Hiroya Kuwahara - Publications, H-index & Citations

Hiroya Kuwahara

tokyo medical and dental university

18H指数

106论文数

1.5K被引数

收录论文 30

发表时间

Isoform analysis of heterozygous putative splicing variants at the allele level using nanopore long-read sequencing 利用纳米孔长读长测序在等位基因水平上对杂合的假说剪接变体进行异构体分析

Scientific Reports

IF3.9

2025-08-08

OAAI

Kokoro Ozaki; Takashi Irioka; Shohei Noma; Akira Machida; Moe Fukunaga; Tatsuro Murano; Chitose Takahashi; Michihira Tagami; Tsugumi Kawashima; Tomoko Hirata; Yuki Yasuoka; Hiroya Kuwahara; Toshiyuki Araki; Ken Yagi; Hidehiro Mizusawa; Kinya Ishikawa; Yasushi Okazaki; Takanori Yokota

Refining Muscle Morphometry Through Machine Learning and Spatial Analysis

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

IF3.4

2025-04-01

OAAI

Ono, Daisuke; Kawai, Honami; Kuwahara, Hiroya; Yokota, Takanori

Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model

NATURE COMMUNICATIONS

IF15.7

2024-09-26

OAAI

Hasegawa, Juri; Nagata, Tetsuya; Ihara, Kensuke; Tanihata, Jun; Ebihara, Satoe; Yoshida-Tanaka, Kie; Yanagidaira, Mitsugu; Ohara, Masahiro; Sasaki, Asuka; Nakayama, Miyu; Yamamoto, Syunsuke; Ishii, Takashi; Iwata-Hara, Rintaro; Naito, Mitsuru; Miyata, Kanjiro; Sakaue, Fumika; Yokota, Takanori

Development of cationic oligodiaminogalactoses specifically binding to duplex RNA, but not to duplex DNA

THERMOCHIMICA ACTA

IF3.5

2024-08-01

PREAI

Torigoe, Hidetaka; Nakayama, Sumire; Shiraishi, Tomomi; Sato, Kazuki; Hara, Rintaro Iwata; Wada, Takeshi

Automated whole slide morphometry of sural nerve biopsy using machine learning 使用机器学习的腓肠神经活检的自动全载玻片形态测量

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

IF3.4

2024-03-06

PREAI

Ono, Daisuke; Kawai, Honami; Kuwahara, Hiroya; Yokota, Takanori

TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate

FEBS LETTERS

IF3

2023-05-26

PREAI

Miura, Motoki; Sakaue, Fumika; Matsuno, Hirokazu; Morita, Kento; Yoshida, Akiko; Hara, Rintaro Iwata; Nishimura, Ren; Nishida, Yurika; Yokogawa, Mariko; Osawa, Masanori; Yokota, Takanori

Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system

NEUROLOGY

IF8.5

2023-04-25

PREAI

Kuwahara, Hiroya; Zeniya, Satoshi; Nagata, Tetsuya; Yokota, Takanori

Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxazaphospholidine Method

ACS OMEGA

IF4.3

2021-07-23

OAAI

Sato, Kazuki; Hagio, Tomoya; Sano, Michi; Muramoto, Kazumasa; Yaoita, Aya; Noro, Mihoko; Hara, Rintaro Iwata; Wada, Takeshi

An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability

SCIENTIFIC REPORTS

IF3.9

2020-09-09

OAAI

Irie, Atsushi; Sato, Kazuki; Hara, Rintaro Iwata; Wada, Takeshi; Shibasaki, Futoshi

Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route

FEBS LETTERS

IF3

2020-02-06

OAAI

Lei Mon, Su Su; Yoshioka, Kotaro; Jia, Chunyan; Kunieda, Taiki; Asami, Yutaro; Yoshida-Tanaka, Kie; Piao, Wenying; Kuwahara, Hiroya; Nishina, Kazutaka; Nagata, Tetsuya; Yokota, Takanori

Solid-Phase Synthesis of Phosphate/Boranophosphate Chimeric DNAs Using the H-Phosphonate-H-Boranophosphonate Method

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2019-10-28

PREAI

Sato, Kazuki; Imai, Hiroki; Shuto, Tomohito; Hara, Rintaro Iwata; Wada, Takeshi

Highly efficient silencing of microRNA by heteroduplex oligonucleotides

NUCLEIC ACIDS RESEARCH

IF13.1

2019-06-19

OAAI

Yoshioka, Kotaro; Kunieda, Taiki; Asami, Yutaro; Guo, Huijia; Miyata, Haruka; Yoshida-Tanaka, Kie; Sujino, Yumiko; Piao, Wenying; Kuwahara, Hiroya; Nishina, Kazutaka; Hara, Rintaro Iwata; Nagata, Tetsuya; Wada, Takeshi; Obika, Satoshi; Yokota, Takanori

Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2019-05-29

PREAI

Hara, Rintaro Iwata; Saito, Tatsuya; Kogure, Tomoki; Hamamura, Yuka; Uchiyama, Naoki; Nukaga, Yohei; Iwamoto, Naoki; Wad, Takeshi

Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo

SCIENTIFIC REPORTS

IF3.9

2018-03-12

OAAI

Kuwahara, Hiroya; Song, Jindong; Shimoura, Takahiro; Yoshida-Tanaka, Kie; Mizuno, Tadahaya; Mochizuki, Tatsuki; Zeniya, Satoshi; Li, Fuying; Nishina, Kazutaka; Nagata, Tetsuya; Ito, Shingo; Kusuhara, Hiroyuki; Yokota, Takanori

Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs

SCIENTIFIC REPORTS

IF3.9

2018-03-12

OAAI

Hara, Rintaro Iwata; Hisada, Yuki; Maeda, Yusuke; Yokota, Takanori; Wada, Takeshi

Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides (vol 54, pg 8526, 2018)

CHEMICAL COMMUNICATIONS

IF4.2

2018-01-01

OAAI

Hara, Rintaro Iwata; Maeda, Yusuke; Fujimaki, Haruna; Wada, Takeshi

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

NATURE COMMUNICATIONS

IF15.7

2017-10-17

202

OAAI

Anraku, Y.; Kuwahara, H.; Fukusato, Y.; Mizoguchi, A.; Ishii, T.; Nitta, K.; Matsumoto, Y.; Toh, K.; Miyata, K.; Uchida, S.; Nishina, K.; Osada, K.; Itaka, K.; Nishiyama, N.; Mizusawa, H.; Yamasoba, T.; Yokota, T.; Kataoka, K.

Silencing of malat1 long non-coding rna with DNA/RNA heteroduplex oligonucleotides exacerbates cerebral ischemia

JOURNAL OF THE NEUROLOGICAL SCIENCES

IF3.2

2017-10-01

PREAI

Ishibashi, S.; Li, F.; Iwasawa, E.; Song, J.; Ichijo, M.; Zhang, Y.; Piao, W.; Yoshida, K.; Yoshioka, K.; Kuwahara, H.; Nagata, T.; Yokota, T.

The effect of DNA/RNA heteroduplex oligonucleotides on muscle

JOURNAL OF THE NEUROLOGICAL SCIENCES

IF3.2

2017-10-01

PREAI

Nagata, T.; Ohyagi, M.; Ihara, K.; Kaburagi, H.; Nishina, K.; Piao, W.; Yoshida-Tanaka, K.; Kuwahara, H.; Yoshioka, K.; Yokota, T.