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The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1 Romero, Rodrigo; Chu, Tinyi; Robles, Tania J. Gonzalez; Smith, Perianne; Xie, Yubin; Kaur, Harmanpreet; Yoder, Sara; Zhao, Huiyong; Mao, Chenyi; Kang, Wenfei; Pulina, Maria V.; Lawrence, Kayla E.; Gopalan, Anuradha; Zaidi, Samir; Yoo, Kwangmin; Choi, Jungmin; Fan, Ning; Gerstner, Olivia; Karthaus, Wouter R.; Destanchina, Elisa; Ruggles, Kelly V.; Westcott, Peter M. K.; Chaligne, Ronan; Pe'er, Dana; Sawyers, Charles L. Share Save
Single- cell analysis of treatment- resistant prostate cancer: Implications of cell state changes for cell surface antigen- targeted therapies Zaidi, Samir; Park, Jooyoung; Chan, Joseph M.; Roudier, Martine P.; Zhao, Jimmy L.; Gopalan, Anuradha; Wadosky, Kristine M.; Patel, Radhika A.; Sayar, Erolcan; Karthaus, Wouter R.; Kates, D. Henry; Chaudhary, Ojasvi; Xu, Tianhao; Masilionis, Ignas; Mazutis, Linas; Chaligne, Ronan; Obradovic, Aleksandar; Linkov, Irina; Barlas, Afsar; Jungbluth, Achim A.; Rekhtman, Natasha; Silber, Joachim; Manova-Todorova, Katia; Watson, Philip A.; True, Lawrence D.; Morrissey, Colm; Scher, Howard I.; Rathkopf, Dana E.; Morris, Michael J.; Goodrich, David W.; Choi, Jungmin; Nelson, Peter S.; Haffner, Michael C.; Sawyers, Charles L. Share Save
CDC7 inhibition prevents neuroendocrine transformation in the lung and prostate through MYC degradation Quintanal-Villalonga, Alvaro; Uddin, Fathema; Kawasaki, Kenta; Redin, Esther; Durani, Vidushi; Sabet, Amin; Karthaus, Wouter; Zhan, Yingqian A.; Zaidi, Samir; Shaffer, Moniquetta; Sridhar, Harsha; Qiu, Juan; Manoj, Parvathy; De Stanchina, Elisa; Haffner, Michael C.; Sawyers, Charles L.; Rudin, Charles M. Share Save
CDC7 inhibition constrains lineage plasticity and prevents resistance and neuroendocrine transformation in the lung and prostate Quintanal-Villalonga, A.; Zaidi, S.; Karthaus, W. R.; Zhan, Y. A.; Shafer, M.; Qiu, J.; de Stanchina, E.; Haffner, M. C.; Sawyers, C. L.; Rudin, C. M. Share Save
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Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers Quintanal-Villalonga, Alvaro; Durani, Vidushi; Sabet, Amin; Redin, Esther; Kawasaki, Kenta; Shafer, Moniquetta; Karthaus, Wouter R.; Zaidi, Samir; Zhan, Yingqian A.; Manoj, Parvathy; Sridhar, Harsha; Shah, Nisargbhai S.; Chow, Andrew; Bhanot, Umesh K.; Linkov, Irina; Asher, Marina; Yu, Helena A.; Qiu, Juan; de Stanchina, Elisa; Patel, Radhika A.; Morrissey, Colm; Haffner, Michael C.; Koche, Richard P.; Sawyers, Charles L.; Rudin, Charles M. Share Save
Allosteric interactions prime androgen receptor dimerization and activation Wasmuth, Elizabeth V.; Vanden Broeck, Arnaud; LaClair, Justin R.; Hoover, Elizabeth A.; Lawrence, Kayla E.; Paknejad, Navid; Pappas, Kyrie; Matthies, Doreen; Wang, Biran; Feng, Weiran; Watson, Philip A.; Zinder, John C.; Karthaus, Wouter R.; de la Cruz, M. Jason; Hite, Richard K.; Manova-Todorova, Katia; Yu, Zhiheng; Weintraub, Susan T.; Klinge, Sebastian; Sawyers, Charles L. Share Save
Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models van de Merbel, Arjanneke F.; van der Horst, Geertje; van der Mark, Maaike H.; Bots, Selas T. F.; van den Wollenberg, Diana J. M.; de Ridder, Corrina M. A.; Stuurman, Debra; Aalders, Tilly; Erkens-Schulz, Sigrun; van Montfoort, Nadine; Karthaus, Wouter R.; Mehra, Niven; Smits, Minke; Schalken, Jack A.; van Weerden, Wytske M.; Hoeben, Rob C.; van der Pluijm, Gabri Share Save
FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer Arruabarrena-Aristorena, Amaia; Maag, Jesper L., V; Kittane, Srushti; Cai, Yanyan; Park, Jane; Razavi, Pedram; Ferrando, Lorenzo; Selenica, Pier; Karthaus, Wouter R.; Kannan, Srinivasaraghavan; Cocco, Emiliano; Ho, Sik Y.; Tan, Daisylyn Senna; Sallaku, Mirna; Sawyers, Charles L.; Reis-Fihlo, Jorge S.; Verma, Chandra S.; Jauch, Ralf; Koche, Richard; Baselga, Jose; Toska, Eneda; Scaltriti, Maurizio Share Save
Acquired stemness by luminal cells Karthaus, Wouter; Hofree, Matan; Choi, Danielle; Linton, Eliot L.; Turkekul, Mesruh; Bejnood, Alborz; Carver, Brett; Gopalan, Anuhandra; Laudone, Vincent; Biton, Moshe; Chaudhary, Ojasvi; Masilionis, Ignas; Mazutis, Linas; Pe'er, Dana; Regev, Aviv; Sawyers, Charles Share Save
A rectal cancer organoid platform to study individual responses to chemoradiation Ganesh, Karuna; Wu, Chao; O'Rourke, Kevin P.; Szeglin, Bryan C.; Zheng, Youyun; Sauve, Charles-Etienne Gabriel; Adileh, Mohammad; Wasserman, Isaac; Marco, Michael R.; Kim, Amanda S.; Shady, Maha; Sanchez-Vega, Francisco; Karthaus, Wouter R.; Won, Helen H.; Choi, Seo-Hyun; Pelossof, Raphael; Barlas, Afsar; Ntiamoah, Peter; Pappou, Emmanouil; Elghouayel, Arthur; Strong, James S.; Chen, Chin-Tung; Harris, Jennifer W.; Weiser, Martin R.; Nash, Garrett M.; Guillem, Jose G.; Wei, Iris H.; Kolesnick, Richard N.; Veeraraghavan, Harini; Ortiz, Eduardo J.; Petkovska, Iva; Cercek, Andrea; Manova-Todorova, Katia O.; Saltz, Leonard B.; Lavery, Jessica A.; DeMatteo, Ronald P.; Massague, Joan; Paty, Philip B.; Yaeger, Rona; Chen, Xi; Patil, Sujata; Clevers, Hans; Berger, Michael F.; Lowe, Scott W.; Shia, Jinru; Romesser, Paul B.; Dow, Lukas E.; Garcia-Aguilar, Julio; Sawyers, Charles L.; Smith, J. Joshua Share Save
Tumor microenvironment derived NRG1 promotes antiandrogen resistance in prostate cancer Zhang, Zeda; Karthaus, Wouter; Mota, Jose Mauricio; Mu, Ping; Wu, Chao; Abida, Wassim; Linton, Eliot; Lee, Young Sun; Lee, Eugine; Mao, Ninghui; Adams, Elizabeth; Choi, Danielle; Rathkopf, Dana E.; Carver, Brett; Gopalan, Anuradha; Jiang, Xuejun; Watson, Philip; Sawyers, Charles Share Save
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Patient derived organoids to model rare prostate cancer phenotypes Puca, Loredana; Bareja, Rohan; Prandi, Davide; Shaw, Reid; Benelli, Matteo; Karthaus, Wouter R.; Hess, Judy; Sigouros, Michael; Donoghue, Adam; Kossai, Myriam; Gao, Dong; Cyrta, Joanna; Sailer, Verena; Vosoughi, Aram; Pauli, Chantal; Churakova, Yelena; Cheung, Cynthia; Deonarine, Lesa Dayal; McNary, Terra J.; Rosati, Rachele; Tagawa, Scott T.; Nanus, David M.; Mosquera, Juan Miguel; Sawyers, Charles L.; Chen, Yu; Inghirami, Giorgio; Rao, Rema A.; Grandori, Carla; Elemento, Olivier; Sboner, Andrea; Demichelis, Francesca; Rubin, Mark A.; Beitrah, Himisha Share Save
Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer Shah, Neel; Wang, Ping; Wongvipat, John; Karthaus, Wouter R.; Abida, Wassim; Armenia, Joshua; Rockowitz, Shira; Drier, Yotam; Bernstein, Bradley E.; Long, Henry W.; Freedman, Matthew L.; Arora, Vivek K.; Zheng, Deyou; Sawyers, Charles L. Share Save
Patient-derived tumor organoids of neuroendocrine prostate cancer Puca, Loredana; Bareja, Rohan; Shaw, Reid; Karthaus, Wouter; Gao, Dong; Pauli, Chantal; Mosquera, Juan Miguel; Cyrta, Joanna; Rosati, Rachele; Rao, Rema; Sboner, Andrea; Grandori, Carla; Inghirami, Giorgio; Chen, Yu; Rubin, Mark A.; Beltran, Himisha Share Save
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 and RB1 deficient prostate cancer Mu, Ping; Zhang, Zeda; Benelli, Matteo; Karthaus, Wouter; Hoover, Elizebeth; Chen, Chi-Chao; Wongvipat, John; Ku, Sheng-Yu; Gao, Dong; Cao, Zhen; Shah, Neel; Adams, Elizabeth; Abida, Wassim; Watson, Philip; Prandi, Davide; Huang, Chun-Hao; de Stanchina, Elisa; Lowe, Scott; Ellis, Leigh; Beltran, Himisha; Rubin, Mark; Goodrich, David; Demichelis, Francesca; Sawyers, Charles L. Share Save
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon Sasaki, Nobuo; Sachs, Norman; Wiebrands, Kay; Ellenbroek, Saskia I. J.; Fumagalli, Arianna; Lyubimova, Anna; Begthel, Harry; van den Born, Maaike; van Es, Johan H.; Karthaus, Wouter R.; Li, Vivian S. W.; Lopez-Iglesias, Carmen; Peters, Peter J.; van Rheenen, Jacco; van Oudenaarden, Alexander; Clevers, Hans Share Save
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