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Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function 抑制PI3K-AKT-MTORC1轴通过促进线粒体吞噬和改善线粒体功能来减轻m.3243A>G mtDNA突变的负担 Chung, Chih-Yao; Singh, Kritarth; Sheshadri, Preethi; Valdebenito, Gabriel E.; Chacko, Anitta R.; Besada, Maria Alicia Costa; Liang, Xiao Fei; Kabir, Lida; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Duchen, Michael R. 分享 收藏
Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration Pingitore, Valeria; Pancholi, Jessica; Hornsby, Thomas W.; Warne, Justin; Pryce, Gareth; Mccormick, Laura J.; Hill, Julia; Bhosale, Gauri; Peng, Jing; Newton, Lydia S.; Towers, Greg J.; Coles, Simon J.; Chan, Ah Wing Edith; Duchen, Michael R.; Szabadkai, Gyorgy; Baker, David; Selwood, David L. 分享 收藏
Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer Menegollo, Michela; Bentham, Robert B.; Henriques, Tiago; Ng, Seow Q.; Ren, Ziyu; Esculier, Clarinde; Agarwal, Sia; Tong, Emily T. Y.; Lo, Clement; Ilangovan, Sanjana; Szabadkai, Zorka; Suman, Matteo; Patani, Neill; Ghanate, Avinash; Bryson, Kevin; Stein, Robert C.; Yuneva, Mariia; Szabadkai, Gyorgy 分享 收藏
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Apoptotic cell death in disease-Current understanding of the NCCD 2023 疾病中的凋亡细胞死亡-对NCCD 2023的当前理解 Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Aqeilan, Rami, I; Arama, Eli; Baehrecke, Eric H.; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A.; Bartek, Jiri; Bazan, Nicolas G.; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu J. M.; Bianchi, Marco E.; Blagosklonny, Mikhail V.; Blander, J. Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D.; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A.; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Ciliberto, Gennaro; Conrad, Marcus; Cubillos-Ruiz, Juan R.; Czabotar, Peter E.; D'Angiolella, Vincenzo; Daugaard, Mads; Dawson, Ted M.; Dawson, Valina L.; De Maria, Ruggero; De Strooper, Bart; Debatin, Klaus-Michael; Deberardinis, Ralph J.; Degterev, Alexei; Del Sal, Giannino; Deshmukh, Mohanish; Di Virgilio, Francesco; Diederich, Marc; Dixon, Scott J.; Dynlacht, Brian D.; El-Deiry, Wafik S.; Elrod, John W.; Engeland, Kurt; Fimia, Gian Maria; Galassi, Claudia; Ganini, Carlo; Garcia-Saez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Gerlic, Motti; Ghosh, Sourav; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Haecker, Georg; Hajnoczky, Gyorgy; Hardwick, J. Marie; Haupt, Ygal; He, Sudan; Heery, David M.; Hengartner, Michael O.; Hetz, Claudio; Hildeman, David A.; Ichijo, Hidenori; Inoue, Satoshi; Jaeaettelae, Marja; Janic, Ana; Joseph, Bertrand; Jost, Philipp J.; Kanneganti, Thirumala-Devi; Karin, Michael; Kashkar, Hamid; Kaufmann, Thomas; Kelly, Gemma L.; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Kluck, Ruth; Krysko, Dmitri, V; Kulms, Dagmar; Kumar, Sharad; Lavandero, Sergio; Lavrik, Inna N.; Lemasters, John J.; Liccardi, Gianmaria; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; Lopez-Otin, Carlos; Luedde, Tom; MacFarlane, Marion; Madeo, Frank; Malorni, Walter; Manic, Gwenola; Mantovani, Roberto; Marchi, Saverio; Marine, Jean-Christophe; Martin, Seamus J.; Martinou, Jean-Claude; Mastroberardino, Pier G.; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Gerry; Melino, Sonia; Miao, Edward A.; Moll, Ute M.; Munoz-Pinedo, Cristina; Murphy, Daniel J.; Niklison-Chirou, Maria Victoria; Novelli, Flavia; Nunez, Gabriel; Oberst, Andrew; Ofengeim, Dimitry; Opferman, Joseph T.; Oren, Moshe; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pentimalli, Francesca; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Pinton, Paolo; Porta, Giovanni; Prehn, Jochen H. M.; Puthalakath, Hamsa; Rabinovich, Gabriel A.; Rajalingam, Krishnaraj; Ravichandran, Kodi S.; Rehm, Markus; Ricci, Jean-Ehrland; Rizzuto, Rosario; Robinson, Nirmal; Rodrigues, Cecilia M. P.; Rotblat, Barak; Rothlin, Carla, V; Rubinsztein, David C.; Rudel, Thomas; Rufini, Alessandro; Ryan, Kevin M.; Sarosiek, Kristopher A.; Sawa, Akira; Sayan, Emre; Schroder, Kate; Scorrano, Luca; Sesti, Federico; Shao, Feng; Shi, Yufang; Sica, Giuseppe S.; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stephanou, Anastasis; Stockwell, Brent R.; Strapazzon, Flavie; Strasser, Andreas; Sun, Liming; Sun, Erwei; Sun, Qiang; Szabadkai, Gyorgy; Tait, Stephen W. G.; Tang, Daolin; Tavernarakis, Nektarios; Troy, Carol M.; Turk, Boris; Urbano, Nicoletta; Vandenabeele, Peter; Vanden Berghe, Tom; Vander Heiden, Matthew G.; Vanderluit, Jacqueline L.; Verkhratsky, Alexei; Villunger, Andreas; von Karstedt, Silvia; Voss, Anne K.; Vousden, Karen H.; Vucic, Domagoj; Vuri, Daniela; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ruoning; Wang, Ying; Weber, Achim; Wood, Will; Yamazaki, Takahiro; Yang, Huang-Tian; Zakeri, Zahra; Zawacka-Pankau, Joanna E.; Zhang, Lin; Zhang, Haibing; Zhivotovsky, Boris; Zhou, Wenzhao; Piacentini, Mauro; Kroemer, Guido; Galluzzi, Lorenzo 分享 收藏
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Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation PI3K-Akt-mTORC1途径的组成型激活维持m.3243 A > G mtDNA突变 Chung, Chih-Yao; Singh, Kritarth; Kotiadis, Vassilios N.; Valdebenito, Gabriel E.; Ahn, Jee Hwan; Topley, Emilie; Tan, Joycelyn; Andrews, William D.; Bilanges, Benoit; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Yuneva, Mariia; Duchen, Michael R. 分享 收藏
VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function (vol 8, 388, 2018) Briston, Thomas; Stephen, Jenna M.; Thomas, Luke W.; Esposito, Cinzia; Chung, Yuen-Li; Syafruddin, Saiful E.; Turmaine, Mark; Maddalena, Lucas A.; Greef, Basma; Szabadkai, Gyorgy; Maxwell, Patrick H.; Vanharanta, Sakari; Ashcroft, Margaret 分享 收藏
Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter FDA批准的线粒体钙单向转运体的正负调节剂的鉴定和功能验证 De Mario, Agnese; Tosatto, Anna; Hill, Julia Marie; Kriston-Vizi, Janos; Ketteler, Robin; Reane, Denis Vecellio; Cortopassi, Gino; Szabadkai, Gyorgy; Rizzuto, Rosario; Mammucari, Cristina 分享 收藏
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response Desai, Radha; East, Daniel A.; Hardy, Liana; Faccenda, Danilo; Rigon, Manuel; Crosby, James; Alvarez, Maria Soledad; Singh, Aarti; Mainenti, Marta; Hussey, Laura Kuhlman; Bentham, Robert; Szabadkai, Gyorgy; Zappulli, Valentina; Dhoot, Gurtej K.; Romano, Lisa E.; Xia, Dong; Coppens, Isabelle; Hamacher-Brady, Anne; Chapple, J. Paul; Abeti, Rosella; Fleck, Roland A.; Vizcay-Barrena, Gema; Smith, Kenneth; Campanella, Michelangelo 分享 收藏
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism Xu, Ruoyan; Jones, William; Wilcz-Villega, Ewa; Costa, Ana S. H.; Rajeeve, Vinothini; Bentham, Robert B.; Bryson, Kevin; Nagano, Ai; Yaman, Busra; Barasa, Sheila Olendo; Wang, Yewei; Chelala, Claude; Cutillas, Pedro; Szabadkai, Gyorgy; Frezza, Christian; Bianchi, Katiuscia 分享 收藏
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Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload (vol 17, pg 315, 2020) Plotegher, Nicoletta; Perocheau, Dany; Ferrazza, Ruggero; Massaro, Giulia; Bhosale, Gauri; Zambon, Federico; Rahim, Ahad A.; Guella, Graziano; Waddington, Simon N.; Szabadkai, Gyorgy; Duchen, Michael R. 分享 收藏
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway Wilcz-Villega, Ewa; Carter, Edward; Ironside, Alastair; Xu, Ruoyan; Mataloni, Isabella; Holdsworth, Julie; Jones, William; Bejar, Rocio Moreno; Uhlik, Lukas; Bentham, Robert B.; Godinho, Susana A.; Dalli, Jesmond; Grose, Richard; Szabadkai, Gyorgy; Jones, Louise; Hodivala-Dilke, Kairbaan; Bianchi, Katiuscia 分享 收藏
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Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload Plotegher, Nicoletta; Perocheau, Dany; Ferrazza, Ruggero; Massaro, Giulia; Bhosale, Gauri; Zambon, Federico; Rahim, Ahad A.; Guella, Graziano; Waddington, Simon N.; Szabadkai, Gyorgy; Duchen, Michael R. 分享 收藏
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