梁欢欢 (Huanhuan Liang)

Chinese Academy of Sciences教授、博导邮箱:lianghh26@mail.sysu.edu.cn

H指数:17

被引数:993

个人简介

任职于中山大学，为“百人计划”引进的青年人才，广东省杰出青年基金获得者，深圳市炎症性疾病重点实验室核心成员。研究方向为运用生物化学和免疫学等多学科方法，深入研究流感病毒复制及宿主细胞因子风暴中关键分子的免疫调控机制，并致力于挖掘新的药物靶点、探索新靶点作用机制及诊断试剂和新型药物的研发。曾获科技部重点研发计划、国家自然基金、广东省杰出青年基金、深圳市科创委重点等项目支持，以（共同）第一或通讯作者在Nucleic Acids Research, Nature Structural & Molecular Biology, Cell reports, PNAS, Molecular Cell, Cell Research, Nature Communications, Angew Chem Int Ed Engl等国际期刊发表论文20多篇。

教育背景

2003.01 – 2009.12
北京大学博士学位物理化学
1999.01 – 2003.12
兰州大学学士学位化学

工作经历

2017.01 – 至今
中山大学药学院（深圳）
教授、博导
2009.01 – 2017.12
中国科学院生物物理研究所
助理研究员，副研究员

荣誉奖项

暂无内容

Cryo-EM structure of influenza polymerase bound to the cRNA promoter provides insights into the mechanism of viral replication

流感聚合酶与cRNA启动子结合的冷冻电镜结构为病毒复制机制提供了见解

Communications Biology

IF5.1

2025-12-290

OAAI

Mutagenesis studies suggest a mechanism for influenza polymerase stalling during polyadenylation

NUCLEIC ACIDS RESEARCH

IF13.1

2024-12-160

OAAI

An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2023-07-247

PRE

Performance improvement of microbial fuel cells through assembling anodes modified with nanoscale materials

组装纳米材料修饰的阳极提高微生物燃料电池的性能

NANOMATERIALS AND NANOTECHNOLOGY

IF3.3

2022-11-0212

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms (vol 0, 1, 2022)

CELL RESEARCH

IF25.9

2022-05-181

H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function

NUCLEIC ACIDS RESEARCH

IF13.1

2022-02-215

OAAI

IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus

CELL REPORTS

IF6.9

2021-12-0115

OAAI

IFP35 family proteins promote neuroinflammation and sclerosis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-08-0616

NMI and IFP35 are key DAMP molecules in inflammatory bowel diseases

FASEB JOURNAL

IF4.2

2020-04-200

PRE

A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-09-0128

OAAI

Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity

睾丸的人类蛋白质-二硫键异构酶样蛋白 (PDILT) 的晶体和溶液结构为其伴侣活性提供了见识

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-01-0110

OAAI

NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury

NMI和IFP35在细胞感染和损伤期间充当促炎阻尼

NATURE COMMUNICATIONS

IF15.7

2017-10-1672

OAAI

pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating

JOURNAL OF GENERAL VIROLOGY

IF4.3

2016-09-018

Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution

MOLECULAR CELL

IF16.6

2015-03-0185

OAAI

Slow and Bimolecular Folding of a De Novo Designed Monomeric Protein DS119

BIOPHYSICAL JOURNAL

IF3.1

2013-11-016

OAAI

Crystal structure and nucleotide selectivity of human IFIT5/ISG58

CELL RESEARCH

IF25.9

2013-06-1834

OAAI

Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5

SCIENCE SIGNALING

IF6.6

2012-11-1339

OAAI

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

CELL RESEARCH

IF25.9

2012-07-2485

OAAI

Crystal structure of the ubiquitin-like domain of human TBK1

PROTEIN & CELL

IF12.8

2012-05-2030

Engineering a zinc binding site into the de novo designed protein DS119 with a βαβ structure

PROTEIN & CELL

IF12.8

2012-01-1014

OAAI

研究方向

病毒关键蛋白的结构与功能感染与自身免疫性疾病的发病机制新的药物靶标的发现，验证及药物研发国家自然基金面上项目，2024-2027，73万，主持，在研Huanhuan Li#, Yixi Wu#流感病毒聚合酶转录与复制机制30(8):1183-1192.结构与机制研究Jian Li#Lena Bergmann#Kimberly M. WebbMadelaine M. GogolPhilipp VoigtH3K36甲基化DNA结合Ioc4募集Isw1b重塑因子功能IFP35作为SARS-CoV-2或流感病毒诱导综合征的生物标志物和治疗靶点37(12):110126.神经炎症多发性硬化症炎症性损伤相关分子模式8(950): 1~11.