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Jan Paul Medema

Laboratory of Experimental Oncology and Radiobiology

86H-index
505Paper Count
5.0WCitation Count
Published Papers 211
Publication Date
Imbalances of mitochondrial dynamics in solid tumors
err2026-05-12
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errCarmen Roskam; H. Rebecca K. Roessler; Jan Paul Medema; Maarten F. Bijlsma
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Zigakibart potently inhibits APRIL-mediated IgA production, addressing IgAN pathogenesis root causes
err2026-04-06
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errJohn Dulos; Joost Kreijtz; Paul Vink; Victoria Cotton; Jay J. Kuo; Jeannette Lo; Wout Jansen; Jeroen Bakker; Lilian Driessen; Marco Guadagnoli; Peter van Zandvoort; Max Warncke; Jan Paul Medema; Jonathan Barratt; Hans van Eenennaam; Andrea Van Elsas
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Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used for Liquid Biopsy Based Diagnostics
err2025-10-30
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errParis J. Asif; Lauri H. Borghuis; Sander R. van Hooff; Anita E. Grootemaat; Monique A. J. van Eijndhoven; Johan de Rooij; Nils J. Groenewegen; Jennifer Perez Boza; Onno Kranenburg; Inne H. M. Borel Rinkes; Cristina Gómez-Martín; Hans F. M. Pruijt; Nicole N. van der Wel; Arezo Torang; Tineke E. Buffart; D. Michiel Pegtel; Jan Paul Medema
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SUNRISE-CRC: a randomized phase II study of high-dose intermittent sunitinib versus trifluridine/tipiracil in metastatic colorectal carcinoma
err2025-10-01
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PREAI
errJanssen, Jorien B. E.; Iyer, Kirti K.; Gerritse, Sophie L.; Janssen, Eline; Gootjes, Elske C.; Labots, Mariette; Buffart, Tineke E.; Wumkes, Miriam L.; Douma, Joeri A. J.; Streppel, Mirte M.; Buffart, Laurien M.; Jonker, Marianne A.; Van Den Hombergh, Erik; Van Erp, Nielka P.; Medema, Jan Paul; Tauriello, Daniele V. F.; Poel, Dennis; Verheul, Henk M. W.
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GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells
err2025-07-13
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errLe Zhang; Lidia Atencia Taboada; Selami Baglamis; Maartje de Kroon; Carolien Elshout; Prashanthi Ramesh; Roxan F.C.P.A Helderman; Arezo Torang; Kate Cameron; Milou S. van Driel; Valérie M. Wouters; Sanne M. van Neerven; Jan Paul Medema
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The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets
err2025-05-29
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PREAI
errJaco C. Knol; Mengge Lyu; Franziska Böttger; Madalena Nunes Monteiro; Thang V. Pham; Frank Rolfs; Andrea Vallés-Martí; Tim Schelfhorst; Richard R. de Goeij-de Haas; Irene V. Bijnsdorp; Shuaiyao Wang; Fangfei Zhang; Jun A; Bart A. Westerman; Barbara Sitek; Janne Lehtiö; Jan Koster; Jan N.M. IJzermans; Hanneke W.M. van Laarhoven; Maarten F. Bijlsma; Jan Paul Medema; Alex A. Henneman; Sander R. Piersma; Ruud H. Brakenhoff; Jacqueline Cloos; Valentina Cordo'; Daphne de Jong; Geert Kazemier; Danijela Koppers-Lalic; Mariette Labots; Tessa Y.S. Le Large; John W.M. Martens; Jules P.P. Meijerink; Madiha Mumtaz; Chantal Scheepbouwer; Robby E. Kibbelaar; David P. Noske; Renske D.M. Steenbergen; Nicole C.T. van Grieken; Winan van Houdt; Elisa Giovannetti; Geert J.L.H. van Leenders; Jos Jonkers; Tong Liu; Meisi Yan; Xiaolu Zhan; Tiannan Guo; Connie R. Jimenez
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Identification of C/EBPδ-Modifying Compounds as Potential Anticancer Agents Using a High-Throughput Drug Screen
err2025-01-31
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errHartl, Leonie; Duitman, Janwillem; Aberson, Hella L.; Medema, Jan Paul; Bijlsma, Maarten F.; Spek, C. Arnold
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NanoCMSer: a consensus molecular subtype stratification tool for fresh-frozen and paraffin-embedded colorectal cancer samples
err2024-12-25
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PREAI
errTorang, Arezo; van de Weerd, Simone; Lammers, Veerle; van Hooff, Sander; van den Berg, Inge; van den Bergh, Saskia; Koopman, Miriam; Ijzermans, Jan N.; Roodhart, Jeanine M. L.; Koster, Jan; Medema, Jan Paul
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UGT8 mediated sulfatide synthesis modulates BAX localization and dictates apoptosis sensitivity of colorectal cancer
err2024-11-23
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errZhang, Le; Ramesh, Prashanthi; Atencia Taboada, Lidia; Roessler, Rebecca; Zijlmans, Dick W.; Vermeulen, Michiel; Picavet-Havik, Daisy I.; van der Wel, Nicole N.; Vaz, Frederic M.; Medema, Jan Paul
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Transcriptome-based classification to predict FOLFIRINOX response in a real-world metastatic pancreatic cancer cohort
err2024-11-01
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errLansbergen, Marjolein F.; Dings, Mark P. G.; Manoukian, Paul; Farina, Arantza; Waasdorp, Cynthia; Hooijer, Gerrit K. J.; Verheij, Joanne; Koster, Jan; Zwijnenburg, Danny A.; Wilmink, Johanna W.; Medema, Jan Paul; Dijk, Frederike; van Laarhoven, Hanneke W. M.; Bijlsma, Maarten F.
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Benefit of adjuvant chemotherapy on recurrence free survival per consensus molecular subtype in stage III colon cancer
err2024-08-08
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errvan de Weerd, Simone; Torang, Arezo; van den Berg, Inge; Lammers, Veerle; van den Bergh, Saskia; Brouwer, Nelleke; Nagtegaal, Iris D.; Koopman, Miriam; Vink, Geraldine R.; van der Baan, Frederieke H.; van Krieken, Han; Koster, Jan; Ijzermans, Jan N.; Roodhart, Jeanine M. L.; Medema, Jan Paul
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The pluripotency factor NANOG contributes to mesenchymal plasticity and is predictive for outcome in esophageal adenocarcinoma
err2024-05-17
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errvan der Zalm, Amber P.; Dings, Mark P. G.; Manoukian, Paul; Boersma, Hannah; Janssen, Reimer; Bailey, Peter; Koster, Jan; Zwijnenburg, Danny; Volckmann, Richard; Bootsma, Sanne; Waasdorp, Cynthia; van Mourik, Monique; Blange, Dionne; van den Ende, Tom; Oyarce, Cesar I.; Derks, Sarah; Creemers, Aafke; Ebbing, Eva A.; Hooijer, Gerrit K.; Meijer, Sybren L.; van Berge Henegouwen, Mark I.; Medema, Jan Paul; van Laarhoven, Hanneke W. M.; Bijlsma, Maarten F.
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Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
err2024-05-01
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errBootsma, Sanne; Dings, Mark P. G.; Kesselaar, Job; Helderman, Roxan F. C. P. A.; van Megesen, Kyah; Constantinides, Alexander; Moreno, Leandro Ferreira; Stelloo, Ellen; Scutigliani, Enzo M.; Bokan, Bella; Torang, Arezo; Hooff, Sander R. van; Zwijnenburg, Danny A.; Wouters, Valerie M.; van de Vlasakker, Vincent C. J.; Galanos, Laskarina J. K.; Nijman, Lisanne E.; Logiantara, Adrian; Veenstra, Veronique L.; Schlingemann, Sophie; van Piggelen, Sterre; van der Wel, Nicole; Krawczyk, Przemek M.; Platteeuw, Johannes J.; Tuynman, Jurriaan B.; de Hingh, Ignace H.; Klomp, Jan P. G.; Oubrie, Arthur; Snaebjornsson, Petur; Medema, Jan Paul; Oei, Arlene L.; Kranenburg, Onno; Elbers, Clara C.; Lenos, Kristiaan J.; Vermeulen, Louis; Bijlsma, Maarten F.
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Consensus molecular subtype transition during progression of colorectal cancer
err2023-09-08
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errvan de Weerd, Simone; Torang, Arezo; Zwager, Liselotte W.; Koelink, Pim J.; Koster, Jan; Bastiaansen, Barbara A. J.; Lammers, Veerle; Longobardi, Ciro; Roodhart, Jeanine M. L.; van Krieken, J. Han; Sarasqueta, Arantza Farina; Dekker, Evelien; Medema, Jan Paul
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Transcriptome-based classification to predict FOLFIRINOX response in a real-world metastatic pancreatic cancer cohort
err2023-06-01
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errLansbergen, M.; Dings, M.; Manoukian, P.; Hooijer, G.; Sarasqueta, A. Farina; Verheij, J.; Koster, J.; Zwijnenburg, D.; Wilmink, J.; Cuppen, E.; Bloemendal, H.; Medema, J.; Dijk, F.; van Laarhoven, H.; Bijlsma, M.
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Estrogen signaling shapes a tumor suppressive stroma in pancreatic cancer
err2023-06-01
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PREAI
errManoukian, P.; Dings, M.; Koster, J.; Medema, J.; Van Laarhoven, H.; Bijlsma, M.
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Apoptotic cell death in disease-Current understanding of the NCCD 2023
err2023-04-26
err143
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errVitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Aqeilan, Rami, I; Arama, Eli; Baehrecke, Eric H.; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A.; Bartek, Jiri; Bazan, Nicolas G.; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu J. M.; Bianchi, Marco E.; Blagosklonny, Mikhail V.; Blander, J. Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D.; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A.; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Ciliberto, Gennaro; Conrad, Marcus; Cubillos-Ruiz, Juan R.; Czabotar, Peter E.; D'Angiolella, Vincenzo; Daugaard, Mads; Dawson, Ted M.; Dawson, Valina L.; De Maria, Ruggero; De Strooper, Bart; Debatin, Klaus-Michael; Deberardinis, Ralph J.; Degterev, Alexei; Del Sal, Giannino; Deshmukh, Mohanish; Di Virgilio, Francesco; Diederich, Marc; Dixon, Scott J.; Dynlacht, Brian D.; El-Deiry, Wafik S.; Elrod, John W.; Engeland, Kurt; Fimia, Gian Maria; Galassi, Claudia; Ganini, Carlo; Garcia-Saez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Gerlic, Motti; Ghosh, Sourav; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Haecker, Georg; Hajnoczky, Gyorgy; Hardwick, J. Marie; Haupt, Ygal; He, Sudan; Heery, David M.; Hengartner, Michael O.; Hetz, Claudio; Hildeman, David A.; Ichijo, Hidenori; Inoue, Satoshi; Jaeaettelae, Marja; Janic, Ana; Joseph, Bertrand; Jost, Philipp J.; Kanneganti, Thirumala-Devi; Karin, Michael; Kashkar, Hamid; Kaufmann, Thomas; Kelly, Gemma L.; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Kluck, Ruth; Krysko, Dmitri, V; Kulms, Dagmar; Kumar, Sharad; Lavandero, Sergio; Lavrik, Inna N.; Lemasters, John J.; Liccardi, Gianmaria; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; Lopez-Otin, Carlos; Luedde, Tom; MacFarlane, Marion; Madeo, Frank; Malorni, Walter; Manic, Gwenola; Mantovani, Roberto; Marchi, Saverio; Marine, Jean-Christophe; Martin, Seamus J.; Martinou, Jean-Claude; Mastroberardino, Pier G.; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Gerry; Melino, Sonia; Miao, Edward A.; Moll, Ute M.; Munoz-Pinedo, Cristina; Murphy, Daniel J.; Niklison-Chirou, Maria Victoria; Novelli, Flavia; Nunez, Gabriel; Oberst, Andrew; Ofengeim, Dimitry; Opferman, Joseph T.; Oren, Moshe; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pentimalli, Francesca; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Pinton, Paolo; Porta, Giovanni; Prehn, Jochen H. M.; Puthalakath, Hamsa; Rabinovich, Gabriel A.; Rajalingam, Krishnaraj; Ravichandran, Kodi S.; Rehm, Markus; Ricci, Jean-Ehrland; Rizzuto, Rosario; Robinson, Nirmal; Rodrigues, Cecilia M. P.; Rotblat, Barak; Rothlin, Carla, V; Rubinsztein, David C.; Rudel, Thomas; Rufini, Alessandro; Ryan, Kevin M.; Sarosiek, Kristopher A.; Sawa, Akira; Sayan, Emre; Schroder, Kate; Scorrano, Luca; Sesti, Federico; Shao, Feng; Shi, Yufang; Sica, Giuseppe S.; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stephanou, Anastasis; Stockwell, Brent R.; Strapazzon, Flavie; Strasser, Andreas; Sun, Liming; Sun, Erwei; Sun, Qiang; Szabadkai, Gyorgy; Tait, Stephen W. G.; Tang, Daolin; Tavernarakis, Nektarios; Troy, Carol M.; Turk, Boris; Urbano, Nicoletta; Vandenabeele, Peter; Vanden Berghe, Tom; Vander Heiden, Matthew G.; Vanderluit, Jacqueline L.; Verkhratsky, Alexei; Villunger, Andreas; von Karstedt, Silvia; Voss, Anne K.; Vousden, Karen H.; Vucic, Domagoj; Vuri, Daniela; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ruoning; Wang, Ying; Weber, Achim; Wood, Will; Yamazaki, Takahiro; Yang, Huang-Tian; Zakeri, Zahra; Zawacka-Pankau, Joanna E.; Zhang, Lin; Zhang, Haibing; Zhivotovsky, Boris; Zhou, Wenzhao; Piacentini, Mauro; Kroemer, Guido; Galluzzi, Lorenzo
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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
err2023-03-03
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errBuikhuisen, Joyce Y.; Gomez Barila, Patricia M.; Cameron, Kate; Suijkerbuijk, Saskia J. E.; Lieftink, Cor; di Franco, Simone; Garcia, Ana Krotenberg; Castro, Rebeca Uceda; Lenos, Kristiaan J.; Nijman, Lisanne E.; Torang, Arezo; Longobardi, Ciro; de Jong, Joan H.; Dekker, Danielle; Stassi, Giorgio; Vermeulen, Louis; Beijersbergen, Roderick L.; van Rheenen, Jacco; Huveneers, Stephan; Medema, Jan Paul
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Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer
err2022-11-01
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errDings, Mark P. G.; van der Zalm, Amber P.; Bootsma, Sanne; van Maanen, Tatum F. J.; Waasdorp, Cynthia; van den Ende, Tom; Liu, Dajia; Bailey, Peter; Koster, Jan; Zwijnenburg, Danny A.; Spek, C. Arnold; Klomp, Jan P. G.; Oubrie, Arthur; Hooijer, Gerrit K. J.; Meijer, Sybren L.; Henegouwen, Mark I. van Berge; Hulshof, Maarten C.; Bergman, Jacques; Oyarce, Cesar; Medema, Jan Paul; van Laarhoven, Hanneke W. M.; Bijlsma, Maarten F.
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Serum levels of iCAF-derived osteoglycin predict favorable outcome in pancreatic cancer
err2022-09-19
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errDings, Mark P. G.; Manoukian, Paul; Waasdorp, Cynthia; Quik, Judith S. E.; Strijker, Marin; Lodestijn, Sophie C.; van Neerven, Sanne M.; Moreno, Leandro F.; de Oliveira, Rodrigo Leite; Bonsing, Bert A.; Bruno, Marco J.; Busch, Olivier R.; Doukas, Michael; van Eijck, Casper H.; Mohammad, Nadia Haj; de Hingh, Ignace H.; Molenaar, Quintus, I; Besselink, Marc G.; Vermeulen, Louis; Medema, Jan Paul; van Laarhoven, Hanneke W. M.; Bijlsma, Maarten F.
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