Not logged in Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells (vol 112, pg 1895, 2015) Caiazza, F.; Mcgowan, P. M.; Mullooly, M.; Murray, A.; Synnott, N.; O'Donovan, N.; Flanagan, L.; Tape, C. J.; Murphy, G.; Crown, J.; Duffy, M. J. Share Save
PP2A inhibition overcomes acquired resistance to HER2 targeted therapy (vol 22, 175, 2023) Mcdermott, Martina S. J.; Browne, Brigid C.; Conlon, Neil T.; O'Brien, Neil A.; Slamon, Dennis J.; Henry, Michael; Meleady, Paula; Clynes, Martin; Dowling, Paul; Crown, John; O'Donovan, Norma Share Save
Alterations in immune cell phenotype and cytotoxic capacity in HER2+breast cancer patients receiving HER2-targeted neo-adjuvant therapy Gaynor, Nicola; Blanco, Alfonso; Madden, Stephen F.; Moran, Barry; Fletcher, Jean M.; Kaukonen, Damien; Ramirez, Javier Sanchez; Eustace, Alex J.; McDermott, Martina S. J.; Canonici, Alexandra; Toomey, Sinead; Teiserskiene, Ausra; Hennessy, Bryan T.; O'Donovan, Norma; Crown, John; Collins, Denis M. Share Save
A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to Cisplatin Mukherjee, Nupur; Browne, Alacoque; Ivers, Laura; Santra, Tapesh; Cremona, Mattia; Hennessy, Bryan T.; O'Donovan, Norma; Crown, John; Kolch, Walter; Fey, Dirk; Eustace, Alex J. Share Save
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo Ding, Xiaokai; Sharko, Amanda C.; McDermott, Martina S. J.; Schools, Gary P.; Chumanevich, Alexander; Ji, Hao; Li, Jing; Zhang, Li; Mack, Zachary T.; Sikirzhytski, Vitali; Shtutman, Michael; Ivers, Laura; O'Donovan, Norma; Crown, John; Gyorffy, Balazs; Chen, Mengqian; Roninson, Igor B.; Broude, Eugenia, V Share Save
The role of infiltrating lymphocytes in the neo-adjuvant treatment of women with HER2-positive breast cancer Eustace, A. J.; Madden, S. F.; Fay, J.; Collins, D. M.; Kay, E. W.; Sheehan, K. M.; Furney, S.; Moran, B.; Fagan, A.; Morris, P. G.; Teiserskiene, A.; Hill, A. D.; Grogan, L.; Walshe, J. M.; Breathnach, O.; Power, C.; Duke, D.; Egan, K.; Gallagher, W. M.; O'Donovan, N.; Crown, J.; Toomey, S.; Hennessy, B. T. Share Save
The effect of neo-adjuvant chemotherapy on immune cell phenotype and cytotoxic capacity in HER2+breast cancer patients Gaynor, Nicola; Blanco, Alfonso; Canonici, Alexandra; Eustace, Alexander J.; McDermott, Martina; Moran, Barry; Fletcher, Jean M.; O'Donovan, Norma; Crown, John; Collins, Denis M. Share Save
Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples Toomey, Sinead; Carr, Aoife; Mezynski, Mateusz Janusz; Elamin, Yasir; Rafee, Shereen; Cremona, Mattia; Morgan, Clare; Madden, Stephen; Abdul-Jalil, Khairun I.; Gately, Kathy; Farrelly, Angela; Kay, Elaine W.; Kennedy, Susan; O'Byrne, Kenneth; Grogan, Liam; Breathnach, Oscar; Morris, Patrick G.; Eustace, Alexander J.; Fay, Joanna; Cummins, Robert; O'Grady, Anthony; Kalachand, Roshni; O'Donovan, Norma; Kelleher, Fergal; O'Reilly, Aine; Doherty, Mark; Crown, John; Hennessy, Bryan T. Share Save
Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer Canonici, Alexandra; Browne, Alacoque L.; Ibrahim, Mohamed F. K.; Fanning, Kevin P.; Roche, Sandra; Conlon, Neil T.; O'Neill, Fiona; Meiller, Justine; Cremona, Mattia; Morgan, Clare; Hennessy, Bryan T.; Eustace, Alex J.; Solca, Flavio; O'Donovan, Norma; Crown, John Share Save
Pilot study of bevacizumab in combination with docetaxel and cyclophosphamide as adjuvant treatment for patients with early stage HER-2 negative breast cancer, including analysis of candidate circulating markers of cardiac toxicity: ICORG 08-10 trial Gullo, Giuseppe; Eustace, Alex J.; Canonici, Alexandra; Collins, Denis M.; Kennedy, Michael J.; Grogan, Liam; Breathhnach, Oscar; McCaffrey, John; Keane, Maccon; Martin, Michael J.; Gupta, Rajnish; Leonard, Gregory; O'Connor, Miriam; Calvert, Paula M.; Donnellan, Paul; Walshe, Janice; McDermott, Enda; Scott, Kathleen; Hernando, Andres; Parker, Imelda; Murray, David W.; O'Farrell, Alice C.; Maratha, Ashwini; Dicker, Patrick; Rafferty, Mairin; Murphy, Verena; O'Donovan, Norma; Gallagher, William M.; Ky, Bonnie; Tryfonopoulos, Dimitrios; Moulton, Brian; Byrne, Annette T.; Crown, John Share Save
Pre-clinical investigation of PP2A inhibitor LB-100 in overcoming and preventing lapatinib resistance in HER2-positive breast cancer Conlon, N.; McDermott, M.; Browne, B.; Roche, S.; O'Neill, F.; Meiller, J.; Browne, A.; Eustace, A.; Collins, D. M.; O'Donovan, N.; Crown, J. Share Save
Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings Leech, Astrid O.; Vellanki, Sri HariKrishna; Rutherford, Emily J.; Keogh, Aoife; Jahns, Hanne; Hudson, Lance; O'Donovan, Norma; Sabri, Siham; Abdulkarim, Bassam; Sheehan, Katherine M.; Kay, Elaine W.; Young, Leonie S.; Hill, Arnold D. K.; Smith, Yvonne E.; Hopkins, Ann M. Share Save
Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL Eustace, Alex J.; Conlon, Neil T.; McDermott, Martina S. J.; Browne, Brigid C.; O'Leary, Patrick; Holmes, Frankie A.; Espina, Virginia; Liotta, Lance A.; O'Shaughnessy, Joyce; Gallagher, Clair; O'Driscoll, Lorraine; Rani, Sweta; Madden, Stephen F.; O'Brien, Neil A.; Ginther, Charles; Slamon, Dennis; Walsh, Naomi; Gallagher, William M.; Zagozdzon, Radoslaw; Watson, William R.; O'Donovan, Norma; Crown, John Share Save
HER-targeted tyrosine kinase inhibitors enhance response to trastuzumab and pertuzumab in HER2-positive breast cancer Canonici, Alexandra; Ivers, Laura; Conlon, Neil T.; Pedersen, Kasper; Gaynor, Nicola; Browne, Brigid C.; O'Brien, Neil A.; Gullo, Giuseppe; Collins, Denis M.; O'Donovan, Norma; Crown, John Share Save
Share Save
Share Save
Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007 Synnott, Naoise C.; Bauer, Matthias R.; Madden, Stephen; Murray, Alyson; Klinger, Rut; O'Donovan, Norma; O'Connor, Darran; Gallagher, William M.; Crown, John; Fersht, Alan R.; Duffy, Michael J. Share Save
Share Save
Share Save
Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies Toomey, Sinead; Eustace, Alexander J.; Fay, Joanna; Sheehan, Katherine M.; Carr, Aoife; Milewska, Malgorzata; Madden, Stephen F.; Teiserskiene, Ausra; Kay, Elaine W.; O'Donovan, Norma; Gallagher, William; Grogan, Liam; Breathnach, Oscar; Walshe, Janice; Kelly, Catherine; Moulton, Brian; Kennedy, M. John; Gullo, Guiseppe; Hill, Arnold D.; Power, Colm; Duke, Deirdre; Hambly, Niamh; Crown, John; Hennessy, Bryan T. Share Save
.png){kind=icon}
Not logged in.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
