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M

Mark Helm

Johannes Gutenberg University Mainz

64H指数
323论文数
1.9W被引数
收录论文 152
发表时间
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Comprehensive post-transcriptional modification profiles in individual Staphylococcus aureus tRNA species个体金黄色葡萄球菌tRNA种类中的全面转录后修饰图谱
errNucleic Acids Research
IF13.1
err2026-08-06
err0
errOAAI
errJose R Jaramillo-Ponce; Philippe Wolff; Virginie Marchand; Yuri Motorin; Maximilian Kohl; Béatrice Chane-Woon-Ming; Hiroki Kanazawa; Aila Ruiz-Paterson; Caroline Paulus; Johana Chicher; Marine Lenon; Martina Krämer; Anne-Sophie Gribling-Burrer; Constantinos Stathopoulos; Redmond Smyth; Mark Helm; Pascale Romby; Stefano Marzi
err分享
err收藏
ModiCal: A Targeted Calibration Workflow for Site-Specific m5C Validation by Nanopore Direct RNA SequencingModiCal：一种用于纳米孔直接RNA测序进行位点特异性m5C验证的靶向校准工作流程
errACS Chemical Biology
IF3.8
err2026-05-19
err0
errOAAI
errZeynep Özrendeci; Stefan Mündnich; Stefan Pastore; Chia Ching Wu; Virginie Marchand; Yuri Motorin; Alessia Ruggieri; Susanne Gerber; Mark Helm
err分享
err收藏
Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing使用长读长纳米孔测序技术对人pre-rRNA的加工和修饰进行单核苷酸分辨率映射
errNature Communications
IF15.7
err2026-03-31
err0
errOAAI
errStefan Pastore; Ludivine Wacheul; Lioba Lehmann; Stefan Mündnich; Beat Lutz; Mark Helm; Susanne Gerber; Denis L. J. Lafontaine; Tamer Butto
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Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications直接RNA测序能够改善转录组评估，并用于追踪RNA修饰以应用于医学领域。
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-12-11
err1
PREAI
errHewel, Charlotte; Wierczeiko, Anna; Miedema, Johannes; Friedrich, Johannes; Hofmann, Felix; Weissbach, Stephan; Dietrich, Vincent; Holthofer, Laura; Haug, Verena; Muendnich, Stefan; Schartel, Lukas; Lehmann, Lioba; Jensen, Kristi L.; Diederich, Stefan; Sys, Stanislav; Butto, Tamer; Paul, Norbert W.; Koch, Jonas; Lyko, Frank; Kraft, Florian; Russo, Alexandra; Schweiger, Susann; Lemke, Edward A.; Helm, Mark; Linke, Matthias; Gerber, Susanne
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Mapping of HOCl-oxidized RNA identifies abasic sites as major damage and oxidation product of oxo8G对HOCl氧化的RNA进行映射鉴定，发现无碱基位点为oxo8G的主要损伤和氧化产物。
errNature Communications
IF15.7
err2025-11-21
err0
errOAAI
errMarlies Weber; Kasturi Raorane; Clara Johanna Grampp; Valérie Bourguignon; Lea-Marie Kilz; David Glänzer; Virginie Marchand; Christoph Kreutz; Yuri Motorin; Mark Helm
err分享
err收藏
Probing the function of Streptomyces albidoflavus J1074 gene XNR_5296 for SPOUT family ribose methyltransferase探究链霉菌Streptomyces albidoflavus J1074基因XNR_5296的功能，该基因编码SPOUT家族核糖甲基转移酶。
errMICROBIOLOGY SPECTRUM
IF3.8
err2025-11-01
err0
PREAI
errTseduliak, Vasylyna-Marta; Koshla, Oksana; Mulartschyk, Sophie N.; Marchand, Virginie; Motorin, Yuri; Helm, Mark; Ostash, Bohdan
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Autophosphorylation of conserved yeast and human casein kinase 1 isozymes regulates Elongator-dependent tRNA modifications保守酵母和人类酪蛋白激酶1同工酶的自身磷酸化调节Elongator依赖性的tRNA修饰
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-09-23
err0
errOAAI
errLandrock, Maria Friederike; Krutyholowa, Roscislaw; Bohnert, Pauline; Mazur, Jaroslaw; Honc, Malgorzata; Hammermeister, Alexander; Bessler, Larissa; Scherf, David; Elms, Anna; Radczuk, Natalia; Skupien-Rabian, Bozena; Jankowska, Urszula; Herberg, Friedrich W.; Helm, Mark; Klassen, Roland; Glatt, Sebastian; Schaffrath, Raffael
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ModiDeC: a multi-RNA modification classifier for direct nanopore sequencingAlagna, N.; Mündnich, S.; Miedema, J.; Pastore, S.; Lehmann, L.; Wierczeiko, A.; Friedrich, J.; Walz, L.; Jörg, M.; Butto, T.; et al. ModiDeC：一种用于直接纳米孔测序的多RNA修饰分类器。Nucleic Acids Res. 2025, 53, gkaf673. [Google Scholar] [CrossRef] [PubMed]
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-08-12
err1
PREAI
errAlagna, Nicolo; Muendnich, Stefan; Miedema, Johannes; Pastore, Stefan; Lehmann, Lioba; Wierczeiko, Anna; Friedrich, Johannes; Walz, Lukas; Joerg, Marko; Butto, Tamer; Friedland, Kristina; Helm, Mark; Gerber, Susanne
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DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding siteDNA编码库筛选发现靶向隐匿别构结合位点的强效DNMT2抑制剂
erriScience
IF4.1
err2025-08-05
err0
errOAAI
errAriane F. Frey; Merlin Schwan; Annabelle C. Weldert; Valerie Kadenbach; Jürgen Kopp; Zarina Nidoieva; Robert A. Zimmermann; Lukas Gleue; Collin Zimmer; Marko Jörg; Kristina Friedland; Mark Helm; Irmgard Sinning; Fabian Barthels
err分享
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Queuosine is incorporated into precursor tRNA before splicing核糖核苷酸queuosine在剪接前掺入前体tRNA中
errNature Communications
IF15.7
err2025-07-31
err0
errOAAI
errWei Guo; Igor Kaczmarczyk; Kevin Kopietz; Florian Flegler; Stefano Russo; Ege Cigirgan; Andrzej Chramiec-Głąbik; Łukasz Koziej; Cansu Cirzi; Jirka Peschek; Klaus Reuter; Mark Helm; Sebastian Glatt; Francesca Tuorto
err分享
err收藏
tRNA binding to Kti12 is crucial for wobble uridine modification by ElongatortRNA与Kti12的结合对于Elongator介导的摆动尿苷修饰至关重要。
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-04-14
err0
errOAAI
errScherf, David; Hammermeister, Alexander; Boehnert, Pauline; Burkard, Alicia; Helm, Mark; Schaffrath, Raffael
err分享
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A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2025-02-03
err0
errOAAI
errNidoieva, Zarina; Sabin, Mark O.; Dewald, Tristan; Weldert, Annabelle C.; Hoba, Sabrina N.; Helm, Mark; Barthels, Fabian
err分享
err收藏
A Direct Chemical Repair of Etheno-Type RNA Damages
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-12-02
err0
errOAAI
errHe, Yin-Ming; Burkard, Alicia; Wu, Chuan-Shuo; Jin, Xiao-Yang; Liu, Li; Helm, Mark; Cheng, Liang
err分享
err收藏
Dual Centrifugation-Based Screening for pH-Responsive Liposomes
errCHEMMEDCHEM
IF3.4
err2024-11-12
err0
errOAAI
errGleue, Lukas; Graefen, Barbara; Voigt, Matthias; Schupp, Jonathan; Schneider, Dirk; Fichter, Michael; Kuske, Michael; Mailaender, Volker; Tuettenberg, Andrea; Helm, Mark
err分享
err收藏
The P(III)-Amidite Based Synthesis of Stable Isotope Labeled mRNA-Cap-Structures Enables their Sensitive Quantitation from Brain Tissue
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-11-02
err0
errOAAI
errRipp, Alexander; Kramer, Martina; Barth, Vanessa; Moser, Patrick; Haas, Thomas M.; Singh, Jyoti; Huck, Tamara; Gleue, Lukas; Friedland, Kristina; Helm, Mark; Jessen, Henning J.
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err收藏
Differential redox sensitivity of tRNA dihydrouridylation
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-10-26
err0
errOAAI
errKilz, Lea-Marie; Zimmermann, Simone; Marchand, Virginie; Bourguignon, Valerie; Sudol, Claudia; Bregeon, Damien; Hamdane, Djemel; Motorin, Yuri; Helm, Mark
err分享
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Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles
errNATURE COMMUNICATIONS
IF15.7
err2024-10-24
err0
errOAAI
errSchartel, Lukas; Jann, Cosimo; Wierczeiko, Anna; Butto, Tamer; Muendnich, Stefan; Marchand, Virginie; Motorin, Yuri; Helm, Mark; Gerber, Susanne; Lemke, Edward A.
err分享
err收藏
DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-09-11
err2
errOAAI
errMarco, Kristen; Marc, Lander; Lea-Marie, Kilz; Lukas, Gleue; Marko, Joerg; Damien, Bregeon; Djemel, Hamdane; Virginie, Marchand; Yuri, Motorin; Kristina, Friedland; Mark, Helm
err分享
err收藏
Esterification of Cyclic N6-Threonylcarbamoyladenosine During RNA Sample Preparation
errCHEMMEDCHEM
IF3.4
err2024-05-26
err0
errOAAI
errBessler, Larissa; Sirleaf, Jason; Kampf, Christopher J.; Frankowska, Katarzyna; Leszczynska, Grazyna; Opatz, Till; Helm, Mark
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Fluoropyrimidines trigger decay of hypomodified tRNA in yeast
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-05-08
err0
errOAAI
errGoerlitz, Katharina; Bessler, Larissa; Helm, Mark; Schaffrath, Raffael; Klassen, Roland
err分享
err收藏

研究方向

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合作学者
合作期刊
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Derek R. Lovley
H 指数: 181 · 论文数: 697
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Hölger Thiele
H 指数: 134 · 论文数: 1.8K
P
Peter Nürnberg
H 指数: 127 · 论文数: 756
K
Katharina Landfester
H 指数: 111 · 论文数: 1.1K
W
Wolfgang Wurst
H 指数: 111 · 论文数: 738
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