Christian P. R. Hackenberger

Leibniz Forschungsinstitut für Molekulare Pharmakologie

44H指数

279论文数

7.1K被引数

收录论文 96

发表时间

A cell-permeable nanobody to restore F508del cystic fibrosis transmembrane conductance regulator activity 细胞穿透性纳米抗体以恢复F508del囊性纤维化跨膜电导调节因子活性

Nature Chemical Biology

IF13.7

2026-04-17

OAAI

Luise Franz; Tihomir Rubil; Anita Balázs; Marie Overtus; Kristin Kemnitz-Hassanin; Cedric Govaerts; Marcus A. Mall; Christian P. R. Hackenberger

Polyfluoroalkyl-Tagged Cell-Penetrating Peptide-Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction 多氟烷基标记的细胞穿透肽添加剂通过持续的单体脂质相互作用增强细胞内蛋白质递送

Angewandte Chemie International Edition

IF16.9

2026-04-14

OAAI

Sarah Hansen; Hana Zupan; Ferhat Mutlu; Jan Vincent V. Arafiles; Rubén Cruz; Palina Dubatouka; Kenichi Ataka; Martin Lehmann; Bettina G. Keller; Joachim Heberle; Christian P. R. Hackenberger

Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting 模块化乙烯基次膦酰胺用于半胱氨酸靶向蛋白质靶向

Journal of the American Chemical Society

IF15.6

2026-02-10

OAAI

Christian E. Stieger; Charlotte Völkel; Mathias B. Bertelsen; Michael Lisurek; Jan Vincent V. Arafiles; Jonathan Franke; Leander Crocker; Karl Schuppe; Yunjae Lim; Christiane Groneberg; Mathias Christmann; Han Sun; Christian P. R. Hackenberger

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases 不饱和磷亲电试剂探测蛋白酪氨酸磷酸酶

Angewandte Chemie International Edition

IF16.9

2026-02-03

OAAI

Eleftheria Poulou; Max Ruwolt; Christian E. Stieger; Kristin Kemnitz-Hassanin; Christian P. R. Hackenberger

Targeting the Membrane-Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight 靶向膜嵌入的菱形蛋白酶GlpG: 抑制剂发现和机制洞察的多模式策略

Angewandte Chemie International Edition

IF16.9

2026-01-28

OAAI

Claudia Bohg; Yurii Dubanych; Spyridon Kosteletos; Taoran Xiao; Martin Neuenschwander; Tillmann Utesch; Michael Lisurek; Carl Öster; Andreas Oder; Carola Seyffarth; Kathrin Bach; Denise-Liù Gracias Leone; František Filandr; Marc Wegert; Sascha Lange; Henry Sawczyc; Jens Peter von Kries; Christian P. R. Hackenberger; Edgar Specker; Han Sun; Kvido Stříšovský; Adam Lange

Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates 通过自降解氨基磷酸酯递送含羟基药物来扩大抗体-药物缀合物的有效载荷范围

Nature Communications

IF15.7

2026-01-20

OAAI

Philipp Ochtrop; Anil P. Jagtap; Jan G. Felber; Simon Vogt; Sarah Herterich; Isabelle Mai; Philipp Cyprys; Saskia Schmitt; Sarah Payer; Annabel Kitowski; Swetlana Wunder; Paul Machui; Julia Brandmeier; Natascia Leonardi; Elizaveta Poliak; Christian P. R. Hackenberger; Olivier Marcq; Dominik Schumacher; Jonas Helma; Annette M. Vogl; Marc-André Kasper

Quantitative analysis of inhibitor-induced assembly disruption in human UDP-GlcNAc 2-epimerase using mass photometry 利用质量光测量法对人类UDP-GlcNAc 2-表异构酶抑制剂诱导的组装破坏进行定量分析

Protein Science

IF5.2

2025-10-16

OAAI

Nico Boback; Jacob Gorenflos López; Christian P. R. Hackenberger; Santiago Di Lella; Daniel C. Lauster

Energy-transfer photoproximity labelling in live cells using an organic cofactor 使用有机辅因子在活细胞中进行能量转移光交联标记

Nature Chemistry

IF20.2

2025-09-17

OAAI

Leander B. Crocker; Jan Vincent V. Arafiles; Judith M. Müchler; Max Ruwolt; Kristin Kemnitz-Hassanin; Kilian Roßmann; Christian E. Stieger; Fan Liu; Nataliya Archipowa; Roger Jan Kutta; Christian P. R. Hackenberger

Outside Back Cover: Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups 封底外：通过生物可逆精氨酸修饰（BioRAM）在氨基上进行内源性蛋白质的细胞内递送

Angewandte Chemie International Edition

IF0

2025-07-23

PREAI

Jonathan Franke; Jan Vincent V. Arafiles; Christian Leis; Christian P. R. Hackenberger

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups 通过生物可逆精氨酸修饰（BioRAM）在氨基上进行内源性蛋白质的细胞内递送

Angewandte Chemie International Edition

IF0

2025-07-09

OAAI

Jonathan Franke; Jan Vincent V. Arafiles; Christian Leis; Christian P. R. Hackenberger

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide-Cyclisation-Bioconjugation 不饱和磷氧化物用于模块化抗体重桥接和单一试剂肽-环化-生物缀合

Angewandte Chemie International Edition

IF0

2025-06-30

PREAI

Dr. Christian E. Stieger; Dr. Alastair J. McMillan; Dr. Mark A. R. de Geus; Dr. Jan Vincent V. Arafiles; Dr. Luise Franz; Prof. Dr. Christian P. R. Hackenberger

Fluorogenic cell surface glycan labelling with fluorescence molecular rotor dyes and nucleic acid stains

CHEMICAL COMMUNICATIONS

IF4.2

2024-01-01

OAAI

Kocak, Alen; Homer, Amal K.; Feida, Antonia; Telschow, Florian; Gorenflos Lopez, Jacob L.; Baydaroglu, Cihan; Gradzielski, Michael; Hackenberger, Christian P. R.; Alexiev, Ulrike; Seitz, Oliver

Rapid building block-economic synthesis of long, multi-O-GalNAcylated MUC5AC tandem repeat peptides

CHEMICAL SCIENCE

IF7.4

2024-01-01

OAAI

Galashov, Arseniy; Kazakova, Ekaterina; Stieger, Christian E.; Hackenberger, Christian P. R.; Seitz, Oliver

Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-10-31

OAAI

Arafiles, Jan Vincent V.; Franke, Jonathan; Franz, Luise; Gomez-Gonzalez, Jacobo; Kemnitz-Hassanin, Kristin; Hackenberger, Christian P. R.

Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-10-12

OAAI

Schmitt, Saskia; Machui, Paul; Mai, Isabelle; Herterich, Sarah; Wunder, Swetlana; Cyprys, Philipp; Gerlach, Marcus; Ochtrop, Philipp; Hackenberger, Christian P. R.; Schumacher, Dominik; Helma, Jonas; Vogl, Annette M.; Kasper, Marc-Andre

Structure-Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell-Penetrating Peptides for Live-Cell Delivery of Synthetic Proteins ( AUG , e202207551 , 2023)

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2023-07-12

OAAI

Saha, A.; Mandal, S.; Arafiles, J. V. V.; Gomez-Gonzalez, J.; Hackenberger, C. P. R.; Brik, A.

(3+2)-Cyclization Reactions of Unsaturated Phosphonites with Aldehydes and Thioketones 不饱和亚膦酸酯与醛和硫酮的 (3 2)-环化反应

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-04-27

OAAI

Munasinghe, Don S.; Kasper, Marc-Andre; Jasinski, Radomir; Kula, Karolina; Palusiak, Marcin; Celeda, Malgorzata; Mloston, Grzegorz; Hackenberger, Christian P. R.

Real-time monitoring of the sialic acid biosynthesis pathway by NMR

CHEMICAL SCIENCE

IF7.4

2023-01-01

OAAI

Lopez, Jacob Gorenflos L.; Schmieder, Peter; Kemnitz-Hassanin, Kristin; Asikoglu, Hatice Ceyda; Celik, Arif; Stieger, Christian E.; Fiedler, Dorothea; Hinderlich, Stephan; Hackenberger, Christian P. R.

Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile

CHEMICAL SCIENCE

IF7.4

2023-01-01

OAAI

Ochtrop, Philipp; Jahzerah, Jahaziel; Machui, Paul; Mai, Isabelle; Schumacher, Dominik; Helma, Jonas; Kasper, Marc-Andre; Hackenberger, Christian P. R.

DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling DFT指导的乙炔基-三唑基-次膦酸酯作为化学选择性半胱氨酸生物缀合和分析的模块化亲电试剂的发现

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2022-08-22

OAAI

Stieger, Christian E.; Park, Yerin; de Geus, Mark A. R.; Kim, Dongju; Huhn, Christiane; Slenczka, J. Sophia; Ochtrop, Philipp; Muechler, Judith M.; Suessmuth, Roderich D.; Broichhagen, Johannes; Baik, Mu-Hyun; Hackenberger, Christian P. R.

研究方向