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G

Gilbert Di Paolo

denali therapeutics
H指数:75
被引数:2.4万

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Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice

小胶质细胞中的TDP-43介导髓鞘修剪并抑制小鼠中Tyrobp内含子的隐藏外显子包含

Nature Neuroscience
IF20
2026-07-080
OAAI
Anne-Claire Compagnion; Andranik Ivanov; Anil Rana; Felipe Espinoza; Thomas Sandmann; Fanny S. Martineau; Katia Monsorno; Roberta Facchinetti; Alessandro Matera; Lionel Rougé; Fernando González Ibáñez; Clarissa Catale; Matteo Bizzotto; Sonia Garel; Michela Matteoli; Yutaro Kashiwagi; Ryuta Koyama; Christian Haass; Marie-Eve Tremblay; Dieter Beule; Ileana Jelescu; Valerio Zerbi; Gilbert Di Paolo; Rosa C. Paolicelli
Multi-omics reveal phosphatidic acid phosphatases modify Niemann-Pick type C disease severity

多组学揭示磷酸酸磷酸酶修饰尼曼-皮克C型疾病的严重程度

iScience
IF4.1
2026-05-280
OAAI
Andrew B. Munkacsi; Gabriella E. Conway; Keri Multerer; Michael D. Jackson; Lauren Csaki; Tamayanthi Rajakumar; Jeffrey P. Sheridan; Eliatan Niktab; Wuh-Liang Hwu; Yin-Hsiu Chien; Mark Walterfang; Cintya Del Rio Hernandez; Robin B. Chan; Bowen Zhou; Renu Nandakumar; Peixang Zhang; Gilbert Di Paolo; Robert A. Maue; Karen Reue; Stephen L. Sturley
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动功效至关重要

Nature Communications
IF15.7
2026-01-240
OA
Astrid F. Feiten; Kilian Dahm; Kai Schlepckow; Bettina van Lengerich; Jung H. Suh; Anika Reifschneider; Benedikt Wefers; Laura M. Bartos; Karin Wind-Mark; Lis de Weerd; Thomas Ulas; Elena De-Domenico; Pia Grundschöttel; Stefan Paulusch; Benjamin Tast; Tamisa Honda; Stephan A. Müller; Matthias Becker; Igor Khalin; Alessio Ricci; Arthur Liesz; Bettina Brunner; Claudia Krenner; Katrin Buschmann; Brigitte Nuscher; Lena Spieth; Niklas Junker; Stefan A. Berghoff; Sonnet S. Davis; Jonas J. Neher; Wolfgang Wurst; Nikolaus Plesnila; Joseph W. Lewcock; Mikael Simons; Stefan F. Lichtenthaler; Gilbert Di Paolo; Matthias Brendel; Anja Capell; Kathryn M. Monroe; Joachim L. Schultze; Christian Haass
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease

PILRA的缺失促进小胶质细胞免疫代谢，以减少阿尔茨海默病细胞和动物模型中的淀粉样蛋白病理。

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2025-12-030
PRE
Weerakkody, Tanya N.; Sabelstrom, Hanna; Andrews, Shan V.; Chadarevian, Jean Paul; Chin, Marcus Y.; Tatarakis, David; Propson, Nicholas E.; Kim, Do Jin; Theolis, Richard; Parico, Gian Carlo G.; Misker, Hiwot; Kung, Jennifer E.; Bandyopadhyay, Abira; Robles Colmenares, Yaneth; Jackson, Taggra-Nicole; Qerqez, Ahlam N.; Balasundar, Srijana; Davis, Sonnet S.; Ha, Connie; Ghosh, Rajarshi; Ravi, Ritesh; Rana, Anil; Germain, Kyla; Tao, Arnold; Xiong, Ken; Braun, Dylan; Raju, Karthik; Huang, Kang-Chieh; Zhan, Lihong; Guo, Jing L.; Safari Yazd, Hoda; Sarrafha, Lily; Capocchi, Joia Kai; Hasselmann, Jonathan; Chadarevian, Alina L.; Tu, Christina; Mansour, Kimiya; Eskandari-Sedighi, Ghazaleh; Tesi, Niccolo; Van Der Lee, Sven; Hulsman, Marc; Oshegov, Georgii; Pijnenburg, Yolande; Calvert, Meredith; Holstege, Henne; Suh, Jung H.; Di Paolo, Gilbert; Davtyan, Hayk; Lewcock, Joseph W.; Blurton-Jones, Mathew; Monroe, Kathryn M.
Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions

ATP13A2缺失导致的溶酶体多胺储存通过改变溶酶体pH值和静电水解酶-脂质相互作用而损害β-葡糖脑苷脂酶

Cell Reports
IF6.9
2025-08-220
PREAI
Madhuja Samaddar; Gabriel A. Fitzgerald; Ann Hong Nguyen; Sonnet S. Davis; Shourya Jain; Jian Guo; Nicholas E. Propson; Bettina van Lengerich; Yajuan Shi; Srijana Balasundar; Lionel Rougé; Jamal Alkabsh; Anil Rana; Julie Yi; Marcus Y. Chin; Isabel A. Becerra; Annie Arguello; Brian M. Fox; Todd Logan; Jung H. Suh; Anastasia G. Henry; Gilbert Di Paolo
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

实验性eIF2B激活剂DNL343在TDP-43病理学的临床前模型和随机临床试验中的ALS患者中调节整合应激反应

Nature Communications
IF15.7
2025-08-180
OAAI
Brittany N. Flores; Seungyoon B. Yu; Isaac V. Cohen; Melania H. Fanok; Wei Luan; Romeo D. Maciuca; Linus D. Sun; Richard M. Tsai; Maurits Vissers; Lars Smits; Tommy M. Bunte; Anna Bakardjiev; Srijana Balasundar; Meredith E. K. Calvert; Marcus Y. Chin; Sarah K. Dobbins; William E. Dowdle; Meng Fang; Jules A. A. C. Heuberger; Connie L. Ha; Fen Huang; Takashi Miyamoto; Maksim Osipov; Lidia Madrid San Martin; Katie Saund; David Tatarakis; Anthony Q. Vu; Chenling Xiong; Gene W. Yeo; Geert Jan Groeneveld; Leonard H. van den Berg; Shyeilla Dhuria; Anthony A. Estrada; Danna Jennings; Thomas Sandmann; Carole Ho; Kimberly Scearce-Levie; Ernie Yulyaningsih; Adam K. Walker; Gilbert Di Paolo; Lesley A. Kane; Matthew D. Troyer; Joseph W. Lewcock
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-12-040
PRE
Dinkel, Lina; Hummel, Selina; Zenatti, Valerio; Malara, Mariagiovanna; Tillmann, Yannik; Colombo, Alessio; Monasor, Laura Sebastian; Suh, Jung H.; Logan, Todd; Roth, Stefan; Paeger, Lars; Hoffelner, Patricia; Bludau, Oliver; Schmidt, Andree; Mueller, Stephan A.; Schifferer, Martina; Nuscher, Brigitte; Njavro, Jasenka Rudan; Prestel, Matthias; Bartos, Laura M.; Wind-Mark, Karin; Slemann, Luna; Hoermann, Leonie; Kunte, Sebastian T.; Gnoerich, Johannes; Lindner, Simon; Simons, Mikael; Herms, Jochen; Paquet, Dominik; Lichtenthaler, Stefan F.; Bartenstein, Peter; Franzmeier, Nicolai; Liesz, Arthur; Grosche, Antje; Bremova-Ertl, Tatiana; Catarino, Claudia; Beblo, Skadi; Bergner, Caroline; Schneider, Susanne A.; Strupp, Michael; Di Paolo, Gilbert; Brendel, Matthias; Tahirovic, Sabina
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

APOE和痴呆症研究的进展: 2023 AAIC进展的亮点: APOE会议

ALZHEIMERS & DEMENTIA
IF11.1
2024-07-191
OA
Kloske, Courtney M.; Belloy, Michael E.; Blue, Elizabeth E.; Bowman, Gregory R.; Carrillo, Maria C.; Chen, Xiaoying; Chiba-Falek, Ornit; Davis, Albert A.; Di Paolo, Gilbert; Garretti, Francesca; Gate, David; Golden, Lesley R.; Heinecke, Jay W.; Herz, Joachim; Huang, Yadong; Iadecola, Costantino; Johnson, Lance A.; Kanekiyo, Takahisa; Karch, Celeste M.; Khvorova, Anastasia; Koppes-den Hertog, Sascha J.; Lamb, Bruce T.; Lawler, Paige E.; Guen, Yann Le; Litvinchuk, Alexandra; Liu, Chia-Chen; Mahinrad, Simin; Marcora, Edoardo; Marino, Claudia; Michaelson, Danny M.; Miller, Justin J.; Morganti, Josh M.; Narayan, Priyanka S.; Naslavsky, Michel S.; Oosthoek, Marlies; Ramachandran, Kapil V.; Ramakrishnan, Abhirami; Raulin, Ana-Caroline; Robert, Aiko; Saleh, Rasha N. M.; Sexton, Claire; Shah, Nilomi; Shue, Francis; Sible, Isabel J.; Soranno, Andrea; Strickland, Michael R.; Julia, T. C. W.; Thierry, Manon; Tsai, Li-Huei; Tuckey, Ryan A.; Ulrich, Jason D.; van der Kant, Rik; Wang, Na; Wellington, Cheryl L.; Weninger, Stacie C.; Yassine, Hussein N.; Zhao, Na; Bu, Guojun; Goate, Alison M.; Holtzman, David M.
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-06-050
PRE
Reich, Marvin; Simon, Matthew J.; Polke, Beate; Paris, Inaki; Werner, Georg; Schrader, Christian; Spieth, Lena; Davis, Sonnet S.; Robinson, Sophie; de Melo, Gabrielly Lunkes; Schlaphoff, Lennart; Buschmann, Katrin; Berghoff, Stefan; Logan, Todd; Nuscher, Brigitte; de Weerd, Lis; Edbauer, Dieter; Simons, Mikael; Suh, Jung H.; Sandmann, Thomas; Kariolis, Mihalis S.; Devos, Sarah L.; Lewcock, Joseph W.; Paquet, Dominik; Capell, Anja; Di Paolo, Gilbert; Haass, Christian
The Genetic Drivers of Juvenile, Young, and Early-Onset Parkinson's Disease in India

印度青少年，年轻和早发性帕金森氏病的遗传驱动因素

MOVEMENT DISORDERS
IF7.6
2023-11-2810
OAAI
Andrews, Shan V.; Kukkle, Prashanth L.; Menon, Ramesh; Geetha, Thenral S.; Goyal, Vinay; Kandadai, Rukmini Mridula; Kumar, Hrishikesh; Borgohain, Rupam; Mukherjee, Adreesh; Wadia, Pettarusp M.; Yadav, Ravi; Desai, Soaham; Kumar, Niraj; Joshi, Deepika; Murugan, Sakthivel; Biswas, Atanu; Pal, Pramod K.; Oliver, Merina; Nair, Sandhya; Kayalvizhi, Anbu; Samson, Praveena L.; Deshmukh, Manjari; Bassi, Akshi; Sandeep, Charugulla; Mandloi, Nitin; Davis, Oliver B.; Roberts, Melissa A.; Leto, Dara E.; Henry, Anastasia G.; Di Paolo, Gilbert; Muthane, Uday; Das, Shymal K.; Peterson, Andrew S.; Sandmann, Thomas; Gupta, Ravi; Ramprasad, Vedam L.
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

Rab12是LRRK2的调节因子，其被受损的溶酶体激活

ELIFE
IF0
2023-10-248
OA
Wang, Xiang; Bondar, Vitaliy V.; Davis, Oliver B.; Maloney, Michael T.; Agam, Maayan; Chin, Marcus Y.; Ho, Audrey Cheuk-Nga; Ghosh, Rajarshi; Leto, Dara E.; Joy, David; Calvert, Meredith E. K.; Lewcock, Joseph W.; Di Paolo, Gilbert; Thorne, Robert G.; Sweeney, Zachary K.; Henry, Anastasia G.

研究方向

暂未获取到该数据
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Robin Chan
H 指数:38论文数:131被引数:5,263
P
Pietro De Camilli
H 指数:146论文数:565被引数:6.9万
B
Bowen Zhou
H 指数:26论文数:158被引数:3,058
J
Joseph W. Lewcock
H 指数:37论文数:120被引数:6,523
S
Sonnet S. Davis
H 指数:18论文数:70被引数:4,270
S
Scott A. Small
H 指数:49论文数:156被引数:1.5万
C
Christian Haass
H 指数:135论文数:669被引数:7.5万
C
Claudia Dall’Armi
H 指数:14论文数:33被引数:1,968
T
Tiago Gil Oliveira
H 指数:20论文数:88被引数:2,337
K
Kathryn M. Monroe
H 指数:20论文数:55被引数:8,062