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U

Umut H. Toprak

Helmholtz Association
H指数:41
被引数:1.7万

个人简介

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教育背景

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荣誉奖项

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Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

增强子-启动子相互作用的改变导致t(7;12)(q36;p13) 小儿急性髓系白血病MNX1表达

BLOOD ADVANCES
IF7.1
2024-09-271
OAAI
Weichenhan, Dieter; Riedel, Anna; Sollier, Etienne; Toprak, Umut H.; Hey, Joschka; Breuer, Kersten; Wierzbinska, Justyna A.; Touzart, Aurore; Lutsik, Pavlo; Baehr, Marion; Ostlund, Anders; Nilsson, Tina; Jacobsson, Susanna; Edler, Marcel; Waraky, Ahmed; Behrens, Yvonne Lisa; Goehring, Gudrun; Schlegelberger, Brigitte; Steinek, Clemens; Harz, Hartmann; Leonhardt, Heinrich; Dolnik, Anna; Reinhardt, Dirk; Bullinger, Lars; Palmqvist, Lars; Lipka, Daniel B.; Plass, Christoph
The genomic and transcriptional landscape of primary central nervous system lymphoma
NATURE COMMUNICATIONS
IF15.7
2022-05-1065
OAAI
Radke, Josefine; Ishaque, Naveed; Koll, Randi; Gu, Zuguang; Schumann, Elisa; Sieverling, Lina; Uhrig, Sebastian; Huebschmann, Daniel; Toprak, Umut H.; Lopez, Cristina; Hostench, Xavier Pastor; Borgoni, Simone; Juraeva, Dilafruz; Pritsch, Fabienne; Paramasivam, Nagarajan; Balasubramanian, Gnana Prakash; Schlesner, Matthias; Sahay, Shashwat; Weniger, Marc; Pehl, Debora; Radbruch, Helena; Osterloh, Anja; Korfel, Agnieszka; Misch, Martin; Onken, Julia; Faust, Katharina; Vajkoczy, Peter; Moskopp, Dag; Wang, Yawen; Joedicke, Andreas; Truemper, Lorenz; Anagnostopoulos, Ioannis; Lenze, Dido; Kueppers, Ralf; Hummel, Michael; Schmitt, Clemens A.; Wiestler, Otmar D.; Wolf, Stephan; Unterberg, Andreas; Eils, Roland; Herold-Mende, Christel; Brors, Benedikt; Siebert, Reiner; Wiemann, Stefan; Heppner, Frank L.
Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas
HAEMATOLOGICA
IF7.9
2022-04-284
OAAI
Lopez, Cristina; Schleussner, Nikolai; Bernhart, Stephan H.; Kleinheinz, Kortine; Sungalee, Stephanie; Sczakiel, Henrike L.; Kretzmer, Helene; Toprak, Umut H.; Glaser, Selina; Wagener, Rabea; Ammerpohl, Ole; Bens, Susanne; Giefing, Maciej; Sanchez, Juan C. Gonzalez; Apic, Gordana; Huebschmann, Daniel; Janz, Martin; Kreuz, Markus; Mottok, Anja; Mueller, Judith M.; Seufert, Julian; Hoffmann, Steve; Korbel, Jan O.; Russell, Robert B.; Schuele, Roland; Truemper, Lorenz; Klapper, Wolfram; Radlwimmer, Bernhard; Lichter, Peter; Kueppers, Ralf; Schlesner, Matthias; Mathas, Stephan; Siebert, Reiner
T-cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level
GENES CHROMOSOMES & CANCER
IF2.8
2022-03-291
OAAI
Patil, Paurnima; Hillebrecht, Sina; Chteinberg, Emil; Lopez, Cristina; Toprak, Umut H.; Seufert, Julian; Bernhart, Stephan H.; Kretzmer, Helene; Bergmann, Anke K.; Bens, Susanne; Hoegel, Josef; Mueller, Annika; Jebaraj, Billy Michael; Schrader, Alexandra; Johansson, Patricia; Costa, Dolors; Schlesner, Matthias; Duerig, Jan; Herling, Marco; Campo, Elias; Stilgenbauer, Stephan; Wiehle, Laura; Siebert, Reiner
Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities
HAEMATOLOGICA
IF7.9
2022-01-2016
OAAI
Giesen, Nicola; Paramasivam, Nagarajan; Toprak, Umut H.; Huebschmann, Daniel; Xu, Jing; Uhrig, Sebastian; Samur, Mehmet; Baehr, Stella; Froehlich, Martina; Mughal, Sadaf S.; Mai, Elias K.; Jauch, Anna; Muller-Tidow, Carsten; Brors, Benedikt; Munshi, Nikhil; Goldschmidt, Hartmut; Weinhold, Niels; Schlesner, Matthias; Raab, Marc S.
Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

形成生发中心衍生的b细胞淋巴瘤的编码和非编码基因组的突变机制

LEUKEMIA
IF13.4
2021-05-0537
OAAI
Huebschmann, Daniel; Kleinheinz, Kortine; Wagener, Rabea; Bernhart, Stephan H.; Lopez, Cristina; Toprak, Umut H.; Sungalee, Stephanie; Ishaque, Naveed; Kretzmer, Helene; Kreuz, Markus; Waszak, Sebastian M.; Paramasivam, Nagarajan; Ammerpohl, Ole; Aukema, Sietse M.; Beekman, Renee; Bergmann, Anke K.; Bieg, Matthias; Binder, Hans; Borkhardt, Arndt; Borst, Christoph; Brors, Benedikt; Bruns, Philipp; Carrillo de Santa Pau, Enrique; Claviez, Alexander; Doose, Gero; Haake, Andrea; Karsch, Dennis; Haas, Siegfried; Hansmann, Martin-Leo; Hoell, Jessica I.; Hovestadt, Volker; Huang, Bingding; Hummel, Michael; Jaeger-Schmidt, Christina; Kerssemakers, Jules N. A.; Korbel, Jan O.; Kube, Dieter; Lawerenz, Chris; Lenze, Dido; Martens, Joost H. A.; Ott, German; Radlwimmer, Bernhard; Reisinger, Eva; Richter, Julia; Rico, Daniel; Rosenstiel, Philip; Rosenwald, Andreas; Schillhabel, Markus; Stilgenbauer, Stephan; Stadler, Peter F.; Martin-Subero, Jose I.; Szczepanowski, Monika; Warsow, Gregor; Weniger, Marc A.; Zapatka, Marc; Valencia, Alfonso; Stunnenberg, Hendrik G.; Lichter, Peter; Moller, Peter; Loeffler, Markus; Eils, Roland; Klapper, Wolfram; Hoffmann, Steve; Trumper, Lorenz; Kueppers, Ralf; Schlesner, Matthias; Siebert, Reiner
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
NATURE COMMUNICATIONS
IF15.7
2021-02-2450
OAAI
Hartlieb, Sabine A.; Sieverling, Lina; Nadler-Holly, Michal; Ziehm, Matthias; Toprak, Umut H.; Herrmann, Carl; Ishaque, Naveed; Okonechnikov, Konstantin; Gartlgruber, Moritz; Park, Young-Gyu; Wecht, Elisa Maria; Savelyeva, Larissa; Henrich, Kai-Oliver; Rosswog, Carolina; Fischer, Matthias; Hero, Barbara; Jones, David T. W.; Pfaff, Elke; Witt, Olaf; Pfister, Stefan M.; Volckmann, Richard; Koster, Jan; Kiesel, Katharina; Rippe, Karsten; Taschner-Mandl, Sabine; Ambros, Peter; Brors, Benedikt; Selbach, Matthias; Feuerbach, Lars; Westermann, Frank
Super enhancers define regulatory subtypes and cell identity in neuroblastoma
NATURE CANCER
IF28.5
2020-12-0785
PREAI
Gartlgruber, Moritz; Sharma, Ashwini Kumar; Quintero, Andres; Dreidax, Daniel; Jansky, Selina; Park, Young-Gyu; Kreth, Sina; Meder, Johanna; Doncevic, Daria; Saary, Paul; Toprak, Umut H.; Ishaque, Naveed; Afanasyeva, Elena; Wecht, Elisa; Koster, Jan; Versteeg, Rogier; Gruenewald, Thomas G. P.; Jones, David T. W.; Pfister, Stefan M.; Henrich, Kai-Oliver; van Nes, Johan; Herrmann, Carl; Westermann, Frank
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone
NATURE COMMUNICATIONS
IF15.7
2020-10-2736
OAAI
Lutsik, Pavlo; Baude, Annika; Mancarella, Daniela; Oz, Simin; Kuhn, Alexander; Toth, Reka; Hey, Joschka; Toprak, Umut H.; Lim, Jinyeong; Viet Ha Nguyen; Jiang, Chao; Mayakonda, Anand; Hartmann, Mark; Rosemann, Felix; Breuer, Kersten; Vonficht, Dominik; Gruenschlaeger, Florian; Lee, Suman; Schuhmacher, Maren Kirstin; Kusevic, Denis; Jauch, Anna; Weichenhan, Dieter; Zustin, Jozef; Schlesner, Matthias; Haas, Simon; Park, Joo Hyun; Park, Yoon Jung; Oppermann, Udo; Jeltsch, Albert; Haller, Florian; Fellenberg, Joerg; Lindroth, Anders M.; Plass, Christoph
Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia
GENES CHROMOSOMES & CANCER
IF2.8
2019-11-2918
OAAI
Patil, Paurnima; Cieslak, Agata; Bernhart, Stephan H.; Toprak, Umut H.; Wagener, Rabea; Lopez, Cristina; Wiehle, Laura; Bens, Susanne; Altmueller, Janine; Franitza, Marek; Scholz, Ingrid; Jayne, Sandrine; Ahearne, Matthew J.; Scheffold, Annika; Jebaraj, Billy M. C.; Schneider, Christof; Costa, Dolors; Braun, Till; Schrader, Alexandra; Campo, Elias; Dyer, Martin J. S.; Nuernberg, Peter; Duerig, Jan; Johansson, Patricia; Boettcher, Sebastian; Schlesner, Matthias; Herling, Marco; Stilgenbauer, Stephan; Macintyre, Elizabeth; Siebert, Reiner
Mutational patterns and regulatory networks in epigenetic subgroups of meningioma
ACTA NEUROPATHOLOGICA
IF9.3
2019-05-0862
PREAI
Paramasivam, Nagarajan; Huebschmann, Daniel; Toprak, Umut H.; Ishaque, Naveed; Neidert, Marian; Schrimpf, Daniel; Stichel, Damian; Reuss, David; Sievers, Philipp; Reinhardt, Annekathrin; Wefers, Annika K.; Jones, David T. W.; Gu, Zuguang; Werner, Johannes; Uhrig, Sebastian; Wirsching, Hans-Georg; Schick, Matthias; Bewerunge-Hudler, Melanie; Beck, Katja; Brehmer, Stephanie; Urbschat, Steffi; Seiz-Rosenhagen, Marcel; Haenggi, Daniel; Herold-Mende, Christel; Ketter, Ralf; Eils, Roland; Ram, Zvi; Pfister, Stefan M.; Wick, Wolfgang; Weller, Michael; Grossmann, Rachel; von Deimling, Andreas; Schlesner, Matthias; Sahm, Felix
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
NATURE COMMUNICATIONS
IF15.7
2019-03-2997
OAAI
Lopez, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Huebschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc A.; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Moeller, Peter; Truemper, Lorenz; Klapper, Wolfram; Hoffmann, Steve; Kueppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner; Wagner, Susanne; Richter, Gesine; Eils, Juergen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Loeffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
NATURE COMMUNICATIONS
IF15.7
2018-11-14106
OAAI
Ishaque, Naveed; Abba, Mohammed L.; Hauser, Christine; Patil, Nitin; Paramasivam, Nagarajan; Huebschmann, Daniel; Leupold, Jorg Hendrik; Balasubramanian, Gnana Prakash; Kleinheinz, Kortine; Toprak, Umut H.; Hutter, Barbara; Benner, Axel; Shavinskaya, Anna; Zhou, Chan; Gu, Zuguang; Kerssemakers, Jules; Marx, Alexander; Moniuszko, Marcin; Kozlowski, Miroslaw; Reszec, Joanna; Niklinski, Jacek; Eils, Juergen; Schlesner, Matthias; Eils, Roland; Brors, Benedikt; Allgayer, Heike

研究方向

暂未获取到该数据
M
Matthias Schlesner
H 指数:72论文数:449被引数:5.5万
B
Benedikt Brors
H 指数:100论文数:789被引数:5.2万
R
Roland Eils
H 指数:138论文数:1,082被引数:11.5万
F
Frank Westermann
H 指数:60论文数:414被引数:1.8万
K
Kortine Kleinheinz
H 指数:47论文数:105被引数:2.1万
C
Cristina López
H 指数:45论文数:210被引数:1.6万
D
Daniel Hübschmann
H 指数:52论文数:265被引数:2.2万
N
Naveed Ishaque
H 指数:41论文数:195被引数:8,025
N
Nagarajan Paramasivam
H 指数:33论文数:120被引数:1.0万
C
Carl Herrmann
H 指数:57论文数:226被引数:2.2万