-28
err1
errOAAI
errMaeder, Christina; Speer, Thimoteus; Wirth, Angela; Boeckel, Jes-Niels; Fatima, Sameen; Shahzad, Khurrum; Freichel, Marc; Laufs, Ulrich; Gaul, Susanne
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Research Directions

No research directions
Co-authors
Cooperation Journals
R
Richard A. Flavell
H-index: 246 · Papers: 1.5K
E
Eric N. Olson
H-index: 224 · Papers: 979
J
Josef Penninger
H-index: 174 · Papers: 1.6K
M
Michael Böhm
H-index: 164 · Papers: 1.8K
H
Hugo A. Katus
H-index: 143 · Papers: 2.1K
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