Gilbert Di Paolo - Publications, H-index & Citations

Gilbert Di Paolo

denali therapeutics

75H指数

213论文数

2.5W被引数

收录论文 112

发表时间

Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice 小胶质细胞中的TDP-43介导髓鞘修剪并抑制小鼠中Tyrobp内含子的隐藏外显子包含

Nature Neuroscience

IF20

2026-07-08

OAAI

Anne-Claire Compagnion; Andranik Ivanov; Anil Rana; Felipe Espinoza; Thomas Sandmann; Fanny S. Martineau; Katia Monsorno; Roberta Facchinetti; Alessandro Matera; Lionel Rougé; Fernando González Ibáñez; Clarissa Catale; Matteo Bizzotto; Sonia Garel; Michela Matteoli; Yutaro Kashiwagi; Ryuta Koyama; Christian Haass; Marie-Eve Tremblay; Dieter Beule; Ileana Jelescu; Valerio Zerbi; Gilbert Di Paolo; Rosa C. Paolicelli

Multi-omics reveal phosphatidic acid phosphatases modify Niemann-Pick type C disease severity 多组学揭示磷酸酸磷酸酶修饰尼曼-皮克C型疾病的严重程度

iScience

IF4.1

2026-05-28

OAAI

Andrew B. Munkacsi; Gabriella E. Conway; Keri Multerer; Michael D. Jackson; Lauren Csaki; Tamayanthi Rajakumar; Jeffrey P. Sheridan; Eliatan Niktab; Wuh-Liang Hwu; Yin-Hsiu Chien; Mark Walterfang; Cintya Del Rio Hernandez; Robin B. Chan; Bowen Zhou; Renu Nandakumar; Peixang Zhang; Gilbert Di Paolo; Robert A. Maue; Karen Reue; Stephen L. Sturley

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动功效至关重要

Nature Communications

IF15.7

2026-01-24

OAAI

Astrid F. Feiten; Kilian Dahm; Kai Schlepckow; Bettina van Lengerich; Jung H. Suh; Anika Reifschneider; Benedikt Wefers; Laura M. Bartos; Karin Wind-Mark; Lis de Weerd; Thomas Ulas; Elena De-Domenico; Pia Grundschöttel; Stefan Paulusch; Benjamin Tast; Tamisa Honda; Stephan A. Müller; Matthias Becker; Igor Khalin; Alessio Ricci; Arthur Liesz; Bettina Brunner; Claudia Krenner; Katrin Buschmann; Brigitte Nuscher; Lena Spieth; Niklas Junker; Stefan A. Berghoff; Sonnet S. Davis; Jonas J. Neher; Wolfgang Wurst; Nikolaus Plesnila; Joseph W. Lewcock; Mikael Simons; Stefan F. Lichtenthaler; Gilbert Di Paolo; Matthias Brendel; Anja Capell; Kathryn M. Monroe; Joachim L. Schultze; Christian Haass

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease PILRA的缺失促进小胶质细胞免疫代谢，以减少阿尔茨海默病细胞和动物模型中的淀粉样蛋白病理。

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2025-12-03

PREAI

Weerakkody, Tanya N.; Sabelstrom, Hanna; Andrews, Shan V.; Chadarevian, Jean Paul; Chin, Marcus Y.; Tatarakis, David; Propson, Nicholas E.; Kim, Do Jin; Theolis, Richard; Parico, Gian Carlo G.; Misker, Hiwot; Kung, Jennifer E.; Bandyopadhyay, Abira; Robles Colmenares, Yaneth; Jackson, Taggra-Nicole; Qerqez, Ahlam N.; Balasundar, Srijana; Davis, Sonnet S.; Ha, Connie; Ghosh, Rajarshi; Ravi, Ritesh; Rana, Anil; Germain, Kyla; Tao, Arnold; Xiong, Ken; Braun, Dylan; Raju, Karthik; Huang, Kang-Chieh; Zhan, Lihong; Guo, Jing L.; Safari Yazd, Hoda; Sarrafha, Lily; Capocchi, Joia Kai; Hasselmann, Jonathan; Chadarevian, Alina L.; Tu, Christina; Mansour, Kimiya; Eskandari-Sedighi, Ghazaleh; Tesi, Niccolo; Van Der Lee, Sven; Hulsman, Marc; Oshegov, Georgii; Pijnenburg, Yolande; Calvert, Meredith; Holstege, Henne; Suh, Jung H.; Di Paolo, Gilbert; Davtyan, Hayk; Lewcock, Joseph W.; Blurton-Jones, Mathew; Monroe, Kathryn M.

Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions ATP13A2缺失导致的溶酶体多胺储存通过改变溶酶体pH值和静电水解酶-脂质相互作用而损害β-葡糖脑苷脂酶

Cell Reports

IF6.9

2025-08-22

PREAI

Madhuja Samaddar; Gabriel A. Fitzgerald; Ann Hong Nguyen; Sonnet S. Davis; Shourya Jain; Jian Guo; Nicholas E. Propson; Bettina van Lengerich; Yajuan Shi; Srijana Balasundar; Lionel Rougé; Jamal Alkabsh; Anil Rana; Julie Yi; Marcus Y. Chin; Isabel A. Becerra; Annie Arguello; Brian M. Fox; Todd Logan; Jung H. Suh; Anastasia G. Henry; Gilbert Di Paolo

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial 实验性eIF2B激活剂DNL343在TDP-43病理学的临床前模型和随机临床试验中的ALS患者中调节整合应激反应

Nature Communications

IF15.7

2025-08-18

OAAI

Brittany N. Flores; Seungyoon B. Yu; Isaac V. Cohen; Melania H. Fanok; Wei Luan; Romeo D. Maciuca; Linus D. Sun; Richard M. Tsai; Maurits Vissers; Lars Smits; Tommy M. Bunte; Anna Bakardjiev; Srijana Balasundar; Meredith E. K. Calvert; Marcus Y. Chin; Sarah K. Dobbins; William E. Dowdle; Meng Fang; Jules A. A. C. Heuberger; Connie L. Ha; Fen Huang; Takashi Miyamoto; Maksim Osipov; Lidia Madrid San Martin; Katie Saund; David Tatarakis; Anthony Q. Vu; Chenling Xiong; Gene W. Yeo; Geert Jan Groeneveld; Leonard H. van den Berg; Shyeilla Dhuria; Anthony A. Estrada; Danna Jennings; Thomas Sandmann; Carole Ho; Kimberly Scearce-Levie; Ernie Yulyaningsih; Adam K. Walker; Gilbert Di Paolo; Lesley A. Kane; Matthew D. Troyer; Joseph W. Lewcock

Stressed microglia turn to the dark side in Alzheimer's disease 应激的小胶质细胞在阿尔茨海默病中转向黑暗面

NEURON

IF15

2025-02-01

PREAI

Di Paolo, Gilbert

Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-12-04

PREAI

Dinkel, Lina; Hummel, Selina; Zenatti, Valerio; Malara, Mariagiovanna; Tillmann, Yannik; Colombo, Alessio; Monasor, Laura Sebastian; Suh, Jung H.; Logan, Todd; Roth, Stefan; Paeger, Lars; Hoffelner, Patricia; Bludau, Oliver; Schmidt, Andree; Mueller, Stephan A.; Schifferer, Martina; Nuscher, Brigitte; Njavro, Jasenka Rudan; Prestel, Matthias; Bartos, Laura M.; Wind-Mark, Karin; Slemann, Luna; Hoermann, Leonie; Kunte, Sebastian T.; Gnoerich, Johannes; Lindner, Simon; Simons, Mikael; Herms, Jochen; Paquet, Dominik; Lichtenthaler, Stefan F.; Bartenstein, Peter; Franzmeier, Nicolai; Liesz, Arthur; Grosche, Antje; Bremova-Ertl, Tatiana; Catarino, Claudia; Beblo, Skadi; Bergner, Caroline; Schneider, Susanne A.; Strupp, Michael; Di Paolo, Gilbert; Brendel, Matthias; Tahirovic, Sabina

First-line treatment in older patients with metastatic colorectal cancer: A large real-world study 晚期结直肠癌老年患者的一线治疗：一项大型真实世界研究

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

Basile, D.; Bergamo, F.; Ongaro, E.; Cinausero, M.; Conca, V.; Ambrosini, M.; Lucchetti, J.; Rosati, G.; Avallone, A.; Di Paolo, G.; Lai, E.; Lutrino, E. S.; Di Nardo, P.; Zurlo, I. V.; Cortese, C.; Carullo, M.; Leo, S.; Di Donato, S.; Pietrantonio, F.; Aprile, G.

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference APOE和痴呆症研究的进展: 2023 AAIC进展的亮点: APOE会议

ALZHEIMERS & DEMENTIA

IF11.1

2024-07-19

OAAI

Kloske, Courtney M.; Belloy, Michael E.; Blue, Elizabeth E.; Bowman, Gregory R.; Carrillo, Maria C.; Chen, Xiaoying; Chiba-Falek, Ornit; Davis, Albert A.; Di Paolo, Gilbert; Garretti, Francesca; Gate, David; Golden, Lesley R.; Heinecke, Jay W.; Herz, Joachim; Huang, Yadong; Iadecola, Costantino; Johnson, Lance A.; Kanekiyo, Takahisa; Karch, Celeste M.; Khvorova, Anastasia; Koppes-den Hertog, Sascha J.; Lamb, Bruce T.; Lawler, Paige E.; Guen, Yann Le; Litvinchuk, Alexandra; Liu, Chia-Chen; Mahinrad, Simin; Marcora, Edoardo; Marino, Claudia; Michaelson, Danny M.; Miller, Justin J.; Morganti, Josh M.; Narayan, Priyanka S.; Naslavsky, Michel S.; Oosthoek, Marlies; Ramachandran, Kapil V.; Ramakrishnan, Abhirami; Raulin, Ana-Caroline; Robert, Aiko; Saleh, Rasha N. M.; Sexton, Claire; Shah, Nilomi; Shue, Francis; Sible, Isabel J.; Soranno, Andrea; Strickland, Michael R.; Julia, T. C. W.; Thierry, Manon; Tsai, Li-Huei; Tuckey, Ryan A.; Ulrich, Jason D.; van der Kant, Rik; Wang, Na; Wellington, Cheryl L.; Weninger, Stacie C.; Yassine, Hussein N.; Zhao, Na; Bu, Guojun; Goate, Alison M.; Holtzman, David M.

Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-06-05

PREAI

Reich, Marvin; Simon, Matthew J.; Polke, Beate; Paris, Inaki; Werner, Georg; Schrader, Christian; Spieth, Lena; Davis, Sonnet S.; Robinson, Sophie; de Melo, Gabrielly Lunkes; Schlaphoff, Lennart; Buschmann, Katrin; Berghoff, Stefan; Logan, Todd; Nuscher, Brigitte; de Weerd, Lis; Edbauer, Dieter; Simons, Mikael; Suh, Jung H.; Sandmann, Thomas; Kariolis, Mihalis S.; Devos, Sarah L.; Lewcock, Joseph W.; Paquet, Dominik; Capell, Anja; Di Paolo, Gilbert; Haass, Christian

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist(vol 112, pg 384,2024)

NEURON

IF15

2024-06-01

OAAI

Litvinchuk, Alexandra; Suh, Jung H.; Guo, Jing L.; Lin, Karin; Davis, Sonnet S.; Bien-Ly, Nga; Tycksen, Eric; Tabor, G. Travis; Serrano, Javier Remolina; Manis, Melissa; Bao, Xin; Lee, Choonghee; Bosch, Megan; Perez, Enmanuel J.; Yuede, Carla M.; Cashikar, Anil G.; Ulrich, Jason D.; Di Paolo, Gilbert; Holtzman, David M.

p16 immunohistochemical (IHC) expression (exp) predicts benefit from irinotecan in metastatic colorectal cancer (mCRC): A translational analysis of the TRIBE and TRIBE2 studies

ANNALS OF ONCOLOGY

IF65.4

2024-06-01

PREAI

Studiale, V.; Germani, M. M.; Moretto, R.; Conca, V.; Signorini, F.; Proietti, A.; Giordano, M.; Rossini, D.; Taravella, A.; Murgioni, S.; Russo, A.; Passardi, A.; Latiano, T. P.; Zaniboni, A.; Aprile, G.; Di Paolo, G.; Pietrantonio, F.; Ugolini, C.; Cremolini, C.

TRIfluridine vs FOLfiri in thIrd-Line Metastatic gastroesophageal adenocarcinoma (mGEA): The TRIFOLIUM study

ANNALS OF ONCOLOGY

IF65.4

2024-06-01

PREAI

Perissinotto, E.; Cerantola, R.; De Grandis, M. C.; Intini, R.; De Rosa, A.; Di Paolo, G.; Prete, A. A.; Barsotti, G.; Ricagno, G.; Sperotto, S.; Procaccio, L.; Piva, V. M.; Roma, A.; Rizzato, M. D.; Djaballah, S. Ahcene; Bof, F.; Gaiani, C.; Bergamo, F.; Lonardi, S.; Murgioni, S.

Assessment of PD-L1 on matched surgical specimen and biopsy in resectable esophagogastric cancer (EGC): The APEROL study

ANNALS OF ONCOLOGY

IF65.4

2024-06-01

PREAI

Nappo, F.; Ricagno, G.; Ceccon, C.; Sabbadin, M.; Djaballah, S. Ahcene; Roma, A.; Di Paolo, G.; Perissinotto, E.; De Rosa, A.; Cerantola, R.; Angerilli, V.; Montagner, I.; Carcea, E.; Pilati, P.; Valmasoni, M.; Scapinello, A.; Bergamo, F.; Lonardi, S.; Fassan, M.; Murgioni, S.

Real-life second-line therapies outcome in metastatic pancreatic cancer (mPDAC) patients previously treated with gemcitabine plus nab-paclitaxel (Gem-Nab): An Italian multicenter study

ANNALS OF ONCOLOGY

IF65.4

2024-06-01

PREAI

Procaccio, L.; Giordano, G.; Barsotti, G.; Zecchetto, C.; Bergamo, F.; Landriscina, M.; Masucci, M.; Di Paolo, G.; De Vita, F.; Gebbia, V.; Mancino, A.; Ricagno, G.; Bianco, R.; Noventa, S.; Lo Re, G.; Vasile, E.; Sperotto, S.; Casalino, S.; Merz, V.; Lonardi, S.

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist

NEURON

IF15

2024-02-01

OAAI

The Genetic Drivers of Juvenile, Young, and Early-Onset Parkinson's Disease in India 印度青少年，年轻和早发性帕金森氏病的遗传驱动因素

MOVEMENT DISORDERS

IF7.6

2023-11-28

OAAI

Andrews, Shan V.; Kukkle, Prashanth L.; Menon, Ramesh; Geetha, Thenral S.; Goyal, Vinay; Kandadai, Rukmini Mridula; Kumar, Hrishikesh; Borgohain, Rupam; Mukherjee, Adreesh; Wadia, Pettarusp M.; Yadav, Ravi; Desai, Soaham; Kumar, Niraj; Joshi, Deepika; Murugan, Sakthivel; Biswas, Atanu; Pal, Pramod K.; Oliver, Merina; Nair, Sandhya; Kayalvizhi, Anbu; Samson, Praveena L.; Deshmukh, Manjari; Bassi, Akshi; Sandeep, Charugulla; Mandloi, Nitin; Davis, Oliver B.; Roberts, Melissa A.; Leto, Dara E.; Henry, Anastasia G.; Di Paolo, Gilbert; Muthane, Uday; Das, Shymal K.; Peterson, Andrew S.; Sandmann, Thomas; Gupta, Ravi; Ramprasad, Vedam L.

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes Rab12是LRRK2的调节因子，其被受损的溶酶体激活

ELIFE

IF0

2023-10-24

OAAI

Wang, Xiang; Bondar, Vitaliy V.; Davis, Oliver B.; Maloney, Michael T.; Agam, Maayan; Chin, Marcus Y.; Ho, Audrey Cheuk-Nga; Ghosh, Rajarshi; Leto, Dara E.; Joy, David; Calvert, Meredith E. K.; Lewcock, Joseph W.; Di Paolo, Gilbert; Thorne, Robert G.; Sweeney, Zachary K.; Henry, Anastasia G.

Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia

TRENDS IN CELL BIOLOGY

IF18.1

2023-04-01

OAAI

Simon, Matthew J.; Logan, Todd; DeVos, Sarah L.; Di Paolo, Gilbert

研究方向