R. A. Pearson

king's college london

43H指数

257论文数

7.7K被引数

收录论文 43

发表时间

Photoreceptor replacement: a disease-agnostic approach for the treatment of advanced retinal degeneration 光感受器替代：一种治疗晚期视网膜退行性病变的疾病非特异性方法

Eye

IF3.2

2026-07-25

OAAI

Rachael A. Pearson

Transplantation of human stem cell-derived cone photoreceptors partially restores vision in aged rd1 mice with advanced retinal degeneration 人源干细胞来源的锥体感光细胞移植部分恢复了具有进展性视网膜退化的老年rd1小鼠的视力

Stem Cells

IF3.6

2026-05-02

OAAI

Christopher A Procyk; Anna Melati; Menahil Tariq; Jingshu Liu; Matthew J Branch; Jamie D Delicata; Philippa Harding; Mahmoud Khazim; Majid Moshtagh Khorasani; Bryan Ladino; Emily P Lanning; Miriam Margari; Ifrax Mahamoud; Christi Mofidi; Krunal Narendra Kumar; Salome Van Heerden; Alexander J Smith; Emma L West; Robin R Ali; Rachael A Pearson; null

Human macula formation involves two waves of retinoic acid suppression via CYP26A1 that modulate cell cycle exit and cone subtype specification 人视网膜黄斑形成涉及通过CYP26A1介导的两轮视黄酸抑制，进而调节细胞周期退出和视锥亚型特化。

Stem Cell Reports

IF5.1

2025-09-25

PREAI

Philippa Harding; Maja Wojtynska; Alexander J. Smith; Robin R. Ali; Rachael A. Pearson

Stromal Gene Therapy Mediates Prolonged Protection Against Corneal Neovascularization Induced by an Aggressive Angiogenic Insult 基质基因疗法介导了对由强烈促血管生成刺激诱导的角膜新生血管的长期保护。

gene therapy

IF4

2025-05-28

PREAI

Basche, Mark; Robbie, Scott; Larkin, D. Frank P.; Smith, Alexander J.; Pearson, Rachael A.; Ali, Robin R.

Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis 人视网膜锥细胞光感受器移植可促进重塑并恢复终末期勒伯先天性黑矇AIPL1模型的视觉功能

STEM CELL REPORTS

IF5.1

2025-04-01

OAAI

Procyk, Christopher A.; Melati, Anna; Ribeiro, Joana; Liu, Jingshu; Branch, Matthew J.; Delicata, Jamie D.; Tariq, Menahil; Kalarygrou, Aikaterini A.; Kapadia, Jessica; Khorsani, Majid Moshtagh; West, Emma L.; Smith, Alexander J.; Gonzalez-Cordero, Anai; Ali, Robin R.; Pearson, Rachael A.

Restoration of vision after transplantation of photoreceptors (vol 485, pg 99, 2012)视力的恢复：光感受器移植后（vol 485, pg 99, 2012）

NATURE

IF48.5

2024-06-06

OAAI

Pearson, R. A.; Barber, A. C.; Rizzi, M.; Hippert, C.; Xue, T.; West, E. L.; Duran, Y.; Smith, A. J.; Chuang, J. Z.; Azam, S. A.; Luhmann, U. F. O.; Benucci, A.; Sung, C. H.; Bainbridge, J. W.; Carandini, M.; Yau, K. -W.; Sowden, J. C.; Ali, R. R.

Extracellular vesicles in the retina-putative roles in physiology and disease

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2023-01-12

OAAI

Kalargyrou, Aikaterini A.; Guilfoyle, Siobhan E.; Smith, Alexander J.; Ali, Robin R.; Pearson, Rachael A.

Identifying the Built, Natural, and Social Factors of Successful and Failed Rural Alaskan Water Projects: Perspectives from State and Regional Professionals

ACS ES&T WATER

IF4.3

2022-11-04

PREAI

Thelemaque, Nathalie; Cotherman, Andrew; Pearson, Rachel; Eichelberger, Laura; Neumann, Rebecca B.; Kaminsky, Jessica A.

A comprehensive atlas of Aggrecan, Versican, Neurocan and Phosphacan expression across time in wildtype retina and in retinal degeneration

SCIENTIFIC REPORTS

IF3.9

2022-05-04

OAAI

Matsuyama, A.; Kalargyrou, A. A.; Smith, A. J.; Ali, R. R.; Pearson, R. A.

Nanotube-like processes facilitate material transfer between photoreceptors

EMBO REPORTS

IF6.2

2021-09-08

OAAI

Kalargyrou, Aikaterini A.; Basche, Mark; Hare, Aura; West, Emma L.; Smith, Alexander J.; Ali, Robin R.; Pearson, Rachael A.

Repeated nuclear translocations underlie photoreceptor positioning and lamination of the outer nuclear layer in the mammalian retina

CELL REPORTS

IF6.9

2021-08-01

OAAI

Aghaizu, Nozie D.; Warre-Cornish, Katherine M.; Robinson, Martha R.; Waldron, Paul, V; Maswood, Ryea N.; Smith, Alexander J.; Ali, Robin R.; Pearson, Rachael A.

RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Muller glial cell hypertrophy in progressive retinal degeneration RNAi介导的波形蛋白或胶质纤维酸性蛋白的抑制可防止进行性视网膜变性中Muller胶质细胞肥大的建立

GLIA

IF5.1

2021-05-24

OAAI

Hippert, Claire; Graca, Anna B.; Basche, Mark; Kalargyrou, Aikaterini A.; Georgiadis, Anastasios; Ribeiro, Joana; Matsuyama, Ayako; Aghaizu, Nozie; Bainbridge, James W.; Smith, Alexander J.; Ali, Robin R.; Pearson, Rachael A.

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

CELL REPORTS

IF6.9

2021-04-01

OAAI

Ribeiro, Joana; Procyk, Christopher A.; West, Emma L.; O'Hara-Wright, Michelle; Martins, Monica F.; Khorasani, Majid Moshtagh; Hare, Aura; Basche, Mark; Fernando, Milan; Goh, Debbie; Jumbo, Neeraj; Rizzi, Matteo; Powell, Kate; Tariq, Menahil; Michaelides, Michel; Bainbridge, James W. B.; Smith, Alexander J.; Pearson, Rachael A.; Gonzalez-Cordero, Anai; Ali, Robin R.

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision

SCIENTIFIC REPORTS

IF3.9

2019-02-19

OAAI

Aldunate, Eduardo Zabala; Di Foggia, Valentina; Di Marco, Fabiana; Hervas, Laura Abelleira; Ribeiro, Joana Claudio; Holder, Daniel L.; Patel, Aara; Jannini, Tommaso B.; Thompson, Dorothy A.; Martinez-Barbera, Juan Pedro; Pearson, Rachael A.; Ali, Robin R.; Sowden, Jane C.

Unlocking the Potential for Endogenous Repair to Restore Sight

NEURON

IF15

2018-11-01

OAAI

Pearson, Rachael A.; Ali, Robin R.

Prevention of Photoreceptor Cell Loss in a Cln6nclf Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells

MOLECULAR THERAPY

IF12

2018-05-01

OAAI

Holthaus, Sophia-Martha Kleine; Ribeiro, Joana; Abelleira-Hervas, Laura; Pearson, Rachael A.; Duran, Yanai; Georgiadis, Anastasios; Sampson, Robert D.; Rizzi, Matteo; Hoke, Justin; Maswood, Ryea; Azam, Selina; Luhmann, Ulrich F. O.; Smith, Alexander J.; Mole, Sara E.; Ali, Robin R.

Measurement of the bone endocortical region using clinical CT

MEDICAL IMAGE ANALYSIS

IF11.8

2018-02-01

OAAI

Pearson, R. A.; Treece, G. M.

Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner

STEM CELL REPORTS

IF5.1

2018-02-01

OAAI

Waldron, Paul V.; Di Marco, Fabiana; Kruczek, Kamil; Ribeiro, Joana; Graca, Anna B.; Hippert, Claire; Aghaizu, Nozie D.; Kalargyrou, Aikaterini A.; Barber, Amanda C.; Grimaldi, Giulia; Duran, Yanai; Blackford, Samuel J. I.; Kloc, Magdalena; Goh, Debbie; Aldunate, Eduardo Zabala; Sampson, Robert D.; Bainbridge, James W. B.; Smith, Alexander J.; Gonzalez-Cordero, Anai; Sowden, Jane C.; Ali, Robin R.; Pearson, Rachael A.

Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors

STEM CELL REPORTS

IF5.1

2017-09-01

196

OAAI

Gonzalez-Cordero, Anai; Kruczek, Kamil; Naeem, Arifa; Fernando, Milan; Kloc, Magdalena; Ribeiro, Joana; Goh, Debbie; Duran, Yanai; Blackford, Samuel J. I.; Abelleira-Hervas, Laura; Sampson, Robert D.; Shum, Ian O.; Branch, Matthew J.; Gardner, Peter J.; Sowden, Jane C.; Bainbridge, James W. B.; Smith, Alexander J.; West, Emma L.; Pearson, Rachael A.; Ali, Robin R.

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration

STEM CELL REPORTS

IF5.1

2017-06-01

OAAI

Kruczek, Kamil; Gonzalez-Cordero, Anai; Goh, Debbie; Naeem, Arifa; Jonikas, Mindaugas; Blackford, Samuel J. I.; Kloc, Magdalena; Duran, Yanai; Georgiadis, Anastasios; Sampson, Robert D.; Maswood, Ryea N.; Smith, Alexander J.; Decembrini, Sarah; Arsenijevic, Yvan; Sowden, Jane C.; Pearson, Rachael A.; West, Emma L.; Ali, Robin R.

研究方向