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Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression Milosevic, Jelena; Fransson, Susanne; Svensson, Johanna; Otte, Jorg; Olsen, Thale K.; Sveinbjornsson, Baldur; Hertwig, Falk; Bartenhagen, Christoph; Abel, Frida; Reinsbach, Susanne E.; Djos, Anna; Javanmardi, Niloufar; Shi, Yao; Hehir-Kwa, Jane Y.; Mensenkamp, Arjen; Tytgat, Godelieve AM.; Holmberg, Johan; Molenaar, Jan J.; Jongmans, Marjolijn; Fischer, Matthias; Baryawno, Ninib; Gisselsson, David; Martinsson, Tommy; Kogner, Per; Johnsen, John Inge Share Save
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Targeted inhibition of WIP1 and histone H3K27 demethylase activity synergistically suppresses neuroblastoma growth Treis, Diana; Lundberg, Kristina Ihrmark; Bell, Nicola; Polychronopoulos, Panagiotis Alkinoos; Tuemmler, Conny; Akerlund, Emma; Aliverti, Stefania; Lilienthal, Ingrid; Pepich, Adena; Seashore-Ludlow, Brinton; Sakaguchi, Kazuyasu; Kogner, Per; Johnsen, John Inge; Wickstroem, Malin Share Save
METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma Thombare, Ketan; Vaid, Roshan; Pucci, Perla; Lundberg, Kristina Ihrmark; Ayyalusamy, Ritish; Baig, Mohammad Hassan; Mendez, Akram; Burgos-Panadero, Rebeca; Hoeppner, Stefanie; Bartenhagen, Christoph; Sjovall, Daniel; Rehan, Aqsa Ali; Nale, Sagar Dattatraya; Djos, Anna; Martinsson, Tommy; Jaako, Pekka; Dong, Jae-June; Kogner, Per; Johnsen, John Inge; Fischer, Matthias; Turner, Suzanne D.; Mondal, Tanmoy Share Save
The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma Pepich, Adena; Tummler, Conny; Abu Ajamieh, Sara; Treis, Diana; Boje, Ammelie Svea; Vellema, Quinty; Tsea, Ioanna; Akerlund, Emma; Seashore-Ludlow, Brinton; Fard, Shahrzad Shirazi; Kogner, Per; Johnsen, John Inge; Wickstrom, Malin Share Save
Heterogeneous SSTR2 target expression and a novel KIAA1549::BRAF fusion clone in a progressive metastatic lesion following 177Lutetium-DOTATATE molecular radiotherapy in neuroblastoma: a case report Park, Se Whee Sammy; Fransson, Susanne; Sundquist, Fredrik; Nilsson, Joachim N.; Gryback, Per; Wessman, Sandra; Stromgren, Jacob; Djos, Anna; Fagman, Henrik; Sjoegren, Helene; Georgantzi, Kleopatra; Herold, Nikolas; Kogner, Per; Granberg, Dan; Gaze, Mark N.; Martinsson, Tommy; Karlsson, Kasper; Stenman, Jakob J. E. Share Save
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Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma Olsen, Thale K.; Otte, Jorg; Mei, Shenglin; Embaie, Bethel Tesfai; Kameneva, Polina; Cheng, Huaitao; Gao, Teng; Zachariadis, Vasilios; Tsea, Ioanna; Bjorklund, Asa; Kryukov, Emil; Hou, Ziyi; Johansson, Anna; Sundstrom, Erik; Martinsson, Tommy; Fransson, Susanne; Stenman, Jakob; Fard, Shahrzad Shirazi; Johnsen, John Inge; Kogner, Per; Adameyko, Igor; Enge, Martin; Kharchenko, Peter V.; Baryawno, Ninib Share Save
Altered methylation of imprinted genes in neuroblastoma: implications for prognostic refinement Suman, Medha; Lofgren, Maja; Fransson, Susanne; Yousuf, Jewahri Idris; Svensson, Johanna; Djos, Anna; Martinsson, Tommy; Kogner, Per; Kling, Teresia; Caren, Helena Share Save
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Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance Djos, Anna; Svensson, Johanna; Gaarder, Jennie; Umapathy, Ganesh; Nilsson, Staffan; Ek, Torben; Vogt, Hartmut; Georgantzi, Kleopatra; Ora, Ingrid; Trager, Catarina; Kogner, Per; Martinsson, Tommy; Fransson, Susanne Share Save
Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors - a nationwide, prospective Swedish study Tesi, Bianca; Robinson, Kristina Lagerstedt; Abel, Frida; Stahl, Teresita Diaz de; Orrsjoe, Sara; Poluha, Anna; Hellberg, Maria; Wessman, Sandra; Samuelsson, Sofie; Frisk, Tony; Vogt, Hartmut; Henning, Karin; Sabel, Magnus; Ek, Torben; Pal, Niklas; Nyman, Per; Giraud, Geraldine; Wille, Joakim; Pronk, Cornelis Jan; Noren-Nystroem, Ulrika; Borssen, Magnus; Fili, Maria; Stalhammar, Gustav; Herold, Nikolas; Tettamanti, Giorgio; Maya-Gonzalez, Carolina; Arvidsson, Linda; Rosen, Anna; Ekholm, Katja; Kuchinskaya, Ekaterina; Hallbeck, Anna-Lotta; Nordling, Margareta; Palmebaeck, Pia; Kogner, Per; Smoler, Gunilla Kanter; Laehteenmaeki, Paeivi; Fransso, Susanne; Martinsson, Tommy; Shamik, Alia; Mertens, Fredrik; Rosenquist, Richard; Wirta, Valtteri; Tham, Emma; Grillner, Pernilla; Sandgren, Johanna; Ljungman, Gustaf; Gisselsson, David; Taylan, Fulya; Nordgren, Ann Share Save
Systems-level immunomonitoring in children with solid tumors Chen, Qi; Zhao, Binbin; Tan, Ziyang; Hedberg, Gustav; Wang, Jun; Gonzalez, Laura; Mugabo, Constantin; Johnsson, Anette; Paez, Laura; Rodriguez, Lucie; James, Anna; Chen, Yang; Mikes, Jaromir; Barcenilla, Hugo; Wang, Chunlin; Davis, Mark M.; Carlson, Lena-Maria; Pal, Niklas; Herold, Nikolas; Blomgren, Klas; Repsilber, Dirk; Lakshmikanth, Tadepally; Kogner, Per; Ljungblad, Linda; Brodin, Petter Share Save
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic Mei, Shenglin; Alchahin, Adele M.; Embaie, Bethel Tesfai; Gavriliuc, Ioana Maria; Verhoeven, Bronte Manouk; Zhao, Ting; Li, Xiangyun; Jeffries, Nathan Elias; Pepich, Adena; Sarkar, Hirak; Olsen, Thale Kristin; Wickstrom, Malin; Stenman, Jakob; Reina-Bedoya, Oscar; Kharchenko, Peter V.; Saylor, Philip J.; Johnsen, John Inge; Sykes, David B.; Kogner, Per; Baryawno, Ninib Share Save
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METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma Vaid, Roshan; Thombare, Ketan; Mendez, Akram; Burgos-Panadero, Rebeca; Djos, Anna; Jachimowicz, Daniel; Lundberg, Kristina Ihrmark; Bartenhagen, Christoph; Kumar, Navinder; Tummler, Conny; Sihlbom, Carina; Fransson, Susanne; Johnsen, John Inge; Kogner, Per; Martinsson, Tommy; Fischer, Matthias; Mondal, Tanmoy Share Save
High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance Zaghmi, Ahlem; Aybay, Erdem; Jiang, Long; Shang, Mingmei; Steinmetz-Spah, Julia; Wermeling, Fredrik; Kogner, Per; Korotkova, Marina; Ostling, Paivi; Jakobsson, Per-Johan; Seashore-Ludlow, Brinton; Larsson, Karin Share Save
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