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J

Jeffrey D. Rothstein

johns hopkins university

108H-index
345Paper Count
5.4WCitation Count
Published Papers 129
Publication Date
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Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion
errGlia
IF5.1
err2025-12-02
err0
errOAAI
errPhilips, Thomas; Thompson, Emily G.; Spead, Olivia; Vijayakumar, Balaji G.; Kent, Erica R.; Miller, Sean J.; Nwokeleme, Treasure; Vidensky, Svetlana; Farah, Mohamed Hassan; Rothstein, Jeffrey D.
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errSave
Biobank-scale genetic characterization of Alzheimer’s disease and related dementias across diverse ancestries
errNature Communications
IF15.7
err2025-08-14
err0
errOAAI
errMarzieh Khani; Fulya Akçimen; Spencer M. Grant; Suleyman Can Akerman; Paul Suhwan Lee; Faraz Faghri; Hampton Leonard; Jonggeol Jeffrey Kim; Mary B. Makarious; Mathew J. Koretsky; Jeffrey D. Rothstein; Cornelis Blauwendraat; Mike A. Nalls; Andrew Singleton; Sara Bandres-Ciga
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errSave
Corrigendum to “Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data”
errMolecular & Cellular Proteomics
IF5.5
err2025-08-07
err0
PREAI
errDušica Vidović; Behrouz Shamsaei; Stephan C. Schürer; Phillip Kogan; Szymon Chojnacki; Michal Kouril; Mario Medvedovic; Wen Niu; Evren U. Azeloglu; Marc R. Birtwistle; Yibang Chen; Tong Chen; Jens Hansen; Bin Hu; Ravi Iyengar; Gomathi Jayaraman; Hong Li; Tong Liu; Eric A. Sobie; Yuguang Xiong; Matthew J. Berberich; Gary Bradshaw; Mirra Chung; Robert A. Everley; Ben Gaudio; Marc Hafner; Marian Kalocsay; Caitlin E. Mills; Maulik K. Nariya; Peter K. Sorger; Kartik Subramanian; Chiara Victor; Maria Banuelos; Victoria Dardov; Ronald Holewinski; Danica-Mae Manalo; Berhan Mandefro; Andrea D. Matlock; Loren Ornelas; Dhruv Sareen; Clive N. Svendsen; Vineet Vaibhav; Jennifer E. Van Eyk; Vidya Venkatraman; Steve Finkbiener; Ernest Fraenkel; Jeffrey Rothstein; Leslie Thompson; Jacob Asiedu; Steven A. Carr; Karen E. Christianson; Desiree Davison; Deborah O. Dele-Oni; Katherine C. DeRuff; Shawn B. Egri; Alvaro Sebastian Vaca Jacome; Jacob D. Jaffe; Daniel Lam; Lev Litichevskiy; Xiaodong Lu; James Mullahoo; Adam Officer; Malvina Papanastasiou; Ryan Peckner; Caidin Toder; Joel Blanchard; Michael Bula; Tak Ko; Li-Huei Tsai; Jennie Z. Young; Vagisha Sharma; Jarek Meller; Michael J. MacCoss
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errSave
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function
errNature Communications
IF15.7
err2025-08-02
err0
errOAAI
errJeffrey D. Rothstein; Olivia Keeley; Caroline Warlick; Timothy M. Miller; Cindy V. Ly; Jonathan D. Glass; Alyssa N. Coyne
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errSave
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
errNature Medicine
IF50
err2025-07-15
err0
errOAAI
errFarhad Imam; Rowan Saloner; Jacob W. Vogel; Varsha Krish; Gamal Abdel-Azim; Muhammad Ali; Lijun An; Federica Anastasi; David Bennett; Alexa Pichet Binette; Adam L. Boxer; Martin Bringmann; Jeffrey M. Burns; Carlos Cruchaga; Jeff L. Dage; Amelia Farinas; Luigi Ferrucci; Caitlin A. Finney; Mark Frasier; Oskar Hansson; Timothy J. Hohman; Erik C. B. Johnson; Mika Kivimaki; Roxanna Korologou-Linden; Agustin Ruiz Laza; Allan I. Levey; Inga Liepelt-Scarfone; Lina Lu; Niklas Mattsson-Carlgren; Lefkos T. Middleton; Kwangsik Nho; Hamilton Se-Hwee Oh; Ronald C. Petersen; Eric M. Reiman; Oliver Robinson; Jeffrey D. Rothstein; Andrew J. Saykin; Artur Shvetcov; Chad Slawson; Bart Smets; Marc Suárez-Calvet; Betty M. Tijms; Maarten Timmers; Fernando Vieira; Natalia Vilor-Tejedor; Pieter Jelle Visser; Keenan A. Walker; Laura M. Winchester; Tony Wyss-Coray; Chengran Yang; Niranjan Bose; Simon Lovestone
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errSave
Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study MT-1186-A02)
errMuscle & Nerve
IF3.1
err2025-06-06
err0
errOAAI
errJeffrey Rothstein; Angela Genge; Shari De Silva; Lorne Zinman; Marvin Chum; Adriano Chio; Gen Sobue; Masashi Aoki; Hiide Yoshino; Manabu Doyu; Daniel Selness
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errSave
Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling
errNEUROCHEMICAL RESEARCH
IF3.8
err2025-01-09
err0
errOAAI
errMartinez-Lozada, Zila; Guillem, Alain M.; Song, Isabella; Gonzalez, Michael V.; Takano, Hajime; Parikh, Esha; Rothstein, Jeffrey D.; Putt, Mary E.; Robinson, Michael B.
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errSave
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2024-12-26
err0
errOAAI
errThompson, Emily G.; Spead, Olivia; Akerman, Suleyman C.; Curcio, Carrie; Zaepfel, Benjamin L.; Kent, Erica R.; Philips, Thomas; Vijayakumar, Balaji G.; Zacco, Anna; Zhou, Weibo; Nagappan, Guhan; Rothstein, Jeffrey D.
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errSave
Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial
errBRAIN
IF11.7
err2024-04-12
err2
PREAI
errBabu, Suma; Nicholson, Katharine A.; Rothstein, Jeffrey D.; Swenson, Andrea; Sampognaro, Paul J.; Pant, Pravin; Macklin, Eric A.; Spruill, Susan; Paganoni, Sabrina; Gendron, Tania F.; Prudencio, Mercedes; Petrucelli, Leonard; Nix, Darrell; Landrette, Sean; Nkrumah, Esther; Fandrick, Keith; Edwards, Joan; Young, Peter R.
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errSave
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons
errACTA NEUROPATHOLOGICA
IF9.3
err2023-11-29
err6
errOAAI
errRothstein, Jeffrey D.; Baskerville, Victoria; Rapuri, Sampath; Mehlhop, Emma; Jafar-Nejad, Paymaan; Rigo, Frank; Bennett, Frank; Mizielinska, Sarah; Isaacs, Adrian; Coyne, Alyssa N.
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errSave
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
errNEURON
IF15
err2023-04-01
err28
errOAAI
errWorkman, Michael J.; Lim, Ryan G.; Wu, Jie; Frank, Aaron; Ornelas, Loren; Panther, Lindsay; Galvez, Erick; Perez, Daniel; Meepe, Imara; Lei, Susan; Valencia, Viviana; Gomez, Emilda; Liu, Chunyan; Moran, Ruby; Pinedo, Louis; Tsitkov, Stanislav; Ho, Ritchie; Kaye, Julia A.; Thompson, Terri; Rothstein, Jeffrey D.; Finkbeiner, Steven; Fraenkel, Ernest; Sareen, Dhruv; Thompson, Leslie M.; Svendsen, Clive N.
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errSave
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2022-09-14
err11
errOAAI
errGao, Junli; Mewborne, Quinlan T.; Girdhar, Amandeep; Sheth, Udit; Coyne, Alyssa N.; Punathil, Ritika; Kang, Bong Gu; Dasovich, Morgan; Veire, Austin; Hernandez, Mariely DeJesus; Liu, Shuaichen; Shi, Zheng; Dafinca, Ruxandra; Fouquerel, Elise; Talbot, Kevin; Kam, Tae-In; Zhang, Yong-Jie; Dickson, Dennis; Petrucelli, Leonard; Van Blitterswijk, Marka; Guo, Lin; Dawson, Ted M.; Dawson, Valina L.; Leung, Anthony K. L.; Lloyd, Thomas E.; Gendron, Tania F.; Rothstein, Jeffrey D.; Zhang, Ke
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errSave
Nuclear Pore Dysfunction in Neurodegeneration
errNEUROTHERAPEUTICS
IF6.9
err2022-07-01
err12
PREAI
errSpead, Olivia; Zaepfel, Benjamin L.; Rothstein, Jeffrey D.
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errSave
The Evolving Landscape of Motor Neuron Disease Therapeutics
errNEUROTHERAPEUTICS
IF6.9
err2022-07-01
err0
errOAAI
errMaragakis, Nicholas J.; Rothstein, Jeffrey D.
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errSave
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
errCELL REPORTS
IF6.9
err2022-07-01
err30
errOAAI
errDuan, Lauren; Zaepfel, Benjamin L.; Aksenova, Vasilisa; Dasso, Mary; Rothstein, Jeffrey D.; Kalab, Petr; Hayes, Lindsey R.
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errSave
Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform
errFRONTIERS IN AGING NEUROSCIENCE
IF4.5
err2022-06-28
err46
errOAAI
errPun, Frank W.; Liu, Bonnie Hei Man; Long, Xi; Leung, Hoi Wing; Leung, Geoffrey Ho Duen; Mewborne, Quinlan T.; Gao, Junli; Shneyderman, Anastasia; Ozerov, Ivan V.; Wang, Ju; Ren, Feng; Aliper, Alexander; Bischof, Evelyne; Izumchenko, Evgeny; Guan, Xiaoming; Zhang, Ke; Lu, Bai; Rothstein, Jeffrey D.; Cudkowicz, Merit E.; Zhavoronkov, Alex
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errSave
Nuclear pore complexes - a doorway to neural injury in neurodegeneration
errNATURE REVIEWS NEUROLOGY
IF33.1
err2022-04-29
err47
errOAAI
errCoyne, Alyssa N.; Rothstein, Jeffrey D.
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errSave
A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS
errANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
IF3.9
err2022-01-10
err24
errOAAI
errKatz, Jonathan S.; Rothstein, Jeffrey D.; Cudkowicz, Merit E.; Genge, Angela; Oskarsson, Bjorn; Hains, Avis B.; Chen, Chen; Galanter, Joshua; Burgess, Braydon L.; Cho, William; Kerchner, Geoffrey A.; Yeh, Felix L.; Ghosh, Arundhati Sengupta; Cheeti, Sravanthi; Brooks, Logan; Honigberg, Lee; Couch, Jessica A.; Rothenberg, Michael E.; Brunstein, Flavia; Sharma, Khema R.; van den Berg, Leonard; Berry, James D.; Glass, Jonathan D.
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errSave
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2021-11-01
err49
errOAAI
errJha, Mithilesh Kumar; Passero, Joseph, V; Rawat, Atul; Ament, Xanthe Heifetz; Yang, Fang; Vidensky, Svetlana; Collins, Samuel L.; Horton, Maureen R.; Hoke, Ahmet; Rutter, Guy A.; Latremoliere, Alban; Rothstein, Jeffrey D.; Morrison, Brett M.
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errSave
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2021-10-27
err46
errOAAI
errBush, Jessica A.; Aikawa, Haruo; Fuerst, Rita; Li, Yue; Ursu, Andrei; Meyer, Samantha M.; Benhamou, Raphael, I; Chen, Jonathan L.; Khan, Tanya; Wagner-Griffin, Sarah; Van Meter, Montina J.; Tong, Yuquan; Olafson, Hailey; McKee, Kendra K.; Childs-Disney, Jessica L.; Gendron, Tania F.; Zhang, Yongjie; Coyne, Alyssa N.; Wang, Eric T.; Yildirim, Ilyas; Wang, Kye Won; Petrucelli, Leonard; Rothstein, Jeffrey D.; Disney, Matthew D.
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Research Directions

No research directions
Co-authors
Cooperation Journals
J
John Q. Trojanowski
H-index: 255 · Papers: 1.8K
S
Solomon H. Snyder
H-index: 222 · Papers: 1.2K
B
Bruce S. McEwen
H-index: 221 · Papers: 1.3K
F
Fred H. Gage
H-index: 219 · Papers: 1.1K
D
Dennis W. Dickson
H-index: 218 · Papers: 2.3K
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