J. Timothy Greenamyre - Publications, H-index & Citations

Back

J. Timothy Greenamyre

university health network toronto

94H-index

275Paper Count

3.4WCitation Count

Published Papers 102

Publication Date

LRRK2 as a Potential Disease-Modifying Target in Sporadic Parkinson's Disease

MOVEMENT DISORDERS

IF7.6

2025-12-01

PREAI

Lang, Anthony E.; Hauser, Robert A.; Kalia, Lorraine V.; Hersh, Bonnie; Berger, Zdenek; Arenas, Roy Llorens; Paisan-ruiz, Coro; Fraser, Kyle; Jennings, Danna; Kluss, Jillian H.; Huntwork-rodriguez, Sarah; Henry, Anastasia G.; Greenamyre, J. Timothy

Save

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

npj Parkinson's Disease

IF0

2025-07-24

OAAI

Maria Tsalenchuk; Kyle Farmer; Sandra Castro; Abigail Scheirer; Yuqian Ye; J. Timothy Greenamyre; Emily M. Rocha; Sarah J. Marzi

Save

LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-10-02

PREAI

Keeney, Matthew T.; Rocha, Emily M.; Hoffman, Eric K.; Farmer, Kyle; Di Maio, Roberto; Weir, Julie; Wagner, Weston G.; Hu, Xiaoping; Clark, Courtney L.; Castro, Sandra L.; Scheirer, Abigail; Fazzari, Marco; De Miranda, Briana R.; Pintchovski, Sean A.; Shrader, William D.; Pagano, Patrick J.; Hastings, Teresa G.; Greenamyre, J. Timothy

Save

LRRK2 kinase inhibition protects against Parkinson's disease-associated environmental toxicants

NEUROBIOLOGY OF DISEASE

IF5.6

2024-06-01

OAAI

Ilieva, Neda M.; Hoffman, Eric K.; Ghalib, Mohammed A.; Greenamyre, J. Timothy; De Miranda, Briana R.

Save

Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative

JOURNAL OF PARKINSONS DISEASE

IF5

2024-04-05

OAAI

Wyse, Richard K.; Isaacs, Tom; Barker, Roger A.; Cookson, Mark R.; Dawson, Ted M.; Devos, David; Dexter, David T.; Duffen, Joy; Federoff, Howard; Fiske, Brian; Foltynie, Thomas; Fox, Susan; Greenamyre, J. Timothy; Kieburtz, Karl; Kordower, Jeffrey H.; Krainc, Dimitri; Matthews, Helen; Moore, Darren J.; Mursaleen, Leah; Schwarzschild, Michael A.; Stott, Simon R. W.; Sulzer, David; Svenningsson, Per; Tanner, Caroline M.; Carroll, Camille; Simon, David K.; Brundin, Patrik

Save

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

NPJ PARKINSONS DISEASE

IF8.2

2023-08-11

OAAI

Van Laar, Amber D.; Webb, Katherine R.; Keeney, Matthew T.; Van Laar, Victor S.; Zharikov, Alevtina; Burton, Edward A.; Hastings, Teresa G.; Glajch, Kelly E.; Hirst, Warren D.; Greenamyre, J. Timothy; Rocha, Emily M.

Save

Neuroprotective actions of a fatty acid nitroalkene in Parkinson's disease

NPJ PARKINSONS DISEASE

IF8.2

2023-04-07

OAAI

Di Maio, Roberto; Keeney, Matthew T.; Cechova, Veronika; Mortimer, Amanda; Sekandari, Ahssan; Rowart, Pascal; Greenamyre, J. Timothy; Freeman, Bruce A.; Fazzari, Marco

Save

NADPH oxidase 2 activity in Parkinson's disease

NEUROBIOLOGY OF DISEASE

IF5.6

2022-08-01

OAAI

Keeney, Matthew T.; Hoffman, Eric K.; Farmer, Kyle; Bodle, Christopher R.; Fazzari, Marco; Zharikov, Alevtina; Castro, Sandra L.; Hu, Xiaoping; Mortimer, Amanda; Kofler, Julia K.; Cifuentes-Pagano, Eugenia; Pagano, Patrick J.; Burton, Edward A.; Hastings, Teresa G.; Greenamyre, J. Timothy; Di Maio, Roberto

Save

The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson?s disease

NEUROBIOLOGY OF DISEASE

IF5.6

2021-06-01

OAAI

De Miranda, Briana R.; Castro, Sandra L.; Rocha, Emily M.; Bodle, Christopher R.; Johnson, Katrina E.; Greenamyre, J. Timothy

Save

Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration

AGING CELL

IF7.1

2021-04-28

OAAI

Buck, Silas A.; Steinkellner, Thomas; Aslanoglou, Despoina; Villeneuve, Michael; Bhatte, Sai H.; Childers, Victoria C.; Rubin, Sophie A.; De Miranda, Briana R.; O'Leary, Emma, I; Neureiter, Elizabeth G.; Fogle, Keri J.; Palladino, Michael J.; Logan, Ryan W.; Glausier, Jill R.; Fish, Kenneth N.; Lewis, David A.; Greenamyre, J. Timothy; McCabe, Brian D.; Cheetham, Claire E. J.; Hnasko, Thomas S.; Freyberg, Zachary

Save

Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

NPJ PARKINSONS DISEASE

IF8.2

2020-12-08

OAAI

De Miranda, Briana R.; Rocha, Emily M.; Castro, Sandra L.; Greenamyre, J. Timothy

Save

Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease

NPJ PARKINSONS DISEASE

IF8.2

2020-11-13

OAAI

Bucher, Meghan L.; Barrett, Caitlyn W.; Moon, Connor J.; Mortimer, Amanda D.; Burton, Edward A.; Timothy Greenamyre, J.; Hastings, Teresa G.

Save

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

NEUROBIOLOGY OF DISEASE

IF5.6

2020-02-01

OAAI

Rocha, Emily M.; De Miranda, Briana R.; Castro, Sandra; Drolet, Robert; Hatcher, Nathan G.; Yao, Lihang; Smith, Sean M.; Keeney, Matthew T.; Di Maio, Roberto; Kofler, Julia; Hastings, Teresa G.; Greenamyre, J. Timothy

Save

Spectrum of tau pathologies in Huntington's disease

LABORATORY INVESTIGATION

IF4.2

2019-07-01

OAAI

Baskota, Swikrity Upadhyay; Lopez, Oscar L.; Greenamyre, J. Timothy; Kofler, Julia

Save

Response to Rotenone and Parkinson's Disease; Reduced Sensitivity in Females

TOXICOLOGICAL SCIENCES

IF4.1

2019-06-04

PREAI

De Miranda, Briana R.; Greenamyre, John Timothy

Save

Phenothiazine normalizes the NADH/NAD+ ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease

REDOX BIOLOGY

IF11.9

2019-06-01

OAAI

Tapias, Victor; McCoy, Jennifer L.; Greenamyre, J. Timothy

Save

Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

NEUROBIOLOGY OF DISEASE

IF5.6

2019-05-01

OAAI

Zharikov, Alevtina; Bai, Qing; De Miranda, Briana R.; Van Laar, Amber; Greenamyre, J. Timothy; Burton, Edward A.

Save

Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence

TOXICOLOGICAL SCIENCES

IF4.1

2019-03-25

OAAI

De Miranda, Briana R.; Fazzari, Marco; Rocha, Emily M.; Castro, Sandra; Greenamyre, J. Timothy

Save

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

NEUROLOGY

IF8.5

2019-02-12

158

OAAI

Espay, Alberto J.; Vizcarra, Joaquin A.; Marsili, Luca; Lang, Anthony E.; Simon, David K.; Merola, Aristide; Josephs, Keith A.; Fasano, Alfonso; Morgante, Francesca; Savica, Rodolfo; Greenamyre, J. Timothy; Cambi, Franca; Yamasaki, Tritia R.; Tanner, Caroline M.; Gan-Or, Ziv; Litvan, Irene; Mata, Ignacio F.; Zabetian, Cyrus P.; Brundin, Patrik; Fernandez, Hubert H.; Standaert, David G.; Kauffman, Marcelo A.; Schwarzschild, Michael A.; Sardi, S. Pablo; Sherer, Todd; Perry, George; Leverenz, James B.

Save

What's wrong with mitochondria in Parkinson's disease?

MOVEMENT DISORDERS

IF7.6

2018-10-04

PREAI

Greenamyre, J. Timothy

Save

Research Directions