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Research autopsy programmes in oncology: shared experience from 14 centres across the world Geukens, Tatjana; Maetens, Marion; Hooper, Jody E.; Oesterreich, Steffi; Lee, Adrian, V; Miller, Lori; Atkinson, Jenny M.; Rosenzweig, Margaret; Puhalla, Shannon; Thorne, Heather; Devereux, Lisa; Bowtell, David; Loi, Sherene; Bacon, Eliza R.; Ihle, Kena; Song, Mihae; Rodriguez-Rodriguez, Lorna; Welm, Alana L.; Gauchay, Lisa; Murali, Rajmohan; Chanda, Pharto; Karacay, Ali; Naceur-Lombardelli, Cristina; Bridger, Hayley; Swanton, Charles; Jamal-Hanjani, Mariam; Kollath, Lori; True, Lawrence; Morrissey, Colm; Chambers, Meagan; Chinnaiyan, Arul M.; Wilson, Allecia; Mehra, Rohit; Reichert, Zachery; Carey, Lisa A.; Perou, Charles M.; Kelly, Erin; Maeda, Daichi; Goto, Akiteru; Kulka, Janina; Szekely, Borbala; Szasz, A. Marcell; Tokes, Anna-Maria; van den Bogaert, Wouter; Floris, Giuseppe; Desmedt, Christine Share Save
Impact of concurrent tumour events on the prostate cancer outcomes of germline BRCA2 mutation carriers Lozano, Rebeca; Castro, Elena; -Campos, Fernando Lopez; Thorne, Heather; Ramirez-Backhaus, Miguel; Aragon, Isabel M.; Cendon-Florez, Ylenia; Gutierrez-Pecharroman, Ana; Salles, Daniela C.; Romero-Laorden, Nuria; Lorente, David; Gonzalez-Peramato, Pilar; Calatrava, Ana; Alonso, Concepcion; Anido, Urbano; Arevalo-Lobera, Sara; Balmana, Judith; Chirivella, Isabel; Juan-Fita, Maria Jose; Llort, Gemma; Cajal, Teresa Ramon Y.; Almagro, Elena; Alameda, Daniel; Lopez-Casas, Pedro P.; Herrera, Bernardo; Mateo, Joaquin; Pritchard, Colin C.; Antonarakis, Emmanuel S.; Lotan, Tamara L.; Rubio-Briones, Jose; Sandhu, Shahneen; Olmos, David Share Save
How inherited mutations affect single cells within the tumor microenvironment in breast tumors stratified by receptor status Pueschl, Dana; Oldridge, Derek A.; Belman, Jonathan; Chandler, William; Nayak, Anupma; Wubbenhorst, Bradley; Pluta, John; Feldman, Michael; Wherry, E. John; Thorne, Heather; Chenevix-Trench, Georgia; Domchek, Susan M.; Nathanson, Katherine L. Share Save
BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme Thorne, Heather; Devereux, Lisa; Li, Jason; Alsop, Kathryn; Christie, Liz; van Geelen, Courtney T.; Burdett, Nikki; Pishas, Kathleen, I; Woodford, Noel; Leditschke, Jodie; Izzath, Mohamed H. M. A.; Strachan, Kate; Young, Gregory; Jaravaza, Rufaro D.; Madadin, Mohammed S.; Archer, Melanie; Glengarry, Joanna; Iles, Linda; Rathnaweera, Ajith; Hampson, Clare; Almazrooei, Khamis; Burke, Michael; Bandara, Pradeep; Ranson, David; Saeedi, Essa; McNally, Orla; Mileshkin, Linda; Hamilton, Anne; Ananda, Sumitra; Au-Yeung, George; Antill, Yoland; Sandhu, Shahneen; Savas, Peter; Francis, Prudence A.; Luen, Stephen; Loi, Sherene; Jennens, Ross; Scott, Clare; Moodie, Kate; Cummings, Margaret; Reid, Andrew; Reed, Amy McCart; Bowtell, David; Lakhani, Sunil R.; Fox, Stephen Share Save
Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer Burdett, Nikki L.; Willis, Madelynne O.; Alsop, Kathryn; Hunt, Allison L.; Pandey, Ahwan; Hamilton, Phineas T.; Abulez, Tamara; Liu, Xuan; Hoang, Therese; Craig, Stuart; Fereday, Sian; Hendley, Joy; Garsed, Dale W.; Milne, Katy; Kalaria, Shreena; Marshall, Ashley; Hood, Brian L.; Wilson, Katlin N.; Conrads, Kelly A.; Pishas, Kathleen, I; Ananda, Sumitra; Scott, Clare L.; Antill, Yoland; McNally, Orla; Mileshkin, Linda; Hamilton, Anne; Au-Yeung, George; Devereux, Lisa; Thorne, Heather; Bild, Andrea; Bateman, Nicholas W.; Maxwell, G. Larry; Chang, Jeffrey T.; Conrads, Thomas P. P.; Nelson, Brad H.; Bowtell, David D. L.; Christie, Elizabeth L. L. Share Save
Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes Trigos, Anna Sofia; Pasam, Anupama; Banks, Patricia; Wallace, Roslyn; Guo, Christina; Keam, Simon; Thorne, Heather; Mitchell, Catherine; Lade, Stephen; Clouston, David; Hakansson, Alexander; Liu, Yang; Blyth, Benjamin; Murphy, Declan; Lawrentschuk, Nathan; Bolton, Damien; Moon, Daniel; Darcy, Phil; Haupt, Ygal; Williams, Scott G.; Castro, Elena; Olmos, David; Goode, David; Neeson, Paul; Sandhu, Shahneen Share Save
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants Li, Hongyan; Engel, Christoph; de la Hoya, Miguel; Peterlongo, Paolo; Yannoukakos, Drakoulis; Livraghi, Luca; Radice, Paolo; Thomassen, Mads; Hansen, Thomas V. O.; Gerdes, Anne-Marie; Nielsen, Henriette R.; Caputo, Sandrine M.; Zambelli, Alberto; Borg, Ake; Solano, Angela; Thomas, Abigail; Parsons, Michael T.; Antoniou, Antonis C.; Leslie, Goska; Yang, Xin; Chenevix-Trench, Georgia; Caldes, Trinidad; Kwong, Ava; Pedersen, Inge Sokilde; Lautrup, Charlotte K.; John, Esther M.; Terry, Mary Beth; Hopper, John L.; Southey, Melissa C.; Andrulis, Irene L.; Tischkowitz, Marc; Janavicius, Ramunas; Boonen, Susanne E.; Kroeldrup, Lone; Varesco, Liliana; Hamann, Ute; Vega, Ana; Palmero, Edenir, I; Garber, Judy; Montagna, Marco; Van Asperen, Christi J.; Foretova, Lenka; Greene, Mark H.; Selkirk, Tina; Moller, Pal; Toland, Amanda E.; Domchek, Susan M.; James, Paul A.; Thorne, Heather; Eccles, Diana M.; Nielsen, Sarah M.; Manoukian, Siranoush; Pasini, Barbara; Caligo, Maria A.; Lazaro, Conxi; Kirk, Judy; Wappenschmidt, Barbara; Spurdle, Amanda B.; Couch, Fergus J.; Schmutzler, Rita; Goldgar, David E. Share Save
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology Risbridger, Gail P.; Clark, Ashlee K.; Porter, Laura H.; Toivanen, Roxanne; Bakshi, Andrew; Lister, Natalie L.; Pook, David; Pezaro, Carmel J.; Sandhu, Shahneen; Keerthikumar, Shivakumar; Urban, Rosalia Quezada; Papargiris, Melissa; Kraska, Jenna; Madsen, Heather B.; Wang, Hong; Richards, Michelle G.; Niranjan, Birunthi; O'Dea, Samantha; Teng, Linda; Wheelahan, William; Li, Zhuoer; Choo, Nicholas; Ouyang, John F.; Thorne, Heather; Devereux, Lisa; Hicks, Rodney J.; Sengupta, Shomik; Harewood, Laurence; Iddawala, Mahesh; Azad, Arun A.; Goad, Jeremy; Grummet, Jeremy; Kourambas, John; Kwan, Edmond M.; Moon, Daniel; Murphy, Declan G.; Pedersen, John; Clouston, David; Norden, Sam; Ryan, Andrew; Furic, Luc; Goode, David L.; Frydenberg, Mark; Lawrence, Mitchell G.; Taylor, Renea A. Share Save
Association between BRCA2 alterations and intraductal and cribriform histologies in prostate cancer Lozano, Rebeca; Salles, Daniela C.; Sandhu, Shahneen; Aragon, Isabel M.; Thorne, Heather; Lopez-Campos, Fernando; Rubio-Briones, Jose; Gutierrez-Pecharroman, Ana M.; Maldonado, Laneisha; di Domenico, Tomas; Sanz, Alejandro; Prieto, Juan D.; Garcia, Isabel; Pacheco, Maria, I; Garces, Teresa; Llacer, Casilda; Romero-Laorden, Nuria; Zambrana, Francisco; Lopez-Casas, Pedro P.; Lorente, David; Mateo, Joaquin; Pritchard, Colin C.; Antonarakis, Emmanuel S.; Olmos, David; Lotan, Tamara L.; Castro, Elena Share Save
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling Vergara, Ismael A.; Mintoff, Christopher P.; Sandhu, Shahneen; McIntosh, Lachlan; Young, Richard J.; Wong, Stephen Q.; Colebatch, Andrew; Cameron, Daniel L.; Kwon, Julia Lai; Wolfe, Rory; Peng, Angela; Ellul, Jason; Dou, Xuelin; Fedele, Clare; Boyle, Samantha; Arnau, Gisela Mir; Raleigh, Jeanette; Hatzimihalis, Athena; Szeto, Pacman; Mooi, Jennifer; Widmer, Daniel S.; Cheng, Phil F.; Amann, Valerie; Dummer, Reinhard; Hayward, Nicholas; Wilmott, James; Scolyer, Richard A.; Cho, Raymond J.; Bowtell, David; Thorne, Heather; Alsop, Kathryn; Cordner, Stephen; Woodford, Noel; Leditschke, Jodie; O'Brien, Patricia; Dawson, Sarah-Jane; McArthur, Grant A.; Mann, Graham J.; Levesque, Mitchell P.; Papenfuss, Anthony T.; Shackleton, Mark Share Save
Clinical impact of somatic alterations in prostate cancer patients with and without previously known germline BRCA1/2 mutations: Results from PROREPAIR-A study Lozano Mejorada, R.; Castro Marcos, E.; Aragon, I. M.; Thorne, H.; Lopez Campos, F.; Sanz, A.; Alonso, C.; Anido, U.; Juan Fita, M. J.; Gutierrez Pecharroman, A. M.; Ramirez-Backhaus, M.; Balmana, J.; Chirivella Gonzalez, I.; Llort, G.; Romero Laorden, N.; Arevalo Lobera, S.; Rubio Briones, J.; Pritchard, C. C.; Sandhu, S.; Olmos Hidalgo, D. Share Save
BRCA2 status and intraductal [IDC] and cribriform [CRIB] histologic variants: Partners in prostate cancer (PC)? Romero Laorden, N.; Llacer Perez, C.; Castro Marcos, E.; Salles, D. C.; Lozano Mejorada, R.; Thorne, H.; Aragon, I. M.; Lopez Campos, F.; Rubio Briones, J.; Gutierrez Pecharroman, A. M.; Prieto, J. D.; Pacheco, M. I.; Garces, T.; Zambrana, F.; Mateo, J.; Lopez-Casas, P. P.; Sandhu, S.; Antonarakis, E. S.; Olmos Hidalgo, D.; Lotan, T. Share Save
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis Escala-Garcia, Maria; Abraham, Jean; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Ashworth, Alan; Auer, Paul L.; Auvinen, Paivi; Beckmann, Matthias W.; Beesley, Jonathan; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Blot, William; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Borresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brucker, Sara Y.; Burwinkel, Barbara; Caldas, Carlos; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J.; Chin, Suet-Feung; Clarke, Christine L.; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Dennis, Joe; Devilee, Peter; Dunn, Janet A.; Dunning, Alison M.; Dwek, Miriam; Earl, Helena M.; Eccles, Diana M.; Eliassen, A. Heather; Ellberg, Carolina; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M.; Garcia-Closas, Montserrat; Garcia-Saenz, Jose A.; Gaudet, Mia M.; George, Angela; Giles, Graham G.; Goldgar, David E.; Gonzalez-Neira, Anna; Grip, Mervi; Guenel, Pascal; Guo, Qi; Haiman, Christopher A.; Hakansson, Niclas; Hamann, Ute; Harrington, Patricia A.; Hiller, Louise; Hooning, Maartje J.; Hopper, John L.; Howell, Anthony; Huang, Chiun-Sheng; Huang, Guanmengqian; Hunter, David J.; Jakubowska, Anna; John, Esther M.; Kaaks, Rudolf; Kapoor, Pooja Middha; Keeman, Renske; Kitahara, Cari M.; Koppert, Linetta B.; Kraft, Peter; Kristensen, Vessela N.; Lambrechts, Diether; Le Marchand, Loic; Lejbkowicz, Flavio; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Maria Elena; Maurer, Tabea; Mavroudis, Dimitrios; Meindl, Alfons; Milne, Roger L.; Mulligan, Anna Marie; Neuhausen, Susan L.; Nevanlinna, Heli; Newman, William G.; Olshan, Andrew F.; Olson, Janet E.; Olsson, Hakan; Orr, Nick; Peterlongo, Paolo; Petridis, Christos; Prentice, Ross L.; Presneau, Nadege; Punie, Kevin; Ramachandran, Dhanya; Rennert, Gad; Romero, Atocha; Sachchithananthan, Mythily; Saloustros, Emmanouil; Sawyer, Elinor J.; Schmutzler, Rita K.; Schwentner, Lukas; Scott, Christopher; Simard, Jacques; Sohn, Christof; Southey, Melissa C.; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Teixeira, Manuel R.; Terry, Mary Beth; Thorne, Heather; Tollenaar, Rob A. E. M.; Tomlinson, Ian; Troester, Melissa A.; Truong, Therese; Turnbull, Clare; Vachon, Celine M.; van der Kolk, Lizet E.; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R.; Ziogas, Argyrios; Pharoah, Paul D. P.; Hall, Per; Wessels, Lodewyk F. A.; Chenevix-Trench, Georgia; Bader, Gary D.; Doerk, Thilo; Easton, Douglas F.; Canisius, Sander; Schmidt, Marjanka K. Share Save
Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers Nones, K.; Johnson, J.; Newell, F.; Patch, A. M.; Thorne, H.; Kazakoff, S. H.; de Luca, X. M.; Parsons, M. T.; Ferguson, K.; Reid, L. E.; Reed, A. E. McCart; Srihari, S.; Lakis, V; Davidson, A. L.; Mukhopadhyay, P.; Holmes, O.; Xu, Q.; Wood, S.; Leonard, C.; Beesley, J.; Harris, J. M.; Barnes, D.; Degasperi, A.; Ragan, M. A.; Spurdle, A. B.; Khanna, K. K.; Lakhani, S. R.; Pearson, J., V; Nik-Zainal, S.; Chenevix-Trench, G.; Waddell, N.; Simpson, P. T. Share Save
Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer Christie, Elizabeth L.; Pattnaik, Swetansu; Beach, Jessica; Copeland, Anthony; Rashoo, Nineveh; Fereday, Sian; Hendley, Joy; Alsop, Kathryn; Brady, Samuel L.; Lamb, Greg; Pandey, Ahwan; deFazio, Anna; Thorne, Heather; Bild, Andrea; Bowtell, David D. L. Share Save
Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology Simpson, P.; Nones, K.; Johnson, J.; Newell, F.; Patch, A-M; Thorne, H.; Kazakoff, S.; De Luca, X.; Parsons, M.; Ferguson, K.; Reid, L.; Reed, A. McCart; Srihari, S.; Lakis, V.; Davidson, A.; Mukhopadhyay, P.; Holmes, O.; Xu, Q.; Wood, S.; Leonard, C.; Beasley, J.; Degasperi, A.; Nik-Zainal, S.; Ragan, M.; Spurdle, A.; Khanna, K. K.; Lakhani, S.; Pearson, J.; Chenevix-Trench, G.; Waddell, N. Share Save
Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy Lawrence, Mitchell G.; Obinata, Daisuke; Sandhu, Shahneen; Selth, Luke A.; Wong, Stephen Q.; Porter, Laura H.; Lister, Natalie; Pook, David; Pezaro, Carmel J.; Goode, David L.; Rebello, Richard J.; Clark, Ashlee K.; Papargiris, Melissa; Van Gramberg, Jenna; Hanson, Adrienne R.; Banks, Patricia; Wang, Hong; Niranjan, Birunthi; Keerthikumar, Shivakumar; Hedwards, Shelley; Huglo, Alisee; Yang, Rendong; Henzler, Christine; Li, Yingming; Lopez-Campos, Fernando; Castro, Elena; Toivanen, Roxanne; Azad, Arun; Bolton, Damien; Goad, Jeremy; Grummet, Jeremy; Harewood, Laurence; Kourambas, John; Lawrentschuk, Nathan; Moon, Daniel; Murphy, Declan G.; Sengupta, Shomik; Snow, Ross; Thorne, Heather; Mitchell, Catherine; Pedersen, John; Clouston, David; Norden, Sam; Ryan, Andrew; Dehm, Scott M.; Tilley, Wayne D.; Pearson, Richard B.; Hannan, Ross D.; Frydenberg, Mark; Furic, Luc; Taylor, Renea A.; Risbridger, Gail P. Share Save
High-risk pathologic and genomic features of BRCA2-mutant prostate cancer. Porter, Laura H.; Lawrence, Mitchell G.; Pezaro, Carmel; Thorne, Heather; Ilic, Dragan; Papargiris, Melissa; Fraser, Michael; Livingstone, Julie; Murphy, Declan G.; Frydenberg, Mark; Bolton, Damien; Moon, Daniel; Clouston, David; van der Kwast, Theo; Boutros, Paul C.; Bristow, Robert G.; Taylor, Renea A.; Risbridger, Gail P. Share Save
Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study Mateo, Joaquin; Cheng, Heather H.; Beltran, Himisha; Dolling, David; Xu, Wen; Pritchard, Colin C.; Mossop, Helen; Rescigno, Pasquale; Perez-Lopez, Raquel; Sailer, Verena; Kolinsky, Michael; Balasopoulou, Ada; Bertan, Claudia; Nanus, David M.; Tagawa, Scott T.; Thorne, Heather; Montgomery, Bruce; Carreira, Suzanne; Sandhu, Shahneen; Rubin, Mark A.; Nelson, Peter S.; de Bono, Johann S. Share Save
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