Dean G. Tang - Publications, H-index & Citations

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Dean G. Tang

pharmacology

75H-index

326Paper Count

1.9WCitation Count

Published Papers 105

Publication Date

DDX5 (p68) and UbE2T as emerging superior cancer therapeutic targets: dual molecular glue target degradation by FL118 for conquering difficult-to-treat cancers

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2026-05-18

OAAI

Fengzhi Li; Xiang Ling; Sayan Chakraborty; Dean G. Tang; Karen McLean; Wenjie Wu; Norbert Sule; Deepak Vadehra; Christos Fountzilas; Ajay Gupta; Clare Twist; Joyce Ohm; Gurkamal Chatta; Scott I. Abrams

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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma

Nature

IF48.5

2026-03-25

OAAI

Jiao Zhang; Winnie Ong; Alexandra Rasnitsyn; Ricardo Daniel Gonzalez; Rodrigo Lopez Gutierrez; Polina Balin; Amr Saadeldin; Xiaochong Wu; Maria C. Vladoiu; Vicente Santa-Maria Lopez; Fernando Gonzalez-Salinas; Navneesh Yadav; Dinesh Mohanakrishnan; Kannan Boosi Narayana Rao; Raja Gopal Reddy Mooli; Hinda Najem; Sebastian Pacheco; Kaitlin Kharas; Cory Richman; David Przelicki; Evan Y. Wang; Haipeng Su; Rachel Naomi Curry; Runze Yang; Michelle Masayo Kameda-Smith; Bryn Livingston; David Scott; Zaili Luo; Mingyang Xia; Namal Abeysundara; Anders W. Erickson; Ncedile Mankahla; Lucas ZhongMing Hu; Chu Pan; Raul Suarez; Ning Huang; Yihao Wu; Hao Wang; Tajana Douglas; Jonelle Pallota; Steven Hébert; Karen Ng; Krystin Mantione; Heather Whetstone; Hassaan Maan; Hussein Lakkis; Juyeun Lee; Sadeesh K. Ramakrishnan; Yanxin Pei; Yujie Tang; Frank Y. Lin; Guillermo Aldave; Marco Gallo; Robert M. Friedlander; Faiyaz Notta; Laura K. Donovan; Murali Chintagumpala; Bo Wang; Yun Li; Daniel D. De Carvalho; Zhaolei Zhang; Ying Mao; Wei Hua; Charles Eberhart; Calixto-Hope G. Lucas; Sriram Venneti; Poul H. Sorensen; Alberto Delaidelli; Hao Li; Wenhao Zhou; Jason Kirk; Dean G. Tang; Tao Jiang; Hailong Liu; Justin D. Lathia; Hiromichi Suzuki; Jeremy N. Rich; Lincoln D. Stein; Nada Jabado; Vijay Ramaswamy; Q. Richard Lu; Amy B. Heimberger; Craig Daniels; Kulandaimanuvel Antony Michealraj; Claudia L. Kleinman; Michael D. Taylor

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Phase Ib study of enzalutamide with venetoclax in patients with metastatic castration-resistant prostate cancer

Cancer Chemotherapy and Pharmacology

IF2.3

2025-11-29

OAAI

Stuthi Perimbeti; Anmbreen Jamroze; Dharmesh Gopalakrishnan; Rohit Jain; Changchuan Jiang; Julianne L. Holleran; Robert A. Parise; Robert Bies; David Quinn; Kristopher Attwood; Xiaozhuo Liu; Kelly Green; Jason S. Kirk; Jan H. Beumer; Dean G. Tang; Gurkamal Chatta

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Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC

Cellular Oncology

IF4.8

2025-11-11

OAAI

Huilan Su; Liqun Huang; Wenwen Xia; Dean G. Tang; Jianjun Zhou; Guosheng Yang

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Clinically and orally compatible formulation-manufactured DDX5 (p68)-targeting molecular glue FL118 products exhibit low toxicity but high efficacy against human cancer

JOURNAL OF PHARMACEUTICAL ANALYSIS

IF8.9

2024-11-01

OAAI

Ling, Xiang; Wu, Wenjie; Yan, Li; Curtin, Leslie; Farrauto, Melanie M.; Sexton, Sandra; Jamroze, Anmbreen; Yu, Changjun; Fountzilas, Christos; Tang, Dean G.; Li, Fengzhi

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Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity

SCIENCE ADVANCES

IF12.5

2024-10-11

OAAI

Fan, Ting; Xu, Congcong; Wu, Jichuan; Cai, Yihua; Cao, Wanlu; Shen, Haifa; Zhang, Mingna; Zhu, Hanfei; Yang, Jingxian; Zhu, Zhounan; Ma, Xiaopin; Ren, Jiale; Huang, Lei; Li, Qianyun; Tang, Yuying; Yu, Bo; Chen, Chunxiu; Xu, Mingcheng; Wang, Qiuhe; Xu, Zhuya; Chen, Fengjia; Liang, Shujing; Zhong, Zhixian; Jamroze, Anmbreen; Tang, Dean G.; Li, Hangwen; Dong, Chunyan

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Inhibition of PRMT5 moderately suppresses prostate cancer growth in vivo but enhances its response to immunotherapy

CANCER LETTERS

IF10.1

2024-10-01

PREAI

He, Qinju; Zhang, Yuanzhen; Li, Wenchao; Chen, Saisai; Xiong, Jiangling; Zhao, Ruizhe; Yuan, Kai; Hu, Qiang; Liu, Song; Gao, Guozhen; Bedford, Mark T.; Tang, Dean G.; Xu, Bin; Zou, Cheng; Zhang, Dingxiao

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Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis

CANCER AND METASTASIS REVIEWS

IF8.7

2024-08-17

OAAI

Wojtukiewicz, Marek Z.; Mysliwiec, Marta; Tokajuk, Anna; Kruszewska, Joanna; Politynska, Barbara; Jamroze, Anmbreen; Wojtukiewicz, Anna M.; Tang, Dean G.; Honn, Kenneth V.

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Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

CELL STEM CELL

IF20.4

2024-08-01

OAAI

Kirk, Jason S.; Wang, Jie; Long, Mark; Rosario, Spencer; Tracz, Amanda; Ji, Yibing; Kumar, Rahul; Liu, Xiaozhuo; Jamroze, Anmbreen; Singh, Prashant K.; Puzanov, Igor; Chatta, Gurkamal; Cheng, Qing; Huang, Jiaoti; Wrana, Jeffrey L.; Lovell, Jonathan; Yu, Han; Liu, Song; Shen, Michael M.; Liu, Tao; Tang, Dean G.

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The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System

SEMINARS IN THROMBOSIS AND HEMOSTASIS

IF4.1

2023-11-20

PREAI

Aleksandrowicz, Karolina; Hempel, Dominika; Politynska, Barbara; Wojtukiewicz, Anna M.; Honn, Kenneth V.; Tang, Dean G.; Wojtukiewicz, Marek Z.

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Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2023-08-19

OAAI

Li, Fengzhi; Ling, Xiang; Chakraborty, Sayan; Fountzilas, Christos; Wang, Jianmin; Jamroze, Anmbreen; Liu, Xiaozhuo; Kalinski, Pawel; Tang, Dean G.

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STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

MOLECULAR CANCER

IF33.9

2023-08-12

OAAI

Pencik, Jan; Philippe, Cecile; Schlederer, Michaela; Atas, Emine; Pecoraro, Matteo; Grund-Groeschke, Sandra; Li, Wen (Jess); Tracz, Amanda; Heidegger, Isabel; Lagger, Sabine; Trachtova, Karolina; Oberhuber, Monika; Heitzer, Ellen; Aksoy, Osman; Neubauer, Heidi A.; Wingelhofer, Bettina; Orlova, Anna; Witzeneder, Nadine; Dillinger, Thomas; Redl, Elisa; Greiner, Georg; D'Andrea, David; Ostman, Johnny R.; Tangermann, Simone; Hermanova, Ivana; Schaefer, Georg; Sternberg, Felix; Pohl, Elena E.; Sternberg, Christina; Varady, Adam; Horvath, Jaqueline; Stoiber, Dagmar; Malcolm, Tim I.; Turner, Suzanne D.; Parkes, Eileen E.; Hantusch, Brigitte; Egger, Gerda; Rose-John, Stefan; Poli, Valeria; Jain, Suneil; Armstrong, Chris W. D.; Hoermann, Gregor; Goffin, Vincent; Aberger, Fritz; Moriggl, Richard; Carracedo, Arkaitz; McKinney, Cathal; Kennedy, Richard D.; Klocker, Helmut; Speicher, Michael R.; Tang, Dean G.; Moazzami, Ali A.; Heery, David M.; Hacker, Marcus; Kenner, Lukas

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Further development of microRNA-34a therapeutics to target castration-resistant prostate cancer

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Li, Wen (Jess); Liu, Xiaozhuo; Abdelaal, Ahmed M.; Kasireddy, Sudarsan; Su, Yafei; Wu, Yun; Kasinski, Andrea L.; Tang, Dean G.

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Lrig1 is a haplo-insufficient tumor suppressor and Lrig1-expressing cells can function as cells-of-origin of tumor development

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Wang, Moyi; Li, Qiuhui; Tracz, Amanda; Kirk, Jason; Jamroze, Anmbreen; Kumar, Rahul; Tang, Dean G.

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Association of active caspase 8 with the mitochondrial membrane during apoptosis: Potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

151

OAAI

Chandra, D; Choy, G; Deng, XD; Bhatia, B; Daniel, P; Tang, DG

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Prostate cancer as a dedifferentiated organ : androgen receptor, cancer stem cells, and cancer stemness

ESSAYS IN BIOCHEMISTRY

IF5.7

2022-09-16

OAAI

Liu, Xiaozhuo; Li, Wen Jess; Puzanov, Igor; Goodrich, David W.; Chatta, Gurkamal; Tang, Dean G.

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LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor

SEMINARS IN CANCER BIOLOGY

IF15.7

2022-07-01

OAAI

Ji, Yibing; Kumar, Rahul; Gokhale, Abhiram; Chao, Hseu-Ping; Rycaj, Kiera; Chen, Xin; Li, Qiuhui; Tang, Dean G.

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A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2022-07-01

OAAI

Kumar, Rahul; Chaudhary, Ajay K.; Woytash, Jordan; Inigo, Joseph R.; Gokhale, Abhiram A.; Bshara, Wiam; Attwood, Kristopher; Wang, Jianmin; Spernyak, Joseph A.; Rath, Eva; Yadav, Neelu; Haller, Dirk; Goodrich, David W.; Tang, Dean G.; Chandra, Dhyan

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Cancer cell heterogeneity and plasticity: From molecular understanding to therapeutic targeting

SEMINARS IN CANCER BIOLOGY

IF15.7

2022-07-01

OAAI

Tang, Dean G.; Kondo, Toru

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Understanding and targeting prostate cancer cell heterogeneity and plasticity

SEMINARS IN CANCER BIOLOGY

IF15.7

2022-07-01

OAAI

Tang, Dean G.

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Research Directions