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A CRISPR-Activation CROP-seq Screen Identifies HMGN1 as a Dosage-Sensitive Regulator of Heart Defects in Down Syndrome CRISPR激活CROP-seq筛选确定了HMGN1是唐氏综合征中心脏缺陷的剂量敏感调节因子 Ranade, Sanjeev; Li, Feiya; Whalen, Sean; Angelo, Pelonero; Ye, Lin; Huang, Yu; Brand, Abigail; Nishino, Tomohiro; Costa, Mauro; Mital, Rahul; Boileau, Ryan; Koback, Frances; Padmanabhan, Arun; Merriman, Alexander; Wallace, Langley; Nguyen, Annie; Poulis, Nikolaus; Gifford, Casey; Pollard, Katherine; Srivastava, Deepak 分享 收藏
Machine learning dissection of human accelerated regions in primate neurodevelopment 灵长类动物神经发育中人类加速区域的机器学习解剖 Whalen, Sean; Inoue, Fumitaka; Ryu, Hane; Fair, Tyler; Markenscoff-Papadimitriou, Eirene; Keough, Kathleen; Kircher, Martin; Martin, Beth; Alvarado, Beatriz; Elor, Orry; Cintron, Dianne Laboy; Williams, Alex; Samee, Abul Hassan; Thomas, Sean; Krencik, Robert; Ullian, Erik M.; Kriegstein, Arnold; Rubenstein, John L.; Shendure, Jay; Pollen, Alex A.; Ahituv, Nadav; Pollard, Katherine S. 分享 收藏
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype 十二种人类细胞类型的薄层相关染色质图谱揭示了一种中间染色质亚型 Shah, Parisha P.; Keough, Kathleen C.; Gjoni, Ketrin; Santini, Garrett T.; Abdill, Richard J.; Wickramasinghe, Nadeera M.; Dundes, Carolyn E.; Karnay, Ashley; Chen, Angela; Salomon, Rachel E. A.; Walsh, Patrick J.; Nguyen, Son C.; Whalen, Sean; Joyce, Eric F.; Loh, Kyle M.; Dubois, Nicole; Pollard, Katherine S.; Jain, Rajan 分享 收藏
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Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity (vol 20, pg 518, 2017) Carcamo-Orive, Ivan; Hoffman, Gabriel E.; Cundiff, Paige; Beckmann, Noam D.; D'Souza, Sunita L.; Knowles, Joshua W.; Patel, Achchhe; Hendry, Caroline; Papatsenko, Dimitri; Abbasi, Fahim; Reaven, Gerald M.; Whalen, Sean; Lee, Philip; Shahbazi, Mohammad; Henrion, Marc Y. R.; Zhu Kuixi; Wang, Sven; Roussos, Panos; Schadt, Eric E.; Pandey, Gaurav; Chang Rui; Quertermous, Thomas; Lemischka, Ihor 分享 收藏
Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes Markenscoff-Papadimitriou, Eirene; Binyameen, Fadya; Whalen, Sean; Price, James; Lim, Kenneth; Ypsilanti, Athena R.; Catta-Preta, Rinaldo; Pai, Emily Ling-Lin; Mu, Xin; Xu, Duan; Pollard, Katherine S.; Nord, Alex S.; State, Matthew W.; Rubenstein, John L. 分享 收藏
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lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements (vol 15, 2387, 2020) Gordon, M. Grace; Inoue, Fumitaka; Martin, Beth; Schubach, Max; Agarwal, Vikram; Whalen, Sean; Feng, Shiyun; Zhao, Jingjing; Ashuach, Tal; Ziffra, Ryan; Kreimer, Anat; Georgakopoulos-Soares, Ilias; Yosef, Nir; Ye, Chun Jimmie; Pollard, Katherine S.; Shendure, Jay; Kircher, Martin; Ahituv, Nadav 分享 收藏
lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements lentiMPRA和MPRAflow用于基因调控元件的高通量功能表征 Gordon, M. Grace; Inoue, Fumitaka; Martin, Beth; Schubach, Max; Agarwal, Vikram; Whalen, Sean; Feng, Shiyun; Zhao, Jingjing; Ashuach, Tal; Ziffra, Ryan; Kreimer, Anat; Georgakopoulous-Soares, Ilias; Yosef, Nir; Ye, Chun Jimmie; Pollard, Katherine S.; Shendure, Jay; Kircher, Martin; Ahituv, Nadav 分享 收藏
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice Engle, Dannielle; Tiriac, Herve; Rivera, Keith; Pommier, Arnaud; Whalen, Sean; Oni, Tobiloba; Alagesan, Brinda; Lee, Eun; Yao, Melissa; Lucito, Matthew; Spielman, Benjamin; Yu, Kenneth; Grutzmann, Robert; Aust, Daniela; Gimotty, Phyllis; Pollard, Katherine; Hruban, Ralph; Goggins, Michael; Pilarsky, Christian; Park, Young; Pappin, Darryl; Hollingsworth, Michael A.; Tuveson, David 分享 收藏
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Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert; Kolcic, Ivana; Loh, Po-Ru; Lunetta, Kathryn L.; Mangino, Massimo; Marco, Brumat; McMahon, George; Medland, Sarah E.; Nolte, Ilja M.; Noordam, Raymond; Nutile, Teresa; Paternoster, Lavinia; Perjakova, Natalia; Porcu, Eleonora; Rose, Lynda M.; Schraut, Katharina E.; Segre, Ayellet V.; Smith, Albert V.; Stolk, Lisette; Teumer, Alexander; Andrulis, Irene L.; Bandinelli, Stefania; Beckmann, Matthias W.; Benitez, Javier; Bergmann, Sven; Bochud, Murielle; Boerwinkle, Eric; Bojesen, Stig E.; Bolla, Manjeet K.; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Broer, Linda; Bruning, Thomas; Buring, Julie E.; Campbell, Harry; Catamo, Eulalia; Chanock, Stephen; Chenevix-Trench, Georgia; Corre, Tanguy; Couch, Fergus J.; Cousminer, Diana L.; Cox, Angela; Crisponi, Laura; Czene, Kamila; Smith, George Davey; de Geus, Eco J. C. N.; de Mutsert, Renee; De Vivo, Immaculata; Dennis, Joe; Devilee, Peter; dos-Santos-Silva, Isabel; Dunning, Alison M.; Eriksson, Johan G.; Fasching, Peter A.; Fernandez-Rhodes, Lindsay; Ferrucci, Luigi; Flesch-Janys, Dieter; Franke, Lude; Gabrielson, Marike; Gandin, Ilaria; Giles, Graham G.; Grallert, Harald; Gudbjartsson, Daniel F.; Guenel, Pascal; Hall, Per; Hallberg, Emily; Hamann, Ute; Harris, Tamara B.; Hartman, Catharina A.; Heiss, Gerardo; Hooning, Maartje J.; Hopper, John L.; Hu, Frank; Hunter, David J.; Ikram, M. Arfan; Im, Hae Kyung; Jarvelin, Marjo-Riitta; Joshi, Peter K.; Karasik, David; Kellis, Manolis; Kutalik, Zoltan; LaChance, Genevieve; Lambrechts, Diether; Langenberg, Claudia; Launer, Lenore J.; Laven, Joop S. E.; Lenarduzzi, Stefania; Li, Jingmei; Lind, Penelope A.; Lindstrom, Sara; Liu, YongMei; Luan, Jian'an; Magi, Reedik; Mannermaa, Arto; Mbarek, Hamdi; McCarthy, Mark I.; Meisinger, Christa; Meitinger, Thomas; Menni, Cristina; Metspalu, Andres; Michailidou, Kyriaki; Milani, Lili; Milne, Roger L.; Montgomery, Grant W.; Mulligan, Anna M.; Nalls, Mike A.; Navarro, Pau; Nevanlinna, Heli; Nyholt, Dale R.; Oldehinkel, Albertine J.; O'Mara, Tracy A.; Padmanabhan, Sandosh; Palotie, Aarno; Pedersen, Nancy; Peters, Annette; Peto, Julian; Pharoah, Paul D. P.; Pouta, Anneli; Radice, Paolo; Rahman, Iffat; Ring, Susan M.; Robino, Antonietta; Rosendaal, Frits R.; Rudan, Igor; Rueedi, Rico; Ruggiero, Daniela; Sala, Cinzia F.; Schmidt, Marjanka K.; Scott, Robert A.; Shah, Mitul; Sorice, Rossella; Southey, Melissa C.; Sovio, Ulla; Stampfer, Meir; Steri, Maristella; Strauch, Konstantin; Tanaka, Toshiko; Tikkanen, Emmi; Timpson, Nicholas J.; Traglia, Michela; Truong, Therese; Tyrer, Jonathan P.; Uitterlinden, Andre G.; Edwards, Digna R. Velez; Vitart, Veronique; Voelker, Uwe; Vollenweider, Peter; Wang, Qin; Widen, Elisabeth; van Dijk, Ko Willems; Willemsen, Gonneke; Winqvist, Robert; Wolffenbuttel, Bruce H. R.; Zhao, Jing Hua; Zoledziewska, Magdalena; Zygmunt, Marek; Alizadeh, Behrooz Z.; Boomsma, Dorret I.; Ciullo, Marina; Cucca, Francesco; Esko, Tonu; Franceschini, Nora; Gieger, Christian; Gudnason, Vilmundur; Hayward, Caroline; Kraft, Peter; Lawlor, Debbie A.; Magnusson, Patrik K. E.; Martin, Nicholas G.; Mook-Kanamori, Dennis O.; Nohr, Ellen A.; Polasek, Ozren; Porteous, David; Price, Alkes L.; Ridker, Paul M.; Snieder, Harold; Spector, Tim D.; Stoeckl, Doris; Toniolo, Daniela; Ulivi, Sheila; Visser, Jenny A.; Voelzke, Henry; Wareham, Nicholas J.; Wilson, James F.; Spurdle, Amanda B.; Thorsteindottir, Unnur; Pollard, Katherine S.; Easton, Douglas F.; Tung, Joyce Y.; Chang-Claude, Jenny; Hinds, David; Murray, Anna; Murabito, Joanne M.; Stefansson, Kari; Ong, Ken K.; Perry, John R. B. 分享 收藏
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity Carcamo-Orive, Ivan; Hoffman, Gabriel E.; Cundiff, Paige; Beckmann, Noam D.; D'Souza, Sunita L.; Knowles, Joshua W.; Patel, Achchhe; Papatsenko, Dimitri; Abbasi, Fahim; Reaven, Gerald M.; Whalen, Sean; Lee, Philip; Shahbazi, Mohammad; Henrion, Marc Y. R.; Zhu, Kuixi; Wang, Sven; Roussos, Panos; Schadt, Eric E.; Pandey, Gaurav; Chang, Rui; Quertermous, Thomas; Lemischka, Ihor 分享 收藏
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