Not logged inImpact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines
Elrick, Hillary; Peterson, Kevin A.; Willis, Brandon J.; Lanza, Denise G.; Acar, Elif F.; Ryder, Edward J.; Teboul, Lydia; Kasparek, Petr; Birling, Marie-Christine; Adams, David J.; Bradley, Allan; Braun, Robert E.; Brown, Steve D.; Caulder, Adam; Codner, Gemma F.; Demayo, Francesco J.; Dickinson, Mary E.; Doe, Brendan; Duddy, Graham; Gertsenstein, Marina; Goodwin, Leslie O.; Herault, Yann; Lintott, Lauri G.; Lloyd, K. C. Kent; Lorenzo, Isabel; Mackenzie, Matthew; Mallon, Ann-Marie; Mckerlie, Colin; Parkinson, Helen; Ramirez-Solis, Ramiro; Seavitt, John R.; Sedlacek, Radislav; Skarnes, William C.; Smedley, Damien; Wells, Sara; White, Jacqueline K.; Wood, Joshua A.; Akhtar, Shaheen; Allan, Alasdair J.; Allen, Susan; Andre, Philippe; Archer, Daniel; Atkins, Sarah; Avery, Ruth; Ayadi, Abdel; Barrett, Daniel; Beyetinova, Tanya; Bell, Toni; Berry, Melissa; Boroviak, Katharina; Bottomley, Joanna; Brendler-Spaeth, Tim; Brown, Ellen; Burvill, Jonathan; Bussell, James; Cardeno, Charis; Carter, Rebecca V.; Castellanos-Penton, Patricia; Christou, Skevoulla; Clark, Greg; Clarke, Shannon; Cleak, James; Crawford, Ronnie; Creighton, Amie; Cruz, Maribelle; Danisment, Ozge; Davis, Charlotte; Doran, Joanne; Erbs, Valerie; Fan-Lan, Qing; Fell, Rachel; Feng, He; Fougerolle, Jean-Victor; Fower, Alex; Frake, Gemma; Fray, Martin D.; Galli, Antonella; Gannon, David; Gardiner, Wendy J.; Gaspero, Angelina; Gleeson, Diane; Godbehere, Chris; Grau, Evelyn; Griffiths, Mark; Griggs, Nicola; Grimsrud, Kristin; Hazeltine, Sarah; Hutchison, Marie; Ingle, Catherine; Iyer, Vivek; Jager, Kayla; Joeng, Joanna; Kales, Susan; Kaur, Perminder; Kenyon, Janet; Kopkanova, Jana; Kujath, Christelle; Kundi, Helen; Kutny, Peter; Laurin, Valerie; Lejeay, Sandrine; Lelliott, Christopher; Loeffler, Jorik; Lorentz, Romain; Mccabe, Christopher V.; Malzer, Elke; Matthews, Peter; Maswood, Ryea; Mckay, Matthew; Meehan, Terrence; Melvin, David; Murphy, Alison; Nakhuda, Asif; Patel, Amit; Paulavets, Ilya; Pavlovic, Guillaume; Pawelka, Ashley; Pike, Fran J.; Platte, Radka; Price, Peter D.; Rajaya, Kiran; Reddy, Shalini; Rich, Whitney; Rosen, Barry; Ross, Victoria; Ruhe, Mark; Santos, Luis; Schaeffer, Laurence; Schwiening, Alix; Selloum, Mohammed; Sethi, Debarati; Sidiangco, Jan R.; Sinclair, Caroline; Sins, Elodie; Sleep, Gillian; Sorg, Tania; Starbuck, Becky; Stewart, Michelle; Swash, Holly; Thomas, Mark; Tondat, Sandra; Urban, Rachel; Urbanova, Jana; Varley, Susan; Von Schiller, Dominque; Wardle-Jones, Hannah; Weavers, Lauren; Woods, Michael; Murray, Stephen A.; Heaney, Jason D.; Nutter, Lauryl M. J. .png)
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SaveMice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle controlChoi, J; Nannenga, B; Demidov, ON; Bulavin, DV; Cooney, A; Brayton, C; Zhang, YX; Mbawuike, IN; Bradley, A; Appella, E; Donehower, LA Share Save Share Save Share Save Share Save BRCTx is a novel, highly conserved RAD18-interacting proteinAdams, DJ; van der Weyden, L; Gergely, FV; Arends, MJ; Ng, BL; Tannahill, D; Kanaar, R; Markus, A; Morris, BJ; Bradley, A Share Save Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle responseWang, XH; Su, H; Copenhagen, LD; Vaishnav, S; Pieri, F; Shope, CD; Brownell, WE; De Biasi, M; Paylor, R; Bradley, A Share Save COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblastYan, J; Walz, K; Nakamura, H; Carattini-Rivera, S; Zhao, Q; Vogel, H; Wei, N; Justice, MJ; Bradley, A; Lupski, JR Share Save Share Save Share Save Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: Phenotypic consequences of gene dosage imbalanceWalz, K; Caratini-Rivera, S; Bi, WM; Fonseca, P; Mansouri, DL; Lynch, J; Vogel, H; Noebels, JL; Bradley, A; Lupski, JR Share Save Share Save Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesisvan der Weyden, L; Arends, MJ; Chausiaux, OE; Ellis, PJ; Lange, UC; Surani, MA; Affara, N; Murakami, Y; Adams, DJ; Bradley, A Share Save Share Save Share Save Share Save In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolutionFischer, Anja; Lersch, Robert; de Andrade Kraetzig, Niklas; Strong, Alexander; Friedrich, Mathias J.; Weber, Julia; Engleitner, Thomas; Oellinger, Rupert; Yen, Hsi-Yu; Kohlhofer, Ursula; Gonzalez-Menendez, Irene; Sailer, David; Kogan, Liz; Lahnalampi, Mari; Laukkanen, Saara; Kaltenbacher, Thorsten; Klement, Christine; Rezaei, Majdaddin; Ammon, Tim; Montero, Juan J.; Schneider, Guenter; Mayerle, Julia; Heikenwaelder, Mathias; Schmidt-Supprian, Marc; Quintanilla-Martinez, Leticia; Steiger, Katja; Liu, Pentao; Cadinanos, Juan; Vassiliou, George S.; Saur, Dieter; Lohi, Olli; Heinaeniemi, Merja; Conte, Nathalie; Bradley, Allan; Rad, Lena; Rad, Roland Share Save Share Save A purine metabolic checkpoint that prevents autoimmunity and autoinflammationSaveljeva, Svetlana; Sewell, Gavin W.; Ramshorn, Katharina; Cader, M. Zaeem; West, James A.; Clare, Simon; Haag, Lea-Maxie; Rodrigues, Rodrigo Pereira de Almeida; Unger, Lukas W.; Iglesias-Romero, Ana Belen; Holland, Lorraine M.; Bourges, Christophe; Md-Ibrahim, Muhammad N.; Jones, James O.; Blumberg, Richard S.; Lee, James C.; Kaneider, Nicole C.; Lawley, Trevor D.; Bradley, Allan; Dougan, Gordon; Kaser, Arthur Share Save METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformationOrellana, Esteban A.; Liu, Qi; Yankova, Eliza; Pirouz, Mehdi; De Braekeleer, Etienne; Zhang, Wencai; Lim, Jihoon; Aspris, Demetrios; Sendinc, Erdem; Garyfallos, Dimitrios A.; Gu, Muxin; Ali, Raja; Gutierrez, Alejandro; Mikutis, Sigitas; Bernardes, Goncalo J. L.; Fischer, Eric S.; Bradley, Allan; Vassiliou, George S.; Slack, Frank J.; Tzelepis, Konstantinos; Gregory, Richard I. Share Save 
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