Damien J. Downes - Publications, H-index & Citations

Damien J. Downes

university of oxford

29H指数

87论文数

3.0K被引数

收录论文 33

发表时间

Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation 凝聚素介导的环化挤出在分化早期增强子激活基因表达中发挥作用

Nature Communications

IF15.7

2026-05-26

OAAI

Rosa J. Stolper; Felice H. Tsang; Emily Georgiades; Lars L. P. Hanssen; Edward A. J. Tunnacliffe; Damien J. Downes; Caroline L. Harrold; Jim R. Hughes; Robert A. Beagrie; Benjamin Davies; Mira T. Kassouf; Douglas R. Higgs

Active regulatory elements recruit cohesin to establish cell specific chromatin domains 活性调节元件招募凝聚素以建立细胞特异性染色质结构域

SCIENTIFIC REPORTS

IF3.9

2025-04-06

OAAI

Georgiades, Emily; Harrold, Caroline; Roberts, Nigel; Kassouf, Mira; Riva, Simone G.; Sanders, Edward; Downes, Damien; Francis, Helena S.; Blayney, Joseph; Oudelaar, A. Marieke; Milne, Thomas A.; Higgs, Douglas; Hughes, Jim R.

The α-globin super-enhancer acts in an orientation-dependent manner ( vol 16, 1033 , 2025)α-球蛋白超级增强子以方向依赖性方式发挥作用（vol 16, 1033, 2025）

NATURE COMMUNICATIONS

IF15.7

2025-03-19

OAAI

Kassouf, Mira T.; Francis, Helena S.; Gosden, Matthew; Suciu, Maria C.; Downes, Damien J.; Harrold, Caroline; Larke, Martin; Oudelaar, Marieke; Cornell, Lucy; Blayney, Joseph; Telenius, Jelena; Xella, Barbara; Shen, Yuki; Sousos, Nikolaos; Sharpe, Jacqueline A.; Sloane-Stanley, Jacqueline; Smith, Andrew J. H.; Babbs, Christian; Hughes, Jim R.; Higgs, Douglas R.

The α-globin super-enhancer acts in an orientation-dependent manner α-球蛋白超级增强子以方向依赖性方式发挥作用

NATURE COMMUNICATIONS

IF15.7

2025-01-25

OAAI

Kassouf, Mira T.; Francis, Helena S.; Gosden, Matthew; Suciu, Maria C.; Downes, Damien J.; Harrold, Caroline; Larke, Martin; Oudelaar, Marieke; Blayney, Joseph; Telenius, Jelena; Xella, Barbara; Shen, Yuki; Sousos, Nikolaos; Sharpe, Jacqueline A.; Sloane-Stanley, Jacqueline; Smith, Andrew J. H.; Babbs, Christian; Hughes, Jim R.; Higgs, Douglas R.

Comparing the two leading erythroid lines BEL-A and HUDEP-2 (vol 105, e389, 2020)

HAEMATOLOGICA

IF7.9

2024-01-01

OAAI

Daniels, Deborah E.; Downes, Damien J.; Ferrer-Vicens, Ivan; Ferguson, Daniel C. J.; Singleton, Belinda K.; Wilson, Marieangela C.; Trakarnsanga, Kongtana; Kurita, Ryo; Nakamura, Yukio; Anstee, David J.; Frayne, Jan

Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture (vol 17, pg 445, 2022)

NATURE PROTOCOLS

IF16

2023-06-27

OAAI

Downes, Damien J.; Smith, Alastair L.; Karpinska, Magdalena A.; Velychko, Taras; Rue-Albrecht, Kevin; Sims, David; Milne, Thomas A.; Davies, James O. J.; Oudelaar, A. Marieke; Hughes, Jim R.

Determining chromatin architecture with Micro Capture-C

NATURE PROTOCOLS

IF16

2023-03-29

OAAI

Hamley, Joseph C.; Li, Hangpeng; Denny, Nicholas; Downes, Damien; Davies, James O. J.

Natural and Experimental Rewiring of Gene Regulatory Regions

annual review of genetics

IF7.9

2022-08-31

PREAI

Downes, Damien J.; Hughes, Jim R.

The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

NATURE COMMUNICATIONS

IF15.7

2022-06-17

OAAI

Truch, Julia; Downes, Damien J.; Scott, Caroline; Gur, E. Ravza; Telenius, Jelena M.; Repapi, Emmanouela; Schwessinger, Ron; Gosden, Matthew; Brown, Jill M.; Taylor, Stephen; Cheong, Pak Leng; Hughes, Jim R.; Higgs, Douglas R.; Gibbons, Richard J.

Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes

OSTEOARTHRITIS AND CARTILAGE

IF9

2022-04-01

OAAI

Chaudhry, N.; Muhammad, H.; Seidl, C.; Downes, D.; Young, D. A.; Hao, Y.; Zhu, L.; Vincent, T. L.

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

NATURE COMMUNICATIONS

IF15.7

2022-02-09

OAAI

Owens, Dominic D. G.; Anselmi, Giorgio; Oudelaar, A. Marieke; Downes, Damien J.; Cavallo, Alessandro; Harman, Joe R.; Schwessinger, Ron; Bucakci, Akin; Greder, Lucas; de Ornellas, Sara; Jeziorska, Danuta; Telenius, Jelena; Hughes, Jim R.; de Bruijn, Marella F. T. R.

Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture

NATURE PROTOCOLS

IF16

2022-02-04

OAAI

Downes, Damien J.; Smith, Alastair L.; Karpinska, Magdalena A.; Velychko, Taras; Rue-Albrecht, Kevin; Sims, David; Milne, Thomas A.; Davies, James O. J.; Oudelaar, A. Marieke; Hughes, Jim R.

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

NATURE GENETICS

IF31.8

2021-11-04

101

OAAI

Downes, Damien J.; Cross, Amy R.; Hua, Peng; Roberts, Nigel; Schwessinger, Ron; Cutler, Antony J.; Munis, Altar M.; Brown, Jill; Mielczarek, Olga; de Andrea, Carlos E.; Melero, Ignacio; Gill, Deborah R.; Hyde, Stephen C.; Knight, Julian C.; Todd, John A.; Sansom, Stephen N.; Issa, Fadi; Davies, James O. J.; Hughes, Jim R.

Reactivation of a developmentally silenced embryonic globin gene

NATURE COMMUNICATIONS

IF15.7

2021-07-21

OAAI

King, Andrew J.; Songdej, Duantida; Downes, Damien J.; Beagrie, Robert A.; Liu, Siyu; Buckley, Megan; Hua, Peng; Suciu, Maria C.; Oudelaar, A. Marieke; Hanssen, Lars L. P.; Jeziorska, Danuta; Roberts, Nigel; Carpenter, Stephanie J.; Francis, Helena; Telenius, Jelena; Olijnik, Aude-Anais; Sharpe, Jacqueline A.; Sloane-Stanley, Jacqueline; Eglinton, Jennifer; Kassouf, Mira T.; Orkin, Stuart H.; Pennacchio, Len A.; Davies, James O. J.; Hughes, Jim R.; Higgs, Douglas R.; Babbs, Christian

Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans

MBIO

IF4.7

2021-06-29

OAAI

Steyer, Joel T.; Downes, Damien J.; Hunter, Cameron C.; Migeon, Pierre A.; Todd, Richard B.

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

NATURE COMMUNICATIONS

IF15.7

2021-06-21

OAAI

Bozhilov, Yavor K.; Downes, Damien J.; Telenius, Jelena; Marieke Oudelaar, A.; Olivier, Emmanuel N.; Mountford, Joanne C.; Hughes, Jim R.; Gibbons, Richard J.; Higgs, Douglas R.

Multi Locus View: an extensible web-based tool for the analysis of genomic data.

COMMUNICATIONS BIOLOGY

IF5.1

2021-05-25

OAAI

Sergeant, Martin J.; Hughes, Jim R.; Hentges, Lance; Lunter, Gerton; Downes, Damien J.; Taylor, Stephen

Enhancers predominantly regulate gene expression during differentiation via transcription initiation

MOLECULAR CELL

IF16.6

2021-03-01

OAAI

Larke, Martin S. C.; Schwessinger, Ron; Nojima, Takayuki; Telenius, Jelena; Beagrie, Robert A.; Downes, Damien J.; Oudelaar, A. Marieke; Truch, Julia; Graham, Bryony; Bender, M. A.; Proudfoot, Nicholas J.; Higgs, Douglas R.; Hughes, Jim R.

Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers

NUCLEIC ACIDS RESEARCH

IF13.1

2021-02-03

OAAI

Bejjani, Fabienne; Tolza, Claire; Boulanger, Mathias; Downes, Damien; Romero, Raphael; Maqbool, Muhammad Ahmad; El Aabidine, Amal Zine; Andrau, Jean-Christophe; Lebre, Sophie; Brehelin, Laurent; Parrinello, Hughes; Rohmer, Marine; Kaoma, Tony; Vallar, Laurent; Hughes, Jim R.; Zibara, Kazem; Lecellier, Charles-Henri; Piechaczyk, Marc; Jariel-Encontre, Isabelle

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

NATURE COMMUNICATIONS

IF15.7

2021-01-22

OAAI

Downes, Damien J.; Beagrie, Robert A.; Gosden, Matthew E.; Telenius, Jelena; Carpenter, Stephanie J.; Nussbaum, Lea; De Ornellas, Sara; Sergeant, Martin; Eijsbouts, Chris Q.; Schwessinger, Ron; Kerry, Jon; Roberts, Nigel; Shivalingam, Arun; El-Sagheer, Afaf; Oudelaar, A. Marieke; Brown, Tom; Buckle, Veronica J.; Davies, James O. J.; Hughes, Jim R.

研究方向