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Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation Chapman, Michael Spencer; Mitchell, Emily; Yoshida, Kenichi; Williams, Nicholas; Fabre, Margarete A.; Ranzoni, Anna Maria; Robinson, Philip S.; Kregar, Lori; Wilk, C. Matthias; Boettcher, Steffen; Mahbubani, Krishnaa; Saeb-Parsy, Kourosh; Ng, Stanley; Vassiliou, George S.; Gowers, Kate; Janes, Sam; Hoare, Matt; Green, Anthony R.; Cvejic, Ana; Manz, Markus G.; Laurenti, Elisa; Martincorena, Inigo; Stratton, Michael; Nangalia, Jyoti; Coorens, Tim H. H.; Campbell, Peter Share Save
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Convergent somatic evolution commences in utero in a germline ribosomopathy Machado, Heather E.; Obro, Nina F.; Williams, Nicholas; Tan, Shengjiang; Boukerrou, Ahmed Z.; Davies, Megan; Belmonte, Miriam; Mitchell, Emily; Baxter, E. Joanna; Mende, Nicole; Clay, Anna; Ancliff, Philip; Koglmeier, Jutta; Killick, Sally B.; Kulasekararaj, Austin; Meyer, Stefan; Laurenti, Elisa; Campbell, Peter J.; Kent, David G.; Nangalia, Jyoti; Warren, Alan J. Share Save
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells Zhang, Yu Wei; Mess, Julian; Aizarani, Nadim; Mishra, Pankaj; Johnson, Carys; Romero-Mulero, Mari Carmen; Rettkowski, Jasmin; Schoenberger, Katharina; Obier, Nadine; Jaecklein, Karin; Woessner, Nadine M.; Lalioti, Maria-Eleni; Velasco-Hernandez, Talia; Sikora, Katarzyna; Waesch, Ralph; Lehnertz, Bernhard; Sauvageau, Guy; Manke, Thomas; Menendez, Pablo; Walter, Sebastian Gottfried; Minguet, Susana; Laurenti, Elisa; Guenther, Stefan; Gruen, Dominic; Cabezas-Wallscheid, Nina Share Save
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Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures Oedekoven, Caroline A.; Belmonte, Miriam; Bode, Daniel; Hamey, Fiona K.; Shepherd, Mairi S.; Che, James Lok Chi; Boyd, Grace; McDonald, Craig; Belluschi, Serena; Diamanti, Evangelia; Bastos, Hugo P.; Bridge, Katherine S.; Gottgens, Berthold; Laurenti, Elisa; Kent, David G. Share Save
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment Choudry, Fizzah A.; Bagger, Frederik O.; Macaulay, Iain C.; Farrow, Samantha; Burden, Frances; Kempster, Carly; McKinney, Harriet; Olsen, Lars R.; Huang, Ni; Downes, Kate; Voet, Thierry; Uppal, Rakesh; Martin, John F.; Mathur, Anthony; Ouwehand, Willem H.; Laurenti, Elisa; Teichmann, Sarah A.; Frontini, Mattia Share Save
Single-cell multi-omics analysis of the immune response in COVID-19 Stephenson, Emily; Reynolds, Gary; Botting, Rachel A.; Calero-Nieto, Fernando J.; Morgan, Michael D.; Tuong, Zewen Kelvin; Bach, Karsten; Sungnak, Waradon; Worlock, Kaylee B.; Yoshida, Masahiro; Kumasaka, Natsuhiko; Kania, Katarzyna; Engelbert, Justin; Olabi, Bayan; Spegarova, Jarmila Stremenova; Wilson, Nicola K.; Mende, Nicole; Jardine, Laura; Gardner, Louis C. S.; Goh, Issac; Horsfall, Dave; McGrath, Jim; Webb, Simone; Mather, Michael W.; Lindeboom, Rik G. H.; Dann, Emma; Huang, Ni; Polanski, Krzysztof; Prigmore, Elena; Gothe, Florian; Scott, Jonathan; Payne, Rebecca P.; Baker, Kenneth F.; Hanrath, Aidan T.; van der Loeff, Ina C. D. Schim; Barr, Andrew S.; Sanchez-Gonzalez, Amada; Bergamaschi, Laura; Mescia, Federica; Barnes, Josephine L.; Kilich, Eliz; de Wilton, Angus; Saigal, Anita; Saleh, Aarash; Janes, Sam M.; Smith, Claire M.; Gopee, Nusayhah; Wilson, Caroline; Coupland, Paul; Coxhead, Jonathan M.; Kiselev, Vladimir Yu; van Dongen, Stijn; Bacardit, Jaume; King, Hamish W.; Rostron, Anthony J.; Simpson, A. John; Hambleton, Sophie; Laurenti, Elisa; Lyons, Paul A.; Meyer, Kerstin B.; Nikolic, Marko Z.; Duncan, Christopher J. A.; Smith, Kenneth G. C.; Teichmann, Sarah A.; Clatworthy, Menna R.; Marioni, John C.; Gottgens, Berthold; Haniffa, Muzlifah Share Save
Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation Xie, Stephanie Z.; Kaufmann, Kerstin B.; Wang, Weijia; Chan-Seng-Yue, Michelle; Gan, Olga, I; Laurenti, Elisa; Garcia-Prat, Laura; Takayanagi, Shin-Ichiro; Ng, Stanley W. K.; Xu, ChangJiang; Zeng, Andy G. X.; Jin, Liqing; McLeod, Jessica; Wagenblast, Elvin; Mitchell, Amanda; Kennedy, James A.; Liu, Qiang; Boutzen, Helena; Kleinau, Melissa; Jargstorf, Joseph; Holmes, Gareth; Zhang, Yang; Voisin, Veronique; Bader, Gary D.; Wang, Jean C. Y.; Hannun, Yusuf A.; Luberto, Chiara; Schroeder, Timm; Minden, Mark D.; Dick, John E. Share Save
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A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis Bond, Jonathan; Krzywon, Aleksandra; Lhermitte, Ludovic; Roumier, Christophe; Roggy, Anne; Belhocine, Mohamed; Kheirallah, Alexander Abdulkader; Villarese, Patrick; Hypolite, Guillaume; Garnache-Ottou, Francine; Castaigne, Sylvie; Boissel, Nicolas; Asnafi, Vahid; Preudhomme, Claude; Dombret, Herve; Laurenti, Elisa; Macintyre, Elizabeth Share Save
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal Xie, Stephanie Z.; Garcia-Prat, Laura; Voisin, Veronique; Ferrari, Robin; Gan, Olga I.; Wagenblast, Elvin; Kaufmann, Kerstin B.; Zeng, Andy G. X.; Takayanagi, Shin-ichiro; Patel, Ishita; Lee, Esther K.; Jargstorf, Joseph; Holmes, Gareth; Romm, Guy; Pan, Kristele; Shoong, Michelle; Vedi, Aditi; Luberto, Chiara; Minden, Mark D.; Bader, Gary D.; Laurenti, Elisa; Dick, John E. Share Save
Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors Belluschi, Serena; Calderbank, Emily F.; Ciaurro, Valerio; Pijuan-Sala, Blanca; Santoro, Antonella; Mende, Nicole; Diamanti, Evangelia; Sham, Kendig Yen Chi; Wang, Xiaonan; Lau, Winnie W. Y.; Jawaid, Wajid; Gottgens, Berthold; Laurenti, Elisa Share Save
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors Horton, Sarah J.; Giotopoulos, George; Yun, Haiyang; Vohra, Shabana; Sheppard, Olivia; Bashford-Rogers, Rachael; Rashid, Mamunur; Clipson, Alexandra; Chan, Wai-In; Sasca, Daniel; Yiangou, Loukia; Osaki, Hikari; Basheer, Faisal; Gallipoli, Paolo; Burrows, Natalie; Erdem, Aysegul; Sybirna, Anastasiya; Foerster, Sarah; Zhao, Wanfeng; Sustic, Tonci; Harrison, Anna Petrunkina; Laurenti, Elisa; Okosun, Jessica; Hodson, Daniel; Wright, Penny; Smith, Ken G.; Maxwell, Patrick; Fitzgibbon, Jude; Du, Ming Q.; Adams, David J.; Huntly, Brian J. P. Share Save
DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation Farlik, Matthias; Halbritter, Florian; Mueller, Fabian; Choudry, Fizzah A.; Ebert, Peter; Klughammer, Johanna; Farrow, Samantha; Santoro, Antonella; Ciaurro, Valerio; Mathur, Anthony; Uppal, Rakesh; Stunnenberg, Hendrik G.; Ouwehand, Willem H.; Laurenti, Elisa; Lengauer, Thomas; Frontini, Mattia; Bock, Christoph Share Save
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