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Stephen R. Bloom

Imperial College London

155H-index
1.4KPaper Count
10.5WCitation Count
Published Papers 175
Publication Date
Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation
err2025-02-01
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errDavies, Iona; Adriaenssens, Alice E.; Scott, William R.; Carling, David; Murphy, Kevin G.; Minnion, James S.; Bloom, Stephen R.; Jones, Ben; Tan, Tricia M-M.
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The physiological impact of an N-terminal Halo-tag on glucose-dependent insulinotropic polypeptide receptor function in mice
err2025-01-30
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errDavies, Iona; Manchanda, Yusman; Sloop, Kyle W.; Bloom, Stephen R.; Tan, Tricia M. -M.; Tomas, Alejandra; Jones, Ben
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Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis
err2024-07-01
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errSuba, K.; Patel, Y.; Martin-Alonso, A.; Hansen, B.; Xu, X.; Roberts, A.; Norton, M.; Chung, P.; Shrewsbury, J.; Kwok, R.; Kalogianni, V; Chen, S.; Liu, X.; Kalyviotis, K.; Rutter, G. A.; Jones, B.; Minnion, J.; Owen, B. M.; Pantazis, P.; Distaso, W.; Drucker, D. J.; Tan, T. M.; Bloom, S. R.; Murphy, K. G.; Salem, V.
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The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
err2024-03-01
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errAlonso, Aldara Martin; Cork, Simon C.; Phuah, Phyllis; Hansen, Benjamin; Norton, Mariana; Cheng, Sijing; Xu, Xiang; Suba, Kinga; Ma, Yue; Dowsett, Georgina K. C.; Tadross, John A.; Lam, Brian Y. H.; Yeo, Giles S. H.; Herzog, Herbert; Bloom, Stephen R.; Arnold, Myrtha; Distaso, Walter; Murphy, Kevin G.; Salem, Victoria
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Adaptive infusion of a glucagon-like peptide-1/glucagon receptor co-agonist G3215, in adults with overweight or obesity: Results from a phase 1 randomized clinical trial
err2024-01-16
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errHope, David C. D.; Ansari, Saleem; Choudhury, Sirazum; Alexiadou, Kleopatra; Tabbakh, Yasmin; Ilesanmi, Ibiyemi; Lazarus, Katharine; Davies, Iona; Jimenez-Pacheco, Lara; Yang, Wei; Ball, Laura-Jayne; Malviya, Reshma; Reglinska, Beata; Khoo, Bernard; Minnion, James; Bloom, Stephen R.; Tan, Tricia M. -M.
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Abolishing β-arrestin recruitment is necessary for the full metabolic benefits of G protein-biased glucagon-like peptide-1 receptor agonists
err2023-10-05
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errHinds, Charlotte E.; Peace, Ellie; Chen, Shiqian; Davies, Iona; El Eid, Liliane; Tomas, Alejandra; Tan, Tricia; Minnion, James; Jones, Ben; Bloom, Stephen R.
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100 years of glucagon and 100 more
err2023-06-27
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errWewer Albrechtsen, Nicolai J.; Holst, Jens J.; Cherrington, Alan D.; Finan, Brian; Gluud, Lise Lotte; Dean, E. Danielle; Campbell, Jonathan E.; Bloom, Stephen R.; Tan, Tricia M. -M.; Knop, Filip K.; Mueller, Timo D.
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Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosis
err2023-05-19
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errMcGlone, Emma Rose; Siebert, Matthieu; Dore, Marian; Hope, David C. D.; Davies, Iona; Owen, Bryn; Khoo, Bernard; Goldin, Rob; Carling, Dave; Bloom, Stephen; Le Gall, Maude; Tan, Tricia M-M.
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Commentary on The road to reliable peptide assays is paved with good guidelines
err2023-03-13
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errKowalka, Anna M. M.; Alexiadou, Kleopatra; Cuenco, Joyceline; Clarke, Rosemary E. E.; Camuzeaux, Stephane; Minnion, James; Williams, Emma L. L.; Bech, Paul; Purkayastha, Sanjay; Ahmed, Ahmed R. R.; Takats, Zoltan; Khoo, Bernard; Whitwell, Harry J. J.; Romero, Maria G. G.; Bloom, Stephen R. R.; Lewis, Matthew R. R.; Tan, Tricia M. -M.
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Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single-blind placebo-controlled study
err2023-03-13
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errBehary, Preeshila; Alessimii, Haya; Miras, Alexander D.; Tharakan, George; Alexiadou, Kleopatra; Aldhwayan, Madhawi M.; Purkayastha, Sanjay; Moorthy, Krishna; Ahmed, Ahmed R.; Bloom, Stephen R.; Tan, Tricia M.
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The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy
err2022-11-28
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errKowalka, Anna M.; Alexiadou, Kleopatra; Cuenco, Joyceline; Clarke, Rosemary E. E.; Minnion, James; Williams, Emma L. L.; Bech, Paul; Purkayastha, Sanjay; Ahmed, Ahmed R. R.; Takats, Zoltan; Whitwell, Harry J. J.; Romero, Maria Gomez; Bloom, Stephen R. R.; Camuzeaux, Stephane; Lewis, Matthew R. R.; Khoo, Bernard; Tan, Tricia M. -M.
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Evaluation of Multimodality LAA Leak Closure Methods Following Incomplete Occlusion The LAA Leak Study
err2022-11-01
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errCharate, Rishi; Ahmed, Adnan; Della Rocca, Domenico G.; Bloom, Stephen; Garg, Jalaj; Pothineni, Naga Venkata K.; DiBiase, Luigi; Turagam, Mohit; Gopinathannair, Rakesh; Horton, Rodney; Kar, Saibal; Fontana, Gregory; Doshi, Shephal K.; Swarup, Vijay; Finn, Aloke; Reddy, Vivek; Natale, Andrea; Lakkireddy, Dhanunjaya
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Hypoaminoacidemia underpins glucagon-mediated energy expenditure and weight loss
err2022-11-01
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errHope, David C. D.; Hinds, Charlotte E.; Lopes, Tatiana; Vincent, Matthew L.; V. Shrewsbury, Jed; Yu, Arthur T. C.; Davies, Iona; Scott, Rebecca; Jones, Ben; Murphy, Kevin G.; Minnion, James S.; Sardini, Alessandro; Carling, David; Lutz, Thomas A.; Bloom, Stephen R.; Tan, Tricia M. M.; Owen, Bryn M.
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Hepatocyte cholesterol content modulates glucagon receptor signalling
err2022-09-01
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errMcGlone, Emma Rose; Ansell, T. Bertie; Dunsterville, Cecilia; Song, Wanling; Carling, David; Tomas, Alejandra; Bloom, Stephen R.; Sansom, Mark S. P.; Tan, Tricia; Jones, Ben
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The Effect of Standard Versus Longer Intestinal Bypass on GLP-1 Regulation and Glucose Metabolism in Patients With Type 2 Diabetes Undergoing Roux-en-Y Gastric Bypass: The Long-Limb Study
err2021-11-06
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errMiras, Alexander Dimitri; Kamocka, Anna; Perez-Pevida, Belen; Purkayastha, Sanjay; Moorthy, Krishna; Patel, Ameet; Chahal, Harvinder; Frost, Gary; Bassett, Paul; Castagnetto-Gissey, Lidia; Coppin, Lucy; Jackson, Nicola; Umpleby, Anne Margot; Bloom, Stephen Robert; Tan, Tricia; Ahmed, Ahmed Rashid; Rubino, Francesco
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Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling
err2021-11-01
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errMcGlone, Emma Rose; Manchanda, Yusman; Jones, Ben; Pickford, Phil; Inoue, Asuka; Carling, David; Bloom, Stephen R.; Tan, Tricia; Tomas, Alejandra
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Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking
err2021-10-01
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errLucey, Maria; Ashik, Tanyel; Marzook, Amaara; Wang, Yifan; Goulding, Joelle; Oishi, Atsuro; Broichhagen, Johannes; Hodson, David J.; Minnion, James; Elani, Yuval; Jockers, Ralf; Briddon, Stephen J.; Bloom, Stephen R.; Tomas, Alejandra; Jones, Ben
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The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction
err2021-08-30
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errJones, Ben; Sands, Caroline; Alexiadou, Kleopatra; Minnion, James; Tharakan, George; Behary, Preeshila; Ahmed, Ahmed R.; Purkayastha, Sanjay; Lewis, Matthew R.; Bloom, Stephen; Li, Jia, V; Tan, Tricia M.
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Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1
err2021-08-01
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errMarzook, Amaara; Chen, Shiqian; Pickford, Phil; Lucey, Maria; Wang, Yifan; Correa, Ivan R. Jr Jr; Broichhagen, Johannes; Hodson, David J.; Salem, Victoria; Rutter, Guy A.; Tan, Tricia M.; Bloom, Stephen R.; Tomas, Alejandra; Jones, Ben
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Weight Loss by Low-Calorie Diet Versus Gastric Bypass Surgery in People With Diabetes Results in Divergent Brain Activation Patterns: A Functional MRI Study
err2021-06-22
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errSalem, Victoria; Demetriou, Lysia; Behary, Preeshila; Alexiadou, Kleopatra; Scholtz, Samantha; Tharakan, George; Miras, Alexander D.; Purkayastha, Sanjay; Ahmed, Ahmed R.; Bloom, Stephen R.; Wall, Matthew B.; Dhillo, Waljit S.; Tan, Tricia M-M
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