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L

Lars K. Nielsen

Technical University of Denmark

77H指数
478论文数
2.0W被引数
收录论文 202
发表时间
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Extracellular vesicle depletion improves transient gene expression performance and alters cellular transcriptional responses in CHO cell外泌体耗竭提高了CHO细胞的瞬时基因表达性能并改变了细胞转录反应
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2026-07-07
err0
errOAAI
errMarzia Rahimi; Pol Pérez-Rubio; Juliana Vargas-Gracia; Paul J. Kempen; Lars K. Nielsen; Jesús Lavado-García
err分享
err收藏
Annotating the pangenome reveals the diversity in the genetic basis for metabolic enzymes泛基因组注释揭示了代谢酶遗传基础的多样性
errScience Advances
IF12.5
err2026-07-01
err0
errOAAI
errOmid Ardalani; Patrick V. Phaneuf; Kalpathy J. Krishnan; David Pride; Lars K. Nielsen; Bernhard O. Palsson
err分享
err收藏
Gas–liquid mass-transfer modeling in industrial-scale bioreactors: A standardized framework and critical assessment工业规模生物反应器中的气-液传质建模：一个标准化的框架和批判性评估
errChemical Engineering Journal Advances
IF7.1
err2025-12-12
err0
errOAAI
errVíctor Puig I. Laborda; Johan Le Nepvou De Carfort; Ulrich Krühne; Krist V. Gernaey; John M. Kavanagh; David F. Fletcher; Lars K. Nielsen
err分享
err收藏
Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli稀有代谢基因的必需性是埃希氏菌(Escherichia coli)微生态位适应的决定因素。
errPLOS PATHOGENS
IF4.9
err2025-12-08
err0
PREAI
errArdalani, Omid; Phaneuf, Patrick V.; Krishnan, Jayanth; Chauhan, Siddharth M.; Pride, David; Zielinski, Daniel C.; Monk, Jonathan M.; Nielsen, Lars K.; Palsson, Bernhard O.
err分享
err收藏
Resolving single-cell gene expression by pseudo-temporal integration of transcriptomic and proteomic datasets通过伪时间整合转录组学和蛋白质组学数据集解析单细胞基因表达
errMolecular & Cellular Proteomics
IF5.5
err2025-11-27
err0
errOAAI
errCraig P. Barry; Gert H. Talbo; Aiden Beauglehole; Dmitry Ovchinnikov; Trent Munro; Stephen Mahler; Kym Baker; Lars K. Nielsen; Tim R. Mercer; Esteban Marcellin
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Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density靶向UDP-葡萄糖神经酰胺葡糖基转移酶的稳定过表达诱导代谢转换，提高高细胞密度下的细胞性能
errFrontiers in Bioengineering and Biotechnology
IF4.8
err2025-10-13
err0
errOAAI
errMarzia Rahimi; Lars K. Nielsen; Jesús Lavado-García
err分享
err收藏
Flow-informed clustering of bioreactor volumes to build CFD-based compartment models基于CFD的生物反应器体积信息流聚类构建隔室模型
errChemical Engineering Science
IF4.3
err2025-09-04
err0
errOAAI
errJohan Le Nepvou De Carfort; Víctor Puig I Laborda; Lars Keld Nielsen; Krist V. Gernaey; Ulrich Krühne
err分享
err收藏
A Multi-Level Systems Biology Analysis of Aldrin’s Metabolic Effects on Prostate Cancer Cells阿尔丁对前列腺癌细胞代谢影响的多层次系统生物学分析
errProteomes 2023, Vol. 11, Page 11
IF3.6
err2025-08-22
err0
PREAI
errCarmen Bedia; Nuria Dalmau; Lars K. Nielsen; Romà Tauler; Igor Marín de Mas
err分享
err收藏
Comparative Genomic Assessment of the Cupriavidus necator Species for One-Carbon Based Biomanufacturing基于一碳的生產制造的节杆菌属的基因组比较评估
errMicrobial Biotechnology
IF5.2
err2025-07-25
err0
errOAAI
errMagnus G. Jespersen; Emil Funk Vangsgaard; Mariana Arango Saavedra; Stefano Donati; Lars K. Nielsen
err分享
err收藏
Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production混和物设计作为一种工具，用于改进重组AAV生产中不同GOIs的全空颗粒比例。
errGene Therapy
IF4.5
err2025-06-20
err0
errOAAI
errKonstantina Tzimou; Pol Hulsbus-Andreu; Ece Bahar Yildirim; Lars K. Nielsen; Jesús Lavado-García
err分享
err收藏
Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration评估靶向整合对CHO培养性能的凋亡基因效率
errACS SYNTHETIC BIOLOGY
IF3.9
err2025-04-23
err0
errOAAI
errCatalán-Tatjer, D; Ganesan, SK; Martínez-Monje, I; Grav, LM; Lavado-García, J; Nielsen, LK
err分享
err收藏
Unsupervised learning bioreactor regimes无监督学习生物反应器制度
errCOMPUTERS & CHEMICAL ENGINEERING
IF3.9
err2025-03-01
err0
errOAAI
errLaborda, Victor Puig, I; Puiman, Lars; Groves, Teddy; Haringa, Cees; Nielsen, Lars Keld
err分享
err收藏
Unlocking DOE potential by selecting the most appropriate design for rAAV optimization通过选择最合适的rAAV优化设计释放DOE潜力
errMOLECULAR THERAPY
IF12
err2024-12-01
err0
errOAAI
errTzimou, Konstantina; Catalan-Tatjer, David; Nielsen, Lars K.; Lavado-Garcia, Jesus
err分享
err收藏
Single-Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies基于人类单克隆抗体的寡克隆混合物的实验性重组蛇咬伤抗蛇毒血清的单批表达
errBIOTECHNOLOGY JOURNAL
IF3.1
err2024-10-09
err2
errOAAI
errAdams, Anna C.; Grav, Lise M.; Ahmadi, Shirin; Dahl, Camilla Holst; Ljungars, Anne; Laustsen, Andreas H.; Nielsen, Lars K.
err分享
err收藏
Pangenome reconstruction of Lactobacillaceae metabolism predicts species-specific metabolic traits乳杆菌科代谢的Pangenome重建可预测物种特异性代谢特征
errMSYSTEMS
IF4.6
err2024-07-23
err2
errOAAI
errArdalani, O.; Phaneuf, P. V.; Mohite, O. S.; Nielsen, L. K.; Palsson, B. O.
err分享
err收藏
Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms在基于动物细胞的平台中阐明重组腺相关病毒 (rAAV) 生产的基本要素
errBIOTECHNOLOGY ADVANCES
IF12.5
err2024-07-01
err2
errOAAI
errCatalan-Tatjer, David; Tzimou, Konstantina; Nielsen, Lars K.; Lavado-Garcia, Jesus
err分享
err收藏
Bayesian Regression Facilitates Quantitative Modeling of Cell Metabolism贝叶斯回归有助于细胞代谢的定量建模
errACS SYNTHETIC BIOLOGY
IF3.9
err2024-04-05
err0
errOAAI
errGroves, Teddy; Cowie, Nicholas Luke; Nielsen, Lars Keld
err分享
err收藏
Adaptive laboratory evolution of Clostridium autoethanogenum to metabolize CO2 and H2 enhances growth rates in chemostat and unravels proteome and metabolome alterations自产乙醇梭菌代谢CO2和H2的适应性实验室进化提高了恒化器的生长速率，并解开了蛋白质组和代谢组的变化
errMICROBIAL BIOTECHNOLOGY
IF5.2
err2024-04-03
err0
errOAAI
errHeffernan, James; Garcia Gonzalez, R. Axayactl; Mahamkali, Vishnu; McCubbin, Tim; Daygon, Dara; Liu, Lian; Palfreyman, Robin; Harris, Audrey; Koepke, Michael; Valgepea, Kaspar; Nielsen, Lars Keld; Marcellin, Esteban
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Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation利用CHO细胞的代谢可塑性来增强灌注培养
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2023-12-11
err0
errOAAI
errNoebel, Matthias; Barry, Craig; Macdonald, Michael A.; Baker, Kym; Shave, Evan; Mahler, Stephen; Munro, Trent; Martinez, Veronica S.; Nielsen, Lars K.; Marcellin, Esteban
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Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy天然和合成C1-trophic微生物的协同研究以促进循环碳经济
errNATURE COMMUNICATIONS
IF15.7
err2023-10-21
err6
errOAAI
errOrsi, Enrico; Nikel, Pablo Ivan; Nielsen, Lars Keld; Donati, Stefano
err分享
err收藏

研究方向

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合作学者
合作期刊
B
Bernhard Ø. Palsson
H 指数: 166 · 论文数: 1.2K
J
Jens Nielsen
H 指数: 161 · 论文数: 1.5K
S
Sang Yup Lee
H 指数: 137 · 论文数: 3.1K
P
Philip Hugenholtz
H 指数: 133 · 论文数: 875
J
John S. Mattick
H 指数: 124 · 论文数: 491
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