未登录 Validation of a model of rheumatoid arthritis using mice reconstituted with patient peripheral blood mononuclear cells 使用经患者外周血单核细胞重建的小鼠验证类风湿关节炎模型 Schuster-Winkelmann, Paula; Wess, Veronika; Schindler, Marietta; Jensen, Morten O.; Shaw, David E.; Alberton, Paolo; Schulze-Koops, Hendrik; Schoenthaler, Silvia; Weinhaeusel, Andreas; Siebeck, Matthias; Gropp, Roswitha; Aszodi, Attila 分享 收藏
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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small- molecule inhibitor of FGFR2 Schonherr, Heike; Ayaz, Pelin; Taylor, Alexander M.; Casaletto, Jessica B.; Toure, B. Barry; Moustakas, Demetri T.; Hudson, Brandi M.; Valverde, Roberto; Zhao, Songping; O'Hearn, Patrick J.; Foster, Lindsey; Sharon, Dina A.; Garfinkle, Sam; Giordanetto, Fabrizio; Lescarbeau, Andre; Kurukulasuriya, Ravi; Gerami-Moayed, Nastaran; Maglic, Dejan; Bruderek, Kamil; Naik, Gaauri; Gunaydin, Hakan; Mader, Mary M.; Boezio, Alessandro A.; Mclean, Thomas H.; Chen, Rongfeng; Wang, Yanxia; Shaw, David E.; Watters, James; Bergstrom, Donald A. 分享 收藏
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia RLY-2608的发现和临床概念验证，这是一种一流的突变选择性变构PI3Kα 抑制剂，可使高胰岛素血症的抗肿瘤活性脱钩 Varkaris, Andreas; Pazolli, Ermira; Gunaydin, Hakan; Wang, Qi; Pierce, Levi; Boezio, Alessandro A.; Bulku, Artemisa; Dipietro, Lucian; Fridrich, Cary; Frost, Adam; Giordanetto, Fabrizio; Hamilton, Erika P.; Harris, Katherine; Holliday, Michael; Hunter, Tamieka L.; Iskandar, Amanda; Ji, Yongli; Larivee, Alexandre; Larochelle, Jonathan R.; Lescarbeau, Andre; Llambi, Fabien; Lormil, Brenda; Mader, Mary M.; Mar, Brenton G.; Martin, Iain; Mclean, Thomas H.; Michelsen, Klaus; Pechersky, Yakov; Puente-Poushnejad, Erika; Raynor, Kevin; Rogala, Dipali; Samadani, Ramin; Schram, Alison M.; Shortsleeves, Kelley; Swaminathan, Sweta; Tajmir, Shahein; Tan, Gege; Tang, Yong; Valverde, Roberto; Wehrenberg, Bryan; Wilbur, Jeremy; Williams, Bret R.; Zeng, Hongtao; Zhang, Hanmo; Walters, W. Patrick; Wolf, Beni B.; Shaw, David E.; Bergstrom, Donald A.; Watters, James; Fraser, James S.; Fortin, Pascal D.; Kipp, D. Randal 分享 收藏
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors Taylor, Alexander M.; Williams, Bret R.; Giordanetto, Fabrizio; Kelley, Elizabeth H.; Lescarbeau, Andre; Shortsleeves, Kelley; Tang, Yong; Walters, W. Patrick; Arrazate, Alfonso; Bowman, Christine; Brophy, Erin; Chan, Emily W.; Deshmukh, Gauri; Greisman, Jack B.; Hunsaker, Thomas L.; Kipp, D. Randal; Lopez-Larrocha, Pablo Saenz; Maddalo, Danilo; Martin, Iain J.; Maragakis, Paul; Merchant, Mark; Murcko, Mark; Nisonoff, Hunter; Nguyen, Vi; Nguyen, Vy; Orozco, Olivia; Owen, Christopher; Pierce, Levi; Schmidt, Molly; Shaw, David E.; Smith, Sherri; Therrien, Eric; Tran, John C.; Watters, Jim; Waters, Nigel J.; Wilbur, Jeremy; Willmore, Lindsay 分享 收藏
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RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations Subbiah, Vivek; Sahai, Vaibhav; Maglic, Dejan; Bruderek, Kamil; Toure, B. Barry; Zhao, Songping; Valverde, Roberto; O'Hearn, Patrick J.; Moustakas, Demetri T.; Schoenherr, Heike; Gerami-Moayed, Nastaran; Taylor, Alexander M.; Hudson, Brandi M.; Houde, Damian J.; Pal, Debjani; Foster, Lindsey; Gunaydin, Hakan; Ayaz, Pelin; Sharon, Dina A.; Goyal, Lipika; Schram, Alison M.; Kamath, Suneel; Sherwin, Cori Ann; Schmidt-Kittler, Oleg; Jen, Kai Yu; Ricard, Fabien; Wolf, Beni B.; Shaw, David E.; Bergstrom, Donald A.; Watters, James; Casaletto, Jessica B. 分享 收藏
Structural mechanism of a drug-binding process involving a large conformational change of the protein target 涉及蛋白质靶标大构象变化的药物结合过程的结构机制 Ayaz, Pelin; Lyczek, Agatha; Paung, YiTing; Mingione, Victoria R.; Iacob, Roxana E.; de Waal, Parker W.; Engen, John R.; Seeliger, Markus A.; Shan, Yibing; Shaw, David E. 分享 收藏
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Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex Chen, James; Wang, Qi; Malone, Brandon; Llewellyn, Eliza; Pechersky, Yakov; Maruthi, Kashyap; Eng, Ed T.; Perry, Jason K.; Campbell, Elizabeth A.; Shaw, David E.; Darst, Seth A. 分享 收藏
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A structural model of a Ras-Raf signalosome Mysore, Venkatesh P.; Zhou, Zhi-Wei; Ambrogio, Chiara; Li, Lianbo; Kapp, Jonas N.; Lu, Chunya; Wang, Qi; Tucker, Maxwell R.; Okoro, Jeffrey J.; Nagy-Davidescu, Gabriela; Bai, Xiaochen; Pluckthun, Andreas; Janne, Pasi A.; Westover, Kenneth D.; Shan, Yibing; Shaw, David E. 分享 收藏
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization Agnew, Christopher; Ayaz, Pelin; Kashima, Risa; Loving, Hanna S.; Ghatpande, Prajakta; Kung, Jennifer E.; Underbakke, Eric S.; Shan, Yibing; Shaw, David E.; Hata, Akiko; Jura, Natalia 分享 收藏
Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis Unterweger, Anna-Lena; Jensen, Morten O.; Giordanetto, Fabrizio; Jogini, Vishwanath; Rueschher, Alena; Seuss, Marietta; Winkelmann, Paula; Koletzko, Leandra; Shaw, David E.; Siebeck, Matthias; Gropp, Roswitha; Beigel, Florian; Aszodi, Attila 分享 收藏
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B.; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T.; Chait, Brian T.; Shaw, David E.; Landick, Robert; Darst, Seth A.; Campbell, Elizabeth A. 分享 收藏
Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling Adamopoulos, Christos; Ahmed, Tamer A.; Tucker, Maxwell R.; Ung, Peter M. U.; Xiao, Min; Karoulia, Zoi; Amabile, Angelo; Wu, Xuewei; Aaronson, Stuart A.; Ang, Celina; Rebecca, Vito W.; Brown, Brian D.; Schlessinger, Avner; Herlyn, Meenhard; Wang, Qi; Shaw, David E.; Poulikakos, Poulikos, I 分享 收藏
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Structural Basis of AZD9291 Selectivity for EGFR T790M Yan, Xiao-E; Ayaz, Pelin; Zhu, Su-Jie; Zhao, Peng; Liang, Ling; Zhang, Casey H.; Wu, Ya-Chuang; Li, Je-Luen; Choi, Hwan Geun; Huang, Xin; Shan, Yibing; Shaw, David E.; Yun, Cai-Hong 分享 收藏
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