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Ole Isacson

Harvard Medical School

101H-index
396Paper Count
3.3WCitation Count
Published Papers 119
Publication Date
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APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons
errPNAS Nexus
IF3.8
err2026-03-03
err0
errOAAI
errDilara O Halim; Erika Di Biase; Amélie Rajon; Luc Jordi; Penelope J Hallett; Ole Isacson; null
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errSave
ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition
errSCIENTIFIC REPORTS
IF3.9
err2025-04-29
err0
errOAAI
errDi Biase, Erika; Connolly, Kyle J.; Crumpton, Ingrid; Cooper, Oliver; Hallett, Penelope J.; Isacson, Ole
errShare
errSave
Neuronal threshold functions: Determining symptom onset in neurological disorders
errPROGRESS IN NEUROBIOLOGY
IF6.1
err2024-11-01
err0
errOAAI
errJordi, Luc; Isacson, Ole
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errSave
Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition
errCELLS
IF5.2
err2023-11-02
err2
errOAAI
errConnolly, Kyle J.; Margaria, Juliette; Di Biase, Erika; Cooper, Oliver; Hallett, Penelope J.; Isacson, Ole
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errSave
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain
errSCIENTIFIC REPORTS
IF3.9
err2023-09-13
err4
errOAAI
errThomas, Ria; Connolly, Kyle J.; Brekk, Oeystein R.; Hinrich, Anthony J.; Hastings, Michelle L.; Isacson, Ole; Hallett, Penelope J.
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errSave
Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease
errHUMAN MOLECULAR GENETICS
IF3.2
err2023-02-08
err10
errOAAI
errKumar, Manoj; Srikanth, Manasa P.; Deleidi, Michela; Hallett, Penelope J.; Isacson, Ole; Feldman, Ricardo A.
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errSave
Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias
errFEBS JOURNAL
IF4.2
err2022-10-12
err11
PREAI
errCooper, Oliver; Hallett, Penny; Isacson, Ole
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errSave
Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2
errMOLECULAR BRAIN
IF2.9
err2021-01-19
err17
errOAAI
errThomas, Ria; Moloney, Elizabeth B.; Macbain, Zachary K.; Hallett, Penelope J.; Isacson, Ole
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errSave
Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-10-15
err62
errOAAI
errBrekk, Oeystein Roed; Honey, Jonathan R.; Lee, Seungil; Hallett, Penelope J.; Isacson, Ole
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errSave
Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice
errMOLECULAR THERAPY-NUCLEIC ACIDS
IF0
err2020-09-01
err30
errOAAI
errKorecka, Joanna A.; Thomas, Ria; Hinrich, Anthony J.; Moskites, Alyssa M.; Macbain, Zach K.; Hallett, Penelope J.; Isacson, Ole; Hastings, Michelle L.
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errSave
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2020-08-06
err18
errOAAI
errBrekk, Oeystein R.; Korecka, Joanna A.; Crapart, Cecile C.; Huebecker, Mylene; MacBain, Zachary K.; Rosenthal, Sara Ann; Sena-Esteves, Miguel; Priestman, David A.; Platt, Frances M.; Isacson, Ole; Hallett, Penelope J.
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errSave
Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients
errFRONTIERS IN CELLULAR NEUROSCIENCE
IF4
err2020-04-03
err29
errOAAI
errOsborn, Teresia M.; Hallett, Penelope J.; Schumacher, James M.; Isacson, Ole
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errSave
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease (vol 14, 40, 2019)
errMOLECULAR NEURODEGENERATION
IF17.5
err2020-01-15
err2
errOAAI
errHuebecker, Mylene; Moloney, Elizabeth B.; van der Spoel, Aarnoud C.; Priestman, David A.; Isacson, Ole; Hallett, Penelope J.; Platt, Frances M.
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errSave
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease
errMOLECULAR NEURODEGENERATION
IF17.5
err2019-11-08
err109
errOAAI
errHuebecker, Mylene; Moloney, Elizabeth B.; van der Spoel, Aarnoud C.; Priestman, David A.; Isacson, Ole; Hallett, Penelope J.; Platt, Frances M.
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errSave
Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells
errStem Cells
IF3.6
err2019-08-09
err9
errOAAI
errMenon, Vishal; Thomas, Ria; Elgueta, Claudio; Horl, Marcus; Osborn, Teresia; Hallett, Penny J.; Bartos, Marlene; Isacson, Ole; Pruszak, Jan
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errSave
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2019-07-22
err74
errOAAI
errHallett, Penelope J.; Engelender, Simone; Isacson, Ole
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errSave
Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts
errHUMAN MOLECULAR GENETICS
IF3.2
err2019-06-04
err48
errOAAI
errKorecka, Joanna A.; Thomas, Ria; Christensen, Dan P.; Hinrich, Anthony J.; Ferrari, Eliza J.; Levy, Simon A.; Hastings, Michelle L.; Hallett, Penelope J.; Isacson, Ole
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errSave
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
errSTEM CELL REPORTS
IF5.1
err2019-01-01
err65
errOAAI
errKorecka, Joanna A.; Talbot, Rsebastien; Osborn, Teresia M.; de Leeuw, Sherida M.; Levy, Simon A.; Ferrari, Eliza J.; Moskites, Alyssa; Atkinson, Elise; Jodelka, Francine M.; Hinrich, Anthony J.; Hastings, Michelle L.; Woolf, Clifford J.; Hallett, Penelope J.; Isacson, Ole
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The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress
errNEUROBIOLOGY OF DISEASE
IF5.6
err2018-12-01
err84
errOAAI
errMoloney, Elizabeth B.; Moskites, Alyssa; Ferrari, Eliza J.; Isacson, Ole; Hallett, Penelope J.
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errSave
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
errSCIENTIFIC REPORTS
IF3.9
err2018-10-12
err26
errOAAI
errBrekk, Oeystein R.; Moskites, Alyssa; Isacson, Ole; Hallett, Penelope J.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Virginia M.‐Y. Lee
H-index: 200 · Papers: 919
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Barry Halliwell
H-index: 190 · Papers: 946
M
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