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Yasushi Okuno

riken

53H指数
410论文数
9.3K被引数
收录论文 132
发表时间
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Digital twin of biomacromolecular thermodynamics in cryo-EM data冷冻电镜数据中生物大分子热力学的数字孪生
errCommunications Chemistry
IF6.2
err2026-06-05
err0
errOAAI
errKimihiro Yamazaki; Mutsuyo Wada; Yuichiro Wada; Atsushi Tokuhisa; Kento Ohga; Akira Nakagawa; Yoshinobu Akinaga; Yoko Sasakura; Takashi Katoh; Shigeyuki Matsumoto; Yasushi Okuno
err分享
err收藏
Chemical genomics language model toward reliable and explainable compound-protein interaction exploration面向可靠和可解释的化合物-蛋白质相互作用探索的化学基因组学语言模型
errJournal of Cheminformatics
IF5.7
err2026-01-30
err0
errOAAI
errTakuto Koyama; Hayato Tsumura; Ryunosuke Okita; Kimihiro Yamazaki; Aki Hasegawa; Keiko Imamura; Takashi Kato; Hiroaki Iwata; Ryosuke Kojima; Haruhisa Inoue; Shigeyuki Matsumoto; Yasushi Okuno
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err收藏
Predicting measurement continuity in home blood pressure monitoring using machine learning利用机器学习预测家庭血压监测中的测量连续性
errHypertension Research
IF4.6
err2025-11-07
err0
errOAAI
errAsami Matsumoto; Yohei Mineharu; Hirohiko Kohjitani; Hiroshi Koshimizu; Yasushi Okuno
err分享
err收藏
Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic VulnerabilitiesCMTR2基因突变在肺腺癌中改变了RNA选择性剪接并揭示了治疗易感性
errNature Communications
IF15.7
err2025-11-06
err0
errOAAI
errShigenari Nukaga; Kouya Shiraishi; Kenta Hamabe; Akifumi Mochizuki; Yu Hamaguchi; Emi Ogawa; Nguyen Thai Le; Yoko Shimada; Hanako Ono; Hitomi Nishinakamura; Yoshihisa Kobayashi; Junko Hamamoto; Ayako Ui; Mitsugu Araki; Yukari Sagae; Keiko Ohgino; Kai Sugihara; Satoshi Endo; Jun Miyakoshi; Yuichi Shiraishi; Hiroyuki Yasuda; Yasushi Okuno; Tatsuya Yoshida; Yasushi Goto; Yuichiro Ohe; Shun-Ichi Watanabe; Yasushi Yatabe; Hiroyoshi Nishikawa; Ryuji Hamamoto; Takashi Kohno; Takashi Nakaoku
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Improving ADME Prediction with Multitask Graph Neural Networks and Assessing Explainability in Lead Optimization利用多任务图神经网络改进ADME预测，并评估先导化合物优化中的可解释性
errJournal of Chemical Information and Modeling
IF5.3
err2025-10-22
err0
errOAAI
errShoma Ito; Takuto Koyama; Shigeyuki Matsumoto; Ryosuke Kojima; Yuji Okamoto; Masataka Kuroda; Hitoshi Kawashima; Reiko Watanabe; Tomoki Yonezawa; Takaaki Sumiyoshi; Kazuyoshi Ikeda; Kenji Mizuguchi; Hiroaki Iwata; Yasushi Okuno
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err收藏
Predicting mortality dynamics in cancer patients: A machine learning approach to pre-death events预测癌症患者死亡率动态：一种针对临终事件的机器学习方法
errPLOS ONE
IF2.6
err2025-09-09
err0
errOAAI
errYamamoto, Tatsuki; Sakuragi, Minoru; Tuji, Yuzuha; Okamoto, Yuji; Uchino, Eiichiro; Yanagita, Motoko; Muto, Manabu; Kamada, Mayumi; Okuno, Yasushi
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Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region通过在铰链区插入肽接头将激动性抗TNFR2双表位抗体转化为拮抗剂
errJournal of Biological Chemistry
IF3.9
err2025-07-31
err0
errOAAI
errTakuya Otsuki; Shigeyuki Matsumoto; Junso Fujita; Tomoko Miyata; Keiichi Namba; Ryo Kanada; Yasushi Okuno; Haruhiko Kamada; Hiroaki Ohno; Hiroki Akiba
err分享
err收藏
kMoL: an open-source machine and federated learning library for drug discoverykMoL: 用于药物发现的开源机器和联合学习库
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2025-02-25
err0
errOAAI
errCozac, Romeo; Hasic, Haris; Choong, Jun Jin; Richard, Vincent; Beheshti, Loic; Froehlich, Cyrille; Koyama, Takuto; Matsumoto, Shigeyuki; Kojima, Ryosuke; Iwata, Hiroaki; Hasegawa, Aki; Otsuka, Takao; Okuno, Yasushi
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Receptor-independent regulation of Ga13 by alpha-1-antitrypsin C-terminal peptides
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
errOAAI
errPark, Yonghak; Matsumoto, Shigeyuki; Ogata, Kosuke; Ma, Biao; Kanada, Ryo; Isaka, Yuta; Arichi, Norihito; Liang, Xiaowen; Maki, Ritsuko; Kozasa, Tohru; Okuno, Yasushi; Ohno, Hiroaki; Ishihama, Yasushi; Toyoshima, Fumiko
err分享
err收藏
Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function
errCELL DEATH & DISEASE
IF9.6
err2024-11-11
err0
errOAAI
errToda, Yusuke; Fujita, Hiroaki; Mino, Koshiki; Koyama, Takuto; Matsuoka, Seiji; Kaizuka, Toshie; Agawa, Mari; Matsumoto, Shigeyuki; Idei, Akiko; Nishikori, Momoko; Okuno, Yasushi; Osada, Hiroyuki; Yoshida, Minoru; Takaori-Kondo, Akifumi; Iwai, Kazuhiro
err分享
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Molecular Dynamics Unveils Multiple-Site Binding of Inhibitors with Reduced Activity on the Surface of Dihydrofolate Reductase
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-10-12
err0
errOAAI
errAraki, Mitsugu; Ekimoto, Toru; Takemura, Kazuhiro; Matsumoto, Shigeyuki; Tamura, Yunoshin; Kokubo, Hironori; Bekker, Gert-Jan; Yamane, Tsutomu; Isaka, Yuta; Sagae, Yukari; Kamiya, Narutoshi; Ikeguchi, Mitsunori; Okuno, Yasushi
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Binding Mechanism between Platelet Glycoprotein and Cyclic Peptide Elucidated by McMD-Based Dynamic Docking
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-05-16
err0
PREAI
errBekker, Gert-Jan; Oshima, Kanji; Araki, Mitsugu; Okuno, Yasushi; Kamiya, Narutoshi
err分享
err收藏
Development of interpretable machine learning models to predict in-hospital prognosis of acute heart failure patients开发可解释的机器学习模型来预测急性心力衰竭患者的住院预后
errESC HEART FAILURE
IF3.7
err2024-05-15
err1
errOAAI
errTanaka, Munekazu; Kohjitani, Hirohiko; Yamamoto, Erika; Morimoto, Takeshi; Kato, Takao; Yaku, Hidenori; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Seko, Yuta; Shiba, Masayuki; Yoshikawa, Yusuke; Yamashita, Yugo; Kitai, Takeshi; Taniguchi, Ryoji; Iguchi, Moritake; Nagao, Kazuya; Kawai, Takafumi; Komasa, Akihiro; Kawase, Yuichi; Morinaga, Takashi; Toyofuku, Mamoru; Furukawa, Yutaka; Ando, Kenji; Kadota, Kazushige; Sato, Yukihito; Kuwahara, Koichiro; Okuno, Yasushi; Kimura, Takeshi; Ono, Koh
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LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-04-04
err0
errOAAI
errMori, Shunta; Izumi, Hiroki; Araki, Mitsugu; Liu, Jie; Tanaka, Yu; Kagawa, Yosuke; Sagae, Yukari; Ma, Biao; Isaka, Yuta; Sasakura, Yoko; Kumagai, Shogo; Sakae, Yuta; Tanaka, Kosuke; Shibata, Yuji; Udagawa, Hibiki; Matsumoto, Shingo; Yoh, Kiyotaka; Okuno, Yasushi; Goto, Koichi; Kobayashi, Susumu
err分享
err收藏
Feature extraction of particle morphologies of pharmaceutical excipients from scanning electron microscope images using convolutional neural networks
errINTERNATIONAL JOURNAL OF PHARMACEUTICS
IF5.2
err2024-03-01
err2
errOAAI
errIwata, Hiroaki; Hayashi, Yoshihiro; Koyama, Takuto; Hasegawa, Aki; Ohgi, Kosuke; Kobayashi, Ippei; Okuno, Yasushi
err分享
err收藏
A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer
errNPJ PRECISION ONCOLOGY
IF8
err2024-02-23
err3
errOAAI
errSuzuki, Mai; Uchibori, Ken; Oh-hara, Tomoko; Nomura, Yumi; Suzuki, Ryusei; Takemoto, Ai; Araki, Mitsugu; Matsumoto, Shigeyuki; Sagae, Yukari; Kukimoto-Niino, Mutsuko; Kawase, Yusuke; Shirouzu, Mikako; Okuno, Yasushi; Nishio, Makoto; Fujita, Naoya; Katayama, Ryohei
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err收藏
Idiopathic pulmonary fibrosis-specific Bayesian network integrating extracellular vesicle proteome and clinical information整合胞外囊泡蛋白质组和临床信息的特发性肺纤维化特异性贝叶斯网络
errSCIENTIFIC REPORTS
IF3.9
err2024-01-15
err2
errOAAI
errTomoto, Mei; Mineharu, Yohei; Sato, Noriaki; Tamada, Yoshinori; Nogami-Itoh, Mari; Kuroda, Masataka; Adachi, Jun; Takeda, Yoshito; Mizuguchi, Kenji; Kumanogoh, Atsushi; Natsume-Kitatani, Yayoi; Okuno, Yasushi
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err收藏
Enhanced Coarse-Grained Molecular Dynamics Simulation with a Smoothed Hybrid Potential Using a Neural Network Model
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2023-12-26
err4
PREAI
errKanada, Ryo; Tokuhisa, Atsushi; Nagasaka, Yusuke; Okuno, Shingo; Amemiya, Koichiro; Chiba, Shuntaro; Bekker, Gert-Jan; Kamiya, Narutoshi; Kato, Koichiro; Okuno, Yasushi
err分享
err收藏
VGAE-MCTS: A New Molecular Generative Model Combining the Variational Graph Auto-Encoder and Monte Carlo Tree Search
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-11-22
err5
errOAAI
errIwata, Hiroaki; Nakai, Taichi; Koyama, Takuto; Matsumoto, Shigeyuki; Kojima, Ryosuke; Okuno, Yasushi
err分享
err收藏
Development of Deep Neural Network Models for Identification of Pulmonary Vein Potentials From Body Surface Electrocardiograms of Patients With Atrial Fibrillation
errCIRCULATION
IF38.6
err2023-11-07
err0
PREAI
errTanaka, Munekazu; Kohjitani, Hirohiko; Inoue, Tomoyuki; Morinaga, Akifumi; Yoneda, Fumiya; Nishiwaki, Shushi; Shizuta, Satoshi; Okuno, Yasushi; Ono, Koh
err分享
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研究方向

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合作学者
合作期刊
S
Shuh Narumiya
H 指数: 138 · 论文数: 867
J
Jeffrey A. Engelman
H 指数: 131 · 论文数: 874
M
Minoru Yoshida
H 指数: 115 · 论文数: 1.9K
A
Alice T. Shaw
H 指数: 115 · 论文数: 686
K
Kazuomi Kario
H 指数: 106 · 论文数: 1.8K
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