Benoit G. Bruneau - Publications, H-index & Citations

Benoit G. Bruneau

Gladstone Institutes

77H指数

260论文数

2.6W被引数

收录论文 107

发表时间

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor 人类三维染色质对与心脏病相关转录因子的剂量依赖性敏感性

Science

IF45.8

2026-07-23

PREAI

Zoe L. Grant; Shuzhen Kuang; Shu Zhang; Abraham J. Horrillo; Zhe Chen; Kavitha S. Rao; Cemre Celen; Vasumathi Kameswaran; Carine Joubran; Pik Ki Lau; Keyi Dong; Bing Yang; Weronika M. Bartosik; Nathan R. Zemke; Bing Ren; Deepak Srivastava; Irfan S. Kathiriya; Katherine S. Pollard; Benoit G. Bruneau

Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease 降低TBX5剂量削弱了人房性心脏病模型中心房心肌细胞表型发育调控

Development

IF3.6

2026-01-01

PREAI

Kathiriya, Irfan S.; Rao, Kavitha S.; Clark, Alexander P.; Hu, Kevin M.; Grant, Zoe L.; Matthews, Megan N.; Chen, Zhe; Hota, Swetansu K.; Saucerman, Jeffrey J.; Bruneau, Benoit G.

A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects 受损的隔室边界是异常心脏构型及先天性心脏缺陷的基础

Nature Cardiovascular Research

IF10.8

2025-12-29

OAAI

Irfan S. Kathiriya; Martin H. Dominguez; Kavitha S. Rao; Jonathon M. Muncie-Vasic; W. Patrick Devine; Kevin M. Hu; Swetansu K. Hota; Bayardo I. Garay; Diego Quintero; Piyush Goyal; Megan N. Matthews; Reuben Thomas; Tatyana Sukonnik; Dario Miguel-Perez; Sarah Winchester; Emily F. Brower; André Forjaz; Pei-Hsun Wu; Denis Wirtz; Ashley L. Kiemen; Benoit G. Bruneau

MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis MEF2C调控引导心管形态发生的分段特异性基因调控网络

GENES & DEVELOPMENT

IF7.7

2025-12-01

PREAI

Muncie-Vasic, Jonathon M.; Sinha, Tanvi; Clark, Alexander P.; Brower, Emily F.; Saucerman, Jeffrey J.; Black, Brian L.; Bruneau, Benoit G.

Author Correction: Brahma safeguards canalization of cardiac mesoderm differentiation 作者更正: 梵文保护心脏中胚层分化的渠化

Nature

IF48.5

2025-11-18

OAAI

Swetansu K. Hota; Kavitha S. Rao; Andrew P. Blair; Ali Khalilimeybodi; Kevin M. Hu; Reuben Thomas; Kevin So; Vasumathi Kameswaran; Jiewei Xu; Benjamin J. Polacco; Ravi V. Desai; Nilanjana Chatterjee; Austin Hsu; Jonathon M. Muncie; Aaron M. Blotnick; Sarah A. B. Winchester; Leor S. Weinberger; Ruth Hüttenhain; Irfan S. Kathiriya; Nevan J. Krogan; Jeffrey J. Saucerman; Benoit G. Bruneau

Advancing the spatiotemporal atlas of the developing human heart 推进发育中人类心脏的时空图谱

Nature Genetics

IF29

2025-10-29

PREAI

Lisa K. Iwamoto-Stohl; Benoit G. Bruneau

Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis 模拟诱导多能干细胞中的SMAD2突变提供了对心血管疾病发病机理的见解

JOURNAL OF THE AMERICAN HEART ASSOCIATION

IF5.3

2025-03-04

PREAI

Ward, Tarsha; Morton, Sarah U.; Venturini, Gabriela; Tai, Warren; Jang, Min Young; Gorham, Joshua; Delaughter, Dan; Wasson, Lauren K.; Khazal, Zahra; Homsy, Jason; Gelb, Bruce D.; Chung, Wendy K.; Bruneau, Benoit G.; Brueckner, Martina; Tristani-Firouzi, Martin; Depalma, Steven R.; Seidman, Christine; Seidman, J. G.

Synthetic organizer cells guide development via spatial and biochemical instructions 合成组织者细胞通过空间和生化指令引导发育

CELL

IF42.5

2025-02-01

PREAI

Yamada, Toshimichi; Trentesaux, Coralie; Brunger, Jonathan M.; Xiao, Yini; Stevens, Adam J.; Martyn, Iain; Kasparek, Petr; Shroff, Neha P.; Aguilar, Angelica; Bruneau, Benoit G.; Boffelli, Dario; Klein, Ophir D.; Lim, Wendell A.

Antagonistic and Cooperative Dynamics of Irx3 and Irx4 in Ventricular Compaction

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Abid, Rimshah; Oh, Yena; Liu, Wei Fan; Bakr, Marwan; Yin, Wenchi; Zhou, Yu-Qing; Zhang, Xiaoyun; Kim, Riyoun; Mo, Rong; Puviindran, Vijitha; van Eede, Matthijs; Henkelman, Mark; Miquerol, Lucile; Bruneau, Benoit; Hui, Chi-Chung; Kim, Kyoung-Han

TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids

DEVELOPMENT

IF3.6

2024-03-28

OAAI

Bulger, Emily A.; Muncie-Vasic, Ivana; Libby, Ashley R. G.; McDevitt, Todd C.; Bruneau, Benoit G.

Spatial and temporal organization of the genome Current state and future aims of the 4D nucleome project

MOLECULAR CELL

IF16.6

2023-08-01

OAAI

Dekker, Job; Alber, Frank; Aufmkolk, Sarah; Beliveau, Brian J.; Bruneau, Benoit G.; Belmont, Andrew S.; Bintu, Lacramioara; Boettiger, Alistair; Calandrelli, Riccardo; Disteche, Christine M.; Gilbert, David M.; Gregor, Thomas; Hansen, Anders S.; Huang, Bo; Huangfu, Danwei; Kalhor, Reza; Leslie, Christina S.; Li, Wenbo; Li, Yun; Ma, Jian; Noble, William S.; Park, Peter J.; Phillips-Cremins, Jennifer E.; Pollard, Katherine S.; Rafelski, Susanne M.; Ren, Bing; Ruan, Yijun; Shav-Tal, Yaron; Shen, Yin; Shendure, Jay; Shu, Xiaokun; Strambio-De-Castillia, Caterina; Vertii, Anastassiia; Zhang, Huaiying; Zhong, Sheng

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors

DEVELOPMENT

IF3.6

2023-05-02

OAAI

Krup, Alexis Leigh; Winchester, Sarah A. B.; Ranade, Sanjeev S.; Agrawal, Ayushi; Devine, W. Patrick; Sinha, Tanvi; Choudhary, Krishna; Dominguez, Martin H.; Thomas, Reuben; Black, Brian L.; Srivastava, Deepak; Bruneau, Benoit G.

Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

156

OAAI

Bruneau, BG; Bao, ZZ; Fatkin, D; Xavier-Neto, J; Georgakopoulos, D; Maguire, CT; Berul, CI; Kass, DA; Kuroski-de Bold, ML; de Bold, AJ; Conner, DA; Rosenthal, N; Cepko, CL; Seidman, CE; Seidman, JG

The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Lebel, M; Agarwal, P; Cheng, CW; Kabir, MG; Chan, TY; Thanabalasingham, V; Zhang, XY; Cohen, DR; Husain, M; Cheng, SH; Bruneau, BG; Hui, CC

Connexin 40, a target of transcription factor Thx5, patterns wrist, digits, and sternum

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Pizard, A; Burgon, PG; Paul, DL; Bruneau, BG; Seidman, CE; Seidman, JG

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma

NATURE COMMUNICATIONS

IF15.7

2023-01-18

OAAI

Ferguson, L. Paige; Gatchalian, Jovylyn; McDermott, Matthew L.; Nakamura, Mari; Chambers, Kendall; Rajbhandari, Nirakar; Lytle, Nikki K.; Rosenthal, Sara Brin; Hamilton, Michael; Albini, Sonia; Wartenberg, Martin; Zlobec, Inti; Galvan, Jose A.; Karamitopoulou, Eva; Vavinskaya, Vera; Wascher, Alexis; Lowy, Andrew M.; Schuerch, Christian M.; Puri, Pier Lorenzo; Bruneau, Benoit G.; Hargreaves, Diana C.; Reya, Tannishtha

Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors

CIRCULATION

IF38.6

2022-09-06

OAAI

Zhu, Lili; Choudhary, Krishna; Gonzalez-Teran, Barbara; Ang, Yen-Sin; Thomas, Reuben; Stone, Nicole R.; Liu, Lei; Zhou, Ping; Zhu, Chenchen; Ruan, Hongmei; Huang, Yu; Jin, Shibo; Pelonero, Angelo; Koback, Frances; Padmanabhan, Arun; Sadagopan, Nandhini; Hsu, Austin; Costa, Mauro W.; Gifford, Casey A.; van Bemmel, Joke; Huttenhain, Ruth; Vedantham, Vasanth; Conklin, Bruce R.; Black, Brian L.; Bruneau, Benoit G.; Steinmetz, Lars; Krogan, Nevan J.; Pollard, Katherine S.; Srivastava, Deepak

Targeting transcription in heart failure via CDK7/12/13 inhibition 通过CDK7/12/13抑制靶向转录在心力衰竭中的作用

NATURE COMMUNICATIONS

IF15.7

2022-07-27

OAAI

Hsu, Austin; Duan, Qiming; Day, Daniel S.; Luo, Xin; McMahon, Sarah; Huang, Yu; Feldman, Zachary B.; Jiang, Zhen; Zhang, Tinghu; Liang, Yanke; Alexanian, Michael; Padmanabhan, Arun; Brown, Jonathan D.; Lin, Charles Y.; Gray, Nathanael S.; Young, Richard A.; Bruneau, Benoit G.; Haldar, Saptarsi M.

Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency

CIRCULATION RESEARCH

IF16.2

2021-04-16

OAAI

Ward, Tarsha; Tai, Warren; Morton, Sarah; Impens, Francis; Van Damme, Petra; Van Haver, Delphi; Timmerman, Evy; Venturini, Gabriela; Zhang, Kehan; Jang, Min Young; Willcox, Jon A. L.; Haghighi, Alireza; Gelb, Bruce D.; Chung, Wendy K.; Goldmuntz, Elizabeth; Porter, George A., Jr.; Lifton, Richard P.; Brueckner, Martina; Yost, H. Joseph; Bruneau, Benoit G.; Gorham, Joshua; Kim, Yuri; Pereira, Alexandre; Homsy, Jason; Benson, Craig C.; DePalma, Steven R.; Varland, Sylvia; Chen, Christopher S.; Arnesen, Thomas; Gevaert, Kris; Seidman, Christine; Seidman, J. G.

Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease

DEVELOPMENTAL CELL

IF8.7

2021-02-01

OAAI

Kathiriya, Irfan S.; Rao, Kavitha S.; Iacono, Giovanni; Devine, W. Patrick; Blair, Andrew P.; Hota, Swetansu K.; Lai, Michael H.; Garay, Bayardo, I; Thomas, Reuben; Gong, Henry Z.; Wasson, Lauren K.; Goyal, Piyush; Sukonnik, Tatyana; Hu, Kevin M.; Akgun, Gunes A.; Bernard, Laure D.; Akerberg, Brynn N.; Gu, Fei; Li, Kai; Speir, Matthew L.; Haeussler, Maximilian; Pu, William T.; Stuart, Joshua M.; Seidman, Christine E.; Seidman, J. G.; Heyn, Holger; Bruneau, Benoit G.

研究方向