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收藏分享 收藏 分享 收藏 Genome-wide CRISPR Screening Identifies NFKB and c-MET as Druggable Targets to Sensitize Lenvatinib Treatment in Hepatocellular Carcinoma全基因组CRISPR筛选鉴定NFKB和c-MET为使肝癌对仑伐替尼治疗敏感的可成药靶点
Wan, Ting-Chi Rebecca; Wei, Lai; Cheng, Lai-Hung; Chin, Wai-Ching; Shen, Jialing; Chan, For-Fan; Kuang, Zhijian; Wang, Cun; Wong, Carmen Chak-Lui; Wong, Chun-Ming 分享 收藏 分享 收藏 m6Am sequesters PCF11 to suppress premature termination and drive neuroblastoma differentiationAn, Huihui; Hong, Yifan; Goh, Yeek Teck; Koh, Casslynn W. Q.; Kanwal, Shahzina; Zhang, Yi; Lu, Zhaoqi; Yap, Phoebe M. L.; Neo, Suat Peng; Wong, Chun-Ming; Wong, Alice S. T.; Yu, Yang; Ho, Jessica Sook Yuin; Gunaratne, Jayantha; Goh, Wee Siong Sho 分享 收藏 Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinomaChan, For-Fan; Yuen, Vincent Wai-Hin; Shen, Jialing; Chin, Don Wai-Ching; Law, Cheuk-Ting; Wong, Bowie Po-Yee; Chan, Cerise Yuen-Ki; Cheu, Jacinth Wing-Sum; Ng, Irene Oi-Lin; Wong, Carmen Chak-Lui; Wong, Chun-Ming 分享 收藏 Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunityChan, Cerise Yuen-Ki; Yuen, Vincent Wai-Hin; Chiu, David Kung-Chun; Goh, Chi-Ching; Thu, Kelsie L.; Cescon, David W.; Soria-Bretones, Isabel; Law, Cheuk-Ting; Cheu, Jacinth Wing-Sum; Lee, Derek; Tse, Aki Pui-Wah; Tan, Kel Vin; Zhang, Misty Shuo; Wong, Bowie Po-Yee; Wong, Chun-Ming; Khong, Pek-Lan; Ng, Irene Oi-Lin; Bray, Mark R.; Mak, Tak Wah; Yau, Thomas Chung-Cheung; Wong, Carmen Chak-Lui 分享 收藏 Using mouse liver cancer models based on somatic genome editing to predict immune checkpoint inhibitor responses使用基于体细胞基因组编辑的小鼠肝癌模型预测免疫检查点抑制剂反应Yuen, Vincent Wai-Hin; Chiu, David Kung-Chun; Law, Cheuk-Ting; Cheu, Jacinth Wing-Sum; Chan, Cerise Yuen-Ki; Wong, Bowie Po-Yee; Goh, Chi-Ching; Zhang, Misty Shuo; Xue, Helen Do-Gai; Tse, Aki Pui-Wah; Zhang, Yan; Lau, Henry Yee-Hin; Lee, Derek; Au-Yeung, Rex K. H.; Wong, Chun-Ming; Chak-Lui, Carmen 分享 收藏 分享 收藏 Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver CancerCheu, Jacinth Wing-Sum; Lee, Derek; Li, Qidong; Goh, Chi Ching; Bao, Macus Hao-Ran; Yuen, Vincent Wai-Hin; Zhang, Misty Shuo; Yang, Chunxue; Chan, Cerise Yuen-Ki; Tse, Aki Pui-Wah; Sit, Grace Fu-Wan; Liu, Cindy Xinqi; Ng, Irene Oi-Lin; Wong, Chun-Ming; Wong, Carmen Chak-Lui 分享 收藏 Acupuncture combined with auricular acupressure for smoking cessation and its effects on tobacco dependence and smoking behavior among Hong Kong smokers: a multicenter pilot clinical studyHo, Lai Fun; Ho, Wai Kwan; Wong, Ling Ling; Chiu, Sze Wan; Tang, Shuk Yu; Wong, Chun Ming; Chan, Kin San; Lam, Chi Lan; Chen, Min; Chan, Kam Leung; Lin, Guohua; Ng, Bacon Fung-Leung; Lin, Zhi Xiu 分享 收藏 Hypoxia-induced macropinocytosis represents a metabolic route for liver cancerZhang, Misty Shuo; Cui, Jane Di; Lee, Derek; Yuen, Vincent Wai-Hin; Chiu, David Kung-Chun; Goh, Chi Ching; Cheu, Jacinth Wing-Sum; Tse, Aki Pui-Wah; Bao, Macus Hao-Ran; Wong, Bowie Po Yee; Chen, Carrie Yiling; Wong, Chun-Ming; Ng, Irene Oi-Lin; Wong, Carmen Chak-Lui 分享 收藏 Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancersShen, Jialing; Yang, Chunxue; Zhang, Misty Shuo; Chin, Don Wai-Ching; Chan, For-Fan; Law, Cheuk-Ting; Wang, Gengchao; Cheng, Carol Lai-Hung; Chen, Mengnuo; Wan, Rebecca Ting-Chi; Wu, Mengjie; Kuang, Zhijian; Sharma, Rakesh; Lee, Terence Kin Wah; Ng, Irene Oi-Lin; Wong, Carmen Chak-Lui; Wong, Chun-Ming 分享 收藏 分享 收藏 Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen SpeciesLee, Derek; Zhang, Misty Shuo; Tsang, Felice Ho-Ching; Bao, Macus Hao-Ran; Xu, Iris Ming-Jing; Lai, Robin Kit-Ho; Chiu, David Kung-Chun; Tse, Aki Pui-Wah; Law, Cheuk-Ting; Chan, Cerise Yuen-Ki; Yuen, Vincent Wai-Hin; Chui, Noreen Nog-Qin; Ng, Irene Oi-Lin; Wong, Chun-Ming; Wong, Carmen Chak-Lui 分享 收藏 Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancerCheng, Carol Lai-Hung; Tsang, Felice Hoi-Ching; Wei, Lai; Chen, Mengnuo; Chin, Don Wai-Ching; Shen, Jialing; Law, Cheuk-Ting; Lee, Derek; Wong, Carmen Chak-Lui; Ng, Irene Oi-Lin; Wong, Chun-Ming 分享 收藏 RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2Wang, Xia; Wang, Jin; Tsui, Yu-Man; Shi, Chaoran; Wang, Ying; Zhang, Xin; Yan, Qian; Chen, Miao; Jiang, Chen; Yuan, Yun-Fei; Wong, Chun-Ming; Liu, Ming; Feng, Zeng-yu; Chen, Honglin; Ng, Irene Oi Lin; Jiang, Lingxi; Guan, Xin-Yuan 分享 收藏 RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinomaChan, Lo-Kong; Ho, Daniel Wai-Hung; Kam, Charles Shing; Chiu, Elley Yung-Tuen; Lo, Irene Lai-Oi; Yau, Derek Tsz-Wai; Cheung, Elaine Tin-Yan; Tang, Chung-Ngai; Tang, Victor Wai-Lun; Lee, Terence Kin-Wah; Wong, Carmen Chak-Lui; Chok, Kenneth Siu-Ho; Chan, Albert Chi-Yan; Cheung, Tan-To; Wong, Chun-Ming; Ng, Irene Oi-Lin 分享 收藏 Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancerBao, Macus Hao-Ran; Yang, Chunxue; Tse, Aki Pui-Wah; Wei, Lai; Lee, Derek; Zhang, Misty Shuo; Goh, Chi Ching; Chiu, David Kung-Chun; Yuen, Vincent Wai-Hin; Law, Cheuk-Ting; Chin, Wai-Ching; Chui, Noreen Nog-Qin; Wong, Bowie Po-Yee; Chan, Cerise Yuen-Ki; Ng, Irene Oi-Lin; Chung, Clive Yik-Sham; Wong, Chun-Ming; Wong, Carmen Chak-Lui 分享 收藏 
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