未登录 Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective (vol 68, pg 24830, 2025) 2024年片段到先导药物化学出版物：第十年度展望（卷 68，第 24830 页，2025年） Twigg, David G.; Arai, Kenta; Arkin, Michelle R.; Erlanson, Daniel A.; de Esch, Iwan J. P.; Farkas, Barbara; Fesik, Stephen W.; Jahnke, Wolfgang; Johnson, Christopher N.; Schroeder, Martin 分享 收藏
Altered Inflammatory Signature in a C9ORF72-ALS iPSC-Derived Motor Neuron and Microglia Coculture Model C9ORF72-ALS iPSC来源的运动神经元和微胶质细胞共培养模型中的炎症特征改变 Gao, Yujing; Brothwood, Jessica L.; Saini, Harpreet; O'Sullivan, Gregory A.; Bento, Carla F.; McCarthy, James M.; Wallis, Nicola G.; Di Daniel, Elena; Graham, Brent; Tams, Daniel M. 分享 收藏
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Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function 整合片段筛选、靶向蛋白降解和遗传拯救以探索eIF4E功能 Sharp, Swee Y.; Martella, Marianna; D'Agostino, Sabrina; Milton, Christopher I.; Ward, George; Woodhead, Andrew J.; Carr, Maria G.; Chiarparin, Elisabetta; Cons, Benjamin D.; Coyle, Joseph; East, Charlotte E.; Hiscock, Steven D.; Martinez-Fleites, Carlos; Mortenson, Paul N.; Palmer, Nick; Pathuri, Puja; Powers, Marissa V.; Saalau, Susanne M.; St. Denis, Jeffrey D.; Swabey, Kate; Vinkovic, Mladen; Walton, Hugh; Williams, Glyn; Clarke, Paul A. 分享 收藏
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Targeting the catalytic HAT domain of CBP/p300 for the treatment of hormone-dependent breast and prostate cancers Hearn, K.; Bevan, L.; Chessari, G.; Clark, M.; Cons, B.; Espana-agusti, J.; Ferro, K.; Hamlett, C.; Howard, A.; Lyons, J.; Martins, V.; Morgillo, C.; Palmer, N.; Rapti, M.; Shah, A.; Smyth, T.; Unbekandt, M.; Varshney, D.; Ahn, M. 分享 收藏
Pulsatile induction of the p53 pathway by MDM2 antagonist ASTX295 shows an enhanced therapeutic index in vivo Fazal, L.; Biondo, A.; Ahn, M.; Bevan, L.; Hearn, K.; Howard, S.; Jueliger, S.; Chessari, G.; Kucia-Tran, J.; Shah, A.; Sims, M.; Wilsher, N.; Keer, H.; Organesian, A.; Wedge, S.; Thomas, H.; Zhao, Y.; Newell, D.; Wallis, N.; Courtin, A. 分享 收藏
Identification of biomarkers predictive of response to ASTX295, a next-generation MDM2 antagonist, in solid tumors carrying wild-type p53 Ahn, M.; Bevan, L.; Biondo, A.; Brothwood, J.; Chessari, G.; Fazal, L.; Ferraldeschi, R.; Ferrari, N.; Gewinner, C.; Jueliger, S.; Kucia-Tran, J.; Saini, H.; Sims, M.; Thompson, N.; Wallis, N.; Ward, G.; Lyons, J. 分享 收藏
A novel small-molecule CBP/p300 HAT domain inhibitor demonstrates potent in vivo activity and a favorable safety profile in preclinical species Hearn, K.; Ahn, M.; Bevan, L.; Chessari, G.; Clark, M.; Cons, B.; Espana-agusti, J.; Ferro, K.; Howard, A.; Lyons, J.; Martins, V.; Morgillo, C.; Palmer, N.; Rapti, M.; Shah, A.; Smyth, T.; Unbekandt, M.; Varshney, D.; Hamlett, C. 分享 收藏
Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery Ramos, Anderson Daniel; Liang, Ying Yu; Surova, Olga; Bacanu, Smaranda; Gerault, Marc-Antoine; Mandal, Tamoghna; Ceder, Sophia; Langeback, Anette; Osterroos, Albin; Ward, George A.; Bergh, Jonas; Wiman, Klas G.; Lehmann, Soren; Prabhu, Nayana; Loof, Sara; Nordlund, Par 分享 收藏
The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1 GBA1的注释已被其蛋白质编码假基因GBAP1所掩盖 Gustavsson, Emil K.; Sethi, Siddharth; Gao, Yujing; Brenton, Jonathan W.; Garcia-Ruiz, Sonia; Zhang, David; Garza, Raquel; Reynolds, Regina H.; Evans, James R.; Chen, Zhongbo; Grant-Peters, Melissa; Macpherson, Hannah; Montgomery, Kylie; Dore, Rhys; Wernick, Anna I.; Arber, Charles; Wray, Selina; Gandhi, Sonia; Esselborn, Julian; Blauwendraat, Cornelis; Douse, Christopher H.; Adami, Anita; Atacho, Diahann A. M.; Kouli, Antonina; Quaegebeur, Annelies; Barker, Roger A.; Englund, Elisabet; Platt, Frances; Jakobsson, Johan; Wood, Nicholas W.; Houlden, Henry; Saini, Harpreet; Bento, Carla F.; Hardy, John; Ryten, Mina 分享 收藏
Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase Palmer, Nick; Agnew, Christopher; Benn, Caroline; Buffham, William J.; Castro, Joan N.; Chessari, Gianni; Clark, Mellissa; Cons, Benjamin D.; Coyle, Joseph E.; Dawson, Lee A.; Hamlett, Christopher C. F.; Hodson, Charlotte; Holding, Finn; Johnson, Christopher N.; Liebeschuetz, John W.; Mahajan, Pravin; McCarthy, James M.; Murray, Christopher W.; O'Reilly, Marc; Peakman, Torren; Price, Amanda; Rapti, Magdalini; Reeks, Judith; Schopf, Patrick; St-Denis, Jeffrey D.; Valenzano, Chiara; Wallis, Nicola G.; Walser, Reto; Weir, Heather; Wilsher, Nicola E.; Woodhead, Andrew; Bento, Carla F.; Tisi, Dominic 分享 收藏
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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2) Day, James E. H.; Berdini, Valerio; Castro, Joan; Chessari, Gianni; Davies, Thomas G.; Day, Philip J.; St. Denis, Jeffrey D.; Fujiwara, Hideto; Fukaya, Satoshi; Hamlett, Christopher C. F.; Hearn, Keisha; Hiscock, Steven D.; Holvey, Rhian S.; Ito, Satoru; Kandola, Navrohit; Kodama, Yasuo; Liebeschuetz, John W.; Martins, Vanessa; Matsuo, Kenichi; Mortenson, Paul N.; Muench, Sandra; Nakatsuru, Yoko; Ochiiwa, Hiroaki; Palmer, Nicholas; Peakman, Torren; Price, Amanda; Reader, Michael; Rees, David C.; Rich, Sharna J.; Shah, Alpesh; Shibata, Yoshihiro; Smyth, Tomoko; Twigg, David G.; Wallis, Nicola G.; Williams, Glyn; Wilsher, Nicola E.; Woodhead, Andrew; Shimamura, Tadashi; Johnson, Christopher N. 分享 收藏
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