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Mediation of Polygenic Asthma Risk Through Gene Expression 多基因哮喘风险的基因表达中介 Natarajan, Rakesh; Szczesny, Brooke; Kanchan, Kanika; Esquinca, Erika; Boorgula, Meher Preethi; Chavan, Sameer; Campbell, Monica; Lorizio, Wendy; Doumatey, Ayo P.; Cruz, Alvaro A.; Watson, Harold; Naureckas, Edward T.; Giles, B. Louise; Arinola, Ganiyu; Sogaolu, Olumide; Falade, Adegoke G.; Hansel, Nadia N.; Olopade, Christopher O.; Rotimi, Charles N.; Landis, R. Clive; Figueiredo, Camila A.; Kenny, Eimear E.; Ruczinski, Ingo; Liu, Andrew H.; Ober, Carole; Taub, Margaret A.; Johnson, Randi K.; Barnes, Kathleen C.; Wojcik, Genevieve L.; Mathias, Rasika A. 分享 收藏
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Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height 333,100个体的全基因组测序揭示了罕见的非编码单一变异和与身高的聚集关联 Hawkes, Gareth; Beaumont, Robin N.; Li, Zilin; Mandla, Ravi; Li, Xihao; Albert, Christine M.; Arnett, Donna K.; Ashley-Koch, Allison E.; Ashrani, Aneel A.; Barnes, Kathleen C.; Boerwinkle, Eric; Brody, Jennifer A.; Carson, April P.; Chami, Nathalie; Chen, Yii-Der Ida; Chung, Mina K.; Curran, Joanne E.; Darbar, Dawood; Ellinor, Patrick T.; Fornage, Myrian; Gordeuk, Victor R.; Guo, Xiuqing; He, Jiang; Hwu, Chii-Min; Kalyani, Rita R.; Kaplan, Robert; Kardia, Sharon L. R.; Kooperberg, Charles; Loos, Ruth J. F.; Lubitz, Steven A.; Minster, Ryan L.; Naseri, Take; Viali, Satupa'itea; Mitchell, Braxton D.; Murabito, Joanne M.; Palmer, Nicholette D.; Psaty, Bruce M.; Redline, Susan; Shoemaker, M. Benjamin; Silverman, Edwin K.; Telen, Marilyn J.; Weiss, Scott T.; Yanek, Lisa R.; Zhou, Hufeng; Liu, Ching-Ti; North, Kari E.; Justice, Anne E.; Locke, Jonathan M.; Owens, Nick; Murray, Anna; Patel, Kashyap; Frayling, Timothy M.; Wright, Caroline F.; Wood, Andrew R.; Lin, Xihong; Manning, Alisa; Weedon, Michael N. 分享 收藏
Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations Szczesny, Brooke; Boorgula, Meher Preethi; Chavan, Sameer; Campbell, Monica; Johnson, Randi K.; Kammers, Kai; Thompson, Emma E.; Cox, Madison S.; Shankar, Gautam; Cox, Corey; Morin, Andreanne; Lorizio, Wendy; Daya, Michelle; Kelada, Samir N. P.; Beaty, Terri H.; Doumatey, Ayo P.; Cruz, Alvaro A.; Watson, Harold; Naureckas, Edward T.; Giles, B. Louise; Arinola, Ganiyu A.; Sogaolu, Olumide; Falade, Adegoke G.; Hansel, Nadia N.; Yang, Ivana V.; Olopade, Christopher O.; Rotimi, Charles N.; Landis, R. Clive; Figueiredo, Camila A.; Altman, Matthew C.; Kenny, Eimear; Ruczinski, Ingo; Liu, Andrew H.; Ober, Carole; Taub, Margaret A.; Barnes, Kathleen C.; Mathias, Rasika A. 分享 收藏
Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes Keener, Rebecca; Chhetri, Surya B.; Connelly, Carla J.; Taub, Margaret A.; Conomos, Matthew P.; Weinstock, Joshua; Ni, Bohan; Strober, Benjamin; Aslibekyan, Stella; Auer, Paul L.; Barwick, Lucas; Becker, Lewis C.; Blangero, John; Bleecker, Eugene R.; Brody, Jennifer A.; Cade, Brian E.; Celedon, Juan C.; Chang, Yi-Cheng; Cupples, L. Adrienne; Custer, Brian; Freedman, Barry I.; Gladwin, Mark T.; Heckbert, Susan R.; Hou, Lifang; Irvin, Marguerite R.; Isasi, Carmen R.; Johnsen, Jill M.; Kenny, Eimear E.; Kooperberg, Charles; Minster, Ryan L.; Naseri, Take; Viali, Satupa'itea; Nekhai, Sergei; Pankratz, Nathan; Peyser, Patricia A.; Taylor, Kent D.; Telen, Marilyn J.; Wu, Baojun; Yanek, Lisa R.; Yang, Ivana V.; Albert, Christine; Arnett, Donna K.; Ashley-Koch, Allison E.; Barnes, Kathleen C.; Bis, Joshua C.; Blackwell, Thomas W.; Boerwinkle, Eric; Burchard, Esteban G.; Carson, April P.; Chen, Zhanghua; Chen, Yii-Der Ida; Darbar, Dawood; de Andrade, Mariza; Ellinor, Patrick T.; Fornage, Myriam; Gelb, Bruce D.; Gilliland, Frank D.; He, Jiang; Islam, Talat; Kaab, Stefan; Kardia, Sharon L. R.; Kelly, Shannon; Konkle, Barbara A.; Kumar, Rajesh; Loos, Ruth J. F.; Martinez, Fernando D.; McGarvey, Stephen T.; Meyers, Deborah A.; Mitchell, Braxton D.; Montgomery, Courtney G.; North, Kari E.; Palmer, Nicholette D.; Peralta, Juan M.; Raby, Benjamin A.; Redline, Susan; Rich, Stephen S.; Roden, Dan; Rotter, Jerome I.; Ruczinski, Ingo; Schwartz, David; Sciurba, Frank; Shoemaker, M. Benjamin; Silverman, Edwin K.; Sinner, Moritz F.; Smith, Nicholas L.; Smith, Albert V.; Tiwari, Hemant K.; Vasan, Ramachandran S.; Weiss, Scott T.; Williams, L. Keoki; Zhang, Yingze; Ziv, Elad; Raffield, Laura M.; Reiner, Alexander P.; Arvanitis, Marios; Greider, Carol W.; Mathias, Rasika A.; Battle, Alexis 分享 收藏
Pharmacogenomic insights in psychiatric care: uncovering novel actionability, allele-specific CYP2D6 copy number variation, and phenoconversion in 15,000 patients Patel, Jai N.; Morris, Sarah A.; Torres, Raul; Rhead, Brooke; Vlangos, Chris; Mueller, Daniel J.; Brown, Lisa C.; Lefkofsky, Hailey; Ali, Muneer; de la Vega, Francisco M.; Barnes, Kathleen C.; Zoghbi, Anthony; Stanton, Joseph D.; Badgeley, Marcus A. 分享 收藏
Determinants of mosaic chromosomal alteration fitness 镶嵌染色体改变适合度的决定因素 Pershad, Yash; Mack, Taralynn; Poisner, Hannah; Jakubek, Yasminka A.; Stilp, Adrienne M.; Mitchell, Braxton D.; Lewis, Joshua P.; Boerwinkle, Eric; Loos, Ruth J. F.; Chami, Nathalie; Wang, Zhe; Barnes, Kathleen; Pankratz, Nathan; Fornage, Myriam; Redline, Susan; Psaty, Bruce M.; Bis, Joshua C.; Shojaie, Ali; Silverman, Edwin K.; Cho, Michael H.; Yun, Jeong H.; DeMeo, Dawn; Levy, Daniel; Johnson, Andrew D.; Mathias, Rasika A.; Taub, Margaret A.; Arnett, Donna; North, Kari E.; Raffield, Laura M.; Carson, April P.; Doyle, Margaret F.; Rich, Stephen S.; Rotter, Jerome I.; Guo, Xiuqing; Cox, Nancy J.; Roden, Dan M.; Franceschini, Nora; Desai, Pinkal; Reiner, Alex P.; Auer, Paul L.; Scheet, Paul A.; Jaiswal, Siddhartha; Weinstock, Joshua S.; Bick, Alexander G. 分享 收藏
Building a vertically integrated genomic learning health system: The biobank at the Colorado Center for Personalized Medicine 建立垂直整合的基因组学习健康系统: 科罗拉多个性化医学中心的生物库 Wiley, Laura K.; Shortt, Jonathan A.; Roberts, Emily R.; Lowery, Jan; Kudron, Elizabeth; Lin, Meng; Mayer, David; Wilson, Melissa; Brunetti, Tonya M.; Chavan, Sameer; Phang, Tzu L.; Pozdeyev, Nikita; Lesny, Joseph; Wicks, Stephen J.; Moore, Ethan T.; Morgenstern, Joshua L.; Roff, Alanna N.; Shalowitz, Elise L.; Stewart, Adrian; Williams, Cole; Edelmann, Michelle N.; Hull, Madelyne; Patton, J. Tacker; Axell, Lisen; Ku, Lisa; Lee, Yee Ming; Jirikowic, Jean; Tanaka, Anna; Todd, Emily; White, Sarah; Peterson, Brett; Hearst, Emily; Zane, Richard; Greene, Casey S.; Mathias, Rasika; Coors, Marilyn; Taylor, Matthew; Ghosh, Debashis; Kahn, Michael G.; Brooks, Ian M.; Aquilante, Christina L.; Kao, David; Rafaels, Nicholas; Crooks, Kristy R.; Hess, Steve; Barnes, Kathleen C.; Gignoux, Christopher R. 分享 收藏
Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing Jakubek, Yasminka A.; Zhou, Ying; Stilp, Adrienne; Bacon, Jason; Wong, Justin W.; Ozcan, Zuhal; Arnett, Donna; Barnes, Kathleen; Bis, Joshua C.; Boerwinkle, Eric; Brody, Jennifer A.; Carson, April P.; Chasman, Daniel I.; Chen, Jiawen; Cho, Michael; Conomos, Matthew P.; Cox, Nancy; Doyle, Margaret F.; Fornage, Myriam; Guo, Xiuqing; Kardia, Sharon L. R.; Lewis, Joshua P.; Loos, Ruth J. F.; Ma, Xiaolong; Machiela, Mitchell J.; Mack, Taralynn M.; Mathias, Rasika A.; Mitchell, Braxton D.; Mychaleckyj, Josyf C.; North, Kari; Pankratz, Nathan; Peyser, Patricia A.; Preuss, Michael H.; Psaty, Bruce; Raffield, Laura M.; Vasan, Ramachandran S.; Redline, Susan; Rich, Stephen S.; Rotter, Jerome I.; Silverman, Edwin K.; Smith, Jennifer A.; Smith, Aaron P.; Taub, Margaret; Taylor, Kent D.; Yun, Jeong; Li, Yun; Desai, Pinkal; Bick, Alexander G.; Reiner, Alexander P.; Scheet, Paul; Auer, Paul L. 分享 收藏
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Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity From the Atopic Dermatitis Research Network (ADRN) Registry Simpson, Eric L.; De Benedetto, Anna; Boguniewicz, Mark; Ong, Peck Y.; Lussier, Stephanie; Villarreal, Miguel; Schneider, Lynda C.; Paller, Amy S.; Guttman-Yassky, Emma; Hanifin, Jon M.; Spergel, Jonathan M.; Barnes, Kathleen C.; David, Gloria; Austin, Briahnna; Leung, Donald Y. M.; Beck, Lisa A. 分享 收藏
A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome Morin, Andreanne; Thompson, Emma E.; Helling, Britney A.; Shorey-Kendrick, Lyndsey E.; Faber, Pieter; Gebretsadik, Tebeb; Bacharier, Leonard B.; Kattan, Meyer; O'Connor, George T.; Rivera-Spoljaric, Katherine; Wood, Robert A.; Barnes, Kathleen C.; Mathias, Rasika A.; Altman, Matthew C.; Hansen, Kasper; McEvoy, Cindy T.; Spindel, Eliot R.; Hartert, Tina; Jackson, Daniel J.; Gern, James E.; McKennan, Chris G.; Ober, Carole 分享 收藏
The IL-4Ra Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice Yang, Barbara; Wilkie, Hazel; Das, Mrinmoy; Timilshina, Maheshwor; Bainter, Wayne; Woods, Brian; Daya, Michelle; Boorgula, Meher P.; Mathias, Rasika A.; Lai, Peggy; Petty, Carter R.; Weller, Edie; Harb, Hani; Chatila, Talal A.; Leung, Donald Y. M.; Beck, Lisa A.; Simpson, Eric L.; Hata, Tissa R.; Barnes, Kathleen C.; Phipatanakul, Wanda; Leyva-Castillo, Juan-Manuel; Geha, Raif S. 分享 收藏
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes Weinstock, Joshua S.; Laurie, Cecelia A.; Broome, Jai G.; Taylor, Kent D.; Guo, Xiuqing; Shuldiner, Alan R.; O'Connell, Jeffrey R.; Lewis, Joshua P.; Boerwinkle, Eric; Barnes, Kathleen C.; Chami, Nathalie; Kenny, Eimear E.; Loos, Ruth J. F.; Fornage, Myriam; Redline, Susan; Cade, Brian E.; Gilliland, Frank D.; Chen, Zhanghua; Gauderman, W. James; Kumar, Rajesh; Grammer, Leslie; Schleimer, Robert P.; Psaty, Bruce M.; Bis, Joshua C.; Brody, Jennifer A.; Silverman, Edwin K.; Yun, Jeong H.; Qiao, Dandi; Weiss, Scott T.; Lasky-Su, Jessica; DeMeo, Dawn L.; Palmer, Nicholette D.; Freedman, Barry I.; Bowden, Donald W.; Cho, Michael H.; Vasan, Ramachandran S.; Johnson, Andrew D.; Yanek, Lisa R.; Becker, Lewis C.; Kardia, Sharon; He, Jiang; Kaplan, Robert; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Arnett, Donna K.; Irvin, Marguerite R.; Tiwari, Hemant; Correa, Adolfo; Raffield, Laura M.; Gao, Yan; de Andrade, Mariza; Rotter, Jerome I.; Rich, Stephen S.; Manichaikul, Ani W.; Konkle, Barbara A.; Johnsen, Jill M.; Wheeler, Marsha M.; Custer, Brian S.; Duggirala, Ravindranath; Curran, Joanne E.; Blangero, John; Gui, Hongsheng; Xiao, Shujie; Williams, L. Keoki; Meyers, Deborah A.; Li, Xingnan; Ortega, Victor; McGarvey, Stephen; Gu, C. Charles; Chen, Yii-Der Ida; Lee, Wen-Jane; Shoemaker, M. Benjamin; Darbar, Dawood; Roden, Dan; Albert, Christine; Kooperberg, Charles; Desai, Pinkal; Blackwell, Thomas W.; Abecasis, Goncalo R.; V. Smith, Albert; Kang, Hyun M.; Mathias, Rasika; Natarajan, Pradeep; Jaiswal, Siddhartha; Reiner, Alexander P.; Bick, Alexander G. 分享 收藏
Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing Jakubek, Yasminka A.; Zhou, Ying; Stilp, Adrienne; Bacon, Jason; Wong, Justin; Ozcan, Zuhal; Arnett, Donna; Barnes, Kathleen; Bis, Josh; Boerwinkle, Eric; Carson, April; Chasman, Daniel; Cho, Michael; Conomos, Matthew; Cox, Nancy; Doyle, Margaret; Fornage, Myriam; Guo, Xiuqing; Kardia, Sharon; Lewis, Joshua; Loos, Ruth; Ma, Xiaolong; Machiela, Mitchell; Mack, Taralynn; Mathias, Rasika; Mitchell, Braxton; North, Kari; Pankratz, Nathan; Peyser, Patricia; Preuss, Michael; Psaty, Bruce; Raffield, Laura; Vasan, Ramachandran; Redline, Susan; Rich, Stephen; Rotter, Jerome; Silverman, Edwin; Smith, Jennifer; Taub, Margaret; Yun, Jeong; Li, Yun; Desai, Pinkal; Bick, Alexander; Reiner, Alexander; Scheet, Paul; Auer, Paul 分享 收藏
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing 多血统转录组全关联分析产生了对烟草使用生物学和药物再利用的见解 Chen, Fang; Wang, Xingyan; Jang, Seon-Kyeong; Quach, Bryan C.; Weissenkampen, J. Dylan; Khunsriraksakul, Chachrit; Yang, Lina; Sauteraud, Renan; Albert, Christine M.; Allred, Nicholette D. D.; Arnett, Donna K.; Ashley-Koch, Allison E.; Barnes, Kathleen C.; Barr, R. Graham; Becker, Diane M.; Bielak, Lawrence F.; Bis, Joshua C.; Blangero, John; Boorgula, Meher Preethi; Chasman, Daniel I.; Chavan, Sameer; Chen, Yii-Der I.; Chuang, Lee-Ming; Correa, Adolfo; Curran, Joanne E.; David, Sean P.; de las Fuentes, Lisa; Deka, Ranjan; Duggirala, Ravindranath; Faul, Jessica D.; Garrett, Melanie E.; Gharib, Sina A.; Guo, Xiuqing; Hall, Michael E.; Hawley, Nicola L.; He, Jiang; Hobbs, Brian D.; Hokanson, John E.; Hsiung, Chao A.; Hwang, Shih-Jen; Hyde, Thomas M.; Irvin, Marguerite R.; Jaffe, Andrew E.; Johnson, Eric O.; Kaplan, Robert; Kardia, Sharon L. R.; Kaufman, Joel D.; Kelly, Tanika N.; Kleinman, Joel E.; Kooperberg, Charles; Lee, I-Te; Levy, Daniel; Lutz, Sharon M.; Manichaikul, Ani W.; Martin, Lisa W.; Marx, Olivia; McGarvey, Stephen T.; Minster, Ryan L.; Moll, Matthew; Moussa, Karine A.; Naseri, Take; North, Kari E.; Oelsner, Elizabeth C.; Peralta, Juan M.; Peyser, Patricia A.; Psaty, Bruce M.; Rafaels, Nicholas; Raffield, Laura M.; Reupena, Muagututi'a Sefuiva; Rich, Stephen S.; Rotter, Jerome I.; Schwartz, David A.; Shadyab, Aladdin H.; Sheu, Wayne H-H.; Sims, Mario; Smith, Jennifer A.; Sun, Xiao; Taylor, Kent D.; Telen, Marilyn J.; Watson, Harold; Weeks, Daniel E.; Weir, David R.; Yanek, Lisa R.; Young, Kendra A.; Young, Kristin L.; Zhao, Wei; Hancock, Dana B.; Jiang, Bibo; Vrieze, Scott; Liu, Dajiang J. 分享 收藏
Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects Johnson, Randi K.; Manke, Jonathan; Campbell, Monica; Armstrong, Michael; Boorgula, Meher Preethi; Pinheiro, Gabriela; Santana, Cinthia Vila Nova; Mathias, Rasika A.; Barnes, Kathleen C.; Cruz, Alvaro; Reisdorph, Nichole; Figueiredo, Camila A. 分享 收藏
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