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David C. Wedge

University of Manchester

87H-index
424Paper Count
6.3WCitation Count
Published Papers 136
Publication Date
Identification and validation of a previously missed mutational signature in colorectal cancer
err2026-08-12
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errOAAI
errMariya Kazachkova; Burçak Otlu; Marcos Díaz-Gay; Ammal Abbasi; Sarah Moody; Zichen Jiang; Sandra Perdomo; David. C. Wedge; Paul Brennan; Michael. R. Stratton; Ludmil. B. Alexandrov
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Author Correction: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
errNature
IF48.5
err2026-08-11
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PREAI
errTongwu Zhang; Wei Zhao; Christopher Wirth; Marcos Díaz-Gay; Jinhu Yin; Monia Cecati; Francesca Marchegiani; Phuc H. Hoang; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Jian Sang; John P. McElderry; Michelle Antony; Alyssa Klein; Azhar Khandekar; Caleb Hartman; Jennifer Rosenbaum; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia W. Lee; Kristine M. Jones; Neil E. Caporaso; Maria Pik Wong; Kin Chung Leung; Chao Agnes Hsiung; Chih-Yi Chen; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai S. Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Milan Savic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Robert Homer; Soo-Ryum Yang; Angela C. Pesatori; Dario Consonni; Lixing Yang; Bin Zhu; Jianxin Shi; Kevin Brown; Nathaniel Rothman; Stephen J. Chanock; Ludmil B. Alexandrov; Jiyeon Choi; Maurizio Cardelli; Qing Lan; Martin A. Nowak; David C. Wedge; Maria Teresa Landi
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Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study
err2026-04-25
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errOAAI
errJue Jiang; Avraam Tapinos; Ruotian Huang; M. S. Riana Bornman; Phillip D. Stricker; Shingai B. A. Mutambirwa; David C. Wedge; Weerachai Jaratlerdsiri; Vanessa M. Hayes
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Longitudinal plasma nano-proteomics reveals acute systemic responses to radiotherapy and predictive biomarkers of late toxicity
err2026-04-01
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errOAAI
errHanan Abumanhal-Masarweh; Salam A. Assi; Xinming Liu; Conrado Guerrero Quiles; Taha Lodhi; Kaye J. Williams; Eleanor J. Cheadle; Kostas Kostarelos; Ananya Choudhury; David C. Wedge; Catharine M. L. West; Marilena Hadjidemetriou
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Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas
err2026-03-04
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errOAAI
errAntonio Pea; Xiaotong He; Rosie Upstill-Goddard; Claudio Luchini; Leonor Patricia Schubert Santana; Stephan Dreyer; Fraser Duthie; Nigel B. Jamieson; Colin J. McKay; Euan J. Dickson; Alessandra Pulvirenti; Selma Rebus; Paola Piccoli; Nicola Sperandio; Rita T. Lawlor; Michele Milella; Fieke E. M. Froeling; Roberto Salvia; Aldo Scarpa; Andrew V. Biankin; David C. Wedge; David K. Chang
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Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types
err2026-02-13
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errOAAI
errAndrew Everall; Avraam Tapinos; Aliah Hawari; Alex J. Cornish; Amit Sud; Daniel Chubb; Ben Kinnersley; Anna Frangou; Miguel Barquin; Josephine Jung; David N. Church; Ludmil B. Alexandrov; Richard S. Houlston; Andreas J. Gruber; David C. Wedge
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Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations
err2025-12-12
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errOAAI
errJohn P. McElderry; Tongwu Zhang; Wei Zhao; Phuc H. Hoang; Samuel Anyaso-Samuel; Jian Sang; Azhar Khandekar; Caleb Hartman; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia Lee; Sunandini Sharma; Kristine M. Jones; Bin Zhu; Marcos Díaz-Gay; Luis Mas; Oscar Gerardo Arrieta Rodriguez; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Vladimir Janout; Dana Mates; Simona Ognjanovic; Milan Savic; Milica Kontic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Maria Pik Wong; Kin Chung Leung; Chih-Yi Chen; Chao Agnes Hsiung; Nathaniel Rothman; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Robert Homer; Soo-Ryum Yang; Qing Lan; Martin A. Nowak; David C. Wedge; Ludmil B. Alexandrov; Stephen J. Chanock; Emily Vogtmann; Christian C. Abnet; Jianxin Shi; Maria Teresa Landi
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Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
errNature
IF48.5
err2025-12-10
err0
PREAI
errTongwu Zhang; Wei Zhao; Christopher Wirth; Marcos Díaz-Gay; Jinhu Yin; Monia Cecati; Francesca Marchegiani; Phuc H. Hoang; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Jian Sang; John P. McElderry; Michelle Antony; Alyssa Klein; Azhar Khandekar; Caleb Hartman; Jennifer Rosenbaum; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia W. Lee; Kristine M. Jones; Neil E. Caporaso; Maria Pik Wong; Kin Chung Leung; Chao Agnes Hsiung; Chih-Yi Chen; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai S. Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Milan Savic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Robert Homer; Soo-Ryum Yang; Angela C. Pesatori; Dario Consonni; Lixing Yang; Bin Zhu; Jianxin Shi; Kevin Brown; Nathaniel Rothman; Stephen J. Chanock; Ludmil B. Alexandrov; Jiyeon Choi; Maurizio Cardelli; Qing Lan; Martin A. Nowak; David C. Wedge; Maria Teresa Landi
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The mutagenic forces shaping the genomes of lung cancer in never smokers
errNature
IF48.5
err2025-07-02
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PREAI
errMarcos Díaz-Gay; Tongwu Zhang; Phuc H. Hoang; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Azhar Khandekar; Wei Zhao; Christopher D. Steele; Burçak Otlu; Shuvro P. Nandi; Raviteja Vangara; Erik N. Bergstrom; Mariya Kazachkova; Oriol Pich; Charles Swanton; Chao Agnes Hsiung; I-Shou Chang; Maria Pik Wong; Kin Chung Leung; Jian Sang; John P. McElderry; Caleb Hartman; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia W. Lee; Kristine M. Jones; Pilar Gallego-García; Yang Yang; Xiaoming Zhong; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai S. Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Millica Kontic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Lixing Yang; Martin A. Nowak; Jianxin Shi; Nathaniel Rothman; David C. Wedge; Robert Homer; Soo-Ryum Yang; Angela C. Pesatori; Dario Consonni; Qing Lan; Bin Zhu; Stephen J. Chanock; Jiyeon Choi; Ludmil B. Alexandrov; Maria Teresa Landi
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APOBEC affects tumor evolution and age at onset of lung cancer in smokers
err2025-05-21
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errOAAI
errZhang, Tongwu; Sang, Jian; Hoang, Phuc H.; Zhao, Wei; Rosenbaum, Jennifer; Johnson, Kofi Ennu; Klimczak, Leszek J.; McElderry, John; Klein, Alyssa; Wirth, Christopher; Bergstrom, Erik N.; Diaz-Gay, Marcos; Vangara, Raviteja; Colon-Matos, Frank; Hutchinson, Amy; Lawrence, Scott M.; Cole, Nathan; Zhu, Bin; Przytycka, Teresa M.; Shi, Jianxin; Caporaso, Neil E.; Homer, Robert; Pesatori, Angela C.; Consonni, Dario; Imielinski, Marcin; Chanock, Stephen J.; Wedge, David C.; Gordenin, Dmitry A.; Alexandrov, Ludmil B.; Harris, Reuben S.; Landi, Maria Teresa
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Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions
err2024-12-01
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PREAI
errZhu, Bin; Tapinos, Avraam; Koka, Hela; Lee, Priscilla Ming Yi; Zhang, Tongwu; Zhu, Wei; Wang, Xiaoyu; Klein, Alyssa; Lee, Donghyuk; Tse, Gary M.; Tsang, Koon-ho; Wu, Cherry; Hua, Min; Highfill, Chad A.; Lenz, Petra; Zhou, Weiyin; Wang, Difei; Luo, Wen; Jones, Kristine; Hutchinson, Amy; Hicks, Belynda; Garcia-Closas, Montserrat; Chanock, Stephen; Tse, Lap Ah; Wedge, David C.; Yang, Xiaohong R.
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Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project
err2024-10-26
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errOAAI
errLeathlobhair, Maire Ni; Frangou, Anna; Kinnersley, Ben; Cornish, Alex J.; Chubb, Daniel; Lakatos, Eszter; Arumugam, Prabhu; Gruber, Andreas J.; Law, Philip; Tapinos, Avraam; Jakobsdottir, G. Maria; Peneva, Iliana; Sahli, Atef; Smyth, Evie M.; Ball, Richard Y.; Sylva, Rushan; Benes, Ksenija; Stark, Dan; Young, Robin J.; Lee, Alexander T. J.; Wolverson, Vincent; Houlston, Richard S.; Sosinsky, Alona; Protheroe, Andrew; Murray, Matthew J.; Wedge, David C.; Verrill, Clare
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Targeting KRAS codon 13 mutations using direct combination approaches in non-small cell lung cancer
err2024-10-01
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PREAI
errAdderley, H.; McDaid, W.; Woodhouse, L.; Carter, M.; Aldea, M.; Marinello, A.; Seamon, K.; Holderfield, M.; Singh, M.; Smith, J.; Aredo, J.; Besse, B.; Wakelee, H.; Blackhall, F.; Wedge, D.; Malliri, A.; Lindsay, C.
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Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma
err2024-07-15
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errOAAI
errCulliford, Richard; Lawrence, Samuel E. D.; Mills, Charlie; Tippu, Zayd; Chubb, Daniel; Cornish, Alex J.; Browning, Lisa; Kinnersley, Ben; Bentham, Robert; Sud, Amit; Pallikonda, Husayn; Frangou, Anna; Gruber, Andreas J.; Litchfield, Kevin; Wedge, David; Larkin, James; Turajlic, Samra; Houlston, Richard S.
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Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology
err2024-06-18
err5
errOAAI
errKinnersley, Ben; Sud, Amit; Everall, Andrew; Cornish, Alex J.; Chubb, Daniel; Culliford, Richard; Gruber, Andreas J.; Larkeryd, Adrian; Mitsopoulos, Costas; Wedge, David; Houlston, Richard
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Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
err2024-05-17
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errHaley, Michael J.; Bere, Leoma; Minshull, James; Georgaka, Sokratia; Garcia-Martin, Natalia; Howell, Gareth; Coope, David J.; Roncaroli, Federico; King, Andrew; Wedge, David C.; Allan, Stuart M.; Pathmanaban, Omar N.; Brough, David; Couper, Kevin N.
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CDH1 mutations predict resistance to neoadjuvant taxane therapy
err2024-05-02
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PREAI
errKnappskog, Stian; Helwa, Reham; Rachakonda, Sivaramakrishna; Gansmo, Liv B.; Denkert, Carsten; Yates, Lucy R.; Solbach, Christine; Untch, Michael; Sinn, Bruno V.; Litmeyer, Anne-Sophie; Ataseven, Beyhan; Huober, Jens; Wedge, David C.; Karn, Thomas; Nikolaienko, Oleksii; Marme, Frederik; Fasching, Peter A.; Eikesdal, Hans Petter; Stickeler, Elmar; Schem, Christian; Jank, Paul; van Mackelenbergh, Marion; Muller, Volkmar; Felder, Baerbel; Holtschmidt, Johannes; Campbell, Peter J.; Loibl, Sibylle; Lonning, Per
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Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
err2024-04-05
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PREAI
errZhang, Tongwu; Zhao, Wei; Wirth, Christopher; Diaz-Gay, Marcos; Yin, Jinhu; Hoang, Phuc H.; Sang, Jian; McElderry, John; Klein, Alyssa; Khandekar, Azhar; Hartman, Caleb; Rosenbaum, Jennifer; Colon-Matos, Frank; Jones, Kristine M.; Caporaso, Neil E.; Homer, Robert; Pesatori, Angela C.; Consonni, Dario; Yang, Lixing; Zhu, Bin; Shi, Jianxin; Brown, Kevin; Rothman, Nathaniel; Chanock, Stephen J.; Alexandrov, Ludmil B.; Choi, Jiyeon; Cardelli, Maurizio; Lan, Qing; Nowak, Martin A.; Wedge, David C.; Landi, Maria Teresa
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Evolutionary trajectories of lung cancer in never smokers
err2024-04-05
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PREAI
errWirth, Christopher; Zhang, Tongwu; Zhao, Wei; Hoang, Phuc; Sang, Jian; Rothman, Nathaniel; Diaz-Gay, Marcos; Teslo, Ruxandra; Ansari-Pour, Naser; Leathlobhair, Maire Ni; Peneva, Iliana; Eagles, William; Yang, Lixing; Alexandrov, Ludmil; Wedge, David C.; Landi, Maria Teresa
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Ultrasensitive Detection of Circulating Tumour DNA enriches for Patients with a Greater Risk of Recurrence of Clinically Localised Prostate Cancer
err2024-04-01
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errOAAI
errPope, Bernard; Park, Gahee; Lau, Edmund; Belic, Jelena; Lach, Radoslaw; George, Anne; McCoy, Patrick; Nguyen, Anne; Grima, Corrina; Campbell, Bethany; Jung, Chol-hee; Ditter, Emma-Jane; Zhao, Hui; Wedge, David C.; Brewer, Daniel S.; Lynch, Andy G.; Dev, Harveer; Gnanpragasam, Vincent J.; Rosenfeld, Nitzan; Hovens, Christopher M.; Corcoran, Niall M.; Massie, Charles E.
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