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THY1: A Therapeutically Targetable Mediator of Treatment Resistance in H3K27M Pediatric Tumors THY1：H3K27M儿童肿瘤中一种可治疗的耐药介质 Syed, Safiulla; Tripathy, Arushi; Ji, Sunjong; Alomary, Yazen; de la Nava Martin, Dani; Mota, Mateus; Chakravarthy, Reka; Huang, Dah-Luen; Wang, Zhuwen; Li, Zian; Zhang, Qiang; Lawrence, Theodore; Wahl, Daniel; Koschmann, Carl; Venneti, Sriram; Rehemtulla, Alnawaz; Al-Holou, Wajd 分享 收藏
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Leveraging the immunomodulatory effects of dordaviprone (ONC201) to induce long-term survival response in diffuse midline glioma patients and models 利用dordaviprone（ONC201）的免疫调节作用，在弥漫性中线胶质瘤患者和模型中诱导长期生存反应 Savary, Clara; Persson, Mika L.; Jackson, Evangeline R.; Duchatel, Ryan J.; Vo, Tuan; Findlay, Izac J.; Douglas, Alicia M.; Bramberger, Liesl; De La Nava, Daniel; Thomas, Bryce C.; Mcewen, Holly P.; Beitaki, Tyrone S.; De La Fuente, Laura Rodriguez; Colino-Sanguino, Yolanda; Mora, Fatima Valdes; Larsen, Martin R.; Faridi, Pouya; Holst, Jeff; Mayall, Jemma; Kline, Cassie N.; Franson, Andrea T.; Venneti, Sriram; Hondermarck, Hubert; Horvat, Jay; Nixon, Brett; Cartaxo, Rodrigo; Nazarian, Javad; Hulleman, Esther; Mueller, Sabine; Vitanza, Nicholas A.; Koschmann, Carl; Alonso, Marta M.; Carvalheiro, Tiago Ferreira; Van Der Lugt, Jasper; Dun, Matthew D. 分享 收藏
EGFR metabolically suppresses differentiation in H3K27M-mutant diffuse midline glioma EGFR代谢性地抑制H3K27M突变型中线弥漫性胶质瘤的分化。 Ji, Sunjong; Doherty, Robert; Mota, Mateus; Natarajan, Siva Kumar; de la Nava, Daniel; Sajjakulnukit, Peter; Peterson, Erik R.; Adam, Tiffany; Niculcea, Michael; Vo, Katie; Wink, Kelsey; Bavani, Subramaniam; Sridevi, Yadavilli; Nazarian, Javad; Phillips, Joanna J.; Mueller, Sabine; Filbin, Mariella; Solomon, David A.; Wahl, Daniel R.; Lyssiotis, Costas; Qin, Tingting; Beck, Alexander; Viswanath, Pavithra; Nuechterlein, Nicholas; Waszak, Sebastian M.; Venneti, Sriram; Koschmann, Carl 分享 收藏
PRECISION ONCOLOGY FOR HIGH-GRADE GLIOMAS: A TUMOR ORGANOID PLATFORM FOR RAPID, PATIENT-SPECIFIC DRUG SCREENING 高分级胶质瘤的精准肿瘤学：一种用于快速、患者特异性药物筛选的肿瘤类器官平台 Tripathy, Arushi; Ji, Sunjong; Alomary, Yazen; Raghunathan, Reka Chakravarthy; Syed, Safiulla; Ravikumar, Visweswaran; Shankar, Sunita; Serhan, Habib; Huang, Dah-Luen; Hara, Toshiro; Clarke, Nathan; Koschmann, Carl; Merrill, Nathan; Merajver, Sofia; Al-Holou, Wajd 分享 收藏
ZFTA-RELA ependymomas produce macrophage-associated itaconate as an oncometabolite to epigenetically sustain pathogenic fusion expression ZFTA-RELA室管膜瘤产生与巨噬细胞相关的衣康酸作为表观遗传学上维持致病融合表达的一种肿瘤代谢物。 Natarajan, Siva Kumar; Lum, Joanna; Haggerty-Skeans, James; Nenwani, Minal; Eyunni, Sanjana; Mota, Mateus; Bayliss, Jill; Deogharkar, Akash; Hamanishi, Erin; Hoffman, Simon; Young, Eleanor; Zhang, Qiuyang; Mehta, Rijul; Parolia, Abhijit; Sajjakulnukit, Peter; Doherty, Robert; Koschmann, Carl; Chinnaiyan, Arul; Lyssiotis, Costas; Nagrath, Deepak; Venneti, Sriram 分享 收藏
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Patient-derived tumor-oids recapitulate the tumor microenvironment and allow for pre-clinical drug screening across the entire spectrum of pediatric brain tumors 患者来源的类器官能够重现肿瘤微环境，并允许对整个谱系的儿童脑肿瘤进行临床前药物筛选。 Wink, Kelsey; Adam, Tiffany; Serhan, Habib; Beale, David R.; Beck, Maxwell; Wadden, Jack; Gehrand, Ashley; Prensner, John; Upadhyaya, Santhosh; Franson, Andrea; Chen, Kevin; Marupudi, Neena; Garton, Hugh; Magge, Suresh N.; Al-Holou, Wajd; Venneti, Sriram; Mody, Rajen; Chinnaiyan, Arul; Rood, Brian R.; Nazarian, Javad; Mueller, Sabine; Mitra, Siddhartha; Green, Adam L.; Kraya, Adam; Merrill, Nathan; Merajver, Sofia D.; Resnick, Adam; Koptyra, Mateus; Koschmann, Carl 分享 收藏
LEVETIRACETAM THERAPEUTICALLY TARGETS GABAERGIC SYNAPSES IN DIFFUSE MIDLINE GLIOMA 左乙拉西坦通过治疗作用靶向弥漫性中线胶质瘤中的GABA能突触 Barron, Tara; Yalcin, Belgin; Su, Minhui; Mochizuki, Aaron; Drexler, Richard; Cantor, Evan; Byun, Youkyeong Gloria; Gavish, Avishai; Shamardani, Kiarash; Xu, Haojun; Ni, Lijun; Soni, Neeraj; Tlais, Dana; Franson, Andrea; Lyons, Samantha; Mehta, Vilina; Kim, Yoon Seok; Taylor, Kathryn R.; Quezada, Michael A.; Keough, Michael B.; Jahan, Samin Malaki; Geraghty, Anna C.; Mancusi, Rebecca; Vo, Linh Thuy; Casteneda, Enrique Herrera; Woo, Pamelyn J.; Ricklefs, Franz L.; Schuller, Ulrich; Petritsch, Claudia K.; Vogel, Hannes; Fisher, Paul G.; Campen, Cynthia J.; Partap, Sonia; Kaila, Kai; Koschmann, Carl; Monje, Michelle 分享 收藏
DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS 阻断整合素信号传导损害H3K27M弥漫性中线胶质瘤的迁移、MYC驱动的嘌呤生物合成和干性。 Cartaxo, Rodrigo T.; De La Nava, Daniel; Nieblas-Bedolla, Edwin; Niculcea, Michael; Ji, Sunjong; Natarajan, Siva Kumar; Adam, Tiffany; Clausen, Madison; Miclea, Madeline; Siada, Ruby; Schwark, Kallen; Gera, Ananya; Doherty, Robert; Lyssiotis, Costas A.; Favro, Noemi; Covato, Carmelo; Brunschwig, Lucas; Waszak, Sebastian M.; Nuechterlein, Nicholas; Filbin, Mariella; Vo, Tuan; Dun, Matthew D.; Venneti, Sriram; Hara, Toshiro; Koschmann, Carl 分享 收藏
Effective targeting of EGFR-driven diffuse midline glioma with BLU5082, a novel brain-penetrant EGFR-targeting tyrosine kinase inhibitor (TKI) BLU5082是一种新型的能够穿透血脑屏障的EGFR靶向酪氨酸激酶抑制剂（TKI），可有效靶向EGFR驱动的中线弥漫性胶质瘤。 Doherty, Robert; Wink, Kelsey; Schwark, Kallen; Ji, Sunjong; Gera, Ananya; Messinger, Dana; de la Martin, Daniel Nava; Knowles, Truman; Subramaniam, Bavani; Millet, Yves; Waszak, Sebastian; Phillips, Joanna; Solomon, David; Nazarian, Javad; Mueller, Sabine; Beck, Alexander; Coppe, Jean-Phillipe; Koschmann, Carl 分享 收藏
THY1 Mediates Treatment Resistance in H3K7M Pediatric Tumors and is Therapeutically Targetable THY1 介导了 H3K7M 儿童肿瘤的治疗抵抗，并且是可进行治疗性靶向的。 Syed, Safiulla; Ji, Sunjong; Tripathy, Arushi; Alomary, Yazen; Chakravarthy, Reka; Mota, Mateus; Huang, Dah-Luen; Wang, Zhuwen; Li, Zian; Zhang, Qiang; de la Martin, Daniel Nava; Lawrence, Theodore; Wahl, Daniel; Koschmann, Carl; Venneti, Sriram; Rehemtulla, Alnawaz; Al-Holou, Wajd 分享 收藏
ATRX LOSS LEADS TO H3K4ME3-DRIVEN EPIGENETIC DYSREGULATION OF OLIGODENDROCYTE DIFFERENTIATION AND CELL CYCLE CONTROL IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMA (DMG) ATRX LOSS 导致 H3K4ME3 介导的少突胶质细胞分化及细胞周期调控的表观遗传失调，见于 H3K27M 突变的弥漫性中线胶质瘤 (DMG)。 Messinger, Dana; Patel, Jina; Doherty, Robert; De La Nava, Daniel; Clausen, Madison; Schwark, Kallen; Stanczak, Alina; Momen, Fareen; Kuchinski, Kennedy; Parsels, Leslie A.; Parsels, Joshua D.; Ji, Sunjong; Mota, Mateus; Venneti, Sriram; Zhang, Qiang; Morgan, Meredith; Qin, Tingting; Yadav, Viveka Nand; Koschmann, Carl 分享 收藏
Combinatorial targeting of avapritinib-driven MAPK activation in pediatric high-grade glioma 阿伐普利尼布诱导的MAPK激活在儿童高级别胶质瘤中的组合靶向治疗 Schwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Munoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppe, Jean-Philippe; Koschmann, Carl 分享 收藏
Tail ligation recombinase polymerase amplification sequencing (TLDRseq) enables sensitive, same-day, multi-gene sequencing for plasma-based detection and timely monitoring of brain tumor ctDNA 尾端连接重组酶聚合酶扩增测序（TLDRseq）能够实现对外周血浆中脑肿瘤细胞游离DNA（ctDNA）进行敏感、当天完成的多基因测序检测和及时监测。 Wadden, Jack; Aittaleb, Rayan; Adam, Tiffany; Jackson, Conner; John, Vishal; Lau, Benison; Calvert, Rebecca; Franson, Andrea; Mody, Rajen; Prensner, John; Upadhyaya, Santhosh; Koschmann, Carl 分享 收藏
Precision Targeting of PI3K/mTOR in Diffuse Midline Glioma: GCT007 as a Novel Brain-Penetrant PIK3CA Inhibitor 弥漫性中线胶质瘤中PI3K/mTOR的精确靶向：GCT007作为新型脑穿透性PIK3CA抑制剂 Jackson, Evangeline; Duchatel, Ryan; Vo, Tuan; Savary, Clara; Germon, Zacary; Riley, Madisen; McEwen, Holly; Persson, Mika; Findlay, Izac; Beitaki, Tyrone; Lally, Marissa; Douglas, Alicia; Rogers, M. Karen Newell; Fonkem, Ekokobe; Franson, Andrea; Kline, Cassie; Nazarian, Javad; Koschmann, Carl; Mueller, Sabine; Dun, Matthew 分享 收藏
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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis 异柠檬酸脱氢酶1为组3型髓母细胞瘤的铜死亡做准备 Derek Dang; Akash Deogharkar; John McKolay; Kyle S. Smith; Pooja Panwalkar; Simon Hoffman; Wentao Tian; Sunjong Ji; Ana P. Azambuja; Siva Kumar Natarajan; Joanna Lum; Jill Bayliss; Katie Manzeck; Stefan R. Sweha; Erin Hamanishi; Matthew Pun; Diya Patel; Sagar Rau; Olamide Animasahun; Abhinav Achreja; Martin P. Ogrodzinski; Jutta Diessl; Jennifer Cotter; Debra Hawes; Fusheng Yang; Robert Doherty; Andrea T. Franson; Allison R. Hanaford; Charles G. Eberhart; Eric H. Raabe; Brent A. Orr; Robert J. Wechsler-Reya; Brandon Chen; Costas A. Lyssiotis; Yatrik M. Shah; Sophia Y. Lunt; Ruma Banerjee; Alexander R. Judkins; John R. Prensner; Carl Koschmann; Sebastian M. Waszak; Deepak Nagrath; Marcos Simoes-Costa; Paul A. Northcott; Sriram Venneti 分享 收藏
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