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J

John M. Sedivy

brown university

79H指数
262论文数
3.2W被引数
收录论文 112
发表时间
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cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammationcGAS缺陷小鼠表现出与LINE1元件去抑制和炎症相关的早衰
errNature Aging
IF19.4
err2026-08-25
err0
errOAAI
errJohn C. Martinez; Francesco Morandini; Cheyenne Rechsteiner; Lucinda Fitzgibbons; Natasha Sieczkiewicz; Xiaoyan Liao; Weijie He; Sung Jae Bae; Michael E. Meadow; Eric Hillpot; Joseph Cutting; Victoria Paige; Max Zacher; Seyed Ali Biashad; Matthew Simon; Ines Meula-Zarzuela; Mario D. Cordero; Martin S. Taylor; John M. Sedivy; Andrei Seluanov; Vera Gorbunova
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Phase 2a Randomized Controlled Trial of TPN-101, A Nucleoside Reverse Transcriptase Inhibitor, in Progressive Supranuclear Palsy2a期随机对照试验：TPN-101（一种核苷类逆转录酶抑制剂）在进行性核上性麻痹中的应用
errMovement Disorders
IF7.6
err2026-08-24
err0
PREAI
errAndrew Satlin MD; Michael G. Cordingley PhD; Debra K. Liebert MS, MBA; Walter Bee PhD; Ethan G. Geier PhD; John M. Sedivy PhD; Jay Soto; Jianmin Duan PhD; Samuel P. Dickson PhD; Leslie Chu PhD; Eckard Weber MD
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Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming Innovations通过干细胞衍生的滋养层类器官和重编程创新推进人胎盘建模
errBiomedicines
IF3.9
err2026-08-20
err0
errOAAI
errSukanta Jash; John M. Sedivy
err分享
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RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations
errFrontiers in Aging
IF4.3
err2026-01-17
err0
errOAAI
errSicheng Wen; Chang Yu; Maxfield M. G. Kelsey; Mandy Pereira; Hannah Alaimo; Em Teixeira; Jenna Pracht; Lori A. Daiello; Jonathan Drake; John M. Sedivy; Zhijin Wu; Peter Quesenberry†; Jill A. Kreiling
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Rapid DNA Cleavage by the LINE-1 Endonuclease Proximal to DNA Ends and at MismatchesLINE-1内切核酸酶在DNA末端附近及错配处的快速DNA切割
errJournal of Biological Chemistry
IF3.9
err2025-11-29
err0
errOAAI
errBryant D. Miller; Benedict A. Smail; Trevor Van Eeuwen; Hanna Kodama; Kazuma Kondo; Hua Jiang; Allison O’Brien; Nan Dai; Robert J. Trachman; Shengxi Guan; Jennifer A. Karlow; Wen-Chih Cheng; John M. Sedivy; Gerwald Jogl; Michael P. Rout; John LaCava; Kathleen H. Burns; Martin S. Taylor
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TE-Seq: a transposable element annotation and RNA-Seq pipelineTE-Seq：一种转座元件注释和RNA测序分析流程
errMobile DNA
IF3.1
err2025-11-27
err0
errOAAI
errMaxfield M. G. Kelsey; Radha L. Kalekar; John M. Sedivy
err分享
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A transcriptomic score to classify the inflammation-dysplasia-cancer sequence lesions in inflammatory bowel disease用于对炎症性肠病中的炎症-发育异常-癌症序列病变进行分类的转录组学评分
errJOURNAL OF CROHNS & COLITIS
IF8.7
err2025-02-13
err0
PREAI
errCremer, Anneline; Rosewick, Nicolas; Kelsey, Maxfield; Trepo, Eric; Libert, Frederick; De Vos, Martine; Baert, Filip; Moreels, Tom; Louis, Edouard; Rahier, Jean-Francois; Demetter, Pieter; Sedivy, John M.; Vermeire, Severine; Franchimont, Denis
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Age-associated clonal B cells drive B cell lymphoma in mice年龄相关克隆性b细胞驱动小鼠b细胞淋巴瘤
errNATURE AGING
IF19.4
err2024-08-08
err1
PREAI
errCastro, Jose P.; Shindyapina, Anastasia V.; Barbieri, Alessandro; Ying, Kejun; Strelkova, Olga S.; Paulo, Joao A.; Tyshkovskiy, Alexander; Meinl, Rico; Kerepesi, Csaba; Petrashen, Anna P.; Mariotti, Marco; Meer, Margarita V.; Hu, Yan; Karamyshev, Alexander; Losyev, Grigoriy; Galhardo, Mafalda; Logarinho, Elsa; Indzhykulian, Artur A.; Gygi, Steven P.; Sedivy, John M.; Manis, John P.; Gladyshev, Vadim N.
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Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonucleaseLINE-1反转录转座子核酸内切酶小分子抑制剂的鉴定和表征
errNATURE COMMUNICATIONS
IF15.7
err2024-05-08
err1
errOAAI
errD'Ordine, Alexandra M.; Jogl, Gerwald; Sedivy, John M.
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Small molecule NSC59984 synergizes with PARP inhibitors in BRCA1 wild type ovarian cancer
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errZhang, Shengliang; Zhou, Lanlan; Zhang, Leiqing; Pinho-Schwermann, Maximilian; Carneiro, Benedito; Sedivy, John; El-Deiry, Wafik S.
err分享
err收藏
Androgen deprivation therapy (ADT) and senescence-associated secretory phenotype (SASP) in vitro: Correlation with SASP in tumor specimens as well as in the serum of patients after ADT
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSchwermann, Maximilian; Hadfield, Matthew; Lu, Shaolei; Srinivasan, Praveen; Tajiknia, Vida; MacDonald, William; George, Andrew; Zhang, Shengliang; Zhang, Leiqing; Meza, Kimberly; De Souza, Andre; Golijanin, Dragan; Hyams, Elias; Lagos, Galina; Holder, Sheldon; Mega, Anthony; Sedivy, John; Safran, Howard; El-Deiry, Wafik; Carneiro, Benedito
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Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart
errELIFE
IF0
err2023-05-19
err5
errOAAI
errBaggett, Brett C.; Murphy, Kevin R.; Sengun, Elif; Mi, Eric; Cao, Yueming; Turan, Nilufer N.; Lu, Yichun; Schofield, Lorraine; Kim, Tae Yun; Kabakov, Anatoli Y.; Bronk, Peter; Qu, Zhilin; Camelliti, Patrizia; Dubielecka, Patrycja; Terentyev, Dmitry; del Monte, Federica; Choi, Bum-Rak; Sedivy, John; Koren, Gideon
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A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-04-01
err197
errOAAI
errNikiforov, MA; Chandriani, S; O'Connell, B; Petrenko, O; Kotenko, I; Beavis, A; Sedivy, JM; Cole, MD
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Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err67
errOAAI
errWeissinger, EM; Eissner, G; Grammer, C; Fackler, S; Haefner, B; Yoon, LS; Lu, KS; Bazarov, A; Sedivy, JM; Mischak, H; Kolch, W
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Myc potentiates apoptosis by stimulating Bax activity at the mitochondria
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err148
errOAAI
errSoucie, EL; Annis, MG; Sedivy, J; Filmus, J; Leber, B; Andrews, DW; Penn, LZ
err分享
err收藏
Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err63
errOAAI
errOster, SK; Marhin, WW; Asker, C; Facchini, LM; Dion, PA; Funa, K; Post, M; Sedivy, JM; Penn, LZ
err分享
err收藏
c-Myc is necessary for DNA damage-induced apoptosis in the G2 phase of the cell cycle
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err95
errOAAI
errAdachi, S; Obaya, AJ; Han, ZY; Ramos-Desimone, N; Wyche, JH; Sedivy, JM
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Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err88
errOAAI
errWei, WY; Jobling, WA; Chen, W; Hahn, WC; Sedivy, JM
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err收藏
Role of p14ARF in replicative and induced senescence of human fibroblasts
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err227
errOAAI
errWei, WY; Hemmer, RM; Sedivy, JM
err分享
err收藏
Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κ13 activation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err383
errOAAI
errYeung, KC; Rose, DW; Dhillon, AS; Yaros, D; Gustafsson, M; Chatterjee, D; McFerran, B; Wyche, J; Kolch, W; Sedivy, JM
err分享
err收藏

研究方向

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合作学者
合作期刊
B
Bert Vogelstein
H 指数: 255 · 论文数: 1.0K
K
Kenneth W. Kinzler
H 指数: 213 · 论文数: 785
S
Steven P. Gygi
H 指数: 195 · 论文数: 1.0K
R
Robert A. Weinberg
H 指数: 194 · 论文数: 673
B
Bharat B. Aggarwal
H 指数: 185 · 论文数: 842
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