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Alessandro Leal

johns hopkins university

15H-index
198Paper Count
4.1KCitation Count
Published Papers 32
Publication Date
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Is There an Ace Up One's Sleeve in the Preanalytical Phase of the Circulating Tumor DNA Analysis?
errBioFactors
IF5
err2026-03-29
err0
errOAAI
errJuscelino Carvalho de Azevedo Junior; Douglas Rafael da Cruz Carneiro; Fernanda Jardim da Silva; Ana Beatriz Lima Belicha; Anna Carolina Lima Rodrigues; Williams Fernandes Barra; Alessandro Leal; Danielle Queiroz Calcagno
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Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases
errScience Translational Medicine
IF14.6
err2026-03-04
err0
PREAI
errAkshaya V. Annapragada; Zachariah H. Foda; Hope Orjuela; Carter Norton; Shashikant Koul; Noushin Niknafs; Sarah Short; Keerti Boyapati; Adrianna Bartolomucci; Dimitrios Mathios; Michael Noë; Chris Cherry; Jacob Carey; Alessandro Leal; Bryan Chesnick; Nicholas C. Dracopoli; Jamie E. Medina; Nicholas A. Vulpescu; Daniel C. Bruhm; Sarah Bacus; Vilmos Adleff; Amy K. Kim; Stephen B. Baylin; Gregory D. Kirk; Andrei Sorop; Razvan Iacob; Speranta Iacob; Liana Gheorghe; Simona Dima; Manuel Ramírez-Zea; Katherine A. McGlynn; Claus L. Feltoft; Julia S. Johansen; John Groopman; Jillian Phallen; Robert B. Scharpf; Victor E. Velculescu
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errSave
Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas
errNature Genetics
IF29
err2025-11-27
err0
PREAI
errSukanya Panja; Padmaja Mantri; Kofi Ennu Johnson; Juan Sebastian Andrade-Martinez; Soo-Ryum Yang; Aditya Deshpande; Huasong Tian; Shaham Beg; Kentaro Ohara; Alessandro Leal; Joel Rosiene; Marlon Stoeckius; Peter Smibert; William D. Travis; Juan Miguel Mosquera; Paz Polak; Marcin Imieliński
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errSave
Diversity of BRAF mutations in non-small cell lung cancer and implications on treatment
errnpj Precision Oncology
IF8
err2025-10-28
err0
errOAAI
errKevin Lu; John Paul Shen; Fernando J. Lopez-Diaz; Alessandro Leal; Isa Mambetsariev; Kaushal Parikh; Antonious Hazim; Brian D. Woodward; Abhinav Madduri; Faisal Khurshid; Jeremy Fricke; Vamsidhar Velcheti; Jonathan W. Riess; Aaron S. Mansfield; Ravi Salgia; Hatim Husain
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Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer
errSCIENCE ADVANCES
IF12.5
err2025-05-23
err0
PREAI
errHruban, Carolyn; Bruhm, Daniel C.; Chen, Inna M.; Koul, Shashikant; Annapragada, Akshaya V.; Vulpescu, Nicholas A.; Short, Sarah; Theile, Susann; Boyapati, Kavya; Alipanahi, Bahar; Skidmore, Zachary L.; Leal, Alessandro; Cristiano, Stephen; Adleff, Vilmos; Johannsen, Julia S.; Scharpf, Robert B.; Foda, Zachariah H.; Phallen, Jillian; Velculescu, Victor E.
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Safety and efficacy of topical testosterone in breast cancer patients receiving ovarian suppression and aromatase inhibitor therapy
errBREAST CANCER RESEARCH
IF5.6
err2024-09-16
err1
errOAAI
errTaranto, Patricia; Sales, Diogo de Brito; Maluf, Fernando Cotait; Guendelmann, Rafael Aliosha Kaliks; Pompei, Luciano de Melo; Leal, Alessandro; Buzaid, Antonio Carlos; Schvartsman, Gustavo
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Cancer treatment monitoring using cell-free DNA fragmentomes
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errFijneman, R.; Rinaldi, L.; Skidmore, Z.; Alipanahi, B.; Keefer, L.; Erve, I. van 't; Lumbard, K.; Carey, J.; Chesnick, B.; Cristiano, S.; Dracopoli, N.; Scharpf, R.; Meijer, G.; Leal, A. I. C.; Velculescu, V.
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errSave
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
errCANCER DISCOVERY
IF33.3
err2024-06-06
err4
errOAAI
errMazzone, Peter J.; Bach, Peter B.; Carey, Jacob; Schonewolf, Caitlin A.; Bognar, Katalin; Ahluwalia, Manmeet S.; Cruz-Correa, Marcia; Gierada, David; Kotagiri, Sonali; Lloyd, Kathryn; Maldonado, Fabien; Ortendahl, Jesse D.; Sequist, Lecia V.; Silvestri, Gerard A.; Tanner, Nichole; Thompson, Jeffrey C.; Vachani, Anil; Wong, Kwok-Kin; Zaidi, Ali H.; Catallini, Joseph; Gershman, Ariel; Lumbard, Keith; Millberg, Laurel K.; Nawrocki, Jeff; Portwood, Carter; Rangnekar, Aakanksha; Sheridan, Carolina Campos; Trivedi, Niti; Wu, Tony; Zong, Yuhua; Cotton, Lindsey; Ryan, Allison; Cisar, Christopher; Leal, Alessandro; Dracopoli, Nicholas; Scharpf, Robert B.; Velculescu, Victor E.; Pike, Luke R. G.
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PLASMUT: An R Package for estimating the probability of tumor-specific mutations in cell-free DNA
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errArun, Adith S.; Medina, Jamie E.; Cristiano, Stephen; Bruhm, Daniel C.; Fijneman, Remond J.; Meijer, Gerrit A.; Leal, Alessandro; Velculescu, Victor E.; Scharpf, Robert B.
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errSave
Robustness of fragmentation-based cell-free DNA approaches to clonal hematopoiesis
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errCristiano, Stephen; Alipanahi, Bahar; Medina, Jamie E.; Rinaldi, Lorenzo; Dracopoli, Nicholas; Scharpf, Robert B.; Leal, Alessandro; Velculescu, Victor E.; Tom, Jennifer
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errSave
Monitoring response to immunotherapy using cell free DNA fragmentomes
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errAlipanahi, Bahar; Sivapalan, Lavanya; Medina, Jamie; Skidmore, Zachary L.; Ghanem, Paola; Peters, Erica; Pereira, Gavin; Rao, Nisha; Velliangiri, Kavya; Konicki, Alissa; Cristiano, Stephen; Millberg, Laurel; Carey, Jacob; Lumbard, Keith; Niknafs, Noushin; Chesnick, Bryan; Tom, Jennifer; Leal, Alessandro; Levy, Benjamin; Forde, Patrick; Bach, Peter; Dracopoli, Nicholas C.; Scharpf, Robert B.; Velculescu, Victor; Rinaldi, Lorenzo; Anagnostou, Valsamo
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Cell-Free DNA Fragmentomes in the Diagnostic Evaluation of Patients With Symptoms Suggestive of Lung Cancer
errCHEST
IF8.6
err2023-10-01
err5
errOAAI
errLeal, Alessandro I. C.; Mathios, Dimitrios; Jakubowski, Debbie; Johansen, Jakob S.; Lau, Anna; Wu, Tony; Cristiano, Stephen; Medina, Jamie E.; Phallen, Jillian; Bruhm, Daniel C.; Carey, Jacob; Dracopoli, Nicholas C.; Bojesen, Stig E.; Scharpf, Robert B.; Velculescu, Victor E.; Vachani, Anil; Bach, Peter B.
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Cell-free DNA fragmentation profiling for monitoring therapeutic response in metastatic colorectal cancer
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errAlipanahi, Bahar; Erve, Iris Van't; Lumbard, Keith; Millberg, Laurel K.; Skidmore, Zach; Rinaldi, Lorenzo; Carey, Jacob; Tom, Jennifer; Punt, Cornelis J. A.; Dracopoli, Nicholas C.; Meijer, Gerrit A.; Scharpf, Robert B.; Velculescu, Victor E.; Fijneman, Remond; Leal, Alessandro
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Ultra-deep targeted sequencing of cell-free DNA and patient-matched white blood cells for treatment response evaluation in patients with metastatic colorectal cancer
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errvan 't Erve, Iris; Medina, Jamie E.; Leal, Alessandro; Papp, Eniko; Phallen, Jillian; Adleff, Vilmos; Chiao, Elaine Jiayuee; Arun, Adith S.; Bolhuis, Karen; Simmons, John K.; Karandikar, Aanavi; Valkenburg, Kenneth C.; Sausen, Mark; Angiuoli, Samuel V.; Scharpf, Robert B.; Punt, Cornelis J.; Meijer, Gerrit J.; Velculescu, Victor E.; Fijneman, Remond J.
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Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
errCLINICAL CANCER RESEARCH
IF10.2
err2022-12-19
err14
errOAAI
errvan 't Erve, Iris; Medina, Jamie E.; Leal, Alessandro; Papp, Eniko; Phallen, Jillian; Adleff, Vilmos; Chiao, Elaine Jiayuee; Arun, Adith S.; Bolhuis, Karen; Simmons, John K.; Karandikar, Aanavi; Valkenburg, Kenneth C.; Sausen, Mark; Angiuoli, Samuel, V; Scharpf, Robert B.; Punt, Cornelis J. A.; Meijer, Gerrit A.; Velculescu, Victor E.; Fijneman, Remond J. A.
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Safety and efficacy of low dose topical testosterone for sexual function improvement in women with breast cancer under treatment with ovarian suppression and aromatase inhibitor
errCANCER RESEARCH
IF16.6
err2022-02-15
err0
PREAI
errTaranto, Patricia; Sales, Diogo de Brito; Pompei, Luciano de Melo; Leal, Alessandro; Schvartsman, Gustavo; Buzaid, Antonio Carlos
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errSave
Differential mutational landscape of duodenal carcinomas: A real-world data analysis from the GENIE Consortium Cohort
errANNALS OF ONCOLOGY
IF65.4
err2021-09-01
err0
errOAAI
errFernandes, I.; Franco, R.; Franco, V.; Carmagnani Pestana, R.; Bugano Diniz Gomes, D.; Saragiotto, D. F.; Leal, A. I. C.
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errSave
Detection and characterization of lung cancer using cell-free DNA fragmentomes
errNATURE COMMUNICATIONS
IF15.7
err2021-08-20
err231
errOAAI
errMathios, Dimitrios; Johansen, Jakob Sidenius; Cristiano, Stephen; Medina, Jamie E.; Phallen, Jillian; Larsen, Klaus R.; Bruhm, Daniel C.; Niknafs, Noushin; Ferreira, Leonardo; Adleff, Vilmos; Chiao, Jia Yuee; Leal, Alessandro; Noe, Michael; White, James R.; Arun, Adith S.; Hruban, Carolyn; Annapragada, Akshaya, V; Jensen, Sarah Ostrup; Orntoft, Mai-Britt Worm; Madsen, Anders Husted; Carvalho, Beatriz; de Wit, Meike; Carey, Jacob; Dracopoli, Nicholas C.; Maddala, Tara; Fang, Kenneth C.; Hartman, Anne-Renee; Forde, Patrick M.; Anagnostou, Valsamo; Brahmer, Julie R.; Fijneman, Remond J. A.; Nielsen, Hans Jorgen; Meijer, Gerrit A.; Andersen, Claus Lindbjerg; Mellemgaard, Anders; Bojesen, Stig E.; Scharpf, Robert B.; Velculescu, Victor E.
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Diagnostic Strategies toward Clinical Implementation of Liquid Biopsy RAS/BRAF Circulating Tumor DNA Analyses in Patients with Metastatic Colorectal Cancer
errJOURNAL OF MOLECULAR DIAGNOSTICS
IF3.4
err2020-12-01
err20
errOAAI
errvan 't Erve, Iris; Greuter, Erve Marjolein J. E.; Bolhuis, Karen; Vessies, Daan C. L.; Leal, Alessandro; Vink, Geraldine R.; van den Broek, Daan; Velculescu, Victor E.; Punt, Cornelis J. A.; Meijer, Gerrit A.; Coupe, Veerle M. H.; Fijneman, Remond J. A.
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Younger age at diagnosis as a prognostic factor in Latin American triple negative breast cancer treated with neoadjuvant chemotherapy
errCANCER RESEARCH
IF16.6
err2020-02-15
err0
PREAI
errNeffa, Maria Fernanda Vicentini; Marta, Guilherme Nader; Dornellas, Abraao Ferreira Lopes; Leal, Alessandro; Testa, Laura
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Research Directions

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Co-authors
Cooperation Journals
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Drew M. Pardoll
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L
L. Rinaldi
H-index: 141 · Papers: 1.9K
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Kwok‐Kin Wong
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