Michael J. Betenbaugh - Publications, H-index & Citations

Michael J. Betenbaugh

johns hopkins university

65H指数

338论文数

1.4W被引数

收录论文 168

发表时间

Purification and concentration of model viruses using single-pass tangential flow filtration 利用单通道切向流过滤纯化和浓缩模型病毒

Biotechnology Progress

IF2.5

2026-07-04

OAAI

Luis Alberto Mejía-Manzano; Lynn Manchester; Grace Wallis; Kan Wang; Bruce P. Lee; Michael Betenbaugh; Caryn L. Heldt

Comparing kinetic versus stoichiometric priorities in hybrid models of CHO metabolism 比较杂交CHO代谢模型中动力学与计量学优先级的差异

npj Systems Biology and Applications

IF3.5

2026-05-29

OAAI

Pratik Khare; Nelson Ndahiro; Stephanie Klaubert; Edward Ma; Tom S. Bertalan; Yannis Kevrekidis; Sarah W. Harcum; Michael J. Betenbaugh

A continuous viral vaccine biomanufacturing platform utilizing multiple bioreactor configurations 利用多种生物反应器配置的连续病毒疫苗生物制造平台

Journal of Biological Engineering

IF6.5

2026-04-24

OAAI

Justin Sargunas; Bradley Priem; Dylan Carman; Taravat Sarvari; Natalie M. Nold; Vaishali Sharma; Andrew Pekosz; Caryn L. Heldt; Michael Betenbaugh

Polyhydroxyalkanoate production by Paramecium caudatum isolated from industrial wastewater: a micro eukaryotic host for bioplastic accumulation (vol 47, 88, 2025)聚羟基脂肪酸酯由来自工业废水的草履虫尾孢虫产生：一种用于生物塑料积累的原核生物宿主（卷47，88，2025）

BIOTECHNOLOGY LETTERS

IF2.1

2025-09-22

OAAI

Shabbir, Usama; Zahra, Itrat; Liaqat, Ayesha; Arshad, Ayesha; Nawaz, Shahid; Betenbaugh, Michael; Ijaz, Roohi; Ibrahim, Awais; Arooj, Tuba; Muneer, Bushra; Ali, Nazish Mazhar; Ramzan, Uzma; Rasheed, Sammi; Ghauri, Ayesha; Ali, Manel Ben; Hedfi, Amor; Shakoori, Abdul R.; Shakoori, Farah R.

Deep Mutational Scanning of the AAV rep Gene to Assess Effects on DNA Packaging in Expi293F Suspension Culture AAV rep基因的深度突变扫描，以评估其对Expi293F悬浮培养中DNA包装的影响

Biotechnology and Bioengineering

IF3.6

2025-08-04

PREAI

Shaun Spisak; Nelson Ndahiro; Michael J. Betenbaugh; Marc Ostermeier

Modulating fatty acid metabolism and composition of CHO cells by feeding high levels of fatty acids complexed using methyl-β-cyclodextrin 通过饲喂经甲基-β-环糊精络合的高水平脂肪酸来调节CHO细胞的脂肪酸代谢和组成

METABOLIC ENGINEERING

IF6.8

2025-05-01

PREAI

Priem, Bradley; Cai, Xiangchen; Hong, Yu-Jun; Gilmore, Karl; Deng, Zijun; Chen, Sabrina; Naik, Harnish Mukesh; Betenbaugh, Michael J.; Antoniewicz, Maciek R.

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing HEK293悬浮细胞培养基的开发，瞬时转染优化工作流程和批量rAAV制造的分析

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2025-04-01

OAAI

Green, Erica A.; Fu, Qiang; Ndhairo, Nelson; Leibiger, Thomas M.; Wang, Yongdan; Lee, Yongsuk; Lee, Kelvin H.; Betenbaugh, Michael; Yoon, Seongkyu; Mcnally, David J.

Investigating subpopulation dynamics in clonal CHO-K1 cells with single-cell RNA sequencing 用单细胞RNA测序研究克隆CHO-K1细胞中的亚群动态

JOURNAL OF BIOTECHNOLOGY

IF3.9

2025-03-01

PREAI

Morina, Luke B.; Cao, Haoyu Chris; Chen, Siqi; Kumar, Swetha; Mcfarland, Kevin S.; Majewska, Natalia I.; Betenbaugh, Michael J.; Timp, Winston

Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications

BIOTECHNOLOGY JOURNAL

IF3.1

2025-03-01

PREAI

Ladiwala, Pranay; Ndahiro, Nelson; Hauk, Pricila; Wen, Junneng; Sargunas, Justin; Chen, Yu-Ju; Barton, Erik; Betenbaugh, Michael J.

Application of machine learning algorithms to identify serological predictors of COVID-19 severity and outcomes

COMMUNICATIONS MEDICINE

IF6.3

2024-11-26

OAAI

Dhakal, Santosh; Yin, Anna; Escarra-Senmarti, Marta; Demko, Zoe O.; Pisanic, Nora; Johnston, Trevor S.; Trejo-Zambrano, Maria Isabel; Kruczynski, Kate; Lee, John S.; Hardick, Justin P.; Shea, Patrick; Shapiro, Janna R.; Park, Han-Sol; Parish, Maclaine A.; Caputo, Christopher; Ganesan, Abhinaya; Mullapudi, Sarika K.; Gould, Stephen J.; Betenbaugh, Michael J.; Pekosz, Andrew; Heaney, Christopher D.; Antar, Annukka A. R.; Manabe, Yukari C.; Cox, Andrea L.; Karaba, Andrew H.; Andrade, Felipe; Zeger, Scott L.; Klein, Sabra L.

Pan-genome-scale metabolic modeling of Bacillus subtilis reveals functionally distinct groups

MSYSTEMS

IF4.6

2024-11-19

OAAI

Neal, Maxwell; Brakewood, William; Betenbaugh, Michael; Zengler, Karsten

Mixed and membrane-separated culturing of synthetic cyanobacteria-yeast consortia reveals metabolic cross-talk mimicking natural cyanolichens

SCIENTIFIC REPORTS

IF3.9

2024-10-25

OAAI

Bohutskyi, Pavlo; Pomraning, Kyle R.; Jenkins, Jackson P.; Kim, Young-Mo; Poirier, Brenton C.; Betenbaugh, Michael J.; Magnuson, Jon K.

Elevated endoplasmic reticulum pH is associated with high growth and bisAb aggregation in CHO cells

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2024-10-22

OAAI

Mcfarland, Kevin S.; Hegadorn, Kaitlin; Betenbaugh, Michael J.; Handlogten, Michael W.

Comprehensive stable- isotope tracing of glucose and amino acids identifies metabolic by- products and their sources in CHO cell culture 葡萄糖和氨基酸的全面稳定同位素示踪可确定CHO细胞培养物中的代谢副产物及其来源

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-10-04

OAAI

Gonzalez, Jacqueline E.; Naik, Harnish Mukesh; Oates, Eleanor H.; Dhara, Venkata Gayatri; Mcconnell, Brian O.; Kumar, Swetha; Betenbaugh, Michael J.; Antoniewicz, Maciek R.

Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism Ala-cys-cys-ala二肽二聚体可缓解培养基配方中的半胱氨酸和胱氨酸水平问题，并增强CHO细胞的生长和代谢

METABOLIC ENGINEERING

IF6.8

2024-09-01

OAAI

Ladiwala, Pranay; Cai, Xiangchen; Naik, Harnish Mukesh; Aliyu, Lateef; Schilling, Martin; Antoniewicz, Maciek R.; Betenbaugh, Michael J.

Top-down and bottom-up microbiome engineering approaches to enable biomanufacturing from waste biomass

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

IF3.2

2024-07-13

OAAI

Lyu, Xuejiao; Nuhu, Mujaheed; Candry, Pieter; Wolfanger, Jenna; Betenbaugh, Michael; Saldivar, Alexis; Zuniga, Cristal; Wang, Ying; Shrestha, Shilva

Biosynthesis of polyhydroxyalkanoates employing a newly isolated Paramecium multimicronucleatum 使用新分离的草履虫多原核生物的聚羟基链烷酸酯的生物合成

INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY

IF3.4

2024-05-13

PREAI

Zahra, I.; Arshad, A.; Betenbaugh, M.; Shabbir, U.; Nawaz, S.; Liaqat, A.; Hussain, T.; Ramzan, U.; Shakoori, A. Rauf; Shakoori, F. Rauf

Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic modeling 使用13C标记实验和动力学模型阐明CHO细胞培养物中二肽的摄取和代谢命运

METABOLIC ENGINEERING

IF6.8

2024-05-01

OAAI

Naik, Harnish Mukesh; Cai, Xiangchen; Ladiwala, Pranay; Reddy, Jayanth Venkatarama; Betenbaugh, Michael J.; Antoniewicz, Maciek R.

Data-driven and physics informed modeling of Chinese Hamster Ovary cell bioreactors

COMPUTERS & CHEMICAL ENGINEERING

IF3.9

2024-04-01

PREAI

Cui, Tianqi; Bertalan, Tom; Ndahiro, Nelson; Khare, Pratik; Betenbaugh, Michael; Maranas, Costas; Kevrekidis, Ioannis G.

Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial

JCI INSIGHT

IF6.1

2024-03-14

OAAI

Park, Han-Sol; Yin, Anna; Barranta, Caelan; Lee, John S.; Caputo, Christopher A.; Sachithanandham, Jaiprasath; Li, Maggie; Yoon, Steve; Sitaras, Ioannis; Jedlicka, Anne; Eby, Yolanda; Ram, Malathi; Fernandez, Reinaldo E.; Baker, Owen R.; Shenoy, Aarthi G.; Mosnaim, Giselle S.; Fukuta, Yuriko; Patel, Bela; Heath, Sonya L.; Levine, Adam C.; Meisenberg, Barry R.; Spivak, Emily S.; Anjan, Shweta; Huaman, Moises A.; Blair, Janis E.; Currier, Judith S.; Paxton, James H.; Gerber, Jonathan M.; Petrini, Joann R.; Broderick, Patrick B.; Rausch, William; Cordisco, Marie Elena; Hammel, Jean; Greenblatt, Benjamin; Cluzet, Valerie C.; Cruser, Daniel; Oei, Kevin; Abinante, Matthew; Hammitt, Laura L.; Sutcliffe, Catherine G.; Forthal, Donald N.; Zand, Martin S.; Cachay, Edward R.; Raval, Jay S.; Kassaye, Seble G.; Marshall, Christi E.; Yarava, Anusha; Lane, Karen; Mcbee, Nichol A.; Gawad, Amy L.; Karlen, Nicky; Singh, Atika; Ford, Daniel E.; Jabs, Douglas A.; Appel, Lawrence J.; Shade, David M.; Lau, Bryan; Ehrhardt, Stephan; Baksh, Sheriza N.; Shapiro, Janna R.; Ou, Jiangda; Na, Yu Bin; Knoll, Maria D.; Ornelas-Gatdula, Elysse; Arroyo-Curras, Netzahualcoyotl; Gniadek, Thomas J.; Caturegli, Patrizio; Wu, Jinke; Ndahiro, Nelson; Betenbaugh, Michael J.; Ziman, Alyssa; Hanley, Daniel F.; Casadevall, Arturo; Shoham, Shmuel; Bloch, Evan M.; Gebo, Kelly A.; Tobian, Aaron A. R.; Laeyendecker, Oliver; Pekosz, Andrew; Klein, Sabra L.; Sullivan, David J.

研究方向