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收藏SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant TargetsSARS-CoV-2感染人肺气-液界面培养物揭示了基底细胞为相关靶点
Baumgardt, Morris; Obermayer, Benedikt; Balazs, Anita; Loewa, Anna; Wyler, Emanuel; Alves, Luiz Gustavo Teixeira; Hellwig, Katharina; Beule, Dieter; Landthaler, Markus; Mueller, Marcel A.; Drosten, Christian; Mall, Marcus A.; Hippenstiel, Stefan; Hoenzke, Katja 分享 收藏 分享 收藏 Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferretsHalwe, Nico Joel; Hamberger, Lea; Sehl-Ewert, Julia; Mache, Christin; Schoen, Jacob; Ulrich, Lorenz; Calvelage, Sten; Tonnies, Mario; Fuchs, Jonas; Bandawane, Pooja; Loganathan, Madhumathi; Abbad, Anass; Carreno, Juan Manuel; Bermudez-Gonzalez, Maria C.; Simon, Viviana; Kandeil, Ahmed; El-Shesheny, Rabeh; Ali, Mohamed A.; Kayali, Ghazi; Budt, Matthias; Hippenstiel, Stefan; Hocke, Andreas C.; Krammer, Florian; Wolff, Thorsten; Schwemmle, Martin; Ciminski, Kevin; Hoffmann, Donata; Beer, Martin 分享 收藏 Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP)包括慢性发病在内的急性新型冠状病毒肺炎分析: 德国深度表型全国大流行队列网络方案 (NAPKON-HAP)Steinbeis, Fridolin; Thibeault, Charlotte; Steinbrecher, Sarah; Ahlgrimm, Yvonne; Haack, Ira An; August, Dietrich; Balzuweit, Beate; Bellinghausen, Carla; Berger, Sarah; Chaplinskaya-Sobol, Irina; Cornely, Oliver; Doeblin, Patrick; Endres, Matthias; Fink, Claudia; Finke, Carsten; Frank, Sandra; Hanss, Sabine; Hartung, Tim; Hellmuth, Johannes Christian; Herold, Susanne; Heuschmann, Peter; Heyckendorf, Jan; Heyder, Ralf; Hippenstiel, Stefan; Hoffmann, Wolfgang; Kelle, Sebastian Ulrich; Knape, Philipp; Koehler, Philipp; Kretzler, Lucie; Leistner, David Manuel; Lienau, Jasmin; Lorbeer, Roberto; Lorenz-Depiereux, Bettina; Luettke, Constanze Dorothea; Mai, Knut; Merle, Uta; Meyer-Arndt, Lil Antonia; Miljukov, Olga; Muenchhoff, Maximilian; Mueller-Plathe, Moritz; Neuhann, Julia; Neuhauser, Hannelore; Nieters, Alexandra; Otte, Christian; Pape, Daniel; Pinto, Rafaela Maria; Pley, Christina; Pudszuhn, Annett; Reuken, Philipp; Rieg, Siegberg; Ritter, Petra; Rohde, Gernot; Roennefarth, Maria; Ruzicka, Michael; Schaller, Jens; Schmidt, Anne; Schmidt, Sein; Schwachmeyer, Verena; Schwanitz, Georg; Seeger, Werner; Stahl, Dana; Stobaeus, Nicole; Stubbe, Hans Christian; Suttorp, Norbert; Temmesfeld, Bettina; Thun, Sylvia; Triller, Paul; Trinkmann, Frederik; Vadasz, Istvan; Valentin, Heike; Vehreschild, Maria; von Kalle, Christof; von Lilienfeld-Toal, Marie; Weber, Joachim; Welte, Tobias; Wildberg, Christian; Wizimirski, Robert; Zvork, Saskia; Sander, Leif Erik; Vehreschild, Janne; Zoller, Thomas; Kurth, Florian; Witzenrath, Martin 分享 收藏 Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot studyCOPD肺炎和急性加重的新型蛋白质生物标志物: 一项初步研究Jung, Anna Lena; Han, Maria; Griss, Kathrin; Bertrams, Wilhelm; Nell, Christoph; Greulich, Timm; Klemmer, Andreas; Pott, Hendrik; Heider, Dominik; Vogelmeier, Claus F.; Hippenstiel, Stefan; Suttorp, Norbert; Schmeck, Bernd 分享 收藏 Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria血浆细胞外囊泡的表面蛋白质组作为疟疾的机制和临床生物标志物Jung, Anna Lena; Moller Jorgensen, Malene; Baek, Rikke; Artho, Marie; Griss, Kathrin; Han, Maria; Bertrams, Wilhelm; Greulich, Timm; Koczulla, Rembert; Hippenstiel, Stefan; Heider, Dominik; Suttorp, Norbert; Schmeck, Bernd 分享 收藏 Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients囊性纤维化跨膜传导调节调节剂可减弱健康供体和新型冠状病毒肺炎患者血液中的血小板活化和聚集Asmus, Erik; Karle, Weronika; Brack, Markus C.; Wittig, Corey; Behrens, Felix; Reinshagen, Leander; Pfeiffer, Moritz; Schulz, Sabrina; Mandzimba-Maloko, Bertina; Erfinanda, Lasti; Perret, Paul L.; Michalick, Laura; Smeele, Patrick J.; Lim, Endry H. T.; van den Brom, Charissa E.; Vonk, Alexander B. A.; Kaiser, Toralf; Suttorp, Norbert; Hippenstiel, Stefan; Sander, Leif E.; Kurth, Florian; Rauch, Ursula; Landmesser, Ulf; Haghikia, Arash; Preissner, Robert; Bogaard, Harm J.; Witzenrath, Martin; Kuebler, Wolfgang M.; Szulcek, Robert; Simmons, Szandor 分享 收藏 Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation内皮CFTR的丧失驱动肺部感染中的屏障衰竭和水肿形成，并且可以通过CFTR增强作用来靶向Erfinanda, Lasti; Zou, Lin; Gutbier, Birgitt; Kneller, Laura; Weidenfeld, Sarah; Michalick, Laura; Lei, Disi; Reppe, Katrin; Alves, Luiz Gustavo Teixeira; Schneider, Bill; Zhang, Qi; Li, Caihong; Fatykhova, Diana; Schneider, Paul; Liedtke, Wolfgang; Sohara, Eisei; Mitchell, Timothy J.; Gruber, Achim D.; Hocke, Andreas; Hippenstiel, Stefan; Suttorp, Norbert; Olschewski, Andrea; Mall, Marcus A.; Witzenrath, Martin; Kuebler, Wolfgang M. 分享 收藏 Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus原代人肺细胞与肺组织样本和人A549肺细胞系的转录组比较突出了甲型流感病毒感染期间的细胞类型特异性反应Bertrams, Wilhelm; Hoenzke, Katja; Obermayer, Benedikt; Toennies, Mario; Bauer, Torsten T. T.; Schneider, Paul; Neudecker, Jens; Rueckert, Jens C.; Stiewe, Thorsten; Nist, Andrea; Eggeling, Stephan; Suttorp, Norbert; Wolff, Thorsten; Hippenstiel, Stefan; Schmeck, Bernd; Hocke, Andreas C. 分享 收藏 Human alveolar progenitors generate dual lineage bronchioalveolar organoids人肺泡祖细胞产生双谱系支气管肺泡类器官Hoffmann, Karen; Obermayer, Benedikt; Hoenzke, Katja; Fatykhova, Diana; Demir, Zeynep; Loewa, Anna; Alves, Luiz Gustavo Teixeira; Wyler, Emanuel; Lopez-Rodriguez, Elena; Mieth, Maren; Baumgardt, Morris; Hoope, Judith; Firsching, Theresa C.; Toennies, Mario; Bauer, Torsten T.; Eggeling, Stephan; Tran, Hong-Linh; Schneider, Paul; Neudecker, Jens; Rueckert, Jens C.; Gruber, Achim D.; Ochs, Matthias; Landthaler, Markus; Beule, Dieter; Suttorp, Norbert; Hippenstiel, Stefan; Hocke, Andreas C.; Kessler, Mirjana 分享 收藏 A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics执行和分析跨物种单肺细胞转录组学的肺科医师指南Pennitz, Peter; Kirsten, Holger; Friedrich, Vincent D.; Wyler, Emanuel; Goekeri, Cengiz; Obermayer, Benedikt; Heinz, Gitta A.; Mashreghi, Mir-Farzin; Buettner, Maren; Trimpert, Jakob; Landthaler, Markus; Suttorp, Norbert; Hocke, Andreas C.; Hippenstiel, Stefan; Toennies, Mario; Scholz, Markus; Kuebler, Wolfgang M.; Witzenrath, Martin; Hoenzke, Katja; Nouailles, Geraldine 分享 收藏 Introducing quality measures in an academic research consortium Lessons and recommendation from implementing an ad hoc quality management system for organ model researchHuelsemann, Maren; Wiebach, Janine; Drude, Natascha Ingrid; Kniffert, Silke; Behm, Laura; Hoenzke, Katja; Baumgardt, Morris; Hippenstiel, Stefan; Hocke, Andreas C.; Dirnagl, Ulrich; Toelch, Ulf 分享 收藏 A multiplex protein panel assay for severity predictionand outcome prognosis in patients with COVID-19:An observational multi-cohort studyWang, Ziyue; Cryar, Adam; Lemke, Oliver; Tober-Lau, Pinkus; Ludwig, Daniela; Helbig, Elisa Theresa; Hippenstiel, Stefan; Sander, Leif-Erik; Blake, Daniel; Lane, Catherine S.; Sayers, Rebekah L.; Mueller, Christoph; Zeiser, Johannes; Townsend, StJohn; Demichev, Vadim; Mulleder, Michael; Kurth, Florian; Sirka, Ernestas; Hartl, Johannes; Ralser, Markus 分享 收藏 Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages由于缺乏ACE2水平，人肺对SARS-CoV-2的允许性有限，但病毒诱导的炎性巨噬细胞扩张Hoenzke, Katja; Obermayer, Benedikt; Mache, Christin; Fathykova, Diana; Kessler, Mirjana; Doekel, Simon; Wyler, Emanuel; Baumgardt, Morris; Loewa, Anna; Hoffmann, Karen; Graff, Patrick; Schulze, Jessica; Mieth, Maren; Hellwig, Katharina; Demir, Zeynep; Biere, Barbara; Brunotte, Linda; Mecate-Zambrano, Angeles; Bushe, Judith; Dohmen, Melanie; Hinze, Christian; Elezkurtaj, Sefer; Toennies, Mario; Bauer, Torsten T.; Eggeling, Stephan; Hong-Linh Tran; Schneider, Paul; Neudecker, Jens; Rueckert, Jens C.; Schmidt-Ott, Kai M.; Busch, Jonas; Klauschen, Frederick; Horst, David; Radbruch, Helena; Radke, Josefine; Heppner, Frank; Corman, Victor M.; Niemeyer, Daniela; Mueller, Marcel A.; Goffinet, Christine; Mothes, Ronja; Pascual-Reguant, Anna; Hauser, Anja Erika; Beule, Dieter; Landthaler, Markus; Ludwig, Stephan; Suttorp, Norbert; Witzenrath, Martin; Gruber, Achim D.; Drosten, Christian; Sander, Leif-Erik; Wolff, Thorsten; Hippenstiel, Stefan; Hocke, Andreas C. 分享 收藏 Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19高度多重免疫组库测序将多个淋巴细胞课程与对新型冠状病毒肺炎的反应严重程度联系起来Dannebaum, Richard; Suwalski, Phillip; Asgharian, Hosseinali; Du Zhipei, Gracie; Lin, Hai; Weiner, January, III; Holtgrewe, Manuel; Thibeault, Charlotte; Mueller, Melina; Wang, Xiaomin; Karadeniz, Zehra; Saccomanno, Jacopo; Doehn, Jan-Moritz; Huebner, Ralf-Harto; Hinzmann, Bernd; Blueher, Anja; Siemann, Sandra; Telman, Dilduz; Suttorp, Norbert; Witzenrath, Martin; Hippenstiel, Stefan; Skurk, Carsten; Poller, Wolfgang; Sander, Leif E.; Beule, Dieter; Kurth, Florian; Guettouche, Toumy; Landmesser, Ulf; Berka, Jan; Luong, Khai; Rubelt, Florian; Heidecker, Bettina 分享 收藏 Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19Wygrecka, Malgorzata; Birnhuber, Anna; Seeliger, Benjamin; Michalick, Laura; Pak, Oleg; Schultz, Astrid-Solveig; Schramm, Fabian; Zacharias, Martin; Gorkiewicz, Gregor; David, Sascha; Welte, Tobias; Schmidt, Julius J.; Weissmann, Norbert; Schermuly, Ralph T.; Barreto, Guillermo; Schaefer, Liliana; Markart, Philipp; Brack, Markus C.; Hippenstiel, Stefan; Kurth, Florian; Sander, Leif E.; Witzenrath, Martin; Kuebler, Wolfgang M.; Kwapiszewska, Grazyna; Preissner, Klaus T. 分享 收藏 Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung InfectionWienhold, Sandra-Maria; Brack, Markus C.; Nouailles, Geraldine; Krishnamoorthy, Gopinath; Korf, Imke H. E.; Seitz, Claudius; Wienecke, Sarah; Dietert, Kristina; Gurtner, Corinne; Kershaw, Olivia; Gruber, Achim D.; Ross, Anton; Ziehr, Holger; Rohde, Manfred; Neudecker, Jens; Lienau, Jasmin; Suttorp, Norbert; Hippenstiel, Stefan; Hocke, Andreas C.; Rohde, Christine; Witzenrath, Martin 分享 收藏 Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant VirusesSchulze, Jessica; Mache, Christin; Balazs, Anita; Frey, Doris; Niemeyer, Daniela; Olze, Heidi; Dommerich, Steffen; Drosten, Christian; Hocke, Andreas C.; Mall, Marcus A.; Hippenstiel, Stefan; Wolff, Thorsten 分享 收藏 Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01Weiner, January; Suwalski, Phillip; Holtgrewe, Manuel; Rakitko, Alexander; Thibeault, Charlotte; Mueller, Melina; Patriki, Dimitri; Quedenau, Claudia; Krueger, Ulrike; Ilinsky, Valery; Popov, Iaroslav; Balnis, Joseph; Jaitovich, Ariel; Helbig, Elisa T.; Lippert, Lena J.; Stubbemann, Paula; Real, Luis M.; Macias, Juan; Pineda, Juan A.; Fernandez-Fuertes, Marta; Wang, Xiaomin; Karadeniz, Zehra; Saccomanno, Jacopo; Doehn, Jan-Moritz; Huebner, Ralf-Harto; Hinzmann, Bernd; Salvo, Mauricio; Blueher, Anja; Siemann, Sandra; Jurisic, Stjepan; Beer, Juerg H.; Rutishauser, Jonas; Wiggli, Benedikt; Schmid, Hansruedi; Danninger, Kathrin; Binder, Ronald; Corman, Victor M.; Muehlemann, Barbara; Arkal, Rao Arjun; Fragiadakis, Gabriela K.; Mick, Eran; Calfee, Carolyn S.; Erle, David J.; Hendrickson, Carolyn M.; Kangelaris, Kirsten N.; Krummel, Matthew F.; Woodruff, Prescott G.; Langelier, Charles R.; Venkataramani, Urmila; Garcia, Federico; Zyla, Joanna; Drosten, Christian; Alice, Braun; Jones, Terry C.; Suttorp, Norbert; Witzenrath, Martin; Hippenstiel, Stefan; Zemojtel, Tomasz; Skurk, Carsten; Poller, Wolfgang; Borodina, Tatiana; Ripke, Stephan; Sander, Leif E.; Beule, Dieter; Landmesser, Ulf; Guettouche, Toumy; Kurth, Florian; Heidecker, Bettina 分享 收藏 
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