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Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture-Based Gene Panel Orsmark-Pietras, Christina; Lyander, Anna; Ladenvall, Claes; Hallstrom, Bjorn; Staffas, Anna; Awier, Hero; Krstic, Aleksandra; Baliakas, Panagiotis; Barbany, Gisela; Hakansson, Cecilia Brunhoff; Gellerbring, Anna; Hagstrom, Anna; Hellstrom-Lindberg, Eva; Juliusson, Gunnar; Lazarevic, Vladimir; Munters, Arielle; Pandzic, Tatjana; Wadelius, Mia; As, Joel; Fogelstrand, Linda; Wirta, Valtteri; Rosenquist, Richard; Cavelier, Lucia; Fioretos, Thoas 分享 收藏
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Genetic insights into resting heart rate and its role in cardiovascular disease 静息心率的遗传学研究及其在心血管疾病中的作用 van de Vegte, Yordi; Eppinga, Ruben P.; van der Ende, M. Yldau; Hagemeijer, Yanick; Mahendran, Yuvaraj V.; Salfati, Elias Y.; Smith, Albert E.; Tan, Vanessa; Arking, Dan V.; Ntalla, Ioanna; Appel, Emil A.; Schurmann, Claudia; Brody, Jennifer; Rueedi, Rico; Polasek, Ozren; Sveinbjornsson, Gardar; Lecoeur, Cecile; Ladenvall, Claes; Zhao, Jing Hua; Isaacs, Aaron; Wang, Lihua; Luan, Jian'an; Hwang, Shih-Jen; Mononen, Nina U.; Auro, Kirsi F.; Jackson, Anne; Bielak, Lawrence; Zeng, Linyao; Shah, Nabi; Nethander, Maria; Campbell, Archie; Rankinen, Tuomo; Pechlivanis, Sonali; Qi, Lu; Zhao, Wei; Rizzi, Federica; Tanaka, Toshiko; Robino, Antonietta; Cocca, Massimiliano; Lange, Leslie; Mueller-Nurasyid, Martina; Roselli, Carolina E.; Zhang, Weihua; Kleber, Marcus J.; Guo, Xiuqing; Lin, Henry E.; Pavani, Francesca; Galesloot, Tessel; Noordam, Raymond E.; Milaneschi, Yuri; Schraut, Katharina; den Hoed, Marcel; Degenhardt, Frauke E.; Trompet, Stella; van den Berg, Marten; Pistis, Giorgio; Tham, Yih-Chung S.; Weiss, Stefan L.; Sim, Xueling J.; Li, Hengtong M.; van der Most, Peter; Nolte, Ilja; Lyytikaeinen, Leo-Pekka R.; Said, M. Abdullah; Witte, Daniel; Iribarren, Carlos M.; Launer, Lenore S.; Ring, Susan; de Vries, Paul; Sever, Peter P.; Linneberg, Allan; Bottinger, Erwin M.; Padmanabhan, Sandosh; Psaty, Bruce; Sotoodehnia, Nona; Kolcic, Ivana; Roshandel, Delnaz D.; Paterson, Andrew O.; Arnar, David F.; Gudbjartsson, Daniel; Holm, Hilma; Balkau, Beverley T.; Silva, Claudia H.; Newton-Cheh, Christopher; Nikus, Kjell; Salo, Perttu L.; Mohlke, Karen A.; Peyser, Patricia; Schunkert, Heribert; Lorentzon, Mattias; Lahti, Jari C.; Rao, Dabeeru C.; Cornelis, Marilyn D.; Faul, Jessica A.; Smith, Jennifer; Stolarz-Skrzypek, Katarzyna; Bandinelli, Stefania; Concas, Maria Pina; Sinagra, Gianfranco; Meitinger, Thomas; Waldenberger, Melanie F.; Sinner, Moritz; Strauch, Konstantin E.; Delgado, Graciela D.; Taylor, Kent; Yao, Jie; Foco, Luisa; Melander, Olle; de Graaf, Jacqueline; de Mutsert, Renee; de Geus, Eco J. C.; Johansson, Asa K.; Joshi, Peter K.; Lind, Lars; Franke, Andre W.; Macfarlane, Peter V.; Tarasov, Kirill; Tan, Nicholas B.; Felix, Stephan; Tai, E-Shyong Q.; Quek, Debra; Snieder, Harold; Ormel, Johan; Ingelsson, Martin; Lindgren, Cecilia P.; Morris, Andrew T.; Raitakari, Olli; Hansen, Torben; Assimes, Themistocles; Gudnason, Vilmundur J.; Timpson, Nicholas C.; Morrison, Alanna B.; Munroe, Patricia P.; Strachan, David; Grarup, Niels; Loos, Ruth J. F. R.; Heckbert, Susan; Vollenweider, Peter; Hayward, Caroline; Stefansson, Kari; Froguel, Philippe; Groop, Leif J.; Wareham, Nicholas M.; van Duijn, Cornelia F.; Feitosa, Mary J.; O'Donnell, Christopher; Kaehoenen, Mika; Perola, Markus; Boehnke, Michael; Kardia, Sharon L. R.; Erdmann, Jeanette; Palmer, Colin N. A.; Ohlsson, Claes J.; Porteous, David G.; Eriksson, Johan; Bouchard, Claude; Moebus, Susanne; Kraft, Peter R.; Weir, David; Cusi, Daniele; Ferrucci, Luigi; Ulivi, Sheila; Girotto, Giorgia; Correa, Adolfo; Kaeaeb, Stefan; Peters, Annette C.; Chambers, John S.; Kooner, Jaspal; Maerz, Winfried I.; Rotter, Jerome A.; Hicks, Andrew; Smith, J. Gustav; Kiemeney, Lambertus A. L. M. O.; Mook-Kanamori, Dennis; Penninx, Brenda W. J. H.; Gyllensten, Ulf F.; Wilson, James; Burgess, Stephen; Sundstroem, Johan; Lieb, Wolfgang; Jukema, J. Wouter; Eijgelsheim, Mark; Lakatta, Edward L. M.; Cheng, Ching-Yu; Doerr, Marcus; Wong, Tien-Yin; Sabanayagam, Charumathi J.; Oldehinkel, Albertine; Riese, Harriette; Lehtimaeki, Terho; Verweij, Niek; van der Harst, Pim 分享 收藏
Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity Malinski, Bartosz; Vertemara, Jacopo; Faustini, Elena; Ladenvall, Claes; Norberg, Anna; Zhang, Yuming; von Castelmur, Eleonore; Baliakas, Panagiotis; Tisi, Renata; Cammenga, Jorg; Lottersberger, Francisca 分享 收藏
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Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus van Zuydam, Natalie R.; Ladenvall, Claes; Voight, Benjamin F.; Strawbridge, Rona J.; Fernandez-Tajes, Juan; Rayner, N. William; Robertson, Neil R.; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E.; Nelson, Christopher P.; Kwee, Lydia Coulter; Esko, Tonu; Mihailov, Evelin; Magi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; Song, Ci; Hartiala, Jaana A.; Pedersen, Nancy L.; Perola, Markus; Gieger, Christian; Peters, Annette; Qu, Liming; Willems, Sara M.; Doney, Alex S. F.; Morris, Andrew D.; Zheng, Yan; Sesti, Giorgio; Hu, Frank B.; Qi, Lu; Laakso, Markku; Thorsteinsdottir, Unnur; Grallert, Harald; van Duijn, Cornelia; Reilly, Muredach P.; Ingelsson, Erik; Deloukas, Panos; Kathiresan, Sek; Metspalu, Andres; Shah, Svati H.; Sinisalo, Juha; Salomaa, Veikko; Hamsten, Anders; Samani, Nilesh J.; Maerz, Winfried; Hazen, Stanley L.; Watkins, Hugh; Saleheen, Danish; Morris, Andrew P.; Colhoun, Helen M.; Groop, Leif; McCarthy, Mark I.; Palmer, Colin N. A. 分享 收藏
Arteria: An automation system for a sequencing core facility Dahlberg, Johan; Hermansson, Johan; Sturlaugsson, Steinar; Lysenkova, Mariya; Smeds, Patrik; Ladenvall, Claes; Guimera, Roman Valls; Reisinger, Florian; Hofmann, Oliver; Larsson, Pontus 分享 收藏
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes 2型糖尿病患者糖尿病肾病的全基因组关联研究 van Zuydam, Natalie R.; Ahlqvist, Emma; Sandholm, Niina; Deshmukh, Harshal; Rayner, N. William; Abdalla, Moustafa; Ladenvall, Claes; Ziemek, Daniel; Fauman, Eric; Robertson, Neil R.; McKeigue, Paul M.; Valo, Erkka; Forsblom, Carol; Harjutsalo, Valma; Perna, Annalisa; Rurali, Erica; Marcovecchio, M. Loredana; Igo, Robert P., Jr.; Salem, Rany M.; Perico, Norberto; Lajer, Maria; Karajamak, Annemari; Imamura, Minako; Kubo, Michiaki; Takahashi, Atsushi; Sim, Xueling; Liu, Jianjun; van Dam, Rob M.; Jiang, Guozhi; Tam, Claudia H. T.; Luk, Andrea O. Y.; Lee, Heung Man; Lim, Cadmon K. P.; Szeto, Cheuk Chun; So, Wing Yee; Chan, Juliana C. N.; Ang, Su Fen; Dorajoo, Rajkumar; Wang, Ling; Clara, Tan Si Hua; McKnight, Amy-Jayne; Duffy, Seamus; Pezzolesi, Marcus G.; Marre, Michel; Gyorgy, Beata; Hadjadj, Samy; Hiraki, Linda T.; Ahluwalia, Tarunveer S.; Almgren, Peter; Schulz, Christina-Alexandra; Orho-Melander, Marju; Linneberg, Allan; Christensen, Cramer; Witte, Daniel R.; Grarup, Niels; Brandslund, Ivan; Melander, Olle; Paterson, Andrew D.; Tregouet, David; Maxwell, Alexander P.; Lim, Su Chi; Ma, Ronald C. W.; Tai, E. Shyong; Maeda, Shiro; Lyssenko, Valeriya; Tuomi, Tiinamaija; Krolewski, Andrzej S.; Rich, Stephen S.; Hirschhorn, Joel N.; Florez, Jose C.; Dunger, David; Pedersen, Oluf; Hansen, Torben; Rossing, Peter; Remuzzi, Giuseppe; Brosnan, Mary Julia; Palmer, Colin N. A.; Groop, Per-Henrik; Colhoun, Helen M.; Groop, Leif C.; McCarthy, Mark I. 分享 收藏
Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin Toenjes, Anke; Scholz, Markus; Krueger, Jacqueline; Krause, Kerstin; Schleinitz, Dorit; Kirsten, Holger; Gebhardt, Claudia; Marzi, Carola; Grallert, Harald; Ladenvall, Claes; Heyne, Henrike; Laurila, Esa; Kriebel, Jennifer; Meisinger, Christa; Rathmann, Wolfgang; Gieger, Christian; Groop, Leif; Prokopenko, Inga; Isomaa, Bo; Beutner, Frank; Kratzsch, Juergen; Fischer-Rosinsky, Antje; Pfeiffer, Andreas; Krohn, Knut; Spranger, Joachim; Thiery, Joachim; Blueher, Matthias; Stumvoll, Michael; Kovacs, Peter 分享 收藏
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 在芬兰人群中富集的低频失活AKT2变体与空腹胰岛素水平和2型糖尿病风险相关 Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung; Teslovich, Tanya M.; Blackwell, Thomas W.; Bork-Jensen, Jette; Burtt, Noel P.; Chen, Yuhui; Green, Todd; Hartl, Christopher; Kang, Hyun Min; Kumar, Ashish; Ladenvall, Claes; Ma, Clement; Moutsianas, Loukas; Pearson, Richard D.; Perry, John R. B.; Rayner, N. William; Robertson, Neil R.; Scott, Laura J.; van de Bunt, Martijn; Eriksson, Johan G.; Jula, Antti; Koskinen, Seppo; Lehtimaki, Terho; Palotie, Aarno; Raitakari, Olli T.; Jacobs, Suzanne B. R.; Wessel, Jennifer; Chu, Audrey Y.; Scott, Robert A.; Goodarzi, Mark O.; Blancher, Christine; Buck, Gemma; Buck, David; Chines, Peter S.; Gabriel, Stacey; Gjesing, Anette P.; Groves, Christopher J.; Hollensted, Mette; Huyghe, Jeroen R.; Jackson, Anne U.; Jun, Goo; Justesen, Johanne Marie; Mangino, Massimo; Murphy, Jacquelyn; Neville, Matt; Onofrio, Robert; Small, Kerrin S.; Stringham, Heather M.; Trakalo, Joseph; Banks, Eric; Carey, Jason; Carneiro, Mauricio O.; DePristo, Mark; Farjoun, Yossi; Fennell, Timothy; Goldstein, Jacqueline I.; Grant, George; de Angelis, Martin Hrabe; Maguire, Jared; Neale, Benjamin M.; Poplin, Ryan; Purcell, Shaun; Schwarzmayr, Thomas; Shakir, Khalid; Smith, Joshua D.; Strom, Tim M.; Wieland, Thomas; Lindstrom, Jaana; Brandslund, Ivan; Christensen, Cramer; Surdulescu, Gabriela L.; Lakka, Timo A.; Doney, Alex S. F.; Nilsson, Peter; Wareham, Nicholas J.; Langenberg, Claudia; Varga, Tibor V.; Franks, Paul W.; Rolandsson, Olov; Rosengren, Anders H.; Farook, Vidya S.; Thameem, Farook; Puppala, Sobha; Kumar, Satish; Lehman, Donna M.; Jenkinson, Christopher P.; Curran, Joanne E.; Hale, Daniel Esten; Fowler, Sharon P.; Arya, Rector; DeFronzo, Ralph A.; Abboud, Hanna E.; Syvanen, Ann-Christine; Hicks, Pamela J.; Palmer, Nicholette D.; Ng, Maggie C. Y.; Bowden, Donald W.; Freedman, Barry I.; Esko, Tonu; Magi, Reedik; Milani, Lili; Mihailov, Evelin; Metspalu, Andres; Narisu, Narisu; Kinnunen, Leena; Bonnycastle, Lori L.; Swift, Amy; Pasko, Dorota; Wood, Andrew R.; Fadista, Joao; Pollin, Toni I.; Barzilai, Nir; Atzmon, Gil; Glaser, Benjamin; Thorand, Barbara; Strauch, Konstantin; Peters, Annette; Roden, Michael; Mueller-Nurasyid, Martina; Liang, Liming; Kriebel, Jennifer; Illig, Thomas; Grallert, Harald; Gieger, Christian; Meisinger, Christa; Lannfelt, Lars; Musani, Solomon K.; Griswold, Michael; Taylor, Herman A., Jr.; Wilson, Gregory, Sr.; Correa, Adolfo; Oksa, Heikki; Scott, William R.; Afzal, Uzma; Tan, Sian-Tsung; Loh, Marie; Chambers, John C.; Sehmi, Jobanpreet; Kooner, Jaspal Singh; Lehne, Benjamin; Cho, Yoon Shin; Lee, Jong-Young; Han, Bok-Ghee; Karajamaki, Annemari; Qi, Qibin; Qi, Lu; Huang, Jinyan; Hu, Frank B.; Melander, Olle; Orho-Melander, Marju; Below, Jennifer E.; Aguilar, David; Wong, Tien Yin; Liu, Jianjun; Khor, Chiea-Chuen; Chia, Kee Seng; Lim, Wei Yen; Cheng, Ching-Yu; Chan, Edmund; Tai, E. Shyong; Aung, Tin; Linneberg, Allan; Isomaa, Bo; Meitinger, Thomas; Tuomi, Tiinamaija; Hakaste, Liisa; Kravic, Jasmina; Jorgensen, Marit E.; Lauritzen, Torsten; Deloukas, Panos; Stirrups, Kathleen E.; Owen, Katharine R.; Farmer, Andrew J.; Frayling, Timothy M.; O'Rahilly, Stephen P.; Walker, Mark; Levy, Jonathan C.; Hodgkiss, Dylan; Hattersley, Andrew T.; Kuulasmaa, Teemu; Stancakova, Alena; Barroso, Ines; Bharadwaj, Dwaipayan; Chan, Juliana; Chandak, Giriraj R.; Daly, Mark J.; Donnelly, Peter J.; Ebrahim, Shah B.; Elliott, Paul; Fingerlin, Tasha; Froguel, Philippe; Hu, Cheng; Jia, Weiping; Ma, Ronald C. W.; McVean, Gilean; Park, Taesung; Prabhakaran, Dorairaj; Sandhu, Manjinder; Scott, James; Sladek, Rob; Tandon, Nikhil; Teo, Yik Ying; Zeggini, Eleftheria; Watanabe, Richard M.; Koistinen, Heikki A.; Kesaniemi, Y. Antero; Uusitupa, Matti; Spector, Timothy D.; Salomaa, Veikko; Rauramaa, Rainer; Palmer, Colin N. A.; Prokopenko, Inga; Morris, Andrew D.; Bergman, Richard N.; Collins, Francis S.; Lind, Lars; Ingelsson, Erik; Tuomilehto, Jaakko; Karpe, Fredrik; Groop, Leif; Jorgensen, Torben; Hansen, Torben; Pedersen, Oluf; Kuusisto, Johanna; Abecasis, GonOalo; Bell, Graeme I.; Blangero, John; Cox, Nancy J.; Duggirala, Ravindranath; Seielstad, Mark; Wilson, James G.; Dupuis, Josee; Ripatti, Samuli; Hanis, Craig L.; Florez, Jose C.; Mohlke, Karen L.; Meigs, James B.; Laakso, Markku; Morris, Andrew P.; Boehnke, Michael; Altshuler, David; McCarthy, Mark I.; Gloyn, Anna L.; Lindgren, Cecilia M. 分享 收藏
The Genetic Landscape of Renal Complications in Type 1 Diabetes Sandholm, Niina; Van Zuydam, Natalie; Ahlqvist, Emma; Juliusdottir, Thorhildur; Deshmukh, Harshal A.; Rayner, N. William; Di Camillo, Barbara; Forsblom, Carol; Fadista, Joao; Ziemek, Daniel; Salem, Rany M.; Hiraki, Linda T.; Pezzolesi, Marcus; Tregouet, David; Dahlstrom, Emma; Valo, Erkka; Oskolkov, Nikolay; Ladenvall, Claes; Marcovecchio, M. Loredana; Cooper, Jason; Sambo, Francesco; Malovini, Alberto; Manfrini, Marco; McKnight, Amy Jayne; Lajer, Maria; Harjutsalo, Valma; Gordin, Daniel; Parkkonen, Maija; Tuomilehto, Jaakko; Lyssenko, Valeriya; McKeigue, Paul M.; Rich, Stephen S.; Brosnan, Mary Julia; Fauman, Eric; Bellazzi, Riccardo; Rossing, Peter; Hadjadj, Samy; Krolewski, Andrzej; Paterson, Andrew D.; Florez, Jose C.; Hirschhorn, Joel N.; Maxwell, Alexander P.; Dunger, David; Cobelli, Claudio; Colhoun, Helen M.; Groop, Leif; McCarthy, Mark I.; Groop, Per-Henrik 分享 收藏
Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes THADA基因变异向2型糖尿病后代的过度母体传播 Prasad, Rashmi B.; Lessmark, Anna; Almgren, Peter; Kovacs, Gyorgyi; Hansson, Ola; Oskolkov, Nikolay; Vitai, Marta; Ladenvall, Claes; Kovacs, Peter; Fadista, Joao; Lachmann, Michael; Zhou, Yuedan; Sonestedt, Emily; Poon, Wenny; Wollheim, Claes B.; Orho-Melander, Marju; Stumvoll, Michael; Tuomi, Tiinamaija; Paeaebo, Svante; Koranyi, Laszlo; Groop, Leif 分享 收藏
Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB Berglund, Lisa M.; Lyssenko, Valeriya; Ladenvall, Claes; Kotova, Olga; Edsfeldt, Andreas; Pilgaard, Kasper; Alkayyali, Sami; Brons, Charlotte; Forsblom, Carol; Jonsson, Anna; Zetterqvist, Anna V.; Nitulescu, Mihaela; McDavitt, Christian Ruiz; Duner, Pontus; Stancakova, Alena; Kuusisto, Johanna; Ahlqvist, Emma; Lajer, Maria; Tarnow, Lise; Madsbad, Sten; Rossing, Peter; Kieffer, Timothy J.; Melander, Olle; Orho-Melander, Marju; Nilsson, Peter; Groop, Per-Henrik; Vaag, Allan; Lindblad, Bengt; Gottsater, Anders; Laakso, Markku; Goncalves, Isabel; Groop, Leif; Gomez, Maria F. 分享 收藏
Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research Spjuth, Ola; Krestyaninova, Maria; Hastings, Janna; Shen, Huei-Yi; Heikkinen, Jani; Waldenberger, Melanie; Langhammer, Arnulf; Ladenvall, Claes; Esko, Tonu; Persson, Mats-Ake; Heggland, Jon; Dietrich, Joern; Ose, Sandra; Gieger, Christian; Ried, Janina S.; Peters, Annette; Fortier, Isabel; de Geus, Eco J. C.; Klovins, Janis; Zaharenko, Linda; Willemsen, Gonneke; Hottenga, Jouke-Jan; Litton, Jan-Eric; Karvanen, Juha; Boomsma, Dorret I.; Groop, Leif; Rung, Johan; Palmgren, Juni; Pedersen, Nancy L.; McCarthy, Mark I.; van Duijn, Cornelia M.; Hveem, Kristian; Metspalu, Andres; Ripatti, Samuli; Prokopenko, Inga; Harris, Jennifer R. 分享 收藏
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