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IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia IL1RAP是正常核型三重突变急性髓系白血病的免疫治疗靶点。 Metois, Arnaud; Bordeleau, Marie-Eve; Theret, Louis; Hajmirza, Azadeh; Moujaber, Ossama; Spinella, Jean-Francois; Chagraoui, Jalila; Mayotte, Nadine; Boivin, Isabel; Audemard, Eric; Aubert, Leo; Lisi, Veronique; Khakipoor, Banafsheh; Farah, Azer; Bonneil, Eric; Robert, Alma; Lippens, Julie; Moraitis, Anna; Beliveau, Francois; Feghaly, Albert; Boucher, Genevieve; Marcotte, Richard; Gendron, Patrick; Thibault, Pierre; Lemieux, Sebastien; Richard-Carpentier, Guillaume; Lavallee, Vincent-Philippe; Hebert, Josee; Roux, Philippe P.; Sauvageau, Guy 分享 收藏
Uncovering Therapeutic Vulnerabilities in Adverse-Risk Pediatric Acute Myeloid Leukemia 揭示不良风险儿童急性髓系白血病的治疗易感点 Halim, Sabrina; Sultan, Noemie; Cardin, Sophie; Ta, Billy; Gress, Verena; El-Hachem, Nehme; Cheetham, Emma Rose; Marmolejo, Carolina; Soufflet, Anne-Cecile; Laramee, Louise; Bilodeau, Melanie; Lavallee, Vincent-Philippe; Goudie, Catherine; Bittencourt, Henrique; Wilhelm, Brian T.; Barabe, Frederic; Hebert, Josee; Cellot, Sonia 分享 收藏
Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines Safa-Tahar-Henni, Safia; Martinez, Karla Paez; Gress, Verena; Esparza, Nayeli; Roques, Elodie; Bonnet-Magnaval, Florence; Bilodeau, Melanie; Gagne, Valerie; Bresson, Eva; Cardin, Sophie; El-Hachem, Nehme; Iasenza, Isabella; Alzial, Gabriel; Boivin, Isabel; Nakamichi, Naoto; Soufflet, Anne-Cecile; Pascariu, Cristina Mirela; Duchaine, Jean; Mathien, Simon; Bonneil, Eric; Eppert, Kolja; Marinier, Anne; Sauvageau, Guy; Deblois, Genevieve; Thibault, Pierre; Hebert, Josee; Eaves, Connie J.; Cellot, Sonia; Barabe, Frederic; Wilhelm, Brian T. 分享 收藏
Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials Elsayed, Abdelrahman H.; Cao, Xueyuan; Marrero, Richard J.; Nguyen, Nam H. K.; Wu, Huiyun; Ni, Yonhui; Ribeiro, Raul C.; Tobias, Herold; Valk, Peter J.; Beliveau, Francois; Richard-Carpentier, Guillaume; Hebert, Josee; Zwaan, C. Michel; Gamis, Alan; Kolb, Edward Anders; Aplenc, Richard; Alonzo, Todd A.; Meshinchi, Soheil; Rubnitz, Jeffrey; Pounds, Stanley; Lamba, Jatinder K. 分享 收藏
Immunotherapeutic targeting of surfaceome heterogeneity in AML Bordeleau, Marie -Eve; Audemard, Eric; Metois, Arnaud; Theret, Louis; Lisi, Veronique; Farah, Azer; Spinella, Jean -Francois; Chagraoui, Jalila; Moujaber, Ossama; Aubert, Leo; Khakipoor, Banafsheh; Mallinger, Laure; Boivin, Isabel; Mayotte, Nadine; Hajmirza, Azadeh; Bonneil, Eric; Beliveau, Francois; Pfammatter, Sybille; Feghaly, Albert; Boucher, Genevieve; Gendron, Patrick; Thibault, Pierre; Barabe, Frederic; Lemieux, Sebastien; Richard-Carpentier, Guillaume; Hebert, Josee; Lavallee, Vincent-Philippe; Roux, Philippe P.; Sauvageau, Guy 分享 收藏
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia Moison, Celine; Gracias, Deanne; Schmitt, Julie; Girard, Simon; Spinella, Jean-Francois; Fortier, Simon; Boivin, Isabel; Mendoza-Sanchez, Rodrigo; Thavonekham, Bounkham; Macrae, Tara; Mayotte, Nadine; Bonneil, Eric; Wittman, Mark; Carmichael, James; Ruel, Rejean; Thibault, Pierre; Hebert, Josee; Marinier, Anne; Sauvageau, Guy 分享 收藏
CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216 Gress, Verena; Roussy, Mathieu; Boulianne, Luc; Bilodeau, Melanie; Cardin, Sophie; El-Hachem, Nehme; Lisi, Veronique; Khakipoor, Banafsheh; Rouette, Alexandre; Farah, Azer; Theret, Louis; Aubert, Leo; Fatima, Furat; Audemard, Eric; Thibault, Pierre; Bonneil, Eric; Chagraoui, Jalila; Laramee, Louise; Gendron, Patrick; Jouan, Loubna; Jammali, Safa; Pare, Bastien; Simpson, Shawn M.; Tran, Thai Hoa; Duval, Michel; Teira, Pierre; Bittencourt, Henrique; Santiago, Raoul; Barab, Frederic; Sauvageau, Guy; Smith, Martin A.; Hebert, Josee; Roux, Philippe P.; Gruber, Tanja A.; Lavallee, Vincent -Philippe; Wilhelm, Brian T.; Cellot, Sonia 分享 收藏
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis Zhang, Yu Wei; Mess, Julian; Lalioti, Maria-Eleni; Romero-Mulero, Mari Carmen; Velasco-Hernandez, Talia; Obier, Nadine; Karantzelis, Nikolaos; Rettkowski, Jasmin; Schoenberger, Katharina; Karabacz, Noemie; Jaecklein, Karin; Morishima, Tatsuya; Trincado, Juan Luis; Romecin, Paola; Martinez, Alba; Takizawa, Hitoshi; Shoumariyeh, Khalid; Renders, Simon; Zeiser, Robert; Pahl, Heike L.; Beliveau, Francois; Hebert, Josee; Lehnertz, Bernhard; Sauvageau, Guy; Menendez, Pablo; Cabezas-Wallscheid, Nina 分享 收藏
DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML Spinella, Jean-Francois; Chagraoui, Jalila; Moison, Celine; Lavallee, Vincent P.; Boivin, Isabel; Gracias, Deanne; Lavallee, Sylvie; Carpentier, Guillaume Richard; Beliveau, Francois; Hebert, Josee; Sauvageau, Guy 分享 收藏
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HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition Moison, Celine; Spinella, Jean-Francois; Chagraoui, Jalila; Lavallee, Vincent-Philippe; Lehnertz, Bernhard; Thiollier, Clarisse; Boivin, Isabel; Mayotte, Nadine; MacRae, Tara; Marinier, Anne; Hebert, Josee; Sauvageau, Guy 分享 收藏
Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia 单等位基因Heb/Tcf12缺失可降低T细胞急性淋巴细胞白血病中NOTCH1过度激活的需求 Veiga, Diogo F. T.; Tremblay, Mathieu; Gerby, Bastien; Herblot, Sabine; Haman, Andre; Gendron, Patrick; Lemieux, Sebastien; Zuniga-Pflucker, Juan Carlos; Hebert, Josee; Cohen, Joseph Paul; Hoang, Trang 分享 收藏
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia He, Lixiazi; Arnold, Christian; Thoma, Judith; Rohde, Christian; Kholmatov, Maksim; Garg, Swati; Hsiao, Cheng-Chih; Viol, Linda; Zhang, Kaiqing; Sun, Rui; Schmidt, Christina; Janssen, Maike; MacRae, Tara; Huber, Karin; Thiede, Christian; Hebert, Josee; Sauvageau, Guy; Spratte, Julia; Fluhr, Herbert; Aust, Gabriela; Muller-Tidow, Carsten; Niehrs, Christof; Pereira, Gislene; Hamann, Joerg; Tanaka, Motomu; Zaugg, Judith B.; Pabst, Caroline 分享 收藏
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia Krosl, Jana; Bordeleau, Marie-Eve; Moison, Celine; MacRae, Tara; Boivin, Isabel; Mayotte, Nadine; Gracias, Deanne; Baccelli, Irene; Lavallee, Vincent-Philippe; Bisaillon, Richard; Lehnertz, Bernhard; Mendoza-Sanchez, Rodrigo; Ruel, Rejean; Bertomeu, Thierry; Coulombe-Huntington, Jasmin; Boucher, Genevieve; Noronha, Nandita; Pabst, Caroline; Tyers, Mike; Gendron, Patrick; Lemieux, Sebastien; Barabe, Frederic; Marinier, Anne; Hebert, Josee; Sauvageau, Guy 分享 收藏
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