David J. Beech - Publications, H-index & Citations

David J. Beech

University of Leeds

65H指数

375论文数

1.4W被引数

收录论文 163

发表时间

PIEZO1 force-sensing in cardiac electrical modelling PIEZO1力传感在心脏电建模中的应用

JOURNAL OF PHYSIOLOGY-LONDON

IF4.4

2026-09-18

PREAI

Yurou Cai; Michael A. Colman; David J Beech

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis 代谢激素β-氨基异丁酸通过PGC1α-BAIBA-PPARδ轴介导运动表现和骨骼肌适应性

Nature Communications

IF15.7

2026-08-18

OAAI

Helene N. Daou; Nicole T. Watt; Shaimaa A. Gad; Amanda DV MacCannell; Aysha Ali; Chew Cheng; Raquel L. Fernando; T. Simon Futers; Sumeet A. Khetarpal; Harrison Gallagher; Luis D. Chinait; Anselmo S. Moriscot; Pim Knuiman; Koen Manusama; Marco Mensink; Irvin Teh; Jurgen E. Schneider; Richard Cubbon; Guy S. Taylor; Daniel J. West; David J. Beech; T. Scott Bowen; Lee D. Roberts

(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation (-)-Englerin A与人类TRPC5结合揭示了通道激活中的芳香族相互作用网络

Nature Communications

IF15.7

2026-04-29

OAAI

Sebastian A. Porav; Alexandra Ptakova; Claudia C. Bauer; Kasia L. R. Hammond; David J. Beech; Viktorie Vlachova; Stephen P. Muench; Robin S. Bon

Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes 内皮衰老驱动心力衰竭合并2型糖尿病患者中内皮细胞-脂肪细胞有害的相互作用

jacc: basic to translational science

IF0

2026-04-10

OAAI

Oliver I. Brown; Katherine I. Bridge; Alexander-Francisco Bruns; Cheukyau Luk; Natallia Makava; Chew W. Cheng; Pradeep Wijayagoonawardana; Muzahir Tayebjee; Christopher E.D. Saunderson; Sam Straw; Michael Drozd; Anna Skroma; Natalie J. Haywood; Hema Viswambharan; Stephe Kamalathasan; John Gierula; David J. Beech; Khalid Naseem; Kathryn J. Griffin; Stephen B. Wheatcroft

Cardiovascular PIEZO discovery continues apace to reveal myocardial nerves feeling posture and blood loss 心血管PIEZO的发现进展迅速，揭示心肌神经感知姿势和失血情况。

Nature Cardiovascular Research

IF10.8

2026-03-24

PREAI

David J. Beech

A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults 一种罕见的ORAI1错义变异与英国白人成年人血管疾病风险相关

PLoS One

IF2.6

2026-02-13

PREAI

Shawer, Heba; Cheng, Chew W.; Hemmings, Karen E.; Aldawsari, Abeer M.; Revilla-Gonzalez, Gonzalo; Stocco, Fabio; Shi, Jian; Beech, David J.; Bailey, Marc A.

PIEZO Force Sensors and the Heart

Cold Spring Harbor Perspectives in Biology

IF8.4

2026-02-01

PREAI

McGrane, Anna; Murray, Michael; Bartoli, Fiona; Giannoudi, Marilena; Conning-Rowland, Marcella; Stewart, Leander; Levelt, Eylem; Cubbon, Richard M.; Dall'armellina, Erica; Griffin, Kathryn J.; Herum, Kate M.; Smith, Andrew J.; Beech, David J.

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels 《简明药理学指南2025/26：离子通道》

British Journal of Pharmacology

IF7.7

2025-12-01

OAAI

Alexander, Stephen P. H.; Striessnig, Jorg; Gibb, Alasdair J.; Mathie, Alistair A.; Veale, Emma L.; Kelly, Eamonn; Peach, Chloe J.; Armstrong, Jane F.; Faccenda, Elena; Harding, Simon D.; Southan, Christopher; Davies, Jamie A.; Aldrich, Richard W.; Attali, Bernard; Baggetta, Austin M.; Becirovic, Elvir; Beech, David J.; Biel, Martin; Bill, Roslyn M.; Caceres, Ana I.; Catterall, William A.; Chua, Han Chow; Conner, Alex C.; Danahay, Henry; Davies, Paul; De Clerq, Katrien; Delling, Markus; Di Virgilio, Francesco; Falzoni, Simonetta; Fang, Wei; Fenske, Stefanie; Fortuny-gomez, Anna; Fountain, Samuel; Chandy, George K.; Ghovanloo, Mohammad-reza; Goldstein, Steve A. N.; Gosling, Martin; Grimm, Christian; Grissmer, Stephan; Ha, Kotdaji; Hales, Tim G.; Hammelmann, Verena; Hanukoglu, Israel; Hu, Meiqin; Ijzerman, Ad P.; Jabba, Sairam V.; Jarvis, Mike; Jensen, Anders A.; Jordt, Sven E.; Kaczmarek, Leonard K.; Kellenberger, Stephan; Kennedy, Charles; King, Brian; Kitchen, Philip; Liu, Qiang; Lynch, Joseph W.; Manville, Rian W.; Meades, Jessica; Mehlfeld, Verena; Nicke, Annette; Offermanns, Stefan; Perez-reyes, Edward; Plant, Leigh D.; Pless, Stephan A.; Rash, Lachlan D.; Ren, Dejian; Rubaiy, Hussein N.; Salman, Mootaz M.; Sieghart, Werner; Sivilotti, Lucia G.; Smart, Trevor G.; Snutch, Terrance P.; Tammaro, Paolo; Tian, Jinbin; Trimmer, James S.; Van Den Eynde, Charlotte; Vergani, Paola; Vriens, Joris; Waxman, Stephen G.; Wei, Aguan D.; Winn, Brenda T.; Wulff, Heike; Xu, Haoxing; Yang, Fan; Yue, Lixia; Zhang, Xiaoli; Zhu, Michael

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity PIEZO力传感在血管生物学中的应用：新知识、新概念与新机遇的爆发式增长

Advanced Science

IF14.1

2025-08-24

OAAI

David J Beech

NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking NAADP介导的钙释放通过调控Rab46依赖性的Weibel-Palade小体转运促进血管生成素2的分泌。

Cell Calcium

IF4

2025-08-14

PREAI

Ryan D. Murray; Melissa Rose; Katarina T. Miteva; David J. Beech; Lynn McKeown

PIEZO1 mechanical insensitivity in generalized lymphatic dysplasia with the potential for pharmacological rescue 全身性淋巴管发育不良中PIEZO1机械不敏感及潜在药物挽救可能性

iScience

IF4.1

2025-07-15

OAAI

Melanie J. Ludlow; Oleksandr V. Povstyan; Deborah M. Linley; Silvia Martin-Almedina; Charlotte Revill; Kevin Cuthbertson; Katie A. Smith; Emily Fay; Elisavet Fotiou; Andrew Bush; Claire Hogg; Tobias Linden; Natalie B. Tan; Susan M. White; Juan C. Del Rey Jimenez; Ege Sackey; Esther Dempsey; Sahar Mansour; Gregory Parsonage; Antreas C. Kalli; Richard Foster; Pia Ostergaard; David J. Beech

Endothelial insulin-like growth factor-1 signalling regulates vascular barrier function and atherogenesis 内皮胰岛素样生长因子-1信号通路调控血管屏障功能和动脉粥样硬化形成

CARDIOVASCULAR RESEARCH

IF13.3

2025-04-02

PREAI

Drozd, Michael; Bruns, Alexander-Francisco; Yuldasheva, Nadira Y.; Maqbool, Azhar; Viswambharan, Hema; Skromna, Anna; Makava, Natallia; Cheng, Chew W.; Sukumar, Piruthivi; Eades, Lauren; Walker, Andrew M. N.; Griffin, Kathryn J.; Galloway, Stacey; Watt, Nicole T.; Haywood, Natalie; Palin, Victoria; Warmke, Nele; Imrie, Helen; Bridge, Katherine; Beech, David J.; Wheatcroft, Stephen B.; Kearney, Mark T.; Cubbon, Richard M.

Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

MOLECULAR AND CELLULAR ENDOCRINOLOGY

IF3.6

2024-12-01

OAAI

Myers, Chloe G.; Viswambharan, Hema; Haywood, Natalie J.; Bridge, Katherine; Turvey, Samuel; Armstrong, Tom; Lunn, Lydia; Meakin, Paul J.; Porter, Karen E.; Clavane, Eva M.; Beech, David J.; Cubbon, Richard M.; Wheatcroft, Stephen B.; McPhillie, Martin J.; Issad, Tarik; Fishwick, Colin WG.; Kearney, Mark T.; Simmons, Katie J.

Endothelial insulin-like growth factor-1 signaling regulates vascular barrier function and atherogenesis

EUROPEAN HEART JOURNAL

IF35.6

2024-10-28

PREAI

Drozd, M.; Bruns, A.; Yuldasheva, N.; Maqbool, A.; Viswambharan, H.; Skromna, A.; Makava, N.; Eades, L.; Watt, N.; Haywood, N.; Bridge, K.; Beech, D.; Wheatcroft, S.; Kearney, M.; Cubbon, R.

Myocardial remodelling in bicuspid aortic valve associated severe aortic stenosis and reverse remodelling after aortic valve replacement

EUROPEAN HEART JOURNAL

IF35.6

2024-10-28

PREAI

Procter, H.; Giannoudi, M.; Kotha, S.; Jex, N.; Chowdhary, A.; Thirunavukarasu, S.; Cash, L.; Xue, H.; Plein, S.; Valkovic, L.; Kellman, P.; Beech, D.; Dweck, M.; Greenwood, J.; Levelt, E.

Pharmacology of PIEZO1 channels PIEZO1通道的药理学

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2024-10-14

OAAI

Kinsella, Jacob A.; Debant, Marjolaine; Parsonage, Gregory; Morley, Lara C.; Bajarwan, Muath; Revill, Charlotte; Foster, Richard; Beech, David J.

Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids

SCIENCE ADVANCES

IF12.5

2024-09-27

OAAI

Lichtenstein, Laeticia; Cheng, Chew W.; Bajarwan, Muath; Evans, Elizabeth L.; Gaunt, Hannah J.; Bartoli, Fiona; Chuntharpursat-Bon, Eulashini; Patel, Shaili; Konstantinou, Charalampos; Futers, T. Simon; Reay, Melanie; Parsonage, Gregory; Moore, J. Bernadette; Bertrand-Michel, Justine; Sukumar, Piruthivi; Roberts, Lee D.; Beech, David J.

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development Piezo1在软骨细胞中的表达控制软骨内骨化和骨关节炎的发展

BONE RESEARCH

IF15

2024-02-23

OAAI

Brylka, Laura J.; Alimy, Assil-Ramin; Tschaffon-Mueller, Miriam E. A.; Jiang, Shan; Ballhause, Tobias Malte; Baranowsky, Anke; von Kroge, Simon; Delsmann, Julian; Pawlus, Eva; Eghbalian, Kian; Pueschel, Klaus; Schoppa, Astrid; Haffner-Luntzer, Melanie; Beech, David J.; Beil, Frank Timo; Amling, Michael; Keller, Johannes; Ignatius, Anita; Yorgan, Timur A.; Rolvien, Tim; Schinke, Thorsten

Pico145 inhibits TRPC4-mediated mICAT and postprandial small intestinal motility Pico145抑制TRPC4-mediated mICAT和餐后小肠运动

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2023-12-01

OAAI

Dryn, Dariia O.; Melnyk, Mariia I.; Bon, Robin S.; Beech, David J.; V. Zholos, Alexander

Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis 2型糖尿病与重度主动脉瓣狭窄患者主动脉瓣置换前后心肌结构、收缩功能、能量学和血流变化的关系

CIRCULATION

IF38.6

2023-10-10

OAAI

Jex, Nicholas; Greenwood, John P.; Cubbon, Richard M.; Rider, Oliver J.; Chowdhary, Amrit; Thirunavukarasu, Sharmaine; Kotha, Sindhoora; Giannoudi, Marilena; Mcgrane, Anna; Maccannell, Amanda; Conning-Rowland, Marcella; Straw, Sam; Procter, Henry; Papaspyros, Sotiris; Evans, Betsy; Javangula, Kalyana; Ferrara, Antonella; Elmahdy, Walid; Kaul, Pankaj; Xue, Hui; Swoboda, Peter; Kellman, Peter; Valkovic, Ladislav; Roberts, Lee; Beech, David; Kearney, Mark T.; Plein, Sven; Dweck, Marc R.; Levelt, Eylem

研究方向