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Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons CAG重复与亨廷顿基因敲除在干细胞来源皮层神经元中的交叉影响 Stocksdale, Jennifer T.; Leventhal, Matthew J.; Lam, Stephanie; Xu, Yu-Xin; Wang, Yang Oliver; Wang, Keona Q.; Thomas, Reuben; Faghihmonzavi, Zohreh; Raghav, Yogindra; Smith, Charlene; Wu, Jie; Miramontes, Ricardo; Sarda, Kanchan; Johnston, Heather; Shin, Min-Gyoung; Huang, Terry; Foster, Mikelle; Barch, Mariya; Amirani, Naufa; Paiz, Chris; Easter, Lindsay; Duderstadt, Erse; Vaibhav, Vineet; Sundararaman, Niveda; Felsenfeld, Dan P.; Vogt, Thomas F.; Van Eyk, Jennifer; Finkbeiner, Steve; Kaye, Julia A.; Thompson, Leslie M. 分享 收藏
A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA 与加速亨廷顿病进展相关的FAN1点突变改变了其PCNA介导的DNA组装。 Aretz, Jonas; Jeyasankar, Gayathri; Salerno-Kochan, Anna; Thomsen, Maren; Thieulin-Pardo, Gabriel; Haque, Tasir; Monteagudo, Edith; Felsenfeld, Dan; Finley, Michael; Vogt, Thomas F.; Boudet, Julien; Prasad, Brinda C. 分享 收藏
Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics Schmartz, Georges P.; Rehner, Jacqueline; Gund, Madline P.; Keller, Verena; Molano, Leidy-Alejandra G.; Rupf, Stefan; Hannig, Matthias; Berger, Tim; Flockerzi, Elias; Seitz, Berthold; Fleser, Sara; Schmitt-Grohe, Sabina; Kalefack, Sandra; Zemlin, Michael; Kunz, Michael; Goetzinger, Felix; Gevaerd, Caroline; Vogt, Thomas; Reichrath, Joerg; Diehl, Lisa; Hecksteden, Anne; Meyer, Tim; Herr, Christian; Gurevich, Alexey; Krug, Daniel; Hegemann, Julian; Bozhueyuek, Kenan; Gulder, Tobias A. M.; Fu, Chengzhang; Beemelmanns, Christine; Schattenberg, Joern M.; Kalinina, Olga V.; Becker, Anouck; Unger, Marcus; Ludwig, Nicole; Seibert, Martina; Stein, Marie-Louise; Hanna, Nikolas Loka; Martin, Marie-Christin; Mahfoud, Felix; Krawczyk, Marcin; Becker, Soeren L.; Mueller, Rolf; Bals, Robert; Keller, Andreas 分享 收藏
Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids Galimberti, Maura; Nucera, Maria R.; Bocchi, Vittoria D.; Conforti, Paola; Vezzoli, Elena; Cereda, Matteo; Maffezzini, Camilla; Iennaco, Raffaele; Scolz, Andrea; Falqui, Andrea; Cordiglieri, Chiara; Cremona, Martina; Espuny-Camacho, Ira; Faedo, Andrea; Felsenfeld, Dan P.; Vogt, Thomas F.; Ranzani, Valeria; Zuccato, Chiara; Besusso, Dario; Cattaneo, Elena 分享 收藏
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Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation Bragg, Robert M.; Coffey, Sydney R.; Cantle, Jeffrey P.; Hu, Shikai; Singh, Sucha; Legg, Samuel R. W.; Mchugh, Cassandra A.; Toor, Amreen; Zeitlin, Scott; Kwak, Seung; Howland, David; Vogt, Thomas F.; Monga, Satdarshan P.; Carroll, Jeffrey B. 分享 收藏
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Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures Wang, Nan; Langfelder, Peter; Stricos, Matthew; Ramanathan, Lalini; Richman, Jeffrey B.; Vaca, Raymond; Plascencia, Mary; Gu, Xiaofeng; Zhang, Shasha; Tamai, T. Katherine; Zhang, Liguo; Gao, Fuying; Ouk, Koliane; Lu, Xiang; Ivanov, Leonid, V; Vogt, Thomas F.; Lu, Qing Richard; Morton, A. Jennifer; Colwell, Christopher S.; Aaronson, Jeffrey S.; Rosinski, Jim; Horvath, Steve; Yang, X. William 分享 收藏
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology 开发HDAC4-Selective蛋白降解剂以研究HDAC4在亨廷顿病病理学中的作用 Macabuag, Natsuko; Esmieu, William; Breccia, Perla; Jarvis, Rebecca; Blackaby, Wesley; Lazari, Ovadia; Urbonas, Liudvikas; Eznarriaga, Maria; Williams, Rachel; Strijbosch, Annelieke; Van de Bospoort, Rhea; Matthews, Kim; Clissold, Cole; Ladduwahetty, Tammy; Vater, Huw; Heaphy, Patrick; Stafford, Douglas G.; Wang, Hong -Jun; Mangette, John E.; McAllister, George; Beaumont, Vahri; Vogt, Thomas F.; Wilkinson, Hilary A.; Doherty, Elizabeth M.; Dominguez, Celia 分享 收藏
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The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities Iennaco, Raffaele; Formenti, Giulio; Trovesi, Camilla; Rossi, Riccardo Lorenzo; Zuccato, Chiara; Lischetti, Tiziana; Bocchi, Vittoria Dickinson; Scolz, Andrea; Martinez-Labarga, Cristina; Rickards, Olga; Pacifico, Michela; Crottini, Angelica; Moller, Anders Pape; Chen, Richard Zhenghuan; Vogt, Thomas Francis; Pavesi, Giulio; Horner, David Stephen; Saino, Nicola; Cattaneo, Elena 分享 收藏
PRECISE MACHINE-LEARNING SUGGESTS THAT NEURONAL DEATH IN HD IS MAINLY DRIVEN BY THE LOSS OF HOMEOSTATIC RESPONSES Megret, Lucile; Gris, Barbara; Nair, Satish Sasidharan; Cevost, Jasmin; Wertz, Mary; Aaronson, Jeff; Rosinski, Jim; Vogt, Thomas; Wilkinson, Hilary; Heiman, Myriam; Neri, Christian 分享 收藏
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Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin Megret, Lucile; Gris, Barbara; Nair, Satish Sasidharan; Cevost, Jasmin; Wertz, Mary; Aaronson, Jeff; Rosinski, Jim; Vogt, Thomas F.; Wilkinson, Hilary; Heiman, Myriam; Neri, Christian 分享 收藏
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DNA methylation study of Huntington's disease and motor progression in patients and in animal models Lu, Ake T.; Narayan, Pritika; Grant, Matthew J.; Langfelder, Peter; Wang, Nan; Kwak, Seung; Wilkinson, Hilary; Chen, Richard Z.; Chen, Jian; Bawden, C. Simon; Rudiger, Skye R.; Ciosi, Marc; Chatzi, Afroditi; Maxwell, Alastair; Hore, Timothy A.; Aaronson, Jeff; Rosinski, Jim; Preiss, Alicia; Vogt, Thomas F.; Coppola, Giovanni; Monckton, Darren; Snell, Russell G.; Yang, X. William; Horvath, Steve 分享 收藏
Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation Lee, Hyeseung; Fenster, Robert J.; Pineda, S. Sebastian; Gibbs, Whitney S.; Mohammadi, Shahin; Davila-Velderrain, Jose; Garcia, Francisco J.; Therrien, Martine; Novis, Hailey S.; Gao, Fan; Wilkinson, Hilary; Vogt, Thomas; Kellis, Manolis; LaVoie, Matthew J.; Heiman, Myriam 分享 收藏
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