A.C.W. Pike - Publications, H-index & Citations

A.C.W. Pike

university of oxford

42H指数

267论文数

1.1W被引数

收录论文 33

发表时间

High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions 人源NHE6和NHE9的高分辨率结构阐明了内体离子和脂质相互作用

Nature Communications

IF15.7

2026-09-03

OAAI

Jesper S. Hansen; Ashley C. W. Pike; Gamma Chi; Gernot Wolf; Jeppe Tranberg-Jensen; Hannah Lichtmannegger; David Speedman; Alvaro Ingles-Prieto; Fabian Goericke; Helena Batoulis; Hartmut Beck; Rajini Rao; Tooraj Mirshahi; David B. Sauer; Giulio Superti-Furga; Kilian V. M. Huber

Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states 人成年肌肉型烟碱型受体在静息和脱敏状态下的结构

CELL REPORTS

IF6.9

2025-05-01

PREAI

Li, Anna; Pike, Ashley C. W.; Webster, Richard; Maxwell, Susan; Liu, Wei-Wei; Chi, Gamma; Palace, Jacqueline; Beeson, David; Sauer, David B.; Dong, Yin Yao

Structural basis of the mechanism and inhibition of a human ceramide synthase

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2024-11-11

OAAI

Pascoa, Tomas C.; Pike, Ashley C. W.; Tautermann, Christofer S.; Chi, Gamma; Traub, Michael; Quigley, Andrew; Chalk, Rod; Stefanic, Sasa; Thamm, Sven; Pautsch, Alexander; Carpenter, Elisabeth P.; Schnapp, Gisela; Sauer, David B.

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 与新型冠状病毒肺炎受体ACE2复合的SIT1脯氨酸转运蛋白的结构和功能

NATURE COMMUNICATIONS

IF15.7

2024-06-29

OAAI

Li, Huanyu Z.; Pike, Ashley C. W.; Lotsaris, Irina; Chi, Gamma; Hansen, Jesper S.; Lee, Sarah C.; Roedstroem, Karin E. J.; Bushell, Simon R.; Speedman, David; Evans, Adam; Wang, Dong; He, Didi; Shrestha, Leela; Nasrallah, Chady; Burgess-Brown, Nicola A.; Vandenberg, Robert J.; Dafforn, Timothy R.; Carpenter, Elisabeth P.; Sauer, David B.

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

NATURE COMMUNICATIONS

IF15.7

2024-05-16

OAAI

Rodstrom, Karin E. J.; Cloake, Alexander; Sormann, Janina; Baronina, Agnese; Smith, Kathryn H. M.; Pike, Ashley C. W.; Ang, Jackie; Proks, Peter; Schewe, Marcus; Holland-Kaye, Ingelise; Bushell, Simon R.; Elliott, Jenna; Pardon, Els; Baukrowitz, Thomas; Owens, Raymond J.; Newstead, Simon; Steyaert, Jan; Carpenter, Elisabeth P.; Tucker, Stephen J.

Structural characterization of human urea transporters UT-A and UT-B and their inhibition

SCIENCE ADVANCES

IF12.5

2023-09-29

OAAI

Chi, Gamma; Dietz, Larissa; Tang, Haiping; Snee, Matthew; Scacioc, Andreea; Wang, Dong; Mckinley, Gavin; Mukhopadhyay, Shubhashish M. M.; Pike, Ashley C. W.; Chalk, Rod; Burgess-Brown, Nicola A.; Timmermans, Jean-Pierre; van Putte, Wouter; Robinson, Carol V.; Durr, Katharina L.

The structural basis of fatty acid elongation by the ELOVL elongases

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2021-06-10

OAAI

Nie, Laiyin; Pascoa, Tomas C.; Pike, Ashley C. W.; Bushell, Simon R.; Quigley, Andrew; Ruda, Gian Filippo; Chu, Amy; Cole, Victoria; Speedman, David; Moreira, Tiago; Shrestha, Leela; Mukhopadhyay, Shubhashish M. M.; Burgess-Brown, Nicola A.; Love, James D.; Brennan, Paul E.; Carpenter, Elisabeth P.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K 内质网扰频酶TMEM16K中脂质扰频和失活的结构基础

NATURE COMMUNICATIONS

IF15.7

2019-09-02

OAAI

Bushell, K. Simon R.; Pike, Ashley C. W.; Falzone, Maria E.; Rorsman, Nils J. G.; Ta, Chau M.; Corey, Robin A.; Newport, Thomas D.; Christianson, John C.; Scofano, Lara F.; Shintre, Chitra A.; Tessitore, Annamaria; Chu, Amy; Wang, Qinrui; Shrestha, Leela; Mukhopadhyay, Shubhashish M. M.; Love, James D.; Burgess-Brown, Nicola A.; Sitsapesan, Rebecca; Stansfeld, Phillip J.; Huiskonen, Juha T.; Tammaro, Paolo; Accardi, Alessio; Carpenter, Elisabeth P.

Understanding Protein-Lipid Interactions of TRP Channels of the Polycystin Family, through MD Simulations and Structural Studies

BIOPHYSICAL JOURNAL

IF3.1

2019-02-01

OAAI

Wang, Qinrui; Hedger, George; Aryal, Prafulla; Grieben, Mariana; Pike, Ashley C. W.; Shi, Jiye; Carpenter, Elisabeth P.; Sansom, Mark S. P.

A Pharmacological Masterkey Mechanism to Unlock the Selectivity Filter Gate in K plus Channels

BIOPHYSICAL JOURNAL

IF3.1

2019-02-01

OAAI

Schewe, Marcus; Sun, Han; Mackenzie, Alexandra; Pike, Ashley C. W.; Schulz, Friederike; Constantin, Christina; Kiper, Aytug K.; Conrad, Linus J.; Gonzalez, Wendy; de Groot, Bert L.; Decher, Niels; Fakler, Bernd; Carpenter, Elisabeth P.; Tucker, Stephen J.; Baukrowitz, Thomas

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2017-01-16

111

OAAI

Wilkes, Martin; Madej, M. Gregor; Kreuter, Lydia; Rhinow, Daniel; Heinz, Veronika; De Sanctis, Silvia; Ruppel, Sabine; Richter, Rebecca M.; Joos, Friederike; Grieben, Marina; Pike, Ashley C. W.; Huiskonen, Juha T.; Carpenter, Elisabeth P.; Kuhlbrandt, Werner; Witzgall, Ralph; Ziegler, Christine

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2016-12-19

155

OAAI

Grieben, Mariana; Pike, Ashley C. W.; Shintre, Chitra A.; Venturi, Elisa; El-Ajouz, Sam; Tessitore, Annamaria; Shrestha, Leela; Mukhopadhyay, Shubhashish; Mahajan, Pravin; Chalk, Rod; Burgess-Brown, Nicola A.; Sitsapesan, Rebecca; Huiskonen, Juha T.; Carpenter, Elisabeth P.

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures 人类RECQ1解旋酶驱动的DNA解旋，退火和分支迁移: 来自DNA复杂结构的见解

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-03-23

OAAI

Pike, Ashley C. W.; Gomathinayagam, Shivasankari; Swuec, Paolo; Berti, Matteo; Zhang, Ying; Schnecke, Christina; Marino, Francesca; von Delft, Frank; Renault, Ludovic; Costa, Alessandro; Gileadi, Opher; Vindigni, Alessandro

A little information goes a long way: Expertise and identity theft 一点信息大有帮助: 专业知识和身份盗窃

AGGRESSION AND VIOLENT BEHAVIOR

IF3.4

2015-01-01

PREAI

Vieraitis, Lynne M.; Copes, Heith; Powell, Zachary A.; Pike, Ashley

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases (vol 288, pg 7803, 2013)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-09-01

OAAI

Canning, Peter; Cooper, Christopher D. O.; Krojer, Tobias; Murray, James W.; Pike, Ashley C. W.; Chaikuad, Apirat; Keates, Tracy; Thangaratnarajah, Chancievan; Hojzan, Viktorija; Ayinampudi, Vikram; Marsden, Brian D.; Gileadi, Opher; Knapp, Stefan; von Delft, Frank; Bullock, Alex N.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-05-28

218

OAAI

Shintre, Chitra A.; Pike, Ashley C. W.; Li, Qiuhong; Kim, Jung-In; Barr, Alastair J.; Goubin, Solenne; Shrestha, Leela; Yang, Jing; Berridge, Georgina; Ross, Jonathan; Stansfeld, Phillip J.; Sansom, Mark S. P.; Edwards, Aled M.; Bountra, Chas; Marsden, Brian D.; von Delft, Frank; Bullock, Alex N.; Gileadi, Opher; Burgess-Brown, Nicola A.; Carpenter, Elisabeth P.

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases Cul3蛋白与E3泛素连接酶的btb-kelch家族组装的结构基础

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-03-01

260

OAAI

Canning, Peter; Cooper, Christopher D. O.; Krojer, Tobias; Murray, James W.; Pike, Ashley C. W.; Chaikuad, Apirat; Keates, Tracy; Thangaratnarajah, Chancievan; Hojzan, Viktorija; Marsden, Brian D.; Gileadi, Opher; Knapp, Stefan; von Delft, Frank; Bullock, Alex N.

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-02-23

OAAI

Adams, Cassandra J.; Pike, Ashley C. W.; Maniam, Sandra; Sharpe, Timothy D.; Coutts, Amanda S.; Knapp, Stefan; La Thangue, Nicholas B.; Bullock, Alex N.

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-01-01

OAAI

Zadjali, Fahad; Pike, Ashley C. W.; Vesterlund, Mattias; Sun, Jianmin; Wu, Chenggang; Li, Shawn S. C.; Ronnstrand, Lars; Knapp, Stefan; Bullock, Alex N.; Flores-Morales, Amilcar

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation

NUCLEIC ACIDS RESEARCH

IF13.1

2010-11-08

OAAI

Lucic, Bojana; Zhang, Ying; King, Oliver; Mendoza-Maldonado, Ramiro; Berti, Matteo; Niesen, Frank H.; Burgess-Brown, Nicola A.; Pike, Ashley C. W.; Cooper, Christopher D. O.; Gileadi, Opher; Vindigni, Alessandro

研究方向