未登录SARS-CoV-2 3CLpro mutations T21I and E166A confer differential resistance to simnotrelvir, bofutrelvir, and ensitrelvirSARS-CoV-2 3CLpro突变T21I和E166A对simnotrelvir、bofutrelvir和ensitrelvir产生不同的抗药性
Chen, Lu; Su, Haixia; Shang, Weijuan; Nie, Tianqing; Kuang, Wenhua; Wang, Chenchen; Shao, Qiang; Zhang, Leike; Liu, Wen; Xu, Yechun; Zhang, Yumin .png)
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收藏分享 收藏 Probing Weak Halogen Bonding in Aqueous Solution在水中探测弱卤素键Herbst, Manuel A.; Wu, Leyun; Woordes, Yannik T.; Peintner, Stefan; Xin, Jian; Boeckler, Frank M.; Xu, Zhijian; Zhu, Weiliang; Navarro-Vazquez, Armando; Erdelyi, Mate 分享 收藏 Development of a Fluorescence Polarization Assay for p300/CBP and Its Application Using a Direct-to-Biology Approach开发p300/CBP荧光偏振分析及其直接生物学方法的应用Liang, Jiayin; Li, Ziyi; Jin, Lu; Wang, Yanlin; Luo, Xiaolin; Li, Xinyuan; Zhong, Hui; Du, Daohai; Luo, Cheng; Xiong, Huan 分享 收藏 P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver diseaseP5CS偶联的脯氨酸代谢调控代谢功能障碍相关脂肪性肝病Lyu, Zan; Yu, Sike; Peng, Chang; Wu, Wenbiao; Yang, Wenhua; Ma, Huan; Sun, Yan; Jing, Liya; Gu, Hongyu; Tang, Erjiang; Zhang, Xuemei; Jiang, Huihong; Jiang, Haowen; Li, Jia 分享 收藏 分享 收藏 Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors发现一种用于识别USP1别构抑制剂的强效荧光偏振探针Cheng, Jiawei; Wang, Peipei; Wang, Pengfei; Wang, Jiamin; Li, Baiyang; Fang, Daqing; He, Jian; Hu, Xiaobei; Kan, Weijuan; Zhou, Yubo; Li, Chunpu; Li, Jia; Liu, Hong 分享 收藏 分享 收藏 分享 收藏 Covalent versus Dimeric Optimization of Nectin-4-Targeted Peptide Radiotracers: A Head-to-Head Comparison in Triple-Negative Breast Cancer Mice Models共价与二聚体优化策略在靶向Nectin-4的肽类放射性示踪剂中的应用比较：基于三阴性乳腺癌小鼠模型的头对头对比研究Pei, Yang; Zhou, Xu; Gao, Fei; Sun, Mingyue; Qiu, Shanshan; Qin, Xiangyu; Qu, Chunrong; Wen, Kai; Du, Jin; Hu, Ji; Cheng, Zhen 分享 收藏 Artemverlotolides A and B, Two Sesquiterpenes from Artemisia verlotorum Lamotte: Structural Elucidation, Bioinspired Synthesis, and Antineuroinflammatory ActivityArtemverlotolides A和B，两种来自Artemisia verlotorum Lamotte的倍半萜：结构解析、仿生合成和抗神经炎症活性Xu, Mingbi; Wang, Mengyu; Zhu, Chiyun; Gong, Qi; Zhang, Ruiyu; Tang, Chunping; Zhang, Haiyan; Ye, Yang; Yao, Sheng 分享 收藏 Development and Validation of a Rapid LC-MS/MS Method for the Quantification of Contezolid in Human Plasma and Liver, and Its Application to a Pharmacokinetic Study in Liver Transplant Patients一种用于测定人血浆和肝脏中康替唑胺含量的快速LC-MS/MS方法的开发与验证及其在肝移植患者药代动力学研究中的应用Tian, Zhuoran; Zhong, Siyi; Wei, Huimin; Pan, Anni; Zhu, Hengkai; Zhu, Dan; Lu, Jianfang; Yu, Jinghua; Diao, Xingxing; Zhuang, Li 分享 收藏 Late-Stage Cyclization of Natural Products and Drug Molecules Enabled by C-C Bond Cleavage of Aryl Ketones通过芳基酮C-C键断裂实现的天然产物和药物分子的晚期环化反应Wang, Xing; Li, Yu-Xi; Zeng, Qing-Ying; Yu, Xin-Ming; Gao, Tian-Qi; Liu, Huan; Zhang, Ling-Xia; Xu, Hui; Wang, Zhen-Yu; Lan, Lefu; Dai, Hui-Xiong 分享 收藏 分享 收藏 NRZ complex facilitates virus infection via enhancing ER-LD contactsNRZ复合物通过增强内质网-脂滴接触促进病毒感染Li, Zhifang; Xing, Yifan; Huang, Xinyi; Tian, Buyun; Mei, Jie; Fu, Xinyue; Huang, Yuhan; Zhang, Qian; Ding, Binbin; Cao, Xiaobao; Xue, Yanhong; Li, Zonghong; Xu, Tao; Jiu, Yaming 分享 收藏 Integrated proteomic and phosphoproteomic profiling unravels an O-GlcNAc-dependent mechanism in DGAT1 inhibition-mediated protection of β-cells from lipotoxicity整合蛋白质组学和磷酸化蛋白质组学分析揭示了O-GlcNAc依赖性机制在DGAT1抑制介导的β细胞抗脂毒性保护中的作用Guo, Jia-Ming; Chen, Guang-Yun; Huang, Jun-Shang; Zhu, Zhen-Yun; Dong, Lin-Yue; Xie, Wen-Fan; Li, Yi-Ming; Hu, You-Hong; Wang, He-Yao; Zhou, Hu 分享 收藏 Cascade-Amplified Ratiometric Fluorescent Probe for Time-Locked Imaging Epilepsy用于时间锁定成像癫痫的级联放大比率荧光探针Wang, Xin; Li, Bohan; Li, Min; Chen, Yuncan; Tang, Yurui; Ji, Aiyan; Zhao, Jing; Sun, Chenchen; Li, Zhenrong; Ni, Dan; Cheng, Yanlong; Sun, Wanbing; Lei, Zuhai; Wang, Jing; Vezzani, Annamaria; Li, Xiaoyu; Li, Cong; Zhu, Xiao; Cheng, Zhen; Wang, Cong 分享 收藏 New Macrocyclolipopeptides and Steroids from Mariana Trench-Derived Fungus Cladosporium sp.Peng, Qingyun; Lan, Shanshan; Li, Qun; Liu, Yunan; Ruan, Wu; Wu, Kun; Shen, Qianqian; Chen, Yi; Wang, Junfeng; Li, Dan; Wang, Ming-Wei 分享 收藏 Design, Synthesis, and Structure-Activity Relationship Studies of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) InhibitorsLiu, Meiying; Tu, Yutong; Xu, Wangyang; Gao, Lixin; Wang, Kun; Zhou, Yang; Xu, Tianfeng; Zhou, Yubo; Zhou, Chuan 分享 收藏 Brain-Targeting Metal-Organic Framework Nanoplatform Reprogramming Ferroptosis Sensitivity of Glioblastoma脑靶向金属有机框架纳米平台重编程胶质母细胞瘤的铁死亡敏感性Wang, Mengzhen; Lai, Yi; Meng, Hanxue; Jin, Aojia; Zhang, Ping; Shen, Yinuo; Lin, Shutong; Yu, Haijun; Xu, Wujun; Lehto, Vesa-Pekka; Zhang, Wen; Xu, Zhiai 分享 收藏 
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