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Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A. Share Save
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants Perez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois Share Save
Synthetic Analogs of the Sponge Sesterterpenoid Alotaketal C are Potent Inhibitors of SARS-CoV-2 Omicron BA.1 and BA.5 Infections of Human Lung Cells Blagojevic, Polina; Perez-Vargas, Jimena; Jian, Kunzhong; Williams, David E.; Villanueva, Ivan; Thompson, Connor A. H.; Ennis, Siobhan; Niikura, Masahiro; Tietjen, Ian; Jean, Francois; Andersen, Raymond J. Share Save
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Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade Cloherty, Alexandra P. M.; Rader, Anusca G.; Patel, Kharishma S.; Perez-Vargas, Jimena; Thompson, Connor A. H.; Ennis, Siobhan; Niikura, Masahiro; Wildenberg, Manon E.; Muncan, Vanesa; Schreurs, Renee R. C. E.; Jean, Francois; Ribeiro, Carla M. S. Share Save
A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process Perez-Vargas, Jimena; Teppa, Elin; Amirache, Fouzia; Boson, Bertrand; de Oliveira, Remi Pereira; Combet, Christophe; Bockmann, Anja; Fusil, Floriane; Freitas, Natalia; Carbone, Alessandra; Cosset, Francois-Loic Share Save
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Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes Unzu, Carmen; Planet, Evarist; Brandenberg, Nathalie; Fusil, Floriane; Cassano, Marco; Perez-Vargas, Jimena; Friedli, Marc; Cosset, Francois-Loic; Lutolf, Matthias P.; Wildhaber, Barbara E.; Trono, Didier Share Save
OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes Del Campo, Judith; Pizzorno, Andres; Djebali, Sophia; Bouley, Julien; Haller, Marjorie; Perez-Vargas, Jimena; Lina, Bruno; Boivin, Guy; Hamelin, Marie-Eve; Nicolas, Florence; Le Vert, Alexandre; Leverrier, Yann; Rosa-Calatrava, Manuel; Marvel, Jacqueline; Hill, Fergal Share Save
Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc Guardado-Calvo, Pablo; Bignon, Eduardo A.; Stettner, Eva; Jeffers, Scott Allen; Perez-Vargas, Jimena; Pehau-Arnaudet, Gerard; Tortoric, M. Alejandra; Jestin, Jean-Luc; England, Patrick; Tischler, Nicole D.; Rey, Felix A. Share Save
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